{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:15:06Z","timestamp":1791918906063,"version":"4.3.4"},"reference-count":380,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["1191874"],"award-info":[{"award-number":["1191874"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Mitochondria are vital organelles in eukaryotic cells that control diverse physiological processes related to energy production, calcium homeostasis, the generation of reactive oxygen species, and cell death. Several studies have demonstrated that structural and functional mitochondrial disturbances are involved in the development of different neuroinflammatory (NI) and neurodegenerative (ND) diseases (NI&amp;NDDs) such as multiple sclerosis, Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and amyotrophic lateral sclerosis. Remarkably, counteracting mitochondrial impairment by genetic or pharmacologic treatment ameliorates neurodegeneration and clinical disability in animal models of these diseases. Therefore, the development of nanosystems enabling the sustained and selective delivery of mitochondria-targeted drugs is a novel and effective strategy to tackle NI&amp;NDDs. In this review, we outline the impact of mitochondrial dysfunction associated with unbalanced mitochondrial dynamics, altered mitophagy, oxidative stress, energy deficit, and proteinopathies in NI&amp;NDDs. In addition, we review different strategies for selective mitochondria-specific ligand targeting and discuss novel nanomaterials, nanozymes, and drug-loaded nanosystems developed to repair mitochondrial function and their therapeutic benefits protecting against oxidative stress, restoring cell energy production, preventing cell death, inhibiting protein aggregates, and improving motor and cognitive disability in cellular and animal models of different NI&amp;NDDs.<\/jats:p>","DOI":"10.3390\/pharmaceutics13122055","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T02:40:02Z","timestamp":1638412802000},"page":"2055","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Nanotechnology-Based Drug Delivery Strategies to Repair the Mitochondrial Function in Neuroinflammatory and Neurodegenerative Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Luis F.","family":"Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Immunology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3122-2338","authenticated-orcid":false,"given":"Lorenzo E.","family":"Bevilacqua","sequence":"additional","affiliation":[{"name":"Immunology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Naves","sequence":"additional","affiliation":[{"name":"Immunology Program, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/CIRCRESAHA.119.316306","article-title":"Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death","volume":"126","author":"Bauer","year":"2020","journal-title":"Circ. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature12985","article-title":"Mitochondrial Form and Function","volume":"505","author":"Friedman","year":"2014","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, Oxidants, and Aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1056\/NEJMra1215233","article-title":"Mitochondrial Dynamics\u2014Mitochondrial Fission and Fusion in Human Diseases","volume":"369","author":"Archer","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan","year":"2020","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/EBC20170104","article-title":"Mitochondrial Dynamics: Overview of Molecular Mechanisms","volume":"62","author":"Tilokani","year":"2018","journal-title":"Essays Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fncel.2020.00138","article-title":"Abnormal Mitochondrial Quality Control in Neurodegenerative Diseases","volume":"14","author":"Yan","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mito.2018.11.002","article-title":"Mitochondrial Dynamics, a Key Executioner in Neurodegenerative Diseases","volume":"47","author":"Panchal","year":"2019","journal-title":"Mitochondrion"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrn3820","article-title":"Polyunsaturated Fatty Acids and Their Metabolites in Brain Function and Disease","volume":"15","author":"Bazinet","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.redox.2018.01.008","article-title":"13 Reasons Why the Brain Is Susceptible To Oxidative Stress","volume":"15","author":"Cobley","year":"2018","journal-title":"Redox Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1093\/brain\/awx258","article-title":"PINK1 Signalling Rescues Amyloid Pathology and Mitochondrial Dysfunction in Alzheimer\u2019s Disease","volume":"140","author":"Du","year":"2017","journal-title":"Brain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1617","DOI":"10.1038\/cddis.2014.581","article-title":"PINK1-Induced Mitophagy Promotes Neuroprotection in Huntington\u2019s Disease","volume":"6","author":"Khalil","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","article-title":"Mitophagy Inhibits Amyloid-\u03b2 and Tau Pathology and Reverses Cognitive Deficits in Models of Alzheimer\u2019s Disease","volume":"22","author":"Fang","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e61798","DOI":"10.7554\/eLife.61798","article-title":"Enhancing Mitochondrial Activity in Neurons Protects against Neurodegeneration in a Mouse Model of Multiple Sclerosis","volume":"10","author":"Rosenkranz","year":"2021","journal-title":"eLife"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.irn.2020.02.008","article-title":"Enhancing mitophagy as a therapeutic approach for neurodegenerative diseases","volume":"Volume 155","author":"Esterline","year":"2020","journal-title":"Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Treating Neurodegenerative Diseases as Metabolic Diseases"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"113620","DOI":"10.1016\/j.expneurol.2021.113620","article-title":"Impairment of Mitochondrial Oxidative Phosphorylation in Skin Fibroblasts of SALS and FALS Patients Is Rescued by in Vitro Treatment with ROS Scavengers","volume":"339","author":"Miller","year":"2021","journal-title":"Exp. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/med.21635","article-title":"The Mitochondrial Permeability Transition Pore in Cell Death: A Promising Drug Binding Bioarchitecture","volume":"40","author":"Nesci","year":"2020","journal-title":"Med. Res. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49812","DOI":"10.1074\/jbc.M304748200","article-title":"The Voltage-Dependent Anion Channel Is the Target for a New Class of Inhibitors of the Mitochondrial Permeability Transition Pore","volume":"278","author":"Cesura","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gammage, P.A., and Frezza, C. (2019). Mitochondrial DNA: The Overlooked Oncogenome?. BMC Biol., 17.","DOI":"10.1186\/s12915-019-0668-y"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ymgme.2020.09.009","article-title":"The Genetic Basis of Isolated Mitochondrial Complex II Deficiency","volume":"131","author":"Fullerton","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-7831-1_1","article-title":"Overview of Mitochondrial Bioenergetics","volume":"1782","author":"Madeira","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/bit.25492","article-title":"Oxidative Phosphorylation Revisited","volume":"112","author":"Nath","year":"2015","journal-title":"Biotechnol. Bioeng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.freeradbiomed.2016.04.001","article-title":"Mitochondrial Generation of Superoxide and Hydrogen Peroxide as the Source of Mitochondrial Redox Signaling","volume":"100","author":"Brand","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_24","first-page":"1490","article-title":"Mitochondrial Production of Reactive Oxygen Species","volume":"78","author":"Grivennikova","year":"2013","journal-title":"Biochemistry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20081386","article-title":"How Mitochondria Produce Reactive Oxygen Species","volume":"417","author":"Murphy","year":"2009","journal-title":"Biochem. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.bbabio.2012.12.002","article-title":"Superoxide Generation by Complex III: From Mechanistic Rationales to Functional Consequences","volume":"1827","author":"Bleier","year":"2013","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fnagi.2021.617588","article-title":"Mitochondrial Dysfunction and Oxidative Stress in Alzheimer\u2019s Disease","volume":"13","author":"Misrani","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Woo, J., Cho, H., Seol, Y., Kim, S.H., Park, C., Yousefian-Jazi, A., Hyeon, S.J., Lee, J., and Ryu, H. (2021). Power Failure of Mitochondria and Oxidative Stress in Neurodegeneration and Its Computational Models. Antioxidants, 10.","DOI":"10.3390\/antiox10020229"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1161\/CIRCRESAHA.118.310082","article-title":"Calcium Signaling and Reactive Oxygen Species in Mitochondria","volume":"122","author":"Bertero","year":"2018","journal-title":"Circ. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"C817","DOI":"10.1152\/ajpcell.00139.2004","article-title":"Calcium, ATP, and ROS: A Mitochondrial Love-Hate Triangle","volume":"287","author":"Brookes","year":"2004","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E8844","DOI":"10.1073\/pnas.1721136115","article-title":"Altered ER-Mitochondria Contact Impacts Mitochondria Calcium Homeostasis and Contributes to Neurodegeneration in Vivo in Disease Models","volume":"115","author":"Lee","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Fan, Y., and Simmen, T. (2019). Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism. Cells, 8.","DOI":"10.3390\/cells8091071"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1\u03b1","volume":"280","author":"Nemoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK Regulates Energy Expenditure by Modulating NAD + Metabolism and SIRT1 Activity","volume":"458","author":"Feige","year":"2009","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/jnr.24042","article-title":"Mitochondrial Biogenesis in Neurodegeneration","volume":"95","author":"Li","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1007\/s11064-018-02711-2","article-title":"Nrf2\/ARE Pathway as a Therapeutic Target for the Treatment of Parkinson Diseases","volume":"44","author":"Gureev","year":"2019","journal-title":"Neurochem. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"113247","DOI":"10.1016\/j.expneurol.2020.113247","article-title":"Transcriptional Activation of Antioxidant Gene Expression by Nrf2 Protects against Mitochondrial Dysfunction and Neuronal Death Associated with Acute and Chronic Neurodegeneration","volume":"328","author":"Goodfellow","year":"2020","journal-title":"Exp. Neurol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"111212","DOI":"10.1016\/j.mad.2020.111212","article-title":"Mitochondrial Fission and Fusion: A Dynamic Role in Aging and Potential Target for Age-Related Disease","volume":"186","author":"Liu","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2015.10.011","article-title":"Mitochondrial Fusion\/Fission Dynamics in Neurodegeneration and Neuronal Plasticity","volume":"90","author":"Bertholet","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tcb.2020.09.008","article-title":"Mitochondrial Fusion: The Machineries In and Out","volume":"31","author":"Gao","year":"2021","journal-title":"Trends Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.4161\/auto.25804","article-title":"Mitochondrial Fission Facilitates Mitophagy in Saccharomyces Cerevisiae","volume":"9","author":"Mao","year":"2013","journal-title":"Autophagy"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and Neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jmb.2019.06.032","article-title":"Outstanding Questions in Mitophagy: What We Do and Do Not Know","volume":"432","author":"Ganley","year":"2020","journal-title":"J. Mol. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neures.2020.01.006","article-title":"The PINK1\u2013Parkin Axis: An Overview","volume":"159","author":"Tanaka","year":"2020","journal-title":"Neurosci. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s40478-020-01062-w","article-title":"PINK1\/PARKIN Signalling in Neurodegeneration and Neuroinflammation","volume":"8","author":"Quinn","year":"2020","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41419-021-03913-3","article-title":"Mitochondrial Ca2+ Oscillation Induces Mitophagy Initiation through the PINK1-Parkin Pathway","volume":"12","author":"Yu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The Ubiquitin Kinase PINK1 Recruits Autophagy Receptors to Induce Mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1523\/JNEUROSCI.1836-13.2013","article-title":"Mitochondrial Alterations near Amyloid Plaques in an Alzheimer\u2019s Disease Mouse Model","volume":"33","author":"Xie","year":"2013","journal-title":"J. Neurosci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-319-71779-1_3","article-title":"Mitochondrial dysfunction in huntington\u2019s disease","volume":"Volume 1049","year":"2018","journal-title":"Polyglutamine Disorders"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104741","DOI":"10.1016\/j.nbd.2020.104741","article-title":"Mitochondrial Fission in Huntington\u2019s Disease Mouse Striatum Disrupts ER-Mitochondria Contacts Leading to Disturbances in Ca2+ Efflux and Reactive Oxygen Species (ROS) Homeostasis","volume":"136","author":"Cherubini","year":"2020","journal-title":"Neurobiol. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/ene.13413","article-title":"Huntington\u2019s Disease: A Clinical Review","volume":"25","author":"McColgan","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/ana.22109","article-title":"Mitochondrial DNA Deletions and Neurodegeneration in Multiple Sclerosis","volume":"69","author":"Campbell","year":"2011","journal-title":"Ann. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"654284","DOI":"10.1007\/s11910-021-01110-5","article-title":"Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis: Pathogenesis and Therapeutic Implications","volume":"21","author":"Simkins","year":"2021","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yu, X., Koczan, D., Sulonen, A.M., Akkad, D.A., Kroner, A., Comabella, M., Costa, G., Corongiu, D., Goertsches, R., and Camina-Tato, M. (2008). MtDNA Nt13708A Variant Increases the Risk of Multiple Sclerosis. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0001530"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s13760-016-0675-5","article-title":"MtDNA T4216C Variation in Multiple Sclerosis: A Systematic Review and Meta-Analysis","volume":"116","author":"Andalib","year":"2016","journal-title":"Acta Neurol. Belg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"13548","DOI":"10.1038\/ncomms13548","article-title":"Defective Mitochondrial DNA Homeostasis in the Substantia Nigra in Parkinson Disease","volume":"7","author":"Nido","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3389\/fnins.2019.00938","article-title":"Impairment of Mitochondrial Redox Status in Peripheral Lymphocytes of Multiple Sclerosis Patients","volume":"13","author":"Gonzalo","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial Bioenergetic Deficit Precedes Alzheimer\u2019s Pathology in Female Mouse Model of Alzheimer\u2019s Disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","article-title":"A Role of Mitochondrial Complex II Defects in Genetic Models of Huntington\u2019s Disease Expressing N-Terminal Fragments of Mutant Huntingtin","volume":"22","author":"Damiano","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Obrador, E., Salvador-Palmer, R., L\u00f3pez-Blanch, R., Jihad-Jebbar, A., Vall\u00e9s, S.L., and Estrela, J.M. (2021). The Link between Oxidative Stress, Redox Status, Bioenergetics and Mitochondria in the Pathophysiology of ALS. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126352"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"636-649.e18","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 Triggers Mitochondrial DNA Release via MPTP to Activate CGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1007\/s12035-018-1335-y","article-title":"Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis","volume":"56","author":"Pinto","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1471-4159.2004.02918.x","article-title":"Cytochrome c Release from Rat Brain Mitochondria Is Proportional to the Mitochondrial Functional Deficit: Implications for Apoptosis and Neurodegenerative Disease","volume":"92","author":"Clayton","year":"2005","journal-title":"J. Neurochem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"33249","DOI":"10.1038\/srep33249","article-title":"Mitochondrial Dysfunction Is an Important Cause of Neurological Deficits in an Inflammatory Model of Multiple Sclerosis","volume":"6","author":"Sadeghian","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.neuron.2014.11.006","article-title":"Pervasive Axonal Transport Deficits in Multiple Sclerosis Models","volume":"84","author":"Sorbara","year":"2014","journal-title":"Neuron"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00401-020-02179-x","article-title":"Enhanced Axonal Response of Mitochondria to Demyelination Offers Neuroprotection: Implications for Multiple Sclerosis","volume":"140","author":"Campbell","year":"2020","journal-title":"Acta Neuropathol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3389\/fphar.2020.00709","article-title":"Changes in PGC-1\u03b1\/SIRT1 Signaling Impact on Mitochondrial Homeostasis in Amyloid-Beta Peptide Toxicity Model","volume":"11","author":"Panes","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13041-020-00727-w","article-title":"Increased O-GlcNAcylation of Drp1 by Amyloid-Beta Promotes Mitochondrial Fission and Dysfunction in Neuronal Cells","volume":"14","author":"Park","year":"2021","journal-title":"Mol. Brain"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e99360","DOI":"10.15252\/embj.201899360","article-title":"Disease-associated Tau Impairs Mitophagy by Inhibiting Parkin Translocation to Mitochondria","volume":"38","author":"Cummins","year":"2019","journal-title":"EMBO J."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Szabo, L., Eckert, A., and Grimm, A. (2020). Insights into Disease-Associated Tau Impact on Mitochondria. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21176344"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13024-019-0349-x","article-title":"Alpha-Synuclein-Induced Mitochondrial Dysfunction Is Mediated via a Sirtuin 3-Dependent Pathway","volume":"15","author":"Park","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e1820","DOI":"10.1038\/cddis.2015.166","article-title":"Aggregated \u03b1-Synuclein and Complex I Deficiency: Exploration of Their Relationship in Differentiated Neurons","volume":"6","author":"Reeve","year":"2015","journal-title":"Cell Death Dis."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/s41467-018-04422-2","article-title":"\u03b1-Synuclein Oligomers Interact with ATP Synthase and Open the Permeability Transition Pore in Parkinson\u2019s Disease","volume":"9","author":"Ludtmann","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm.4130","article-title":"The Inhibition of TDP-43 Mitochondrial Localization Blocks Its Neuronal Toxicity","volume":"22","author":"Wang","year":"2016","journal-title":"Nat. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"165580","DOI":"10.1016\/j.bbadis.2019.165580","article-title":"TDP-43 Inhibitory Peptide Alleviates Neurodegeneration and Memory Loss in an APP Transgenic Mouse Model for Alzheimer\u2019s Disease","volume":"1866","author":"Gao","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1523\/JNEUROSCI.4385-04.2005","article-title":"Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice","volume":"25","author":"Vijayvergiya","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"RC215","DOI":"10.1523\/JNEUROSCI.22-06-j0001.2002","article-title":"Mutant Cu, Zn Superoxide Dismutase That Causes Motoneuron Degeneration Is Present in Mitochondria in the CNS","volume":"22","author":"Higgins","year":"2002","journal-title":"J. Neurosci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1080\/15548627.2020.1728096","article-title":"Mutant HTT (Huntingtin) Impairs Mitophagy in a Cellular Model of Huntington Disease","volume":"17","author":"Montpeyo","year":"2021","journal-title":"Autophagy"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1093\/hmg\/ddr475","article-title":"Mutant Huntingtin\u2019s Interaction with Mitochondrial Protein Drp1 Impairs Mitochondrial Biogenesis and Causes Defective Axonal Transport and Synaptic Degeneration in Huntington\u2019s Disease","volume":"21","author":"Shirendeb","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"a024091","DOI":"10.1101\/cshperspect.a024091","article-title":"Cell Biology and Pathophysiology of \u03b1-Synuclein","volume":"8","author":"Sharma","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"690293","DOI":"10.3389\/fnagi.2021.690293","article-title":"Alpha-Synuclein Post-Translational Modifications: Implications for Pathogenesis of Lewy Body Disorders","volume":"13","author":"Manzanza","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00401-017-1704-z","article-title":"\u03b1-Synuclein Binds to the ER\u2013Mitochondria Tethering Protein VAPB to Disrupt Ca2+ Homeostasis and Mitochondrial ATP Production","volume":"134","author":"Paillusson","year":"2017","journal-title":"Acta Neuropathol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000354382","article-title":"SIRT3: As Simple as It Seems?","volume":"60","author":"Lombard","year":"2014","journal-title":"Gerontology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s12035-016-9717-5","article-title":"Pramipexole, a Dopamine D2\/D3 Receptor-Preferring Agonist, Prevents Experimental Autoimmune Encephalomyelitis Development in Mice","volume":"54","author":"Lieberknecht","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.mcn.2006.01.007","article-title":"Upregulation of \u03b1-Synuclein in Neurons and Glia in Inflammatory Demyelinating Disease","volume":"31","author":"Papadopoulos","year":"2006","journal-title":"Mol. Cell. Neurosci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1471-4159.2012.07749.x","article-title":"Cerebrospinal Fluid \u03b1-Synuclein Levels Are Elevated in Multiple Sclerosis and Neuromyelitis Optica Patients during Replase","volume":"122","author":"Wang","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s12264-018-0249-z","article-title":"Clinical Research on Alzheimer\u2019s Disease: Progress and Perspectives","volume":"34","author":"Sun","year":"2018","journal-title":"Neurosci. Bull."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1111\/febs.15225","article-title":"Amyloid Protein Aggregates: New Clients for Mitochondrial Energy Production in the Brain?","volume":"287","author":"Sivanesan","year":"2020","journal-title":"FEBS J."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.biopsych.2020.02.001","article-title":"The \u03b2-Secretase BACE1 in Alzheimer\u2019s Disease","volume":"89","author":"Hampel","year":"2021","journal-title":"Biol. Psychiatry"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1093\/hmg\/dds360","article-title":"Abnormal Interaction of VDAC1 with Amyloid Beta and Phosphorylated Tau Causes Mitochondrial Dysfunction in Alzheimer\u2019s Disease","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","article-title":"ABAD Directly Links A\u03b2 to Mitochondrial Toxicity in Alzheimer\u2019s Disease","volume":"304","author":"Lustbader","year":"2004","journal-title":"Science"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1093\/hmg\/dds072","article-title":"Abnormal Interaction between the Mitochondrial Fission Protein Drp1 and Hyperphosphorylated Tau in Alzheimer\u2019s Disease Neurons: Implications for Mitochondrial Dysfunction and Neuronal Damage","volume":"21","author":"Manczak","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1093\/hmg\/ddr139","article-title":"Impaired Mitochondrial Dynamics and Abnormal Interaction of Amyloid Beta with Mitochondrial Protein Drp1 in Neurons from Patients with Alzheimer\u2019s Disease: Implications for Neuronal Damage","volume":"20","author":"Manczak","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00401-018-1934-8","article-title":"Mitochondria, ER, and Nuclear Membrane Defects Reveal Early Mechanisms for Upper Motor Neuron Vulnerability with Respect to TDP-43 Pathology","volume":"137","author":"Gautam","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/hmg\/ddt528","article-title":"Abnormal Mitochondrial Transport and Morphology Are Common Pathological Denominators in SOD1 and TDP43 ALS Mouse Models","volume":"23","author":"Cortez","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ymthe.2016.10.013","article-title":"Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization","volume":"25","author":"Wang","year":"2017","journal-title":"Mol. Ther."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1038\/s41467-020-16318-1","article-title":"Truncation of Mutant Huntingtin in Knock-in Mice Demonstrates Exon1 Huntingtin Is a Key Pathogenic Form","volume":"11","author":"Yang","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"e336","DOI":"10.1002\/ctm2.336","article-title":"Improving Mitochondria and ER Stability Helps Eliminate Upper Motor Neuron Degeneration That Occurs Due to MSOD1 Toxicity and TDP-43 Pathology","volume":"11","author":"Gautam","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"578993","DOI":"10.3389\/fnins.2020.578993","article-title":"Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson\u2019s Disease","volume":"14","author":"Gilmozzi","year":"2020","journal-title":"Front. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nm.2313","article-title":"Mutant Huntingtin Binds the Mitochondrial Fission GTPase Dynamin-Related Protein-1 and Increases Its Enzymatic Activity","volume":"17","author":"Song","year":"2011","journal-title":"Nat. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21146","DOI":"10.1073\/pnas.1014862107","article-title":"ALS-Linked Mutant Superoxide Dismutase 1 (SOD1) Alters Mitochondrial Protein Composition and Decreases Protein Import","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2010.07.019","article-title":"Misfolded Mutant SOD1 Directly Inhibits VDAC1 Conductance in a Mouse Model of Inherited ALS","volume":"67","author":"Israelson","year":"2010","journal-title":"Neuron"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Tak, Y.J., Park, J.H., Rhim, H., and Kang, S. (2020). ALS-Related Mutant SOD1 Aggregates Interfere with Mitophagy by Sequestering the Autophagy Receptor Optineurin. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21207525"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fncel.2019.00489","article-title":"Mitoautophagy: A Unique Self-Destructive Path Mitochondria of Upper Motor Neurons With TDP-43 Pathology Take, Very Early in ALS","volume":"13","author":"Gautam","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"32656","DOI":"10.1038\/srep32656","article-title":"Inhibition of Drp1 Mitochondrial Translocation Provides Neural Protection in Dopaminergic System in a Parkinson\u2019s Disease Model Induced by MPTP","volume":"6","author":"Filichia","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1523\/JNEUROSCI.2385-16.2017","article-title":"Inhibition of Drp1 Ameliorates Synaptic Depression, A\u03b2 Deposition, and Cognitive Impairment in an Alzheimer\u2019s Disease Model","volume":"37","author":"Baek","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1172\/JCI70911","article-title":"Inhibition of Mitochondrial Fragmentation Diminishes Huntington\u2019s Disease-Associated Neurodegeneration","volume":"123","author":"Guo","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1038\/ncomms6244","article-title":"Drp1 Inhibition Attenuates Neurotoxicity and Dopamine Release Deficits in Vivo","volume":"5","author":"Rappold","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhao, F., Austria, Q., Wang, W., and Zhu, X. (2021). Mfn2 Overexpression Attenuates Mptp Neurotoxicity in Vivo. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020601"},{"key":"ref_111","first-page":"523","article-title":"Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer\u2019s Disease","volume":"70","author":"Gargini","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-genom-082410-101440","article-title":"Recent Advances in the Genetics of Parkinson\u2019s Disease","volume":"12","author":"Martin","year":"2011","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary Early-Onset Parkinson\u2019s Disease Caused by Mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"612476","DOI":"10.3389\/fcell.2021.612476","article-title":"PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson\u2019s Disease","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"113510","DOI":"10.1016\/j.physbeh.2021.113510","article-title":"Silibinin Attenuates Motor Dysfunction in a Mouse Model of Parkinson\u2019s Disease by Suppression of Oxidative Stress and Neuroinflammation along with Promotion of Mitophagy","volume":"239","author":"Liu","year":"2021","journal-title":"Physiol. Behav."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13843","DOI":"10.1074\/jbc.M808515200","article-title":"Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission","volume":"284","author":"Dagda","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1002\/glia.23839","article-title":"Neuroglial Transmitophagy and Parkinson\u2019s Disease","volume":"68","author":"Morales","year":"2020","journal-title":"Glia"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1080\/15548627.2020.1848130","article-title":"Alternative Mitochondrial Quality Control Mediated by Extracellular Release","volume":"17","author":"Choong","year":"2021","journal-title":"Autophagy"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5084","DOI":"10.1007\/s12035-020-02059-1","article-title":"Decreased Mitochondrial Function, Biogenesis, and Degradation in Peripheral Blood Mononuclear Cells from Amyotrophic Lateral Sclerosis Patients as a Potential Tool for Biomarker Research","volume":"57","author":"Araujo","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Drabik, K., Mali\u0144ska, D., Piecyk, K., D\u0119bska-Vielhaber, G., Vielhaber, S., Duszy\u0144ski, J., and Szczepanowska, J. (2021). Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover. Antioxidants, 10.","DOI":"10.3390\/antiox10060938"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.mito.2020.05.012","article-title":"Alzheimer\u2019s and Parkinson\u2019s Brain Tissues Have Reduced Expression of Genes for MtDNA OXPHOS Proteins, Mitobiogenesis Regulator PGC-1\u03b1 Protein and MtRNA Stabilizing Protein LRPPRC (LRP130)","volume":"53","author":"Bennett","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00401-012-1052-y","article-title":"Reduced Expression of PGC-1\u03b1 Partly Underlies Mitochondrial Changes and Correlates with Neuronal Loss in Multiple Sclerosis Cortex","volume":"125","author":"Witte","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1750-3639.2009.00266.x","article-title":"Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I\/II of Alzheimer\u2019s Disease Pathology","volume":"20","author":"Terni","year":"2010","journal-title":"Brain Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1089\/ars.2011.4149","article-title":"Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer\u2019s Disease","volume":"16","author":"Swerdlow","year":"2012","journal-title":"Antioxidants Redox Signal."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"101594","DOI":"10.1016\/j.nicl.2018.11.004","article-title":"FDG-PET Hypometabolism Is More Sensitive than MRI Atrophy in Parkinson\u2019s Disease: A Whole-Brain Multimodal Imaging Meta-Analysis","volume":"21","author":"Albrecht","year":"2019","journal-title":"NeuroImage Clin."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.bbrc.2016.09.065","article-title":"Energy Defects in Huntington\u2019s Disease: Why \u201cin Vivo\u201d Evidence Matters","volume":"483","author":"Liot","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13195-020-00619-0","article-title":"The Combined Effects of Microglia Activation and Brain Glucose Hypometabolism in Early-Onset Alzheimer\u2019s Disease","volume":"12","author":"Tondo","year":"2020","journal-title":"Alzheimer\u2019s Res. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-Scale Proteomic Analysis of Alzheimer\u2019s Disease Brain and Cerebrospinal Fluid Reveals Early Changes in Energy Metabolism Associated with Microglia and Astrocyte Activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat. Med."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13578-020-00511-2","article-title":"CNS Glucose Metabolism in Amyotrophic Lateral Sclerosis: A Therapeutic Target?","volume":"11","author":"Tefera","year":"2021","journal-title":"Cell Biosci."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"847","DOI":"10.14336\/AD.2018.0814","article-title":"The Metabolic Activity of Caudate and Prefrontal Cortex Negatively Correlates with the Severity of Idiopathic Parkinson\u2019s Disease","volume":"10","author":"Chu","year":"2019","journal-title":"Aging Dis."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.nicl.2018.08.006","article-title":"FDG PET Parkinson\u2019s Disease-Related Pattern as a Biomarker for Clinical Trials in Early Stage Disease","volume":"20","author":"Matthews","year":"2018","journal-title":"NeuroImage Clin."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1096\/fj.06-7703com","article-title":"Amyloid Beta Oligomers Induce Impairment of Neuronal Insulin Receptors","volume":"22","author":"Zhao","year":"2008","journal-title":"FASEB J."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.bbadis.2016.08.018","article-title":"Is Alzheimer\u2019s Disease a Type 3 Diabetes? A Critical Appraisal","volume":"1863","author":"Kandimalla","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.expneurol.2017.08.005","article-title":"Insulin Prevents Aberrant Mitochondrial Phenotype in Sensory Neurons of Type 1 Diabetic Rats","volume":"297","author":"Aghanoori","year":"2017","journal-title":"Exp. Neurol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Hong, C.T., Chen, K.Y., Wang, W., Chiu, J.Y., Wu, D., Chao, T.Y., Hu, C.J., Chau, K.Y.D., and Bamodu, O.A. (2020). Insulin Resistance Promotes Parkinson\u2019s Disease through Aberrant Expression of \u03b1-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling. Cells, 9.","DOI":"10.3390\/cells9030740"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/hbm.24473","article-title":"Regional Multimodal Relationships between Tau, Hypometabolism, Atrophy, and Fractional Anisotropy in Atypical Alzheimer\u2019s Disease","volume":"40","author":"Sintini","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41573-020-0072-x","article-title":"Brain Energy Rescue: An Emerging Therapeutic Concept for Neurodegenerative Disorders of Ageing","volume":"19","author":"Cunnane","year":"2020","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s13311-019-00755-y","article-title":"Consequences of Metabolic Disruption in Alzheimer\u2019s Disease Pathology","volume":"16","author":"Ryu","year":"2019","journal-title":"Neurotherapeutics"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ana.20736","article-title":"Mitochondrial Dysfunction as a Cause of Axonal Degeneration in Multiple Sclerosis Patients","volume":"59","author":"Dutta","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41593-019-0385-4","article-title":"Bassoon Proteinopathy Drives Neurodegeneration in Multiple Sclerosis","volume":"22","author":"Schattling","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neuro.2014.10.004","article-title":"Potential of Protease Inhibitor in 3-Nitropropionic Acid Induced Huntington\u2019s Disease like Symptoms: Mitochondrial Dysfunction and Neurodegeneration","volume":"45","author":"Hariharan","year":"2014","journal-title":"Neurotoxicology"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.08.028","article-title":"Protective Effect of Hesperidin and Naringin against 3-Nitropropionic Acid Induced Huntington\u2019s like Symptoms in Rats: Possible Role of Nitric Oxide","volume":"206","author":"Kumar","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/978-1-0716-1495-2_10","article-title":"Generation of mitochondrial toxin rodent models of Parkinson\u2019s disease using 6-OHDA, MPTP, and rotenone","volume":"Volume 2322","author":"Imai","year":"2021","journal-title":"Experimental Models of Parkinson\u2019s Disease"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Prasad, E.M., and Hung, S.Y. (2020). Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson\u2019s Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9101007"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Teil, M., Arotcarena, M.L., and Dehay, B. (2021). A New Rise of Non-Human Primate Models of Synucleinopathies. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030272"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00702-017-1715-x","article-title":"The Use of Nonhuman Primate Models to Understand Processes in Parkinson\u2019s Disease","volume":"125","author":"Blesa","year":"2018","journal-title":"J. Neural Transm."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/jnc.14819","article-title":"Altered Glucose Catabolism in the Presynaptic and Perisynaptic Compartments of SOD1G93A Mouse Spinal Cord and Motor Cortex Indicates That Mitochondria Are the Site of Bioenergetic Imbalance in ALS","volume":"151","author":"Ravera","year":"2019","journal-title":"J. Neurochem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.freeradbiomed.2019.07.037","article-title":"Nitration of Drp1 Provokes Mitophagy Activation Mediating Neuronal Injury in Experimental Autoimmune Encephalomyelitis","volume":"143","author":"Li","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1126\/science.1171091","article-title":"\u03b2-Amyloid-Related Mitochondrial Fission and Neuronal Injury","volume":"324","author":"Cho","year":"2009","journal-title":"Science"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jconrel.2010.11.004","article-title":"Endosomal Escape Pathways for Delivery of Biologicals","volume":"151","author":"Varkouhi","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1038\/cdd.2014.72","article-title":"Cerium Oxide Nanoparticles Protect against A\u03b2-Induced Mitochondrial Fragmentation and Neuronal Cell Death","volume":"21","author":"Dowding","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijbiomac.2019.03.215","article-title":"Self-Assembled Nanoparticles Composed of Glycol Chitosan-Dequalinium for Mitochondria-Targeted Drug Delivery","volume":"132","author":"Mallick","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Mursaleen, L., Noble, B., Chan, S.H.Y., Somavarapu, S., and Zariwala, M.G. (2020). N-Acetylcysteine Nanocarriers Protect against Oxidative Stress in a Cellular Model of Parkinson\u2019s Disease. Antioxidants, 9.","DOI":"10.3390\/antiox9070600"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","article-title":"Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"key":"ref_155","first-page":"183","article-title":"Conjugation of triphenylphosphonium cation to hydrophobic moieties to prepare mitochondria-targeting nanocarriers","volume":"Volume 2000","author":"Weissig","year":"2019","journal-title":"Pharmaceutical Nanotechnology"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.freeradbiomed.2020.12.023","article-title":"Mitochondria-Targeted Phenolic Antioxidants Induce ROS-Protective Pathways in Primary Human Skin Fibroblasts","volume":"163","author":"Teixeira","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Chavarria, D., Da Silva, O., Benfeito, S., Barreiro, S., Garrido, J., Cagide, F., Soares, P., Remi\u00e3o, F., Brazzolotto, X., and Nachon, F. (2021). Fine-tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases. Antioxidants, 10.","DOI":"10.3390\/antiox10020329"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"102037","DOI":"10.1016\/j.redox.2021.102037","article-title":"A Mitochondria-Targeted Caffeic Acid Derivative Reverts Cellular and Mitochondrial Defects in Human Skin Fibroblasts from Male Sporadic Parkinson\u2019s Disease Patients","volume":"45","author":"Deus","year":"2021","journal-title":"Redox Biol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.freeradbiomed.2014.03.003","article-title":"The Mitochondria-Targeted Antioxidant MitoQ Extends Lifespan and Improves Healthspan of a Transgenic Caenorhabditis Elegans Model of Alzheimer Disease","volume":"71","author":"Ng","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Benfeito, S., Fernandes, C., Vilar, S., Remi\u00e3o, F., Uriarte, E., and Borges, F. (2020). Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer\u2019s Disease Pathophysiological Hallmarks. Molecules, 25.","DOI":"10.3390\/molecules25020276"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1089\/ars.2016.6905","article-title":"Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice","volume":"27","author":"Langley","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1021\/acsnano.5b08045","article-title":"Mitochondria-Targeting Ceria Nanoparticles as Antioxidants for Alzheimer\u2019s Disease","volume":"10","author":"Kwon","year":"2016","journal-title":"ACS Nano"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1002\/anie.201805052","article-title":"Ceria Nanoparticle Systems for Selective Scavenging of Mitochondrial, Intracellular, and Extracellular Reactive Oxygen Species in Parkinson\u2019s Disease","volume":"57","author":"Kwon","year":"2018","journal-title":"Angew. Chemie Int. Ed."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s40199-019-00283-2","article-title":"Synthesis, Characterization and Efficacy of Mitochondrial Targeted Delivery of TPP-Curcumin in Rotenone-Induced Toxicity","volume":"27","author":"Hasan","year":"2019","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Kotha, R.R., and Luthria, D.L. (2019). Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects. Molecules, 24.","DOI":"10.3390\/molecules24162930"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of Curcumin: Problems and Promises","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharm."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijpharm.2011.06.030","article-title":"Curcumin and Its Nano-Formulation: The Kinetics of Tissue Distribution and Blood-Brain Barrier Penetration","volume":"416","author":"Tsai","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"16288","DOI":"10.1073\/pnas.1210096109","article-title":"Engineering of Blended Nanoparticle Platform for Delivery of Mitochondria-Acting Therapeutics","volume":"109","author":"Marrache","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.actbio.2020.03.029","article-title":"Neuronal Mitochondria-Targeted Delivery of Curcumin by Biomimetic Engineered Nanosystems in Alzheimer\u2019s Disease Mice","volume":"108","author":"Gao","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11481-016-9650-4","article-title":"Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson\u2019s Disease","volume":"11","author":"Ghosh","year":"2016","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.nano.2016.10.004","article-title":"Neuronal Protection against Oxidative Insult by Polyanhydride Nanoparticle-Based Mitochondria-Targeted Antioxidant Therapy","volume":"13","author":"Brenza","year":"2017","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1038\/s41598-017-03411-7","article-title":"Chronic Treatment with a Smart Antioxidative Nanoparticle for Inhibition of Amyloid Plaque Propagation in Tg2576 Mouse Model of Alzheimer\u2019s Disease","volume":"7","author":"Boonruamkaew","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Pichla, M., Bartosz, G., Stefaniuk, I., and Sadowska-Bartosz, I. (2021). Ph-Responsive Redox Nanoparticles Protect Sh-Sy5y Cells at Lowered Ph in a Cellular Model of Parkinson\u2019s Disease. Molecules, 26.","DOI":"10.3390\/molecules26030543"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"9260748","DOI":"10.1155\/2020\/9260748","article-title":"Nitroxide Radical-Containing Redox Nanoparticles Protect Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine Toxicity","volume":"2020","author":"Pichla","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_175","first-page":"8409329","article-title":"Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer\u2019s Disease?","volume":"2019","author":"Romeiro","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.yrtph.2018.03.025","article-title":"Neuroprotective Effect of the Carnosine\u2013\u03b1-Lipoic Acid Nanomicellar Complex in a Model of Early-Stage Parkinson\u2019s Disease","volume":"95","author":"Kulikova","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"5666","DOI":"10.1039\/D0NA00688B","article-title":"Antioxidant Lipoic Acid Ligand-Shell Gold Nanoconjugates against Oxidative Stress Caused by \u03b1-Synuclein Aggregates","volume":"2","author":"Piersimoni","year":"2020","journal-title":"Nanoscale Adv."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/978-3-030-42667-5_7","article-title":"Polyphenols as an effective therapeutic intervention against cognitive decline during normal and pathological brain aging","volume":"Volume 1260","author":"Guest","year":"2020","journal-title":"Reviews on New Drug Targets in Age-Related Disorders"},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Fukutomi, R., Ohishi, T., Koyama, Y., Pervin, M., Nakamura, Y., and Isemura, M. (2021). Beneficial Effects of Epigallocatechin-3-o-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases. Molecules, 26.","DOI":"10.3390\/molecules26020415"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/mnfr.200700290","article-title":"Quantification of Free and Protein-Bound Trans-Resveratrol Metabolites and Identification of Trans-Resveratrol-C\/O-Conjugated Diglucuronides - Two Novel Resveratrol Metabolites in Human Plasma","volume":"52","author":"Burkon","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1039\/c1fo10025d","article-title":"The Metabolism and Analysis of Isoflavones and Other Dietary Polyphenols in Foods and Biological Systems","volume":"2","author":"Barnes","year":"2011","journal-title":"Food Funct."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2174\/15734064113096660053","article-title":"Chemistry, Stability and Bioavailability of Resveratrol","volume":"10","author":"Franciosoa","year":"2014","journal-title":"Med. Chem."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.foodchem.2013.10.095","article-title":"Flavonoid Metabolites Transport across a Human BBB Model","volume":"149","author":"Faria","year":"2014","journal-title":"Food Chem."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbrep.2016.12.012","article-title":"Blood Brain Barrier Permeability of (\u2212)-Epigallocatechin Gallate, Its Proliferation-Enhancing Activity of Human Neuroblastoma SH-SY5Y Cells, and Its Preventive Effect on Age-Related Cognitive Dysfunction in Mice","volume":"9","author":"Pervin","year":"2017","journal-title":"Biochem. Biophys. Reports"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"11676","DOI":"10.1021\/acs.jafc.1c02898","article-title":"Evaluation of Blood-Brain Barrier Permeability of Polyphenols, Anthocyanins, and Their Metabolites","volume":"69","author":"Shimazu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols Journey through Blood-Brain Barrier towards Neuronal Protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2478\/s11658-010-0006-4","article-title":"Flavonoid Transport across RBE4 Cells: A Blood-Brain Barrier Model","volume":"15","author":"Faria","year":"2010","journal-title":"Cell. Mol. Biol. Lett."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3233\/BPL-200099","article-title":"Low Molecular Weight (Poly)Phenol Metabolites Across the Blood-Brain Barrier: The Underexplored Journey","volume":"6","author":"Carecho","year":"2020","journal-title":"Brain Plast."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.addr.2012.09.015","article-title":"Nanoparticulate Systems for Brain Delivery of Drugs","volume":"64","author":"Kreuter","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_190","first-page":"749","article-title":"Systemic Delivery to Central Nervous System by Engineered PLGA Nanoparticles","volume":"8","author":"Cai","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejpb.2009.09.003","article-title":"Drug Delivery to the Brain Using Surfactant-Coated Poly(Lactide-Co-Glycolide) Nanoparticles: Influence of the Formulation Parameters","volume":"74","author":"Gelperina","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"121086","DOI":"10.1016\/j.biomaterials.2021.121086","article-title":"Surfactants Influence Polymer Nanoparticle Fate within the Brain","volume":"277","author":"Joseph","year":"2021","journal-title":"Biomaterials"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"17545","DOI":"10.1021\/jp050431+","article-title":"Effects of Ionic Strength and Surface Charge on Protein Adsorption at PEGylated Surfaces","volume":"109","author":"Pasche","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"149ra119","DOI":"10.1126\/scitranslmed.3003594","article-title":"A Dense Poly(Ethylene Glycol) Coating Improves Penetration of Large Polymeric Nanoparticles within Brain Tissue","volume":"4","author":"Nance","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijpharm.2014.12.057","article-title":"Lactoferrin- and Antitransferrin-Modified Liposomes for Brain Targeting of the NK3 Receptor Agonist Senktide: Preparation and in Vivo Evaluation","volume":"479","author":"Lai","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11095-011-0513-7","article-title":"Self-Assembled Polymersomes Conjugated with Lactoferrin as Novel Drug Carrier for Brain Delivery","volume":"29","author":"Yu","year":"2012","journal-title":"Pharm. Res."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"120339","DOI":"10.1016\/j.biomaterials.2020.120339","article-title":"Brain-Targeted Delivery Shuttled by Black Phosphorus Nanostructure to Treat Parkinson\u2019s Disease","volume":"260","author":"Xiong","year":"2020","journal-title":"Biomaterials"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1039\/D0BM01765E","article-title":"Targeted Graphene Oxide for Drug Delivery as a Therapeutic Nanoplatform against Parkinson\u2019s Disease","volume":"9","author":"Xiong","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.2147\/IJN.S239608","article-title":"Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer\u2019s Disease-Related Pathology in APP\/PS-1 Mice","volume":"15","author":"Kong","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3233\/JAD-190083","article-title":"Neuroprotective Potential of Curcumin-Loaded Nanostructured Lipid Carrier in an Animal Model of Alzheimer\u2019s Disease: Behavioral and Biochemical Evidence","volume":"69","author":"Malvajerd","year":"2019","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/nyas.13431","article-title":"Resveratrol for Alzheimer\u2019s Disease","volume":"1403","author":"Sawda","year":"2017","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jpba.2009.03.026","article-title":"Quantification of Trans-Resveratrol and Its Metabolites in Rat Plasma and Tissues by HPLC","volume":"51","author":"Juan","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and Pharmacokinetics of Resveratrol and Pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"BioFactors"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1007\/s13346-018-0540-6","article-title":"In Situ Nanostructured Hydrogel of Resveratrol for Brain Targeting: In Vitro-in Vivo Characterization","volume":"8","author":"Rajput","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3390\/nu7075246","article-title":"Ferulic Acid: A Hope for Alzheimer\u2019s Disease Therapy from Plants","volume":"7","author":"Sgarbossa","year":"2015","journal-title":"Nutrients"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"113278","DOI":"10.1016\/j.ejmech.2021.113278","article-title":"A Review on Ferulic Acid and Analogs Based Scaffolds for the Management of Alzheimer\u2019s Disease","volume":"215","author":"Singh","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"112257","DOI":"10.1016\/j.ejmech.2020.112257","article-title":"Design, Synthesis and Biological Evaluation of Novel Naturally-Inspired Multifunctional Molecules for the Management of Alzheimer\u2019s Disease","volume":"198","author":"Singh","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ptr.6523","article-title":"Ferulic Acid Reinstates Mitochondrial Dynamics through PGC1\u03b1 Expression Modulation in 6-Hydroxydopamine Lesioned Rats","volume":"34","author":"Anis","year":"2020","journal-title":"Phyther. Res."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1080\/10715760903214454","article-title":"Ferulic Acid Inhibits Oxidative Stress and Cell Death Induced by Ab Oligomers: Improved Delivery by Solid Lipid Nanoparticles","volume":"43","author":"Picone","year":"2009","journal-title":"Free Radic. Res."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neuint.2010.05.011","article-title":"Neuroprotective Effect of Osthole on MPP+-Induced Cytotoxicity in PC12 Cells via Inhibition of Mitochondrial Dysfunction and ROS Production","volume":"57","author":"Liu","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.jss.2013.06.044","article-title":"Osthole Attenuates Spinal Cord Ischemia-Reperfusion Injury through Mitochondrial Biogenesis-Independent Inhibition of Mitochondrial Dysfunction in Rats","volume":"185","author":"Zhou","year":"2013","journal-title":"J. Surg. Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"11719","DOI":"10.3390\/molecules200711719","article-title":"Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-PHaMDR Cell Monolayer - An in Vitro Model for Blood-Brain Barrier Permeability","volume":"20","author":"Yang","year":"2015","journal-title":"Molecules"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"8844455","DOI":"10.1155\/2021\/8844455","article-title":"Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer\u2019s Disease via Intranasal Administration","volume":"2021","author":"Song","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.01.032","article-title":"Quercetin Up-Regulates Mitochondrial Complex-I Activity to Protect against Programmed Cell Death in Rotenone Model of Parkinson\u2019s Disease in Rats","volume":"236","author":"Karuppagounder","year":"2013","journal-title":"Neuroscience"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbadis.2012.11.018","article-title":"Quercetin Supplementation Is Effective in Improving Mitochondrial Dysfunctions Induced by 3-Nitropropionic Acid: Implications in Huntington\u2019s Disease","volume":"1832","author":"Sandhir","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"El-Saber Batiha, G., Beshbishy, A.M., Ikram, M., Mulla, Z.S., Abd El-Hack, M.E., Taha, A.E., Algammal, A.M., and Ali Elewa, Y.H. (2020). The Pharmacological Activity, Biochemical Properties, and Pharmacokinetics of the Major Natural Polyphenolic Flavonoid: Quercetin. Foods, 9.","DOI":"10.3390\/foods9030374"},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Dabeek, W.M., and Marra, M.V. (2019). Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans. Nutrients, 11.","DOI":"10.3390\/nu11102288"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"598617","DOI":"10.3389\/fnins.2020.598617","article-title":"Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl3-Induced Neurotoxicity in a Rat Model of Alzheimer\u2019s Disease via Antioxidant Genes, APP Gene, and MiRNA-101","volume":"14","author":"Esmaeili","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2025914","DOI":"10.1155\/2018\/2025914","article-title":"The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-like Pathological Changes in Vitro","volume":"2018","author":"Liu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"117237","DOI":"10.1016\/j.lfs.2019.117237","article-title":"Antioxidative and Antiapoptosis: Neuroprotective Effects of Dauricine in Alzheimer\u2019s Disease Models","volume":"243","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"624339","DOI":"10.3389\/fcell.2020.624339","article-title":"Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer\u2019s Disease","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1080\/10717544.2021.1895909","article-title":"Intranasal Administration of Dauricine Loaded on Graphene Oxide: Multi-Target Therapy for Alzheimer\u2019s Disease","volume":"28","author":"Wang","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.lfs.2018.05.041","article-title":"Puerarin Attenuates Palmitate-Induced Mitochondrial Dysfunction, Impaired Mitophagy and Inflammation in L6 Myotubes","volume":"206","author":"Chen","year":"2018","journal-title":"Life Sci."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Song, X., Bai, X., Liu, S., Dong, L., Deng, H., and Wang, C. (2016). A Novel Microspheres Formulation of Puerarin: Pharmacokinetics Study and in Vivo Pharmacodynamics Evaluations. Evid.-Based Complement. Altern. Med., 2016.","DOI":"10.1155\/2016\/4016963"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1021\/acs.molpharmaceut.8b01012","article-title":"Oral Delivery of Puerarin Nanocrystals to Improve Brain Accumulation and Anti-Parkinsonian Efficacy","volume":"16","author":"Xiong","year":"2019","journal-title":"Mol. Pharm."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1080\/19390211.2018.1472706","article-title":"Rahul Effect of Genistein on the Transgenic Drosophila Model of Parkinson\u2019s Disease","volume":"16","author":"Siddique","year":"2019","journal-title":"J. Diet. Suppl."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"314560","DOI":"10.1155\/2015\/314560","article-title":"Protective Mechanisms of Flavonoids in Parkinson\u2019s Disease","volume":"2015","author":"Magalingam","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Ferramosca, A., Lorenzetti, S., Di Giacomo, M., Lunetti, P., Murrieri, F., Capobianco, L., Dolce, V., Coppola, L., and Zara, V. (2021). Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols. Antioxidants, 10.","DOI":"10.3390\/antiox10020217"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1142\/S0192415X21500439","article-title":"Genistein Triggers Translocation of Estrogen Receptor-Alpha in Mitochondria to Induce Expressions of ATP Synthesis-Associated Genes and Improves Energy Production and Osteoblast Maturation","volume":"49","author":"Wu","year":"2021","journal-title":"Am. J. Chin. Med."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1021\/jf801051d","article-title":"Dose-Dependent Absorption, Metabolism, and Excretion of Genistein in Rats","volume":"56","author":"Zhou","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_231","first-page":"529","article-title":"Macrophage Membrane-Coated Nanocarriers Co-Modified by RVG29 and TPP Improve Brain Neuronal Mitochondria-Targeting and Therapeutic Efficacy in Alzheimer\u2019s Disease Mice","volume":"6","author":"Han","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1080\/10717544.2020.1745328","article-title":"Neuronal Mitochondria-Targeted Therapy for Alzheimer\u2019s Disease by Systemic Delivery of Resveratrol Using Dual-Modified Novel Biomimetic Nanosystems","volume":"27","author":"Han","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ajps.2019.11.002","article-title":"Intranasal Delivery of Paeoniflorin Nanocrystals for Brain Targeting","volume":"15","author":"Wu","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00210-018-1474-8","article-title":"Improved Neuroprotective Effect of Resveratrol Nanoparticles as Evinced by Abrogation of Rotenone-Induced Behavioral Deficits and Oxidative and Mitochondrial Dysfunctions in Rat Model of Parkinson\u2019s Disease","volume":"391","author":"Palle","year":"2018","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"317","DOI":"10.32598\/bcn.9.5.317","article-title":"Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence","volume":"9","author":"Ghaffari","year":"2018","journal-title":"Basic Clin. Neurosci."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Babylon, L., Grewal, R., Stahr, P.L., Eckert, R.W., Keck, C.M., and Eckert, G.P. (2021). Hesperetin Nanocrystals Improve Mitochondrial Function in a Cell Model of Early Alzheimer Disease. Antioxidants, 10.","DOI":"10.3390\/antiox10071003"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s13346-020-00888-0","article-title":"Investigating Hesperetin Nanocrystals with Tailor-Made Sizes for the Prevention and Treatment of Alzheimer\u2019s Disease","volume":"11","author":"Stahr","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2018.05.002","article-title":"Production of Pure Drug Nanocrystals and Nano Co-Crystals by Confinement Methods","volume":"131","author":"Fontana","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.apsb.2021.02.015","article-title":"The Contribution of Absorption of Integral Nanocrystals to Enhancement of Oral Bioavailability of Quercetin","volume":"11","author":"Shen","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1038\/s41598-018-27614-8","article-title":"High Throughput Screening of Mitochondrial Bioenergetics in Human Differentiated Myotubes Identifies Novel Enhancers of Muscle Performance in Aged Mice","volume":"8","author":"Biesemann","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s10571-014-0098-x","article-title":"Hesperidin Alleviates Cognitive Impairment, Mitochondrial Dysfunction and Oxidative Stress in a Mouse Model of Alzheimer\u2019s Disease","volume":"34","author":"Wang","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fphys.2018.00044","article-title":"Coenzyme Q10 Supplementation in Aging and Disease","volume":"9","author":"Bernier","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.mito.2014.07.004","article-title":"Inhibition of Stress Induced Premature Senescence in Presenilin-1 Mutated Cells with Water Soluble Coenzyme Q10","volume":"17","author":"Ma","year":"2014","journal-title":"Mitochondrion"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exger.2017.03.009","article-title":"Protective Roles of Nanomelatonin in Cerebral Ischemia-Reperfusion of Aged Brain: Matrixmetalloproteinases as Regulators","volume":"92","author":"Sarkar","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12017-013-8261-y","article-title":"Curcumin Nanoparticles Attenuate Neurochemical and Neurobehavioral Deficits in Experimental Model of Huntington\u2019s Disease","volume":"16","author":"Sandhir","year":"2014","journal-title":"NeuroMolecular Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11101-014-9384-y","article-title":"Huperzine A from Huperzia Serrata: A Review of Its Sources, Chemistry, Pharmacology and Toxicology","volume":"15","author":"Ferreira","year":"2016","journal-title":"Phytochem. Rev."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/jnr.20791","article-title":"Huperzine A Attenuates Mitochondrial Dysfunction in \u03b2-Amyloid-Treated PC12 Cells by Reducing Oxygen Free Radicals Accumulation and Improving Mitochondrial Energy Metabolism","volume":"83","author":"Gao","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.freeradbiomed.2009.02.028","article-title":"Huperzine A Protects Isolated Rat Brain Mitochondria against \u03b2-Amyloid Peptide","volume":"46","author":"Gao","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","article-title":"Intranasal Delivery of Huperzine A to the Brain Using Lactoferrin-Conjugated N-Trimethylated Chitosan Surface-Modified PLGA Nanoparticles for Treatment of Alzheimer\u2019s Disease","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"9217","DOI":"10.2147\/IJN.S214657","article-title":"The Optimization Design of Lactoferrin Loaded Hupa Nanoemulsion for Targeted Drug Transport via Intranasal Route","volume":"14","author":"Jiang","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s11095-013-1055-y","article-title":"The Use of Borneol as an Enhancer for Targeting Aprotinin-Conjugated PEG-PLGA Nanoparticles to the Brain","volume":"30","author":"Zhang","year":"2013","journal-title":"Pharm. Res."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2217\/nmt.13.73","article-title":"Brain Insulin Resistance in Alzheimer\u2019s Disease and Its Potential Treatment with GLP-1 Analogs","volume":"4","author":"Talbot","year":"2014","journal-title":"Neurodegener. Dis. Manag."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"104707","DOI":"10.1016\/j.neuint.2020.104707","article-title":"Insulin Signaling Pathway and Related Molecules: Role in Neurodegeneration and Alzheimer\u2019s Disease","volume":"135","author":"Akhtar","year":"2020","journal-title":"Neurochem. Int."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/13543784.2020.1738383","article-title":"Brain Insulin Resistance: Role in Neurodegenerative Disease and Potential for Targeting","volume":"29","year":"2020","journal-title":"Expert Opin. Investig. Drugs"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s12035-019-01821-4","article-title":"Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function","volume":"57","author":"Pharaoh","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2018.09.015","article-title":"The Role of Insulin-like Growth Factor 1 in ALS Cell and Mouse Models: A Mitochondrial Protector","volume":"144","author":"Wen","year":"2019","journal-title":"Brain Res. Bull."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1039\/C8RA10103E","article-title":"Enhancement of Neural Stem Cell Survival, Proliferation and Differentiation by IGF-1 Delivery in Graphene Oxide-Incorporated PLGA Electrospun Nanofibrous Mats","volume":"9","author":"Qi","year":"2019","journal-title":"RSC Adv."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11892-019-1270-y","article-title":"Thiazolidinediones: The Forgotten Diabetes Medications","volume":"19","author":"Lebovitz","year":"2019","journal-title":"Curr. Diab. Rep."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12640-013-9437-9","article-title":"Role of Nuclear Receptor on Regulation of BDNF and Neuroinflammation in Hippocampus of \u03b2-Amyloid Animal Model of Alzheimer\u2019s Disease","volume":"25","author":"Prakash","year":"2014","journal-title":"Neurotox. Res."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"7267","DOI":"10.1007\/s12035-019-1586-2","article-title":"Reverting Metabolic Dysfunction in Cortex and Cerebellum of APP\/PS1 Mice, a Model for Alzheimer\u2019s Disease by Pioglitazone, a Peroxisome Proliferator-Activated Receptor Gamma (PPAR\u03b3) Agonist","volume":"56","author":"Chang","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"9287","DOI":"10.1523\/JNEUROSCI.3348-08.2008","article-title":"Complete Rescue of Cerebrovascular Function in Aged Alzheimer\u2019s Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor \u03b3 Agonist","volume":"28","author":"Nicolakakis","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Wong, L.R., Wong, P., and Ho, P.C.L. (2020). Metabolic Profiling of Female Tg2576 Mouse Brains Provides Novel Evidence Supporting Intranasal Low-Dose Pioglitazone for Long-Term Treatment at an Early Stage of Alzheimer\u2019s Disease. Biomedicines, 8.","DOI":"10.3390\/biomedicines8120589"},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"e38744","DOI":"10.7554\/eLife.38744","article-title":"Metformin Reverses Early Cortical Network Dysfunction and Behavior Changes in Huntington\u2019s Disease","volume":"7","author":"Arnoux","year":"2018","journal-title":"eLife"},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.bbi.2017.12.009","article-title":"Metformin Treatment Prevents Amyloid Plaque Deposition and Memory Impairment in APP\/PS1 Mice","volume":"69","author":"Ou","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/db11-0416","article-title":"Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose via the LKB1\/AMPK\/ROS Pathway and Therapeutic Effects of Metformin","volume":"61","author":"Zheng","year":"2012","journal-title":"Diabetes"},{"key":"ref_266","doi-asserted-by":"crossref","unstructured":"Song, Y.M., Lee, W.K., Lee, Y.H., Kang, E.S., Cha, B.S., and Lee, B.W. (2016). Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic P53. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010122"},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"1511-1523.e5","DOI":"10.1016\/j.celrep.2019.09.070","article-title":"Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK","volume":"29","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1158\/0008-5472.CAN-15-2534","article-title":"Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells","volume":"76","author":"Cheng","year":"2016","journal-title":"Cancer Res."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"20160109","DOI":"10.1098\/rsfs.2016.0109","article-title":"Mitochondria-Targeted Metformins: Antitumour and Redox Signalling Mechanisms","volume":"7","author":"Kalyanaraman","year":"2017","journal-title":"Interface Focus"},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"101665","DOI":"10.1016\/j.redox.2020.101665","article-title":"Teaching the Basics of Repurposing Mitochondria-Targeted Drugs: From Parkinson\u2019s Disease to Cancer and Back to Parkinson\u2019s Disease","volume":"36","author":"Kalyanaraman","year":"2020","journal-title":"Redox Biol."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s40266-021-00853-7","article-title":"The Future of Incretin-Based Approaches for Neurodegenerative Diseases in Older Adults: Which to Choose? A Review of Their Potential Efficacy and Suitability","volume":"38","author":"Girges","year":"2021","journal-title":"Drugs Aging"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"114578","DOI":"10.1016\/j.bcp.2021.114578","article-title":"GLP-1 Improves the Neuronal Supportive Ability of Astrocytes in Alzheimer\u2019s Disease by Regulating Mitochondrial Dysfunction via the CAMP\/PKA Pathway","volume":"188","author":"Xie","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"101180","DOI":"10.1016\/j.molmet.2021.101180","article-title":"GLP-1 Improves the Supportive Ability of Astrocytes to Neurons by Promoting Aerobic Glycolysis in Alzheimer\u2019s Disease","volume":"47","author":"Zheng","year":"2021","journal-title":"Mol. Metab."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbr.2018.08.006","article-title":"Neural Correlates of Liraglutide Effects in Persons at Risk for Alzheimer\u2019s Disease","volume":"356","author":"Watson","year":"2019","journal-title":"Behav. Brain Res."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.brainres.2017.10.012","article-title":"Neuroprotective Effects of a Triple GLP-1\/GIP\/Glucagon Receptor Agonist in the APP\/PS1 Transgenic Mouse Model of Alzheimer\u2019s Disease","volume":"1678","author":"Tai","year":"2018","journal-title":"Brain Res."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.2231","article-title":"The GLP-1\/GIP Dual-Receptor Agonist DA5-CH Inhibits the NF-\u039aB Inflammatory Pathway in the MPTP Mouse Model of Parkinson\u2019s Disease More Effectively than the GLP-1 Single-Receptor Agonist NLY01","volume":"11","author":"Lv","year":"2021","journal-title":"Brain Behav."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3233\/JPD-202318","article-title":"Neuroprotective Effects of a GLP-2 Analogue in the MPTP Parkinson\u2019s Disease Mouse Model","volume":"11","author":"Zhang","year":"2021","journal-title":"J. Parkinson\u2019s Dis."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"170184","DOI":"10.1016\/j.peptides.2019.170184","article-title":"GIP Has Neuroprotective Effects in Alzheimer and Parkinson\u2019s Disease Models","volume":"125","author":"Zhang","year":"2020","journal-title":"Peptides"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1007\/s13311-021-01088-5","article-title":"Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis","volume":"18","author":"Gharagozloo","year":"2021","journal-title":"Neurotherapeutics"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1007\/s12035-017-0550-2","article-title":"Activation of Glucagon-Like Peptide-1 Receptor Promotes Neuroprotection in Experimental Autoimmune Encephalomyelitis by Reducing Neuroinflammatory Responses","volume":"55","author":"Lee","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"15201","DOI":"10.1021\/acsami.8b19669","article-title":"Sustained Release of Exendin 4 Using Injectable and Ionic-Nano-Complex Forming Polymer Hydrogel System for Long-Term Treatment of Type 2 Diabetes Mellitus","volume":"11","author":"Seo","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ijpharm.2015.08.084","article-title":"Mono-Lithocholated Exendin-4-Loaded Glycol Chitosan Nanoparticles with Prolonged Antidiabetic Effects","volume":"495","author":"Son","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2019.03.014","article-title":"Sustained Release of Exendin-4 from Tannic Acid\/Fe (III) Nanoparticles Prolongs Blood Glycemic Control in a Mouse Model of Type II Diabetes","volume":"301","author":"He","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12951-020-00619-0","article-title":"Oral Delivery of Exenatide-Loaded Hybrid Zein Nanoparticles for Stable Blood Glucose Control and \u03b2-Cell Repair of Type 2 Diabetes Mice","volume":"18","author":"Bao","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejpb.2020.04.025","article-title":"Hydrophobic Ion Pairing of a GLP-1 Analogue for Incorporating into Lipid Nanocarriers Designed for Oral Delivery","volume":"152","author":"Ismail","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"120583","DOI":"10.1016\/j.ijpharm.2021.120583","article-title":"Utilization of PLGA Nanoparticles in Yeast Cell Wall Particle System for Oral Targeted Delivery of Exenatide to Improve Its Hypoglycemic Efficacy","volume":"601","author":"Ren","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jconrel.2019.12.014","article-title":"A Polyphenol-Metal Nanoparticle Platform for Tunable Release of Liraglutide to Improve Blood Glycemic Control and Reduce Cardiovascular Complications in a Mouse Model of Type II Diabetes","volume":"318","author":"He","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s12035-019-01780-w","article-title":"Gold Nanoparticles Treatment Reverses Brain Damage in Alzheimer\u2019s Disease Model","volume":"57","author":"Arruda","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1039\/D0RA10927D","article-title":"Impact of Porous Nanomaterials on Inhibiting Protein Aggregation Behaviour","volume":"11","author":"Bardhan","year":"2021","journal-title":"RSC Adv."},{"key":"ref_290","doi-asserted-by":"crossref","first-page":"19060","DOI":"10.1039\/C5NR06282A","article-title":"Graphene Quantum Dots for the Inhibition of \u03b2 Amyloid Aggregation","volume":"7","author":"Liu","year":"2015","journal-title":"Nanoscale"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1039\/C8NR01041B","article-title":"Mechanistic Insights into the Inhibition and Size Effects of Graphene Oxide Nanosheets on the Aggregation of an Amyloid-\u03b2 Peptide Fragment","volume":"10","author":"Chen","year":"2018","journal-title":"Nanoscale"},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"190271","DOI":"10.1098\/rsos.190271","article-title":"Modulation of \u03b2-Amyloid Aggregation by Graphene Quantum Dots","volume":"6","author":"Liu","year":"2019","journal-title":"R. Soc. Open Sci."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"19450","DOI":"10.1039\/D0NR05003B","article-title":"Graphene Oxide Sheets and Quantum Dots Inhibit A-Synuclein Amyloid Formation by Different Mechanisms","volume":"12","author":"Ghaeidamini","year":"2020","journal-title":"Nanoscale"},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/s41565-018-0179-y","article-title":"Graphene Quantum Dots Prevent \u03b1-Synucleinopathy in Parkinson\u2019s Disease","volume":"13","author":"Kim","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1021\/acschemneuro.8b00545","article-title":"Biodegradable Nanoparticles Containing Mechanism Based Peptide Inhibitors Reduce Polyglutamine Aggregation in Cell Models and Alleviate Motor Symptoms in a Drosophila Model of Huntington\u2019s Disease","volume":"10","author":"Joshi","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"11908","DOI":"10.7150\/thno.50616","article-title":"Graphene Oxide Improves Postoperative Cognitive Dysfunction by Maximally Alleviating Amyloid Beta Burden in Mice","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"102088","DOI":"10.1016\/j.nano.2019.102088","article-title":"Recuperative Effect of Metformin Loaded Polydopamine Nanoformulation Promoting EZH2 Mediated Proteasomal Degradation of Phospho-\u03b1-Synuclein in Parkinson\u2019s Disease Model","volume":"24","author":"Sardoiwala","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"117435","DOI":"10.1016\/j.carbpol.2020.117435","article-title":"Chitosan Nanocarrier for FTY720 Enhanced Delivery Retards Parkinson\u2019s Disease via PP2A-EzH2 Signaling in Vitro and Ex Vivo","volume":"254","author":"Sardoiwala","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_299","doi-asserted-by":"crossref","unstructured":"Rojas-Prats, E., Tosat-Bitri\u00e1n, C., Mart\u00ednez-Gonz\u00e1lez, L., Nozal, V., P\u00e9rez, D.I., and Mart\u00ednez, A. (2021). Increasing Brain Permeability of PHA-767491, a Cell Division Cycle 7 Kinase Inhibitor, with Biodegradable Polymeric Nanoparticles. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020180"},{"key":"ref_300","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3389\/fnagi.2018.00244","article-title":"EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer\u2019s Disease","volume":"10","author":"Singh","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.7150\/thno.28295","article-title":"\u201cCell-Addictive\u201d Dual-Target Traceable Nanodrug for Parkinson\u2019s Disease Treatment via Flotillins Pathway","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2019.03.010","article-title":"Dual-Drug Loaded Nanoparticles of Epigallocatechin-3-Gallate (EGCG)\/Ascorbic Acid Enhance Therapeutic Efficacy of EGCG in a APPswe\/PS1dE9 Alzheimer\u2019s Disease Mice Model","volume":"301","author":"Cano","year":"2019","journal-title":"J. Control. Release"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"125058","DOI":"10.1016\/j.colsurfa.2020.125058","article-title":"Quercetin-Loaded Selenium Nanoparticles Inhibit Amyloid-\u03b2 Aggregation and Exhibit Antioxidant Activity","volume":"602","author":"Qi","year":"2020","journal-title":"Colloids Surfaces A Physicochem. Eng. Asp."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s11671-018-2720-1","article-title":"Enhanced Effect of Combining Chlorogenic Acid on Selenium Nanoparticles in Inhibiting Amyloid \u03b2 Aggregation and Reactive Oxygen Species Formation In Vitro","volume":"13","author":"Yang","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.7150\/thno.23734","article-title":"Localized Delivery of Curcumin into Brain with Polysorbate 80-Modified Cerasomes by Ultrasound-Targeted Microbubble Destruction for Improved Parkinson\u2019s Disease Therapy","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/acsnano.9b06453","article-title":"A Self-Assembled \u03b1-Synuclein Nanoscavenger for Parkinson\u2019s Disease","volume":"14","author":"Liu","year":"2020","journal-title":"ACS Nano"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"2007765","DOI":"10.1002\/adfm.202007765","article-title":"Multiple Protective Roles of Nanoliposome-Incorporated Baicalein against Alpha-Synuclein Aggregates","volume":"31","author":"Aliakbari","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/27724336MTA31NzQh0","article-title":"Berberine Nanoencapsulation Attenuates Hallmarks of Scoplomine Induced Alzheimer\u2019s-like Disease in Rats","volume":"16","author":"Saleh","year":"2021","journal-title":"Curr. Rev. Clin. Exp. Pharmacol."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jmst.2019.10.013","article-title":"Neuroprotective Effect of Chitosan Nanoparticle Gene Delivery System Grafted with Acteoside (ACT) in Parkinson\u2019s Disease Models","volume":"43","author":"Xue","year":"2020","journal-title":"J. Mater. Sci. Technol."},{"key":"ref_310","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1074\/jbc.M111.288720","article-title":"Cellular Model of TAR DNA-Binding Protein 43 (TDP-43) Aggregation Based on Its C-Terminal Gln\/Asn-Rich Region","volume":"287","author":"Budini","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abb.2014.01.007","article-title":"Structural Characterization of the Minimal Segment of TDP-43 Competent for Aggregation","volume":"545","author":"Buratti","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"108113","DOI":"10.1016\/j.abb.2019.108113","article-title":"del C.; Carri\u00f3n-V\u00e1zquez, M.; Laurents, D. V. Molecular Mechanism of the Inhibition of TDP-43 Amyloidogenesis by QBP1","volume":"675","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Herv\u00e1s, R., Oroz, J., Galera-Prat, A., Go\u00f1i, O., Valbuena, A., Vera, A.M., G\u00f3mez-Sicilia, \u00c0., Losada-Urz\u00e1iz, F., Uversky, V.N., and Men\u00e9ndez, M. (2012). Common Features at the Start of the Neurodegeneration Cascade. PLoS Biol., 10.","DOI":"10.1371\/journal.pbio.1001335"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1074\/jbc.275.14.10437","article-title":"Inhibition of Polyglutamine Protein Aggregation and Cell Death by Novel Peptides Identified by Phage Display Screening","volume":"275","author":"Nagai","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_315","doi-asserted-by":"crossref","unstructured":"Kim, M.R., Feng, T., Zhang, Q., Chan, H.Y.E., and Chau, Y. (2019). Co-Encapsulation and Co-Delivery of Peptide Drugs via Polymeric Nanoparticles. Polymers, 11.","DOI":"10.3390\/polym11020288"},{"key":"ref_316","first-page":"2","article-title":"Tau Protein Hyperphosphorylation and Aggregation in Alzheimer\u2019s Disease and Other Tauopathies, and Possible Neuroprotective Strategies","volume":"6","author":"Wray","year":"2016","journal-title":"Biomolecules"},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Wood, A., Gurfinkel, Y., Polain, N., Lamont, W., and Lyn Rea, S. (2021). Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094705"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1007\/s11357-021-00383-5","article-title":"Regulation of TDP-43 Phosphorylation in Aging and Disease","volume":"43","author":"Eck","year":"2021","journal-title":"GeroScience"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3389\/fimmu.2019.01564","article-title":"Immunological Aspects of Approved MS Therapeutics","volume":"10","author":"Rommer","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2019.05.029","article-title":"FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor Levels and Reduces \u03b1-Synuclein Pathology in Parkinsonian GM2 +\/\u2212 Mice","volume":"411","author":"Najera","year":"2019","journal-title":"Neuroscience"},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41594-020-00537-7","article-title":"TDP-43 Aggregation Induced by Oxidative Stress Causes Global Mitochondrial Imbalance in ALS","volume":"28","author":"Zuo","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_322","doi-asserted-by":"crossref","unstructured":"L\u00e9vy, E., El Banna, N., Ba\u00eflle, D., Heneman-Masurel, A., Truchet, S., Rezaei, H., Huang, M.E., B\u00e9ringue, V., Martin, D., and Vernis, L. (2019). Causative Links between Protein Aggregation and Oxidative Stress: A Review. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163896"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.nbd.2011.12.002","article-title":"Oxidative Stress Induced by Glutathione Depletion Reproduces Pathological Modifications of TDP-43 Linked to TDP-43 Proteinopathies","volume":"45","author":"Iguchi","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"6571484","DOI":"10.1155\/2020\/6571484","article-title":"Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of Da Neurons in a Parkinsonian Mouse Model","volume":"2020","author":"Singh","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fbioe.2020.00112","article-title":"Antioxidant Nanoparticles for Concerted Inhibition of \u03b1-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation","volume":"8","author":"Zhao","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.3389\/fphar.2018.01555","article-title":"Plant Extracts and Phytochemicals Targeting \u03b1-Synuclein Aggregation in Parkinson\u2019s Disease Models","volume":"9","author":"Javed","year":"2019","journal-title":"Front. Pharmacol."},{"key":"ref_327","doi-asserted-by":"crossref","unstructured":"Ardah, M.T., Ghanem, S.S., Abdulla, S.A., Lv, G., Emara, M.M., Paleologou, K.E., Vaikath, N.N., Lu, J.H., Li, M., and Vekrellis, K. (2020). Inhibition of Alpha-Synuclein Seeded Fibril Formation and Toxicity by Herbal Medicinal Extracts. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-2849-1"},{"key":"ref_328","doi-asserted-by":"crossref","unstructured":"Rehman, H., Krishnasamy, Y., Haque, K., Thurman, R.G., Lemasters, J.J., Schnellmann, R.G., and Zhong, Z. (2013). Green Tea Polyphenols Stimulate Mitochondrial Biogenesis and Improve Renal Function after Chronic Cyclosporin A Treatment in Rats. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065029"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.bbadis.2012.12.011","article-title":"Epigallocatechin-3-Gallate Prevents Oxidative Phosphorylation Deficit and Promotes Mitochondrial Biogenesis in Human Cells from Subjects with Down\u2019s Syndrome","volume":"1832","author":"Valenti","year":"2013","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s11064-013-1147-4","article-title":"Selenium Compounds Prevent Amyloid \u03b2-Peptide Neurotoxicity in Rat Primary Hippocampal Neurons","volume":"38","author":"Godoi","year":"2013","journal-title":"Neurochem. Res."},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Kur\u0161vietien\u0117, L., Mongirdien\u0117, A., Bernatonien\u0117, J., \u0160ulinskien\u0117, J., and Stanevi\u010dien\u0117, I. (2020). Selenium Anticancer Properties and Impact on Cellular Redox Status. Antioxidants, 9.","DOI":"10.3390\/antiox9010080"},{"key":"ref_332","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jep.2016.10.040","article-title":"Baicalein Attenuates \u03b1-Synuclein Aggregation, Inflammasome Activation and Autophagy in the MPP+-Treated Nigrostriatal Dopaminergic System in Vivo","volume":"194","author":"Hung","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.phymed.2018.09.215","article-title":"Neuroprotective Effects of Baicalein in Animal Models of Parkinson\u2019s Disease: A Systematic Review of Experimental Studies","volume":"55","author":"Zhu","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"9968","DOI":"10.1038\/s41598-017-07442-y","article-title":"Therapeutic Effects of Baicalein on Rotenone-Induced Parkinson\u2019s Disease through Protecting Mitochondrial Function and Biogenesis","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_335","doi-asserted-by":"crossref","unstructured":"Yuan, N.N., Cai, C.Z., Wu, M.Y., Su, H.X., Li, M., and Lu, J.H. (2019). Neuroprotective Effects of Berberine in Animal Models of Alzheimer\u2019s Disease: A Systematic Review of Pre-Clinical Studies. BMC Complement. Altern. Med., 19.","DOI":"10.1186\/s12906-019-2510-z"},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/WNR.0000000000001365","article-title":"Berberine Alleviates Rotenone-Induced Cytotoxicity by Antioxidation and Activation of PI3K\/Akt Signaling Pathway in SH-SY5Y Cells","volume":"31","author":"Deng","year":"2020","journal-title":"Neuroreport"},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"7593608","DOI":"10.1155\/2019\/7593608","article-title":"Berberine Alleviates Amyloid \u03b2-Induced Mitochondrial Dysfunction and Synaptic Loss","volume":"2019","author":"Zhao","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"101005","DOI":"10.1016\/j.isci.2020.101005","article-title":"Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity","volume":"23","author":"Rajasekhar","year":"2020","journal-title":"iScience"},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1271\/bbb.130101","article-title":"Inhibition of Amyloid \u03b2 Aggregation by Acteoside, a Phenylethanoid Glycoside","volume":"77","author":"Kurisu","year":"2013","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.brainres.2009.05.101","article-title":"Acteoside Protects Human Neuroblastoma SH-SY5Y Cells against \u03b2-Amyloid-Induced Cell Injury","volume":"1283","author":"Wang","year":"2009","journal-title":"Brain Res."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1186\/s12974-020-01976-1","article-title":"Neuroprotective Effects of Verbascoside against Alzheimer\u2019s Disease via the Relief of Endoplasmic Reticulum Stress in A\u03b2-Exposed U251 Cells and APP\/PS1 Mice","volume":"17","author":"Wang","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"ref_342","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1021\/acsabm.0c00794","article-title":"NIR-II-Activated Yolk-Shell Nanostructures as an Intelligent Platform for Parkinsonian Therapy","volume":"3","author":"Liu","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"1703458","DOI":"10.1002\/adma.201703458","article-title":"Black Phosphorus Nanosheets as a Neuroprotective Nanomedicine for Neurodegenerative Disorder Therapy","volume":"30","author":"Chen","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s12274-016-1000-6","article-title":"Polyoxometalate-Based Nanozyme: Design of a Multifunctional Enzyme for Multi-Faceted Treatment of Alzheimer\u2019s Disease","volume":"9","author":"Gao","year":"2016","journal-title":"Nano Res."},{"key":"ref_345","doi-asserted-by":"crossref","first-page":"26721","DOI":"10.1021\/acsami.1c04163","article-title":"Polyoxometalates as Effective Nano-Inhibitors of Amyloid Aggregation of Pro-Inflammatory S100A9 Protein Involved in Neurodegenerative Diseases","volume":"13","author":"Chaudhary","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"101027","DOI":"10.1016\/j.nantod.2020.101027","article-title":"Nanozyme Scavenging ROS for Prevention of Pathologic \u03b1-Synuclein Transmission in Parkinson\u2019s Disease","volume":"36","author":"Liu","year":"2021","journal-title":"Nano Today"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.biomaterials.2019.01.037","article-title":"Sustained Release of Bioactive Hydrogen by Pd Hydride Nanoparticles Overcomes Alzheimer\u2019s Disease","volume":"197","author":"Zhang","year":"2019","journal-title":"Biomaterials"},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/s41598-020-58709-w","article-title":"Nanocatalytic Activity of Clean-Surfaced, Faceted Nanocrystalline Gold Enhances Remyelination in Animal Models of Multiple Sclerosis","volume":"10","author":"Robinson","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"2001736","DOI":"10.1002\/adhm.202001736","article-title":"Incorporation of a Biocompatible Nanozyme in Cellular Antioxidant Enzyme Cascade Reverses Huntington\u2019s Like Disorder in Preclinical Model","volume":"10","author":"Adhikari","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"14267","DOI":"10.1002\/anie.201708573","article-title":"A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson\u2019s Disease Model","volume":"56","author":"Singh","year":"2017","journal-title":"Angew. Chemie Int. Ed."},{"key":"ref_351","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/j.nano.2016.06.009","article-title":"Cerium Oxide Nanoparticles with Antioxidant Properties Ameliorate Strength and Prolong Life in Mouse Model of Amyotrophic Lateral Sclerosis","volume":"12","author":"DeCoteau","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_352","doi-asserted-by":"crossref","unstructured":"Ruotolo, R., De Giorgio, G., Minato, I., Bianchi, M.G., Bussolati, O., and Marmiroli, N. (2020). Cerium Oxide Nanoparticles Rescue \u03b1-Synuclein-Induced Toxicity in a Yeast Model of Parkinson\u2019s Disease. Nanomaterials, 10.","DOI":"10.3390\/nano10020235"},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biomaterials.2016.05.005","article-title":"Ceria\/POMs Hybrid Nanoparticles as a Mimicking Metallopeptidase for Treatment of Neurotoxicity of Amyloid-\u03b2 Peptide","volume":"98","author":"Guan","year":"2016","journal-title":"Biomaterials"},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1002\/anie.202011711","article-title":"A Cerium Vanadate Nanozyme with Specific Superoxide Dismutase Activity Regulates Mitochondrial Function and ATP Synthesis in Neuronal Cells","volume":"60","author":"Singh","year":"2021","journal-title":"Angew. Chemie Int. Ed."},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"119752","DOI":"10.1016\/j.biomaterials.2019.119752","article-title":"Mitochondria-Targeted TPP-MoS2 with Dual Enzyme Activity Provides Efficient Neuroprotection through M1\/M2 Microglial Polarization in an Alzheimer\u2019s Disease Model","volume":"232","author":"Ren","year":"2020","journal-title":"Biomaterials"},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/jacs.8b11856","article-title":"Chiral Molecule-Mediated Porous Cu x O Nanoparticle Clusters with Antioxidation Activity for Ameliorating Parkinson\u2019s Disease","volume":"141","author":"Hao","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"1700595","DOI":"10.1002\/advs.201700595","article-title":"Graphene Oxide Quantum Dots Reduce Oxidative Stress and Inhibit Neurotoxicity In Vitro and In Vivo through Catalase-Like Activity and Metabolic Regulation","volume":"5","author":"Ren","year":"2018","journal-title":"Adv. Sci."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s11671-015-0953-9","article-title":"Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics","volume":"10","author":"Ye","year":"2015","journal-title":"Nanoscale Res. Lett."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.freeradbiomed.2004.07.002","article-title":"A Biologically Effective Fullerene (C 60) Derivative with Superoxide Dismutase Mimetic Properties","volume":"37","author":"Ali","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"ref_360","doi-asserted-by":"crossref","unstructured":"Gonchar, O.O., Maznychenko, A.V., Klyuchko, O.M., Mankovska, I.M., Butowska, K., Borowik, A., Piosik, J., and Sokolowska, I. (2021). C60 Fullerene Reduces 3-Nitropropionic Acid-Induced Oxidative Stress Disorders and Mitochondrial Dysfunction in Rats by Modulation of P53, Bcl-2 and Nrf2 Targeted Proteins. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115444"},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1021\/acsami.9b22214","article-title":"Near-Infrared Responsive Dopamine\/Melatonin-Derived Nanocomposites Abrogating in Situ Amyloid \u03b2 Nucleation, Propagation, and Ameliorate Neuronal Functions","volume":"12","author":"Srivastava","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"119822","DOI":"10.1016\/j.biomaterials.2020.119822","article-title":"Intelligently Thermoresponsive Flower-like Hollow Nano-Ruthenium System for Sustained Release of Nerve Growth Factor to Inhibit Hyperphosphorylation of Tau and Neuronal Damage for the Treatment of Alzheimer\u2019s Disease","volume":"237","author":"Zhou","year":"2020","journal-title":"Biomaterials"},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"6795","DOI":"10.1039\/C8CS00387D","article-title":"Black Phosphorus Quantum Dots: Synthesis, Properties, Functionalized Modification and Applications","volume":"47","author":"Gui","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.carbon.2015.07.075","article-title":"Revealing the Importance of Surface Morphology of Nanomaterials to Biological Responses: Adsorption of the Villin Headpiece onto Graphene and Phosphorene","volume":"94","author":"Zhang","year":"2015","journal-title":"Carbon N. Y."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1021\/acs.accounts.9b00140","article-title":"Nanozymes: From New Concepts, Mechanisms, and Standards to Applications","volume":"52","author":"Liang","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00401-013-1208-4","article-title":"The Role of Pro-Inflammatory S100A9 in Alzheimer\u2019s Disease Amyloid-Neuroinflammatory Cascade","volume":"127","author":"Wang","year":"2014","journal-title":"Acta Neuropathol."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12974-018-1210-9","article-title":"Co-Aggregation of pro-Inflammatory S100A9 with \u03b1-Synuclein in Parkinson\u2019s Disease: Ex Vivo and in Vitro Studies","volume":"15","author":"Horvath","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"ref_368","doi-asserted-by":"crossref","unstructured":"Ha, T.Y., Chang, K.A., Kim, J.A., Kim, H.S., Kim, S., Chong, Y.H., and Suh, Y.H. (2010). S100a9 Knockdown Decreases the Memory Impairment and the Neuropathology in Tg2576 Mice, AD Animal Model. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0008840"},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.brainres.2013.08.025","article-title":"Serum Nicotinamide Adenine Dinucleotide Levels through Disease Course in Multiple Sclerosis","volume":"1537","author":"Braidy","year":"2013","journal-title":"Brain Res."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"e041479","DOI":"10.1136\/bmjopen-2020-041479","article-title":"Study Protocol of RESCUE-ALS: A Phase 2, Randomised, Double-Blind, Placebo-Controlled Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients to Assess Bioenergetic Catalysis with CNM-Au8 as a Mechanism to Slow Disease Progression","volume":"11","author":"Vucic","year":"2021","journal-title":"BMJ Open"},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1039\/C7SC05476A","article-title":"ROS Scavenging Mn3O4 Nanozymes for: In Vivo Anti-Inflammation","volume":"9","author":"Yao","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_372","doi-asserted-by":"crossref","unstructured":"Nelson, B.C., Johnson, M.E., Walker, M.L., Riley, K.R., and Sims, C.M. (2016). Antioxidant Cerium Oxide Nanoparticles in Biology and Medicine. Antioxidants, 5.","DOI":"10.3390\/antiox5020015"},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/acsnano.7b07625","article-title":"Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer\u2019s Disease","volume":"12","author":"Chen","year":"2018","journal-title":"ACS Nano"},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"10582","DOI":"10.1021\/nn403743b","article-title":"Custom Cerium Oxide Nanoparticles Protect against a Free Radical Mediated Autoimmune Degenerative Disease in the Brain","volume":"7","author":"Heckman","year":"2013","journal-title":"ACS Nano"},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.2147\/IJN.S220380","article-title":"Cerium Oxide NPs Mitigate the Amyloid Formation of \u03b1-Synuclein and Associated Cytotoxicity","volume":"14","author":"Zand","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_376","doi-asserted-by":"crossref","unstructured":"Mikheev, I.V., Sozarukova, M.M., Izmailov, D.Y., Kareev, I.E., Proskurnina, E.V., and Proskurnin, M.A. (2021). Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and Gd@c82. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115838"},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1600-0625.2007.00545.x","article-title":"Carboxyfullerenes Localize within Mitochondria and Prevent the UVB-Induced Intrinsic Apoptotic Pathway","volume":"16","author":"Chirico","year":"2007","journal-title":"Exp. Dermatol."},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neurobiolaging.2006.09.014","article-title":"A Carboxyfullerene SOD Mimetic Improves Cognition and Extends the Lifespan of Mice","volume":"29","author":"Quick","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1073\/pnas.94.17.9434","article-title":"Carboxyfullerenes as Neuroprotective Agents","volume":"94","author":"Dugan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/ana.24220","article-title":"Carboxyfullerene Neuroprotection Postinjury in Parkinsonian Nonhuman Primates","volume":"76","author":"Dugan","year":"2014","journal-title":"Ann. 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