{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:56:37Z","timestamp":1782564997043,"version":"3.54.5"},"reference-count":85,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Drug-eluting stents (DESs) are commonly used for the treatment of coronary artery disease. The evolution of the drug-eluting layer on the surface of the metal stent plays an important role in DES functionality. Here, the use of biodegradable polymers has emerged as an attractive strategy because it minimizes the occurrence of late thrombosis after stent implantation. Furthermore, understanding the drug-release behavior of DESs is also important for improving the safety and efficacy of stent treatments. Drug release from biodegradable polymers has attracted extensive research attention because biodegradable polymers with different properties show different drug-release behaviors. Molecular weight, composition, glass transition temperature, crystallinity, and the degradation rate are important properties affecting the behavior of polymers. Sirolimus is a conventional anti-proliferation drug and is the most widely used drug in DESs. Sirolimus-release behavior affects endothelialization and thrombosis formation after DES implantation. In this review, we focus on sirolimus release from biodegradable polymers, including synthetic and natural polymers widely used in the medical field. We hope this review will provide valuable up-to-date information on this subject and contribute to the further development of safe and efficient DESs.<\/jats:p>","DOI":"10.3390\/pharmaceutics14030492","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T21:11:07Z","timestamp":1645737067000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sirolimus Release from Biodegradable Polymers for Coronary Stent Application: A Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1332-3189","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"first","affiliation":[{"name":"Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan"},{"name":"Charlie Lab Inc., Kumamoto 860-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-8708","authenticated-orcid":false,"given":"Takuro","family":"Niidome","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1056\/NEJM198703193161201","article-title":"Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty","volume":"19","author":"Sigwart","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0735-1097(98)00348-9","article-title":"Long-term endothelial dysfunction is more pronounced after stenting than after balloon angioplasty in porcine coronary arteries","volume":"32","author":"Whelan","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1253\/circj.71.220","article-title":"Impaired endothelial vasomotor function after sirolimus-eluting stent implantation","volume":"71","author":"Fuke","year":"2007","journal-title":"Circ. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.ahj.2005.08.011","article-title":"Bare metal stent restenosis is not a benign clinical entity","volume":"151","author":"Chen","year":"2006","journal-title":"Am. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e007023","DOI":"10.1161\/CIRCINTERVENTIONS.118.007023","article-title":"Restenosis of drug-eluting stents, A new classification system based on disease mechanism to guide treatment and state-of-the-art review","volume":"12","author":"Shlofmitz","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jcin.2013.06.015","article-title":"Risk of stent thrombosis among bare-metal stents, first-generation drug-eluting stents, and second-generation drug-eluting stents","volume":"6","author":"Tada","year":"2013","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jvs.2019.06.217","article-title":"Efficacy and safety of sirolimus in the treatment of vascular anomalies: A systematic review","volume":"71","author":"Freixo","year":"2020","journal-title":"J. Vasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Shen, Y., Li, X., and Le, Y. (2018). Amorphous nanoparticulate formulation of sirolimus and its tablets. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030155"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.18433\/jpps32053","article-title":"Factors influencing 1st and 2nd generation drug-eluting stent performance: Understanding the basic pharmaceutical drug-in-polymer formulation factors contributing to stent thrombosis do we really need to eliminate the polymer?","volume":"24","author":"Srdanovic","year":"2021","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jacc.2016.11.055","article-title":"10-Year clinical outcome after randomization to treatment by sirolimus- or paclitaxel-eluting coronary stents","volume":"69","author":"Thuesen","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2011.01.011","article-title":"The pathology of neoatherosclerosis in human coronary implants: Bare-metal and drug-eluting stents","volume":"57","author":"Nakazawa","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1080\/17425247.2016.1227788","article-title":"The absorb bioresorbable vascular scaffold for the treatment of coronary artery disease","volume":"13","author":"Collet","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.111.046599","article-title":"Very late stent thrombosis and late target lesion revascularization after sirolimus-eluting stent implantation","volume":"125","author":"Kimura","year":"2012","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1001\/jama.299.16.1903","article-title":"Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease","volume":"299","author":"Stone","year":"2008","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jacc.2012.01.008","article-title":"A randomized controlled trial in second-generation zotarolimus-eluting resolute stents versus everolimus-eluting xience v stents in real-world patients: The twente trial","volume":"59","author":"Basalus","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/CIRCULATIONAHA.110.003210","article-title":"Stent Thrombogenicity Early in High-Risk Interventional Settings Is Driven by Stent Design and Deployment and Protected by Polymer-Drug Coatings","volume":"123","author":"Kolandaivelu","year":"2011","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s43044-019-0025-z","article-title":"In-stent restenosis of drug-eluting stents: Clinical presentation and outcomes in a real-world scenario","volume":"71","author":"Paramasivam","year":"2019","journal-title":"Egypt Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1111\/j.1538-7836.2011.04456.x","article-title":"Management of patients with recently implanted coronary stents on dual antiplatelet therapy who need to undergo major surgery","volume":"9","author":"Savonitto","year":"2011","journal-title":"J. Thromb. Haemost."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.2147\/DDDT.S165440","article-title":"Current development of biodegradable polymeric materials for biomedical applications","volume":"12","author":"Song","year":"2018","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/CIRCULATIONAHA.120.051700","article-title":"Durable polymer versus biodegradable polymer drug-eluting stents after percutaneous coronary intervention in patients with acute coronary syndrome","volume":"143","author":"Kim","year":"2021","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2041731417731546","DOI":"10.1177\/2041731417731546","article-title":"Recent advances to accelerate re-endothelialization for vascular stents","volume":"8","author":"Bedair","year":"2017","journal-title":"J. Tissue. Eng."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Visan, A.I., Popescu-Pelin, G., and Socol, G. (2021). Degradation behavior of polymers used as coating materials for drug delivery-A basic review. Polymers, 13.","DOI":"10.3390\/polym13081272"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/neuonc\/nov152","article-title":"Differentiating the mTOR inhibitors everolimus and sirolimus in the treatment of tuberous sclerosis complex","volume":"17","author":"MacKeigan","year":"2015","journal-title":"Neuro-Oncology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jacc.2015.11.051","article-title":"Safety and efficacy of everolimus-versus sirolimus-eluting stents: 5-year results from SORT OUT IV","volume":"23","author":"Jensen","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Maqsood, M., and Seide, G. (2020). Biodegradable flame retardants for biodegradable polymer. Biomolecules, 10.","DOI":"10.3390\/biom10071038"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1126\/science.1109778","article-title":"The Convergence of Synthetic Organic and Polymer Chemistries","volume":"309","author":"Hawker","year":"2005","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Balla, E., Daniilidis, V., Karlioti, G., Kalamas, T., Stefanidou, M., Bikiaris, N.D., Vlachopoulos, A., Koumentakou, I., and Bikiaris, D.N. (2021). Poly(lactic Acid): A versatile biobased polymer for the future with multifunctional properties\u2014From monomer synthesis, polymerization techniques and molecular weight increase to PLA applications. Polymers, 13.","DOI":"10.3390\/polym13111822"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"106668","DOI":"10.1016\/j.compositesa.2021.106668","article-title":"The effect of processing conditions and polymer crystallinity on the mechanical properties of unidirectional self-reinforced PLA composites","volume":"152","author":"Beauson","year":"2022","journal-title":"Compos. Part A Appl. Sci. Manuf."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.medengphy.2014.09.014","article-title":"Computational analysis of the radial mechanical performance of PLLA coronary artery stents","volume":"37","author":"Pauck","year":"2015","journal-title":"Med. Eng. Phys."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S0735-1097(96)00584-0","article-title":"Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model","volume":"29","author":"Lincoff","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.addr.2016.06.012","article-title":"Physical and mechanical properties of PLA, and their functions in widespread applications-A comprehensive review","volume":"107","author":"Langer","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/ccd.23113","article-title":"Sustained clinical safety and efficacy of a biodegradable-polymer coated sirolimus-eluting stent in \u201creal-world\u201d practice: Three-year outcomes of the CREATE (multi-center registry of Excel biodegradable polymer drug eluting stents) study","volume":"79","author":"Han","year":"2012","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1161\/CIRCULATIONAHA.118.034456","article-title":"Newer-generation ultrathin strut drug-eluting stents versus older second-generation thicker strut drug-eluting stents for coronary artery disease","volume":"138","author":"Bangalore","year":"2018","journal-title":"Circulation"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.colsurfb.2017.12.032","article-title":"Optimized polymer coating for magnesium alloy-based bioresorbable scaffolds for long-lasting drug release and corrosion resistance","volume":"163","author":"Xu","year":"2018","journal-title":"Colloids. Surf. B"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1515\/cdbme-2018-0142","article-title":"In vitro study of sirolimus release from nonwoven PLLA matrices","volume":"4","author":"Illner","year":"2018","journal-title":"Curr. Direc. Biomed. Eng."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1161\/CIRCULATIONAHA.110.000901","article-title":"Long-term (>10 years) clinical outcomes of first-in-man biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents","volume":"125","author":"Nishio","year":"2012","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1253\/circj.CJ-20-0040","article-title":"Comparative analysis of the paclitaxel-eluting peripheral igaki-tamai stent and the drug-free Igaki-Tamai stent using optical coherence tomography and histological analysis in a porcine iliac artery model","volume":"84","author":"Kuwabara","year":"2020","journal-title":"Circ. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s00289-011-0682-x","article-title":"Short-term effects of fully bioabsorbable PLLA coronary stents in a porcine model","volume":"68","author":"Shen","year":"2012","journal-title":"Polym. Bull."},{"key":"ref_39","unstructured":"Kaul, U. (2016). Fully Bioresorbable PLA-Based Sirolimus-Eluting MeRes 100 Scaffold (Meril Life Science), Asia PCR. Available online: https:\/\/media.pcronline.com\/diapos\/AsiaPCR2016\/45-20160121_1741_Room_336_Kaul_Upendra_1111_(2000)\/Kaul_Upendra_20160121_1705_Room_336.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"923","DOI":"10.21037\/jtd.2017.06.30","article-title":"Mechanical behavior of polymer-based vs. metallic-based bioresorbable stents","volume":"9","author":"Ang","year":"2017","journal-title":"J. Tborac. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4330\/wjc.v10.i10.165","article-title":"Undiscovered pathology of transient scaffolding remains a driver of failures in clinical trials","volume":"10","author":"Kharlamov","year":"2018","journal-title":"World J. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"118565","DOI":"10.1016\/j.ijpharm.2019.118565","article-title":"Amorphous binary dispersions of chloramphenicol in enantiomeric pure and racemic poly-lactic acid: Morphology, molecular relaxations, and controlled drug release","volume":"568","author":"Valenti","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/ccd.23280","article-title":"Randomized comparison of the nobori biolimus A9-eluting stent with the sirolimus-eluting stent in patients with stenosis in native coronary arteries","volume":"80","author":"Kadota","year":"2012","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1956015","DOI":"10.1155\/2020\/1956015","article-title":"Everolimus-eluting biodegradable abluminal coating stent versus durable conformal coating stent: Termination of the inflammatory response associated with neointimal healing in a porcine coronary model","volume":"2020","author":"Mori","year":"2020","journal-title":"J. Interven. Cardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"B114","DOI":"10.1016\/j.jacc.2021.09.1131","article-title":"TCT-278 Five-Year Outcomes After Revascularization with the Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Orsiro Stent or the Biodegradable Polymer Biolimus-Eluting Nobori Stent in Patients with and Without Acute Coronary Syndromes: From the SORT OUT VII Trial","volume":"78","author":"Noori","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.3889\/oamjms.2019.241","article-title":"Real world experience of a biodegradable polymer sirolimus-eluting stent (Yukon choice PC elite) in patients with acute ST-segment elevation myocardial infarction undergoing primary angioplasty: A multicentric observational study (The elite India study)","volume":"7","author":"Verma","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/ccd.28051","article-title":"Safety and efficacy of a novel abluminal groove-filled biodegradable polymer sirolimus-eluting stent for the treatment of de novo coronary lesions: Final five-year results of the patient-level pooled analysis from the TARGET I and TARGET II trials","volume":"93","author":"Li","year":"2019","journal-title":"Cardiac. Cardiovascular. Interv."},{"key":"ref_48","first-page":"e004801","article-title":"Serial assessment of strut coverage of biodegradable polymer drug-eluting stent at 1, 2, and 3 months after stent implantation by optical frequency domain imaging","volume":"10","author":"Chevalier","year":"2017","journal-title":"Circulation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s11998-019-00284-5","article-title":"Corrosion resistance of HF-treated Mg alloy stent following balloon expansion and its improvement through biodegradable polymer coating","volume":"17","author":"Xu","year":"2020","journal-title":"J. Coat. Technol. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijcard.2019.01.053","article-title":"Safety and efficacy of the COMBO bio-engineered stent in an all-comer PCI cohort: 1-Year final clinical outcomes from the MASCOT post-marketing registry","volume":"283","author":"Colombo","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jddst.2018.08.026","article-title":"In vitro release study of sirolimus from a PDLLA matrix on a bioresorbable drug-eluting stent","volume":"48","author":"Li","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.msec.2017.04.024","article-title":"The effect of solvents and hydrophilic additice on stable coating and controllable sirolimus release system for drug-eluting stent","volume":"78","author":"Kim","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"(2019). Biocompatibility, biodegradation and biomedical applications of poly(lactic acid)\/poly(lactic-co-glycolic acid) micro and nanoparticles. J. Pharm. Investig., 49, 347\u2013380.","DOI":"10.1007\/s40005-019-00439-x"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.3390\/ijms15033640","article-title":"An overview of poly(lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering","volume":"15","author":"Gentile","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jcin.2014.09.001","article-title":"A randomized comparison of novel biodegradable polymer- and durable polymer-coated cobalt-chromium sirolimus-eluting stents","volume":"7","author":"Han","year":"2014","journal-title":"J. Am. Coll. Cardiol. Intv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2019.06.053","article-title":"Twelve-month angiographic and clinical outcomes of the Xinsorb bioresorbable sirolimus-eluting scaffold and a metallic stent in patients with coronary artery disease","volume":"293","author":"Wu","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_57","first-page":"149","article-title":"A novel platinum chromium everolimus-eluting stent for the treatment of coronary artery disease","volume":"7","author":"Bennett","year":"2013","journal-title":"Biologics"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/ccd.27030","article-title":"Real-life clinical outcomes with everolimus eluting platinum chromium stent with an abluminal biodegradable polymer in patients from the Swedish coronary angiography and angioplasty registry (SCAAR)","volume":"90","author":"Sarno","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jconrel.2018.02.007","article-title":"Defining drug and target protein distributions after stent-based drug release: Durable versus deployable coatings","volume":"274","author":"Tzafriri","year":"2018","journal-title":"J. Control. Rel."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e008737","DOI":"10.1161\/CIRCINTERVENTIONS.119.008737","article-title":"Final 3-year outcomes of MiStent biodegradable polymer crystalline sirolimus-eluting stent versus Xience permanent polymer everolimus-eluting stent","volume":"13","author":"Takahashi","year":"2020","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.jacc.2016.03.475","article-title":"Biodegradable polymer-based sirolimus-eluting stents with differing elution and absorption kinetics","volume":"67","author":"Xu","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ccd.28288","article-title":"Two-year safety evaluation of a biodegradable polymer sirolimus-eluting stent with increased drug elution and polymer absorption kinetics in complex patient and lesion cohort","volume":"95","author":"Jia","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1021\/acs.biomac.9b00159","article-title":"Biocompatibility of resorbable polymers: A historical perspective and framework for the future","volume":"20","author":"Pappalardo","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3390\/polym3031377","article-title":"Poly lactic-co-glycolic acid (PLGA) as biodegradable controlled drug delivery carrier","volume":"3","author":"Makadia","year":"2011","journal-title":"Polymers"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/jbm.a.35357","article-title":"A mechanistic model for drug release in PLGA biodegradable stent coatings coupled with polymer degradation and erosion","volume":"103","author":"Zhu","year":"2014","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Chu, Z., Li, X., Kang, H., Yang, X., and Fan, Y. (2017). The effect of fluid shear stress on the in vitro release kinetics of sirolimus from PLGA films. Polymers, 9.","DOI":"10.3390\/polym9110618"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"102446","DOI":"10.1016\/j.jddst.2021.102446","article-title":"On the importance physical and mechanical properties of PLGA films during drug release","volume":"63","author":"Abbasnezhad","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1021\/acs.chemrev.5b00346","article-title":"Degradable controlled-release polymers and polymeric nanoparticles: Mechanisms of controlling drug release","volume":"116","author":"Kamaly","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Abbasnezhad, N., Kebdani, M., Shirinbayan, M., Champmartin, S., Tcharkhtchi, A., Kouidri, S., and Bakir, F. (2021). Development of a model based on physical mechanisms for the explanation of drug release: Application to diclofenac release from polyurethane films. Polymers, 13.","DOI":"10.3390\/polym13081230"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Reddy, M.S.B., Ponnamma, D., Choudhary, R., and Sadasivuni, K.K. (2021). A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds. Polymers, 12.","DOI":"10.3390\/polym13071105"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Bealer, E.J., Onissema-Karimu, S., Rivera-Galletti, A., Francis, M., Wilkowski, J., Salas-de la Cruz, D., and Hu, X. (2020). Protein-polysaccharide composite materials: Fabrication and applications. Polymers, 12.","DOI":"10.3390\/polym12020464"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Le\u00f3n-L\u00f3pez, A., Morales-Pe\u00f1aloza, A., Mart\u00ednez-Ju\u00e1rez, V.M., Vargas-Torres, A., Zeugolis, D.I., and Aguirre-\u00c1lvarez, G. (2019). Hydrolyzed Collagen\u2014Sources and Applications. Molecules, 24.","DOI":"10.3390\/molecules24224031"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Jafari, H., Lista, A., Siekapen, M.M., Ghaffari-Bohlouli, P., Nie, L., Alimoradi, H., and Shavandi, A. (2020). Fish collagen: Extraction, characterization, and applications for biomaterials engineering. Polymers, 12.","DOI":"10.3390\/polym12102230"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/jbm.a.32820","article-title":"Heparin\/collagen multilayer as a thromboresistant and endothelial favorable coating for intravascular stent","volume":"96","author":"Lin","year":"2011","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jconrel.2005.07.022","article-title":"A novel drug-eluting stent spray-coated with multi-layers of collagen and sirolimus","volume":"108","author":"Chen","year":"2005","journal-title":"J. Control. Rel."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.addr.2003.08.004","article-title":"Collagen gel systems for sustained delivery and tissue engineering","volume":"55","author":"Wallace","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.addr.2015.11.013","article-title":"Collagen interactions: Drug design and delivery","volume":"97","author":"An","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fphar.2017.00560","article-title":"Inhibition of collagen-induced platelet aggregation by the Secobutanolide Secolincomolide A from Lindera obtusiloba Blume","volume":"8","author":"Jung","year":"2017","journal-title":"Front Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"121055","DOI":"10.1016\/j.biomaterials.2021.121055","article-title":"A tailored extracellular matrix (ECM)\u2014Mimetic coating for cardiovascular stents by stepwise assembly of hyaluronic acid and recombinant human type III collagen","volume":"276","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/acs.macromol.5b00160","article-title":"Analysis of the structure of Bombyx mori silk fibroin by NMR","volume":"48","author":"Asakura","year":"2015","journal-title":"Macromolecules"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1021\/acsbiomaterials.8b01482","article-title":"Advanced silk fibroin biomaterials and application to small-diameter silk vascular grafts","volume":"5","author":"Asakura","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/acsabm.9b00957","article-title":"Silk fibroin as a coating polymer for sirolimus-eluting magnesium alloy stents","volume":"3","author":"Xu","year":"2020","journal-title":"ACS Appl. Bio. Mater."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.msec.2015.07.041","article-title":"The outermost surface properties of silk fibroin films reflect ethanol-treatment conditions used in biomaterials preparation","volume":"58","author":"Terada","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2021.10.024","article-title":"Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery","volume":"340","author":"Lee","year":"2021","journal-title":"J. Control. Rel."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"585077","DOI":"10.3389\/fchem.2020.585077","article-title":"Multi-responsive silk fibroin-based nanoparticles for drug delivery","volume":"8","author":"Ma","year":"2020","journal-title":"Front Chem."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/492\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:26:22Z","timestamp":1760135182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":85,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["pharmaceutics14030492"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14030492","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,24]]}}}