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The pulmonary aerosolization of antifungal agents can theoretically increase their concentration at the infectious site, which could improve their efficacy while limiting their systemic exposure and toxicity. However, clinical experience is poor and thus inhaled agent utilization remains unclear in term of indications, drugs, and devices. This comprehensive literature review aims to describe the pharmacokinetic behavior and the efficacy of inhaled antifungal drugs as prophylaxes and curative treatments both in animal models and humans.<\/jats:p>","DOI":"10.3390\/pharmaceutics14030641","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T02:56:20Z","timestamp":1647312980000},"page":"641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Inhaled Antifungal Agents for Treatment and Prophylaxis of Bronchopulmonary Invasive Mold Infections"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-5840","authenticated-orcid":false,"given":"K\u00e9vin","family":"Brunet","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM U1070, P\u00f4le Biologie Sant\u00e9, 1 rue Georges Bonnet, 86022 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et Pharmacie, Universit\u00e9 de Poitiers, 6 rue de la Mil\u00e9trie, 86073 Poitiers, France"},{"name":"Laboratoire de Mycologie-Parasitologie, Centre Hospitalier Universitaire de Poitiers, 2 rue de la Mil\u00e9trie, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Martellosio","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM U1070, P\u00f4le Biologie Sant\u00e9, 1 rue Georges Bonnet, 86022 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et Pharmacie, Universit\u00e9 de Poitiers, 6 rue de la Mil\u00e9trie, 86073 Poitiers, France"},{"name":"Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Poitiers, 2 rue de la Mil\u00e9trie, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7865-718X","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Tewes","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM U1070, P\u00f4le Biologie Sant\u00e9, 1 rue Georges Bonnet, 86022 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et Pharmacie, Universit\u00e9 de Poitiers, 6 rue de la Mil\u00e9trie, 86073 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Marchand","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM U1070, P\u00f4le Biologie Sant\u00e9, 1 rue Georges Bonnet, 86022 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et Pharmacie, Universit\u00e9 de Poitiers, 6 rue de la Mil\u00e9trie, 86073 Poitiers, France"},{"name":"Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalier Universitaire de Poitiers, 2 rue de la Mil\u00e9trie, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blandine","family":"Rammaert","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, INSERM U1070, P\u00f4le Biologie Sant\u00e9, 1 rue Georges Bonnet, 86022 Poitiers, France"},{"name":"Facult\u00e9 de M\u00e9decine et Pharmacie, Universit\u00e9 de Poitiers, 6 rue de la Mil\u00e9trie, 86073 Poitiers, France"},{"name":"Service de Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Poitiers, 2 rue de la Mil\u00e9trie, 86021 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1345\/aph.1A015","article-title":"Amphotericin B Disposition after Aerosol Inhalation in Lung Transplant Recipients","volume":"36","author":"Marra","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1086\/586739","article-title":"Aerosolized Liposomal Amphotericin B for the Prevention of Invasive Pulmonary Aspergillosis during Prolonged Neutropenia: A Randomized, Placebo-Controlled Trial","volume":"46","author":"Rijnders","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S328","DOI":"10.1093\/mmy\/myz012","article-title":"Antifungal Drugs: What Brings the Future?","volume":"57","author":"Spriet","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S1053-2498(01)00364-3","article-title":"Nebulized Amphotericin B Prophylaxis for Aspergillus Infection in Lung Transplantation: Study of Risk Factors","volume":"20","author":"Monforte","year":"2001","journal-title":"J. Heart Lung Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Brillault, J., and Tewes, F. (2020). Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12040387"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41120-015-0002-x","article-title":"Scope and Relevance of a Pulmonary Biopharmaceutical Classification System AAPS\/FDA\/USP Workshop March 16\u201317th, 2015 in Baltimore, MD","volume":"2","author":"Hastedt","year":"2016","journal-title":"AAPS Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.addr.2014.06.008","article-title":"Emerging Aerosol Drug Delivery Strategies: From Bench to Clinic","volume":"75","author":"Rubin","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF01739026","article-title":"Use of Amphotericin B Aerosols for the Prevention of Pulmonary Aspergillosis","volume":"22","author":"Beyer","year":"1994","journal-title":"Infection"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1016\/S0924-8579(08)70019-0","article-title":"Invasive Fungal Infections in Lung Transplantation: Role of Aerosolised Amphotericin B","volume":"32","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s12281-010-0011-0","article-title":"Aerosolized Delivery of Antifungal Agents","volume":"4","author":"Le","year":"2010","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/089426803772455631","article-title":"Lung Deposition and Respirable Mass during Wet Nebulization","volume":"16","author":"Sangwan","year":"2003","journal-title":"J. Aerosol Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/17425247.2015.995087","article-title":"Nebulizers for Drug Delivery to the Lungs","volume":"12","author":"Martin","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1513\/AnnalsATS.201311-395FR","article-title":"Inhaled Antibiotics for Lower Airway Infections","volume":"11","author":"Quon","year":"2014","journal-title":"Ann. Am. Thorac Soc."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Adorni, G., Seifert, G., Buttini, F., Colombo, G., Stecanella, L.A., Kr\u00e4mer, I., and Rossi, A. (2019). 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Transplant."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.healun.2009.11.603","article-title":"Feasibility, Tolerability, and Outcomes of Nebulized Liposomal Amphotericin B for Aspergillus Infection Prevention in Lung Transplantation","volume":"29","author":"Monforte","year":"2010","journal-title":"J. Heart Lung Transplant."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/tri.12679","article-title":"10 Years of Prophylaxis with Nebulized Liposomal Amphotericin B and the Changing Epidemiology of Aspergillus spp. Infection in Lung Transplantation","volume":"29","author":"Peghin","year":"2016","journal-title":"Transpl. Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ijpharm.2018.07.050","article-title":"Pharmacokinetics and Pharmacodynamics of High Doses of Inhaled Dry Powder Drugs","volume":"549","author":"Hickey","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/mmy\/myv111","article-title":"Comparison between Liposomal Formulations of Amphotericin B","volume":"54","author":"Gangneux","year":"2016","journal-title":"Med. Mycol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1128\/AAC.45.3.922-926.2001","article-title":"Pharmacodynamics of Amphotericin B in a Neutropenic-Mouse Disseminated-Candidiasis Model","volume":"45","author":"Andes","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1128\/AAC.50.2.469-473.2006","article-title":"Pharmacodynamic Activity of Amphotericin B Deoxycholate Is Associated with Peak Plasma Concentrations in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis","volume":"50","author":"Wiederhold","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/CMR.00046-13","article-title":"Tissue Penetration of Antifungal Agents","volume":"27","author":"Felton","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1183\/09031936.95.08081263","article-title":"Deposition of Amphotericin B Aerosols in Pulmonary Aspergilloma","volume":"8","author":"Diot","year":"1995","journal-title":"Eur. Respir. J."},{"key":"ref_25","first-page":"45","article-title":"Preparation, Statistical Optimization and In-Vitro Characterization of a Dry Powder Inhaler (DPI) Containing Solid Lipid Nanoparticles Encapsulating Amphotericin B: Ion Paired Complexes with Distearoyl Phosphatidylglycerol","volume":"19","author":"Bagheri","year":"2020","journal-title":"Iran J. Pharm. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"101975","DOI":"10.1016\/j.pupt.2020.101975","article-title":"Advanced Spray Dried Proliposomes of Amphotericin B Lung Surfactant-Mimic Phospholipid Microparticles\/Nanoparticles as Dry Powder Inhalers for Targeted Pulmonary Drug Delivery","volume":"64","author":"Gomez","year":"2020","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e02673-18","DOI":"10.1128\/AAC.02673-18","article-title":"In Vitro and In Vivo Exposure-Effect Relationship of Liposomal Amphotericin B against Aspergillus Fumigatus","volume":"63","author":"Siopi","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s40265-016-0538-7","article-title":"Liposomal Amphotericin B (AmBisome\u00ae): A Review of the Pharmacokinetics, Pharmacodynamics, Clinical Experience and Future Directions","volume":"76","author":"Stone","year":"2016","journal-title":"Drugs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S260","DOI":"10.1093\/cid\/ciz076","article-title":"Clinical Pharmacokinetics, Pharmacodynamics, Safety and Efficacy of Liposomal Amphotericin B","volume":"68","author":"Groll","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/AAC.34.1.29","article-title":"Pharmacokinetics of Aerosol Amphotericin B in Rats","volume":"34","author":"Niki","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1128\/AAC.42.7.1597","article-title":"Pharmacokinetic Evaluation of Amphotericin B in Lung Tissue: Lung Lymph Distribution after Intravenous Injection and Airspace Distribution after Aerosolization and Inhalation of Amphotericin B","volume":"42","author":"Koizumi","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S501","DOI":"10.1093\/clinids\/17.Supplement_2.S501","article-title":"New Methods of Delivery of Amphotericin B","volume":"17","author":"Schmitt","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1021\/js9604218","article-title":"Disposition of Aerosolized Liposomal Amphotericin B","volume":"86","author":"Lambros","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1211\/0022357001774417","article-title":"Aerosol Delivery of Amphotericin B Desoxycholate (Fungizone) and Liposomal Amphotericin B (AmBisome): Aerosol Characteristics and in-Vivo Amphotericin B Deposition in Rats","volume":"52","author":"Ruijgrok","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1211\/jpp.57.10.0007","article-title":"Nebulization of Four Commercially Available Amphotericin B Formulations in Persistently Granulocytopenic Rats with Invasive Pulmonary Aspergillosis: Evidence for Long-Term Biological Activity","volume":"57","author":"Ruijgrok","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/jac\/34.6.1001","article-title":"Prophylactic Efficacy of Aerosolized Liposomal (AmBisome) and Non-Liposomal (Fungizone) Amphotericin B in Murine Pulmonary Aspergillosis","volume":"34","author":"Allen","year":"1994","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1128\/AAC.41.2.259","article-title":"Efficacy of Prophylactic Aerosol Amphotericin B Lipid Complex in a Rat Model of Pulmonary Aspergillosis","volume":"41","author":"Cicogna","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_38","first-page":"383","article-title":"Amphotericin B and Pulmonary Surfactant","volume":"3","author":"Griese","year":"1998","journal-title":"Eur. J. Med. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/jac\/48.1.89","article-title":"Efficacy of Aerosolized Amphotericin B Desoxycholate and Liposomal Amphotericin B in the Treatment of Invasive Pulmonary Aspergillosis in Severely Immunocompromised Rats","volume":"48","author":"Ruijgrok","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2005.02.003","article-title":"Aerosolized Liposome-Based Delivery of Amphotericin B to Alveolar Macrophages","volume":"296","author":"Vyas","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S362","DOI":"10.1080\/13693780802464430","article-title":"Functionalized Nanocarrier(s) to Image and Target Fungi Infected Immune Cells","volume":"47","author":"Vyas","year":"2009","journal-title":"Med. Mycol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s13346-019-00662-x","article-title":"Biodistribution and Histopathology Studies of Amphotericin B Sodium Deoxycholate Sulfate Formulation Following Intratracheal Instillation in Rat Models","volume":"10","author":"Usman","year":"2019","journal-title":"Drug. Deliv. Transl. Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"464","DOI":"10.2174\/1567201812666150326110821","article-title":"Development and Characterization of Spray Dried Microparticles for Pulmonary Delivery of Antifungal Drug","volume":"12","author":"Mathpal","year":"2015","journal-title":"Curr. Drug Deliv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/ajt.12691","article-title":"Epidemiology of Invasive Mold Infections in Lung Transplant Recipients","volume":"14","author":"Doligalski","year":"2014","journal-title":"Am. J. Transplant."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1097\/01.TP.0000054233.60100.7A","article-title":"Nebulized Amphotericin B Concentration and Distribution in the Respiratory Tract of Lung-Transplanted Patients","volume":"75","author":"Monforte","year":"2003","journal-title":"Transplantation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ijpharm.2012.07.012","article-title":"Aerosolized Liposomal Amphotericin B: Prediction of Lung Deposition, in Vitro Uptake and Cytotoxicity","volume":"436","author":"Fauvel","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/TP.0b013e3181f995ea","article-title":"Intrapulmonary Disposition of Amphotericin B After Aerosolized Delivery of Amphotericin B Lipid Complex (Abelcet; ABLC) in Lung Transplant Recipients","volume":"90","author":"Husain","year":"2010","journal-title":"Transplantation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.healun.2008.11.004","article-title":"Nebulized Liposomal Amphotericin B Prophylaxis for Aspergillus Infection in Lung Transplantation: Pharmacokinetics and Safety","volume":"28","author":"Monforte","year":"2009","journal-title":"J. Heart Lung Transplant."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1007\/978-3-642-78350-0_138","article-title":"Inhalation of Amphotericin B for Prophylaxis of Invasive Fungal Infections During Intensive Leukemia Therapy","volume":"Volume 36","author":"Hiddemann","year":"1994","journal-title":"Acute Leukemias IV."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1128\/AAC.37.6.1367","article-title":"Aerosol Amphotericin B for Prevention of Invasive Pulmonary Aspergillosis","volume":"37","author":"Beyer","year":"1993","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF01726364","article-title":"Tolerance and Efficacy of Amphotericin B Inhalations for Prevention of Invasive Pulmonary Aspergillosis in Haematological Patients","volume":"16","author":"Erjavec","year":"1997","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1399-3062.2007.00209.x","article-title":"Safety of Aerosolized Liposomal versus Deoxycholate Amphotericin B Formulations for Prevention of Invasive Fungal Infections Following Lung Transplantation: A Retrospective Study","volume":"9","author":"Lowry","year":"2007","journal-title":"Transpl. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/00007890-200108150-00036","article-title":"Safety of Aerosolized Amphotericin B Lipid Complex in Lung Transplant Recipients","volume":"72","author":"Palmer","year":"2001","journal-title":"Transplantation"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/10428199209054909","article-title":"A Pilot Study of Prophylactic Aerosolized Amphotericin B in Patients at Risk for Prolonged Neutropenia","volume":"8","author":"Myers","year":"1992","journal-title":"Leuk. Lymphoma"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.healun.2012.11.013","article-title":"Prophylaxis with Nebulized Liposomal Amphotericin B for Aspergillus Infection in Lung Transplant Patients Does Not Cause Changes in the Lipid Content of Pulmonary Surfactant","volume":"32","author":"Monforte","year":"2013","journal-title":"J. Heart Lung Transplant."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1128\/AAC.32.11.1676","article-title":"Aerosol Amphotericin B Is Effective for Prophylaxis and Therapy in a Rat Model of Pulmonary Aspergillosis","volume":"32","author":"Schmitt","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1439-0507.1991.tb00660.x","article-title":"Combination Therapy in a Model of Pulmonary Aspergillosis","volume":"34","author":"Schmitt","year":"1991","journal-title":"Mycoses"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1128\/AAC.49.7.3028-3030.2005","article-title":"Efficacy of Nebulized Liposomal Amphotericin B in Treatment of Experimental Pulmonary Aspergillosis","volume":"49","author":"Gomis","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1128\/AAC.50.5.1852-1854.2006","article-title":"Nebulized Amphotericin B Combined with Intravenous Amphotericin B in Rats with Severe Invasive Pulmonary Aspergillosis","volume":"50","author":"Ruijgrok","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1128\/AAC.00285-09","article-title":"Efficacy of Combination Antifungal Therapy with Intraperitoneally Administered Micafungin and Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Aspergillosis","volume":"53","author":"Takazono","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jconrel.2012.04.004","article-title":"The Efficacy of Aerosol Treatment with Non-Ionic Surfactant Vesicles Containing Amphotericin B in Rodent Models of Leishmaniasis and Pulmonary Aspergillosis Infection","volume":"160","author":"Alsaadi","year":"2012","journal-title":"J. Control Release"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.nano.2015.02.012","article-title":"Nebulised Amphotericin B-Polymethacrylic Acid Nanoparticle Prophylaxis Prevents Invasive Aspergillosis","volume":"11","author":"Shirkhani","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11046-017-0117-9","article-title":"Nebulized Liposomal Amphotericin B for Treatment of Pulmonary Infection Caused by Hormographiella Aspergillata: Case Report and Literature Review","volume":"182","author":"Godet","year":"2017","journal-title":"Mycopathologia"},{"key":"ref_64","first-page":"437","article-title":"Treatment of Aspergillus-Related Ulcerative Tracheobronchitis in Lung Transplant Recipients","volume":"17","author":"Birsan","year":"1998","journal-title":"J. Heart Lung Transplant."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijid.2016.11.419","article-title":"Pulmonary Aspergillosis Treated with Inhaled Amphotericin B","volume":"54","author":"Zhou","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_66","first-page":"1236","article-title":"Pseudomembranous Necrotizing Tracheobronchial Aspergillosis: An Analysis of 16 Cases","volume":"125","author":"Huang","year":"2012","journal-title":"Chin. Med. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1469-0691.2009.02923.x","article-title":"Isolated Invasive Aspergillus Tracheobronchitis: A Clinical Study of 19 Cases","volume":"16","author":"Wu","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1439-0507.1996.tb00156.x","article-title":"Tracheobronchial Aspergillosis in a Patient with AIDS Treated with Aerosolized Amphotericin B Combined with Itraconazole","volume":"39","author":"Riva","year":"1996","journal-title":"Mycoses"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1136\/thx.54.11.1047","article-title":"Successful Treatment of Post-Influenza Pseudomembranous Necrotising Bronchial Aspergillosis with Liposomal Amphotericin, Inhaled Amphotericin B, Gamma Interferon and GM-CSF","volume":"54","author":"Boots","year":"1999","journal-title":"Thorax"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/thx.39.1.78","article-title":"Invasive Pulmonary Aspergillosis in a Non-Immunosuppressed Patient: Successful Management with Systemic Amphotericin and Flucytosine and Inhaled Amphotericin","volume":"39","author":"Rodenhuis","year":"1984","journal-title":"Thorax"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/S1053-2498(00)00154-6","article-title":"Topical Amphotericin B Application in Severe Bronchial Aspergillosis after Lung Transplantation: Report of Experiences in 3 Cases","volume":"19","author":"Boettcher","year":"2000","journal-title":"J. Heart Lung Transplant."},{"key":"ref_72","first-page":"309","article-title":"Pulmonary mucormycosis: Benefit of aerosol amphotericin B?","volume":"18","author":"Furco","year":"2001","journal-title":"Rev. Mal. Respir."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/LBR.0b013e3181aa2583","article-title":"Endobronchial Instillations of Amphotericin B: Complementary Treatment for Pulmonary Mucormycosis","volume":"16","author":"Alfageme","year":"2009","journal-title":"J. Bronchology Interv. Pulmonol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.healun.2007.05.010","article-title":"Mucormycosis of the Bronchial Anastomosis: A Case of Successful Medical Treatment and Historic Review","volume":"26","author":"McGuire","year":"2007","journal-title":"J. Heart Lung Transplant."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.bmt.1704552","article-title":"Efficacy and Feasibility of Aerosolized Amphotericin B Lipid Complex Therapy in Caspofungin Breakthrough Pulmonary Zygomycosis","volume":"34","author":"Safdar","year":"2004","journal-title":"Bone Marrow Transplant."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1179\/joc.2007.19.3.339","article-title":"Nebulized Liposomal Amphotericin B and Combined Systemic Antifungal Therapy for the Treatment of Severe Pulmonary Aspergillosis after Allogeneic Hematopoietic Stem Cell Transplant for a Fatal Mitochondrial Disorder","volume":"19","author":"Castagnola","year":"2007","journal-title":"J. Chemother."},{"key":"ref_77","first-page":"44","article-title":"Aerosolized Amphotericin B Lipid Complex and Invasive Pulmonary Aspergillosis: A Case Report","volume":"23","author":"Canetti","year":"2015","journal-title":"Infez. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11046-019-00331-0","article-title":"Aerosolized Lipid Amphotericin B for Complementary Therapy and\/or Secondary Prophylaxis in Patients with Invasive Pulmonary Aspergillosis: A Single-Center Experience","volume":"184","author":"Venanzi","year":"2019","journal-title":"Mycopathologia"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/phar.1309","article-title":"Aerosolized Amphotericin B Lipid Complex as Adjunctive Treatment for Fungal Lung Infection in Patients with Cancer-Related Immunosuppression and Recipients of Hematopoietic Stem Cell Transplantation","volume":"33","author":"Safdar","year":"2013","journal-title":"Pharmacotherapy"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.transproceed.2009.06.017","article-title":"Intrabronchial Instillation of Amphotericin B Lipid Complex: A Case Report","volume":"41","author":"Morales","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mmcr.2019.01.002","article-title":"Endobronchial Fusariosis in a Child Following Bilateral Lung Transplant","volume":"23","author":"Huynh","year":"2019","journal-title":"Med. Mycol. Case. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e12806","DOI":"10.1111\/tid.12806","article-title":"Necrotizing Microascus Tracheobronchitis in a Bilateral Lung Transplant Recipient","volume":"20","author":"Taton","year":"2018","journal-title":"Transpl. Infect. Dis."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e13501","DOI":"10.1111\/tid.13501","article-title":"Invasive Pulmonary Aspergillosis Associated with COVID-19 in a Kidney Transplant Recipient","volume":"23","author":"Trujillo","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"ref_84","first-page":"101484","article-title":"Pulmonary Microascus Cirrosus Infection in an Immunocompetent Patient with Bronchiectasis: A Case Report","volume":"34","author":"Liu","year":"2021","journal-title":"Respir. Med. Case Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e13544","DOI":"10.1111\/ctr.13544","article-title":"Invasive Aspergillosis in Solid-Organ Transplant Recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Husain","year":"2019","journal-title":"Clin. Transplant."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciw326","article-title":"Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America","volume":"63","author":"Patterson","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.healun.2016.01.007","article-title":"The 2015 International Society for Heart and Lung Transplantation Guidelines for the Management of Fungal Infections in Mechanical Circulatory Support and Cardiothoracic Organ Transplant Recipients: Executive Summary","volume":"35","author":"Husain","year":"2016","journal-title":"J. Heart Lung Transplant."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1128\/AAC.39.8.1784","article-title":"Aerosol and Parenteral Pneumocandins Are Effective in a Rat Model of Pulmonary Aspergillosis","volume":"39","author":"Kurtz","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1128\/jcm.29.7.1317-1322.1991","article-title":"Model of Recurrent Pulmonary Aspergillosis in Rats","volume":"29","author":"Niki","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/jac\/dkr567","article-title":"Prophylactic Efficacy of Single Dose Pulmonary Administration of Amphotericin B Inhalation Powder in a Guinea Pig Model of Invasive Pulmonary Aspergillosis","volume":"67","author":"Kirkpatrick","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jiac.2013.09.002","article-title":"Efficacy of Aerosolized Liposomal Amphotericin B against Murine Invasive Pulmonary Mucormycosis","volume":"20","author":"Mihara","year":"2014","journal-title":"J. Infect. Chemother."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ijid.2014.11.004","article-title":"Aerosolized Amphotericin B as Prophylaxis for Invasive Pulmonary Aspergillosis: A Meta-Analysis","volume":"30","author":"Xia","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_93","first-page":"403","article-title":"Nebulized Amphotericin B as Prophylaxis against Invasive Aspergillosis in Granulocytopenic Patients","volume":"5","author":"Conneally","year":"1990","journal-title":"Bone Marrow Transplant."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF01716080","article-title":"Amphotericin B Prophylaxis against Invasive Fungal Infections in Neutropenic Patients: A Single Center Experience from 1980 to 1995","volume":"24","author":"Matteocci","year":"1996","journal-title":"Infection"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF01695915","article-title":"Low Incidence of Invasive Fungal Infections after Bone Marrow Transplantation in Patients Receiving Amphotericin B Inhalations during Neutropenia","volume":"68","author":"Hertenstein","year":"1994","journal-title":"Ann. Hematol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9343(05)80056-7","article-title":"Intranasal Amphotericin B Reduces the Frequency of Invasive Aspergillosis in Neutropenic Patients","volume":"90","author":"Jeffery","year":"1991","journal-title":"Am. J. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/bmt.2010.76","article-title":"Addition of Aerosolized Deoxycholate Amphotericin B to Systemic Prophylaxis to Prevent Airways Invasive Fungal Infections in Allogeneic Hematopoietic SCT: A Single-Center Retrospective Study","volume":"46","author":"Morello","year":"2011","journal-title":"Bone Marrow Transplant."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1399-3062.2011.00661.x","article-title":"Low Incidence of Invasive Aspergillosis in Allogeneic Stem Cell Transplant Recipients Receiving Amphotericin B Inhalation Prophylaxis","volume":"14","author":"Nihtinen","year":"2012","journal-title":"Transpl. Infect. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1056\/NEJMoa061094","article-title":"Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia","volume":"356","author":"Cornely","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01697981","article-title":"Aerosol Amphotericin B Inhalations for Prevention of Invasive Pulmonary Aspergillosis in Neutropenic Cancer Patients","volume":"71","author":"Behre","year":"1995","journal-title":"Ann. Hematol."},{"key":"ref_101","first-page":"3654","article-title":"Aerosolized Amphotericin B Inhalations as Prophylaxis of Invasive Aspergillus Infections during Prolonged Neutropenia: Results of a Prospective Randomized Multicenter Trial","volume":"93","author":"Schwartz","year":"1999","journal-title":"Blood"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijantimicag.2015.02.023","article-title":"Aerosolised Liposomal Amphotericin B to Prevent Aspergillosis in Acute Myeloid Leukaemia: Efficacy and Cost Effectiveness in Real-Life","volume":"46","author":"Chong","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000327802","article-title":"Prophylactic Application of Nebulized Liposomal Amphotericin B in Hematologic Patients with Neutropenia","volume":"34","author":"Holler","year":"2011","journal-title":"Onkologie"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.healun.2003.09.028","article-title":"A Survey of Anti-Fungal Management in Lung Transplantation","volume":"23","author":"Dummer","year":"2004","journal-title":"J. Heart Lung Transplant."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/tid.12337","article-title":"Practice Variation in Aspergillus Prophylaxis and Treatment among Lung Transplant Centers: A National Survey","volume":"17","author":"He","year":"2015","journal-title":"Transpl. Infect. Dis."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1399-3062.2006.00156.x","article-title":"Variation in Antifungal Prophylaxis Strategies in Lung Transplantation","volume":"8","author":"Husain","year":"2006","journal-title":"Transpl. Infect. Dis."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/petr.12263","article-title":"International Pediatric Lung Transplant Collaborative (IPLTC) Antifungal Prophylaxis in Pediatric Lung Transplantation: An International Multicenter Survey","volume":"18","author":"Mead","year":"2014","journal-title":"Pediatr. Transplant."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-6143.2010.03375.x","article-title":"Antifungal Prophylaxis in Lung Transplantation--a World-Wide Survey","volume":"11","author":"Neoh","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1016\/j.transproceed.2008.09.020","article-title":"Efficiency and Safety of Inhaled Amphotericin B Lipid Complex (Abelcet) in the Prophylaxis of Invasive Fungal Infections Following Lung Transplantation","volume":"40","author":"Borro","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/j.1600-6143.2009.02734.x","article-title":"Antifungal Prophylaxis with Voriconazole or Itraconazole in Lung Transplant Recipients: Hepatotoxicity and Effectiveness","volume":"9","author":"Cadena","year":"2009","journal-title":"Am. J. Transplant."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1016\/j.transproceed.2010.09.116","article-title":"Control of Early Aspergillus Mortality after Lung Transplantation: Outcome and Risk Factors","volume":"42","author":"Eriksson","year":"2010","journal-title":"Transplant. Proc."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/TP.0b013e318255f864","article-title":"A Targeted Peritransplant Antifungal Strategy for the Prevention of Invasive Fungal Disease after Lung Transplantation: A Sequential Cohort Analysis","volume":"94","author":"Koo","year":"2012","journal-title":"Transplantation"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/cid\/ciaa652","article-title":"Isavuconazole Is as Effective as and Better Tolerated Than Voriconazole for Antifungal Prophylaxis in Lung Transplant Recipients","volume":"73","author":"Samanta","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.riam.2021.06.002","article-title":"Invasive Scedosporiosis in Lung Transplant Recipients: A Nine-Year Retrospective Study in a Tertiary Care Hospital","volume":"38","author":"Pastor","year":"2021","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/cid\/ciz156","article-title":"Invasive Fungal Infection After Lung Transplantation: Epidemiology in the Setting of Antifungal Prophylaxis","volume":"70","author":"Baker","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"58","DOI":"10.6002\/ect.2020.0187","article-title":"Nebulized Amphotericin B Dosing Regimen for Aspergillus Prevention After Lung Transplant","volume":"19","author":"Alissa","year":"2021","journal-title":"Exp. Clin. Transplant."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1378\/chest.115.5.1301","article-title":"Antifungal Prophylaxis during the Early Postoperative Period of Lung Transplantation. Valencia Lung Transplant Group","volume":"115","author":"Calvo","year":"1999","journal-title":"Chest"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1399-3062.2002.t01-2-02002.x","article-title":"The Incidence of Invasive Aspergillosis among Solid Organ Transplant Recipients and Implications for Prophylaxis in Lung Transplants","volume":"4","author":"Minari","year":"2002","journal-title":"Transpl. Infect. Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0041-1345(96)00363-6","article-title":"Significant Reduction in the Number of Fungal Infections after Lung-, Heart-Lung, and Heart Transplantation Using Aerosolized Amphotericin B Prophylaxis","volume":"29","author":"Reichenspurner","year":"1997","journal-title":"Transplant. Proc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e13448","DOI":"10.1111\/tid.13448","article-title":"Evaluation of Targeted versus Universal Prophylaxis for the Prevention of Invasive Fungal Infections Following Lung Transplantation","volume":"23","author":"Linder","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.TP.0000101516.08327.A9","article-title":"Comparative Safety of Amphotericin B Lipid Complex and Amphotericin B Deoxycholate as Aerosolized Antifungal Prophylaxis in Lung-Transplant Recipients","volume":"77","author":"Drew","year":"2004","journal-title":"Transplantation"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13054-021-03728-w","article-title":"Inhaled Liposomal Amphotericin-B as a Prophylactic Treatment for COVID-19-Associated Pulmonary Aspergillosis\/Aspergillus Tracheobronchitis","volume":"25","author":"Rutsaert","year":"2021","journal-title":"Crit. Care"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00277-017-3196-2","article-title":"Primary Prophylaxis of Invasive Fungal Infections in Patients with Haematological Malignancies: 2017 Update of the Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO)","volume":"97","author":"Mellinghoff","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cmi.2018.01.002","article-title":"Diagnosis and Management of Aspergillus Diseases: Executive Summary of the 2017 ESCMID-ECMM-ERS Guideline","volume":"24","author":"Ullmann","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_125","first-page":"3221","article-title":"European Guidelines for Primary Antifungal Prophylaxis in Adult Haematology Patients: Summary of the Updated Recommendations from the European Conference on Infections in Leukaemia","volume":"73","author":"Maertens","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1378\/chest.108.3.750","article-title":"The Physiologic Effects of Inhaled Amphotericin B","volume":"108","author":"Dubois","year":"1995","journal-title":"Chest"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1097\/00000421-199302000-00011","article-title":"The Toxicity of Daily Inhaled Amphotericin B","volume":"16","author":"Gryn","year":"1993","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1399-3062.2006.00125.x","article-title":"Non-Comparative Evaluation of the Safety of Aerosolized Amphotericin B Lipid Complex in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation","volume":"8","author":"Alexander","year":"2006","journal-title":"Transpl. Infect. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.pupt.2008.09.001","article-title":"Tolerability of Prophylactic Aerosolized Liposomal Amphotericin-B and Impact on Pulmonary Function: Data from a Randomized Placebo-Controlled Trial","volume":"21","author":"Slobbe","year":"2008","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s11908-013-0380-y","article-title":"Anti-Aspergillus Prophylaxis in Lung Transplantation: A Systematic Review and Meta-Analysis","volume":"15","author":"Bhaskaran","year":"2013","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1183\/09031936.00163511","article-title":"Remarkably Efficient Inhaled Antifungal Monotherapy for Invasive Pulmonary Aspergillosis","volume":"40","author":"Hilberg","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1097\/TP.0000000000002697","article-title":"Aerosolization of Second-Generation Triazoles: In Vitro Evaluation and Application in Therapy of Invasive Airway Aspergillosis","volume":"103","author":"Thanukrishnan","year":"2019","journal-title":"Transplantation"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijpharm.2009.06.003","article-title":"Dose Tolerability of Chronically Inhaled Voriconazole Solution in Rodents","volume":"379","author":"Tolman","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1128\/AAC.01657-08","article-title":"Inhaled Voriconazole for Prevention of Invasive Pulmonary Aspergillosis","volume":"53","author":"Tolman","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/13693780802262115","article-title":"Designing Voriconazole Treatment for Racing Pigeons: Balancing between Hepatic Enzyme Auto Induction and Toxicity","volume":"47","author":"Beernaert","year":"2009","journal-title":"Med. Mycol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejpb.2008.12.014","article-title":"Characterization and Pharmacokinetic Analysis of Aerosolized Aqueous Voriconazole Solution","volume":"72","author":"Tolman","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/bcpt.12820","article-title":"Voriconazole Concentrations in Plasma and Epithelial Lining Fluid after Inhalation and Oral Treatment","volume":"121","author":"Andersen","year":"2017","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nano.2012.04.005","article-title":"Poly-Lactide-Co-Glycolide Nanoparticles Containing Voriconazole for Pulmonary Delivery: In Vitro and in Vivo Study","volume":"9","author":"Sinha","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ejpb.2012.04.019","article-title":"Dry Powder Insufflation of Crystalline and Amorphous Voriconazole Formulations Produced by Thin Film Freezing to Mice","volume":"81","author":"Beinborn","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1021\/acs.molpharmaceut.5b00064","article-title":"Pulmonary Delivery of Voriconazole Loaded Nanoparticles Providing a Prolonged Drug Level in Lungs: A Promise for Treating Fungal Infection","volume":"12","author":"Das","year":"2015","journal-title":"Mol. Pharm."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/nnm-2017-0291","article-title":"Chitosan-Coated Nanoparticles Enhanced Lung Pharmacokinetic Profile of Voriconazole upon Pulmonary Delivery in Mice","volume":"13","author":"Paul","year":"2018","journal-title":"Nanomedicine"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijpharm.2019.01.057","article-title":"Porous and Highly Dispersible Voriconazole Dry Powders Produced by Spray Freeze Drying for Pulmonary Delivery with Efficient Lung Deposition","volume":"560","author":"Liao","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jcf.2013.10.014","article-title":"Nebulized Voriconazole in Infections with Scedosporium Apiospermum--Case Report and Review of the Literature","volume":"13","author":"Holle","year":"2014","journal-title":"J. Cyst. Fibros."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"i17","DOI":"10.1093\/jac\/dki220","article-title":"Making Sense of Itraconazole Pharmacokinetics","volume":"56","author":"Prentice","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijpharm.2006.04.012","article-title":"Cryogenic Liquids, Nanoparticles, and Microencapsulation","volume":"324","author":"Purvis","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1517\/17425240802457188","article-title":"Drug Delivery Strategies for Improved Azole Antifungal Action","volume":"5","author":"Yang","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s11095-006-9904-6","article-title":"Targeted High Lung Concentrations of Itraconazole Using Nebulized Dispersions in a Murine Model","volume":"23","author":"McConville","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2006.01.006","article-title":"Single Dose and Multiple Dose Studies of Itraconazole Nanoparticles","volume":"63","author":"Vaughn","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2007.02.014","article-title":"Murine Airway Histology and Intracellular Uptake of Inhaled Amorphous Itraconazole","volume":"338","author":"Vaughn","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijpharm.2008.05.003","article-title":"High Bioavailability from Nebulized Itraconazole Nanoparticle Dispersions with Biocompatible Stabilizers","volume":"361","author":"Yang","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1128\/AAC.50.4.1552-1554.2006","article-title":"In Vivo Efficacy of Aerosolized Nanostructured Itraconazole Formulations for Prevention of Invasive Pulmonary Aspergillosis","volume":"50","author":"Hoeben","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jinf.2007.01.014","article-title":"Aerosolized Nanostructured Itraconazole as Prophylaxis against Invasive Pulmonary Aspergillosis","volume":"55","author":"Alvarez","year":"2007","journal-title":"J. Infect."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejps.2010.01.001","article-title":"In Vitro Characterization and Pharmacokinetics in Mice Following Pulmonary Delivery of Itraconazole as Cyclodextrin Solubilized Solution","volume":"39","author":"Yang","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejpb.2010.01.011","article-title":"Comparison of Bioavailability of Amorphous versus Crystalline Itraconazole Nanoparticles via Pulmonary Administration in Rats","volume":"75","author":"Yang","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejpb.2012.09.018","article-title":"Inhalable Highly Concentrated Itraconazole Nanosuspension for the Treatment of Bronchopulmonary Aspergillosis","volume":"83","author":"Rundfeldt","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3109\/13693786.2013.803166","article-title":"A Model for Treating Avian Aspergillosis: Serum and Lung Tissue Kinetics for Japanese Quail (Coturnix Japonica) Following Single and Multiple Aerosol Exposures of a Nanoparticulate Itraconazole Suspension","volume":"51","author":"Rundfeldt","year":"2013","journal-title":"Med. Mycol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s11046-015-9885-2","article-title":"Activity and Safety of Inhaled Itraconazole Nanosuspension in a Model Pulmonary Aspergillus Fumigatus Infection in Inoculated Young Quails","volume":"180","author":"Knaga","year":"2015","journal-title":"Mycopathologia"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejpb.2016.07.018","article-title":"Itraconazole-Loaded Nanostructured Lipid Carriers (NLC) for Pulmonary Treatment of Aspergillosis in Falcons","volume":"108","author":"Pardeike","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ejpb.2012.04.004","article-title":"In Vitro and in Vivo Evaluation of a Dry Powder Endotracheal Insufflator Device for Use in Dose-Dependent Preclinical Studies in Mice","volume":"81","author":"Duret","year":"2012","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejpb.2013.03.005","article-title":"Pharmacokinetic Evaluation in Mice of Amorphous Itraconazole-Based Dry Powder Formulations for Inhalation with High Bioavailability and Extended Lung Retention","volume":"86","author":"Duret","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejpb.2017.02.013","article-title":"Enhanced Pulmonary Absorption of Poorly Soluble Itraconazole by Micronized Cocrystal Dry Powder Formulations","volume":"115","author":"Karashima","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijpharm.2018.09.018","article-title":"Dry Powder Inhaler Formulations of Poorly Water-Soluble Itraconazole: A Balance between in-Vitro Dissolution and in-Vivo Distribution Is Necessary","volume":"551","author":"Huang","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"e02280-16","DOI":"10.1128\/AAC.02280-16","article-title":"In Vitro and In Vivo Antifungal Profile of a Novel and Long-Acting Inhaled Azole, PC945, on Aspergillus Fumigatus Infection","volume":"61","author":"Colley","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s40265-021-01611-0","article-title":"The Antifungal Pipeline: Fosmanogepix, Ibrexafungerp, Olorofim, Opelconazole, and Rezafungin","volume":"81","author":"Hoenigl","year":"2021","journal-title":"Drugs"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"e00690","DOI":"10.1002\/prp2.690","article-title":"Safety and Nonclinical and Clinical Pharmacokinetics of PC945, a Novel Inhaled Triazole Antifungal Agent","volume":"9","author":"Cass","year":"2021","journal-title":"Pharmacol. Res. Perspect."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"e00124-17","DOI":"10.1128\/AAC.00124-17","article-title":"In Vivo Biomarker Analysis of the Effects of Intranasally Dosed PC945, a Novel Antifungal Triazole, on Aspergillus Fumigatus Infection in Immunocompromised Mice","volume":"61","author":"Kimura","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1038\/s41598-019-45890-w","article-title":"Antifungal Synergy of a Topical Triazole, PC945, with a Systemic Triazole against Respiratory Aspergillus Fumigatus Infection","volume":"9","author":"Colley","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e01941-17","DOI":"10.1128\/AAC.01941-17","article-title":"In Vitro and In Vivo Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus Fumigatus Infection","volume":"62","author":"Colley","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1093\/jac\/dkz302","article-title":"Anti-Fungal Activity of a Novel Triazole, PC1244, against Emerging Azole-Resistant Aspergillus Fumigatus and Other Species of Aspergillus","volume":"74","author":"Colley","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0940-2993(96)80075-3","article-title":"Imidazole Fungicides Provoke Histamine Release from Mast Cells and Induce Airway Contraction","volume":"48","author":"Gietzen","year":"1996","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/jamp.2020.1645","article-title":"Pharmacokinetic and Pharmacodynamic Comparison of Intravenous and Inhaled Caspofungin","volume":"34","author":"Yu","year":"2021","journal-title":"J. Aerosol. Med. Pulm. Drug Deliv."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Yu, I.G., and Ryckman, D.M. (2021). Assessment and Development of the Antifungal Agent Caspofungin for Aerosolized Pulmonary Delivery. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13040504"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"e02174-20","DOI":"10.1128\/AAC.02174-20","article-title":"Nebulized Micafungin Treatment for Scopulariopsis\/Microascus Tracheobronchitis in Lung Transplant Recipients","volume":"65","author":"Berastegui","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_174","first-page":"317","article-title":"Aerosol Hamycin Is Effective for Prophylaxis and Therapy in a Rat Model of Pulmonary Aspergillosis","volume":"46","author":"Dhuley","year":"2001","journal-title":"Rocz. Akad. Med. Bialymst."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1647\/2012-003R.1","article-title":"Pharmacokinetics of Nebulized Terbinafine in Hispaniolan Amazon Parrots (Amazona Ventralis)","volume":"26","author":"Emery","year":"2012","journal-title":"J. Avian. Med. Surg."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1007\/BF01967386","article-title":"Inactivity of Terbinafine in a Rat Model of Pulmonary Aspergillosis","volume":"9","author":"Schmitt","year":"1990","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/641\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:36:24Z","timestamp":1760135784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/3\/641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":176,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["pharmaceutics14030641"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14030641","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,14]]}}}