{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:24:55Z","timestamp":1784114695073,"version":"3.55.0"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant of the President of the Russian Federation","award":["\u041c\u041a-4273.2021.1.4"],"award-info":[{"award-number":["\u041c\u041a-4273.2021.1.4"]}]},{"name":"Russian Federation Grant","award":["14.Z50.31.0044"],"award-info":[{"award-number":["14.Z50.31.0044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Bacterial infections are a severe medical problem, especially in traumatology, orthopedics, and surgery. The local use of antibiotics-elution materials has made it possible to increase the effectiveness of acute infections treatment. However, the infection prevention problem remains unresolved. Here, we demonstrate the fabrication of polylactic acid (PLA) \u201csmart\u201d films with microchamber arrays. These microchambers contain ceftriaxone as a payload in concentrations ranging from 12 \u00b1 1 \u03bcg\/cm2 to 38 \u00b1 8 \u03bcg\/cm2, depending on the patterned film thickness formed by the different PLA concentrations in chloroform. In addition, the release profile of the antibiotic can be prolonged up to 72 h in saline. At the same time, on the surface of agar plates, the antibiotic release time increases up to 96 h, which has been confirmed by the growth suppression of the Staphylococcus aureus bacteria. The efficient loading and optimal release rate are obtained for patterned films formed by the 1.5 wt % PLA in chloroform. The films produced from 1.5 and 2 wt % PLA solutions (thickness\u20140.42 \u00b1 0.12 and 0.68 \u00b1 0.16 \u00b5m, respectively) show an accelerated ceftriaxone release upon the trigger of the therapeutic ultrasound, which impacted as an expansion of the bacterial growth inhibition zone around the samples. Combining prolonged drug elution with the on-demand release ability of large cargo amount opens up new approaches for personalized and custom-tunable antibacterial therapy.<\/jats:p>","DOI":"10.3390\/pharmaceutics14010042","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:06:54Z","timestamp":1640567214000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["\u201cSmart\u201d Polylactic Acid Films with Ceftriaxone Loaded Microchamber Arrays for Personalized Antibiotic Therapy"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1773-9015","authenticated-orcid":false,"given":"Ekaterina A.","family":"Mordovina","sequence":"first","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina O.","family":"Plastun","sequence":"additional","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkady S.","family":"Abdurashitov","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel I.","family":"Proshin","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Raikova","sequence":"additional","affiliation":[{"name":"Saratov Hygiene Medical Research Center of the FBSI \u00abFSC Medical and Preventive Health Risk Management Technologies\u00bb, 1A Zarechnaya Str., 410022 Saratov, Russia"},{"name":"Department of Microbiology, Virology, and Immunology, Saratov State Medical University, 112 Bolshaya Kazachia Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-4478","authenticated-orcid":false,"given":"Daniil N.","family":"Bratashov","sequence":"additional","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Inozemtseva","sequence":"additional","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1781-6180","authenticated-orcid":false,"given":"Irina Yu.","family":"Goryacheva","sequence":"additional","affiliation":[{"name":"Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-0562","authenticated-orcid":false,"given":"Gleb B.","family":"Sukhorukov","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia"},{"name":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-4157","authenticated-orcid":false,"given":"Olga A.","family":"Sindeeva","sequence":"additional","affiliation":[{"name":"Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobel Str., 143005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3855\/jidc.819","article-title":"Chronic bacterial and parasitic infections and cancer: A review","volume":"4","author":"Samaras","year":"2010","journal-title":"J. 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