{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:49:52Z","timestamp":1787989792739,"version":"build-2784847793"},"reference-count":16,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T00:00:00Z","timestamp":1648339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union's Horizon 2020 Research and Innovation program under the Marie Sk\u0142odow-ska-Curie grant agreement -Ministry of Science and Higher Education of Poland","award":["778051"],"award-info":[{"award-number":["778051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The bioavailability of orally administered bisphosphonates is very low (&lt;1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration. For this purpose, a combination of three methods was applied: (1) evaluation of sorption capacity for rows of digested food samples in a simulated intestinal environment; (2) evaluation of drug availability in simulated chyme; and (3) evaluation of drug availability using a simulating needle device. The results indicate that food products such as egg white and white bread are most suitable for consumption during oral bisphosphonate intake.<\/jats:p>","DOI":"10.3390\/pharmaceutics14040717","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"717","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Effects of Various Food Products on Bisphosphonate\u2019s Availability"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-6270","authenticated-orcid":false,"given":"Monika","family":"Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Chemical Technology and Engineering, Pozna\u0144 University of Technology, ul. Berdychowo 4, 60-965 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-0329","authenticated-orcid":false,"given":"Grzegorz","family":"Garbacz","sequence":"additional","affiliation":[{"name":"Physiolution Polska sp. z o.o., Pi\u0142sudskiego 74, 50-020 Wroc\u0142aw, Poland"},{"name":"Physiolution GmbH, Walther-Rathenau-Stra\u00dfe 49 a, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Sczodrok","sequence":"additional","affiliation":[{"name":"Physiolution GmbH, Walther-Rathenau-Stra\u00dfe 49 a, 17489 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-8952","authenticated-orcid":false,"given":"Adam","family":"Voelkel","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology and Engineering, Pozna\u0144 University of Technology, ul. Berdychowo 4, 60-965 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2013.01.032","article-title":"Biomedical applications of bisphosphonates","volume":"167","author":"Elisabeth","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bartl, R., Frisch, B., Tresckow, B., and Bartl, C. (2007). Bisphosphonates in Medical Practice: Actions-Side Effects-Indications-Strategies, Springer.","DOI":"10.1007\/978-3-540-69870-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejps.2014.07.009","article-title":"Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability","volume":"63","author":"Stappaerts","year":"2014","journal-title":"Eur. J. Pharm. 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Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jpba.2008.05.028","article-title":"Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological material: A review of analytical methods","volume":"48","author":"Zacharis","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s13738-018-1484-y","article-title":"Risedronate extraction from artificial urine with using monolithic polymer-based anion exchangers","volume":"16","author":"Voelkel","year":"2019","journal-title":"J. Iran. Chem. 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