{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:18:32Z","timestamp":1784546312444,"version":"3.55.0"},"reference-count":65,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007414","name":"Qassim University","doi-asserted-by":"publisher","award":["10103-pharmacy-2020-1-3-1"],"award-info":[{"award-number":["10103-pharmacy-2020-1-3-1"]}],"id":[{"id":"10.13039\/501100007414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: CXCL16 attracts T-cells to the site of inflammation after cleaving by A Disintegrin and Metalloproteinase (ADAM10). Aim: The current study explored the role of ADAM10\/CXCL16\/T-cell\/NF-\u03baB in the initiation of type 1 diabetes (T1D) with special reference to the potential protecting role of resveratrol (RES). Methods: Four sets of Balb\/c mice were created: a diabetes mellitus (DM) group (streptozotocin (STZ) 55 mg\/kg, i.p.], a control group administered buffer, a RES group [RES, 50 mg\/kg, i.p.), and a DM + RES group (RES (50 mg\/kg, i.p.) and STZ (55 mg\/kg, i.p.) administered daily for 12 days commencing from the fourth day of STZ injection). Histopathological changes, fasting blood insulin (FBI), glucose (FBG), serum and pancreatic ADAM10, CXCL16, NF-\u03baB, T-cells pancreatic expression, inflammatory, and apoptotic markers were analyzed. Results: FBG, inflammatory and apoptotic markers, serum TNF-\u03b1, cellular CXCL16 and ADAM10 protein expression, pancreatic T-cell migration and NF-\u03baB were significantly increased in diabetic mice compared to normal mice. RES significantly improved the biochemical and inflammatory parameters distorted in STZ-treated mice. Conclusions: ADAM10 promotes the cleaved form of CXCL16 driving T-cells into the islets of the pancreatic in T1D. RES successfully prevented the deleterious effect caused by STZ. ADAM10 and CXCL16 may serve as novel therapeutic targets for T1D.<\/jats:p>","DOI":"10.3390\/pharmaceutics14030594","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T01:53:54Z","timestamp":1646790834000},"page":"594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resveratrol Inhibited ADAM10 Mediated CXCL16-Cleavage and T-Cells Recruitment to Pancreatic \u03b2-Cells in Type 1 Diabetes Mellitus in Mice"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0426-5458","authenticated-orcid":false,"given":"Mohamed S.","family":"Abdel-Bakky","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah 52471, Saudi Arabia"},{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulmajeed","family":"Alqasoumi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraydah 52471, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed M.","family":"Altowayan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Qassim University, Buraydah 52471, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-3974","authenticated-orcid":false,"given":"Elham","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62514, Egypt"},{"name":"Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah 52471, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa A.","family":"Darwish","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni Suef 11787, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteom."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.076398","article-title":"Ectodomain shedding and ADAMs in development","volume":"139","author":"Weber","year":"2012","journal-title":"Development"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.semcdb.2008.09.005","article-title":"The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer","volume":"20","author":"Pruessmeyer","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ejcb.2011.09.003","article-title":"The role of ADAM-mediated shedding in vascular biology","volume":"91","author":"Dreymueller","year":"2012","journal-title":"Eur. J. Cell Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fang, Y., Henderson, F.C., Yi, Q., Lei, Q., Li, Y., and Chen, N. (2014). Chemokine CXCL16 expression suppresses migration and invasiveness and induces apoptosis in breast cancer cells. Mediat. Inflamm., 2014.","DOI":"10.1155\/2014\/478641"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopha.2017.12.063","article-title":"CXCL16\/ROCK1 signaling pathway exacerbates acute kidney injury induced by ischemia-reperfusion","volume":"98","author":"Liang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fcell.2018.00153","article-title":"Renal ADAM10 and 17: Their physiological and medical meanings","volume":"6","author":"Kato","year":"2018","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ki.2008.181","article-title":"Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney","volume":"74","author":"Schramme","year":"2008","journal-title":"Kidney Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1038\/s41598-019-38766-6","article-title":"Higher CXCL16 exodomain is associated with aggressive ovarian cancer and promotes the disease by CXCR6 activation and MMP modulation","volume":"9","author":"Mir","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.clinbiochem.2012.05.014","article-title":"Soluble CXC chemokine ligand 16 levels are increased in gout patients","volume":"45","author":"Gong","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1365-2362.2011.02473.x","article-title":"Increased plasma CXCL16 levels in patients with chronic kidney diseases","volume":"41","author":"Lin","year":"2011","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1074\/jbc.M311660200","article-title":"CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I\u03baB kinase, and nuclear factor-\u03baB and induces cell-cell adhesion and aortic smooth muscle cell proliferation","volume":"279","author":"Chandrasekar","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6362","DOI":"10.4049\/jimmunol.172.10.6362","article-title":"The transmembrane CXC-chemokine ligand 16 is induced by IFN-\u03b3 and TNF-\u03b1 and shed by the activity of the disintegrin-like metalloproteinase ADAM10","volume":"172","author":"Abel","year":"2004","journal-title":"J. Immunol."},{"key":"ref_14","first-page":"9","article-title":"Circulating CXCL16 in type 2 diabetes mellitus Egyptian patients","volume":"14","author":"Tawfik","year":"2021","journal-title":"J. Radiat. Res. Appl. Sci."},{"key":"ref_15","first-page":"184","article-title":"Serum CXCL16 as a novel biomarker of coronary artery disease in type 2 diabetes mellitus: A pilot study","volume":"46","author":"Zhou","year":"2016","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/1479164117728011","article-title":"CXC chemokine ligand 16 is increased in gestational diabetes mellitus and preeclampsia and associated with lipoproteins in gestational diabetes mellitus at 5 years follow-up","volume":"14","author":"Lekva","year":"2017","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Devi, L., Alldred, M.J., Ginsberg, S.D., and Ohno, M. (2012). Mechanisms underlying insulin deficiency-induced acceleration of \u03b2-amyloidosis in a mouse model of Alzheimer\u2019s disease. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0032792"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yang, K., Lu, L., Liu, Y., Zhang, Q., Pu, L.J., Wang, L.J., Zhu, Z.B., Wang, Y.N., Meng, H., and Zhang, X.J. (2013). Increase of ADAM10 level in coronary artery in-stent restenosis segments in diabetic minipigs: High ADAM10 expression promoting growth and migration in human vascular smooth muscle cells via Notch 1 and 3. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0083853"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/cdd.2012.67","article-title":"C\/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in \u03b2-cells","volume":"19","author":"Allagnat","year":"2012","journal-title":"Cell Death Differ."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.2353\/ajpath.2007.060065","article-title":"Inhibition of CXCL16 attenuates inflammatory and progressive phases of anti-glomerular basement membrane antibody-associated glomerulonephritis","volume":"170","author":"Garcia","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"119250","DOI":"10.1016\/j.lfs.2021.119250","article-title":"Resveratrol inhibits macrophage infiltration of pancreatic islets in streptozotocin-induced type 1 diabetic mice via attenuation of the CXCL16\/NF-\u03ba\u0392 p65 signaling pathway","volume":"272","author":"Darwish","year":"2021","journal-title":"Life Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.pharep.2014.04.006","article-title":"Therapeutic potential of resveratrol in diabetic complications: In vitro and in vivo studies","volume":"66","author":"Ciddi","year":"2014","journal-title":"Pharmacol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.biopha.2016.06.004","article-title":"Effect of resveratrol and rosuvastatin on experimental diabetic nephropathy in rats","volume":"82","author":"Hussein","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_24","first-page":"540","article-title":"Resveratrol effects on a diabetic rat model with coronary heart disease","volume":"25","author":"Huo","year":"2019","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9737483","DOI":"10.1155\/2016\/9737483","article-title":"Antidiabetic effects of resveratrol: The way forward in its clinical utility","volume":"2016","author":"Oyenihi","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2337\/db09-1431","article-title":"Resveratrol inhibits neuronal apoptosis and elevated Ca2+\/ calmodulin-dependent protein kinase II activity in diabetic mouse retina","volume":"59","author":"Kim","year":"2010","journal-title":"Diabetes"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.pnpbp.2008.03.024","article-title":"Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice","volume":"32","author":"Blanchet","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1124\/jpet.107.122655","article-title":"Simvastatin protects against multiple low-dose streptozotocin-induced type 1 diabetes in CD-1 mice and recurrence of disease in nonobese diabetic mice","volume":"323","author":"Rydgren","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/db16-0547","article-title":"Islet-expressed CXCL10 promotes autoimmune destruction of islet isografts in mice with type 1 diabetes","volume":"66","author":"Bender","year":"2017","journal-title":"Diabetes"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/niox.2000.0319","article-title":"A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite","volume":"5","author":"Miranda","year":"2001","journal-title":"Nitric Oxide"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Abdel-bakky, M.S., Hammad, M.A., Walker, L.A., and Ashfaq, M.K. (2011). Silencing of tissue factor by antisense deoxyoligonucleotide prevents monocrotaline \/ LPS renal injury in mice. Arch. Toxicol., 1245\u20131256.","DOI":"10.1007\/s00204-011-0663-8"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.4049\/jimmunol.178.7.4623","article-title":"The Chemokine Binding Protein M3 Prevents Diabetes Induced by Multiple Low Doses of Streptozotocin","volume":"178","author":"Martin","year":"2007","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ars.2016.6755","article-title":"The role of oxidative stress and hypoxia in pancreatic beta-cell dysfunction in diabetes mellitus","volume":"26","author":"Gerber","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2337\/diab.40.4.405","article-title":"Role of oxidative stress in development of complications in diabetes","volume":"40","author":"Baynes","year":"1991","journal-title":"Diabetes"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nrendo.2009.21","article-title":"The role of inflammation in insulitis and \u03b2-cell loss in type 1 diabetes","volume":"5","author":"Eizirik","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.carbpol.2011.04.051","article-title":"Purification, characterization and hypoglycemic activity of extracellular polysaccharides from Lachnum calyculiforme","volume":"86","author":"Ye","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/0471141755.ph0547s70","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr. Protoc. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/dmr.5610030308","article-title":"Mouse models of insulin dependent diabetes: Low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice","volume":"3","author":"Kolb","year":"1987","journal-title":"Diabetes. Metab. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.ijbiomac.2018.02.042","article-title":"Antidiabetic activities of polysaccharides from Anoectochilus roxburghii and Anoectochilus formosanus in STZ-induced diabetic mice","volume":"112","author":"Tang","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cyto.2012.02.009","article-title":"Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-\u03b1 in THP-1 macrophages","volume":"58","author":"Suzuki","year":"2012","journal-title":"Cytokine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","article-title":"Inflammation and insulin resistance","volume":"582","author":"Olefsky","year":"2008","journal-title":"FEBS Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.metabol.2009.02.010","article-title":"Acute hyperinsulinemia raises plasma interleukin-6 in both nondiabetic and type 2 diabetes mellitus subjects, and this effect is inversely associated with body mass index","volume":"58","author":"Ruge","year":"2009","journal-title":"Metabolism"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s13105-014-0317-4","article-title":"The effects of resveratrol on tissue injury, oxidative damage, and pro-inflammatory cytokines in an experimental model of acute pancreatitis","volume":"70","author":"Gulcubuk","year":"2014","journal-title":"J. Physiol. Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s12958-015-0114-0","article-title":"Resveratrol relieves gestational diabetes mellitus in mice through activating AMPK","volume":"13","author":"Yao","year":"2015","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1096\/fasebj.8.8.8181671","article-title":"Nitric oxide generation from streptozotocin 1","volume":"8","author":"Kwon","year":"1994","journal-title":"FASEB J."},{"key":"ref_47","first-page":"S37","article-title":"The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: Experimental and clinical implications","volume":"49","author":"Haluzik","year":"2000","journal-title":"Physiol. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.2147\/DDDT.S184785","article-title":"Resveratrol downregulates TNF-\u03b1-induced monocyte chemoattractant protein-1 in primary rat pulmonary artery endothelial cells by P38 mitogen-activated protein kinase signaling","volume":"13","author":"Lin","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e202000506","DOI":"10.1590\/s0102-865020200050000006","article-title":"Resveratrol inhibits TNF-\u03b1-induced inflammation to protect against renal ischemia\/reperfusion injury in diabetic rats","volume":"35","author":"Wang","year":"2020","journal-title":"Acta Cir. Bras."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11010-019-03582-z","article-title":"Protective effects of resveratrol on hepatic ischemia reperfusion injury in streptozotocin-induced diabetic rats","volume":"460","author":"Ozel","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"ref_51","first-page":"3809","article-title":"CXCL16 and oxLDL are induced in the onset of diabetic nephropathy","volume":"13","author":"Gutwein","year":"2009","journal-title":"Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.bbrc.2008.03.088","article-title":"The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells","volume":"370","author":"Schramme","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"174059","DOI":"10.1016\/j.ejphar.2021.174059","article-title":"Resveratrol mitigates pancreatic TF activation and autophagy-mediated beta cell death via inhibition of CXCL16\/ox-LDL pathway: A novel protective mechanism against type 1 diabetes mellitus in mice","volume":"901","author":"Darwish","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhao, L., Wu, F., Jin, L., Lu, T., Yang, L., Pan, X., Shao, C., Li, X., and Lin, Z. (2014). Serum CXCL16 as a novel marker of renal injury in type 2 diabetes mellitus. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087786"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"120224","DOI":"10.1016\/j.lfs.2021.120224","article-title":"Simvastatin mitigates streptozotocin-induced type 1 diabetes in mice through downregulation of ADAM10 and ADAM17","volume":"289","author":"Alqasoumi","year":"2022","journal-title":"Life Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2337\/db13-1037","article-title":"Long-term IKK2\/NF-\u03baB signaling in pancreatic \u03b2-cells induces immune-mediated diabetes","volume":"63","author":"Salem","year":"2014","journal-title":"Diabetes"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"El-Asrar, A.M.A., Nawaz, M.I., Ahmad, A., De Zutter, A., Siddiquei, M.M., Blanter, M., Allegaert, E., Gikandi, P.W., De Hertogh, G., and Van Damme, J. (2020). Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.601639"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.04.001","article-title":"Prostate cancer cells hyper-activate CXCR6 signaling by cleaving CXCL16 to overcome effect of docetaxel","volume":"454","author":"Kapur","year":"2019","journal-title":"Cancer Lett."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/01.ATV.0000114565.42679.c6","article-title":"Upregulation of SR-PSOX\/CXCL16 and recruitment of CD8+ T cells in cardiac valves during inflammatory valvular heart disease","volume":"24","author":"Yamauchi","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/jid.2011.371","article-title":"CXCL16 and CXCR6 are upregulated in psoriasis and mediate cutaneous recruitment of human CD8+ T cells","volume":"132","author":"Kaesler","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/art.21004","article-title":"Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints","volume":"52","author":"Toonen","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3892\/or.2012.2185","article-title":"Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating natural killer T cells in a murine model","volume":"29","author":"Kee","year":"2013","journal-title":"Oncol. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.intimp.2019.04.021","article-title":"CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease","volume":"72","author":"Zhu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kee, J.-Y., Ito, A., Hojo, S., Hashimoto, I., Igarashi, Y., Tsuneyama, K., Tsukada, K., Irimura, T., Shibahara, N., and Takasaki, I. (2014). CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-\u03b1-induced apoptosis by tumor-associated macrophages. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-949"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"31652","DOI":"10.18632\/oncotarget.9386","article-title":"CXCL16 regulates cisplatin-induced acute kidney injury","volume":"7","author":"Liang","year":"2016","journal-title":"Oncotarget"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/594\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:33:22Z","timestamp":1760135602000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":65,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["pharmaceutics14030594"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14030594","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}