{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:17:34Z","timestamp":1787987854673,"version":"build-2784847793"},"reference-count":160,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1I1A1A01061296"],"award-info":[{"award-number":["NRF-2019R1I1A1A01061296"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2021R1I1A1A01040732"],"award-info":[{"award-number":["NRF-2021R1I1A1A01040732"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Alopecia or baldness is a common diagnosis in clinical practice. Alopecia can be scarring or non-scarring, diffuse or patchy. The most prevalent type of alopecia is non-scarring alopecia, with the majority of cases being androgenetic alopecia (AGA) or alopecia areata (AA). AGA is traditionally treated with minoxidil and finasteride, while AA is treated with immune modulators; however, both treatments have significant downsides. These drawbacks compel us to explore regenerative therapies that are relatively devoid of adverse effects. A thorough literature review was conducted to explore the existing proven and experimental regenerative treatment modalities in non-scarring alopecia. Multiple treatment options compelled us to classify them into growth factor-rich and stem cell-rich. The growth factor-rich group included platelet-rich plasma, stem cell-conditioned medium, exosomes and placental extract whereas adult stem cells (adipose-derived stem cell-nano fat and stromal vascular fraction; bone marrow stem cell and hair follicle stem cells) and perinatal stem cells (umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), Wharton jelly-derived MSCs (WJ-MSCs), amniotic fluid-derived MSCs (AF-MSCs), and placental MSCs) were grouped into the stem cell-rich group. Because of its regenerative and proliferative capabilities, MSC lies at the heart of regenerative cellular treatment for hair restoration. A literature review revealed that both adult and perinatal MSCs are successful as a mesotherapy for hair regrowth. However, there is a lack of standardization in terms of preparation, dose, and route of administration. To better understand the source and mode of action of regenerative cellular therapies in hair restoration, we have proposed the \u201c\u00c0 La Mode Classification\u201d. In addition, available evidence-based cellular treatments for hair regrowth have been thoroughly described.<\/jats:p>","DOI":"10.3390\/pharmaceutics14030612","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:19:10Z","timestamp":1646943550000},"page":"612","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9954-5179","authenticated-orcid":false,"given":"Talagavadi Channaiah","family":"Anudeep","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Topiwala National Medical College and BYL Nair Ch. Hospital, Mumbai 400008, India"},{"name":"Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India"},{"name":"\u00c0 La Mode Esth\u00e9tique Studio, Mysuru 570011, India"},{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-9493","authenticated-orcid":false,"given":"Madhan","family":"Jeyaraman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India"},{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"},{"name":"Department of Orthopaedics, Faculty of Medicine\u2014Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600095, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-4354","authenticated-orcid":false,"given":"Sathish","family":"Muthu","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India"},{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"},{"name":"Department of Orthopaedics, Government Medical College and Hospital, Dindigul 624304, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-0854","authenticated-orcid":false,"given":"Ramya Lakshmi","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0658-4604","authenticated-orcid":false,"given":"Prakash","family":"Gangadaran","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea"},{"name":"BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhu Chandra","family":"Mishra","sequence":"additional","affiliation":[{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Sharma","sequence":"additional","affiliation":[{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"},{"name":"Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-0755","authenticated-orcid":false,"given":"Saurabh Kumar","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India"},{"name":"International Association of Stem Cell and Regenerative Medicine (IASRM), New Delhi 110092, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-3929","authenticated-orcid":false,"given":"Byeong-Cheol","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, Korea"},{"name":"BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.31128\/AJGP-02-18-4498","article-title":"Female pattern hair loss","volume":"47","author":"Chan","year":"2018","journal-title":"Aust. 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