{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:36:52Z","timestamp":1789612612464,"version":"build-2803163510"},"reference-count":133,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Centre Poland \u201cMiniatura 4&quot;","award":["2020\/04\/X\/NZ7\/01515"],"award-info":[{"award-number":["2020\/04\/X\/NZ7\/01515"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Scutellarie baicalensis radix, as a flavone-rich source, exhibits antibacterial, antifungal, antioxidant, and anti-inflammatory activity. It may be used as a therapeutic agent to treat various diseases, including vaginal infections. In this study, six binary mixtures of chitosan with stable S. baicalensis radix lyophilized extract were obtained and identified by spectral (ATR-FTIR, XRPD) and thermal (TG and DSC) methods. The changes in dissolution rates of active compounds and the significant increase in the biological properties towards metal chelating activity were observed, as well as the inhibition of hyaluronic acid degradation after mixing plant extract with chitosan. Moreover, the combination of S. baicalensis radix lyophilized extract with a carrier allowed us to obtain the binary systems with a higher antifungal activity than the pure extract, which may be effective in developing new strategies in the vaginal infections treatment, particularly vulvovaginal candidiasis.<\/jats:p>","DOI":"10.3390\/pharmaceutics14040740","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:41:30Z","timestamp":1648590090000},"page":"740","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Chitosan-Based System with Scutellariae baicalensis radix Extract for the Local Treatment of Vaginal Infections"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-1450","authenticated-orcid":false,"given":"Justyna","family":"Chanaj-Kaczmarek","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4722-6413","authenticated-orcid":false,"given":"Natalia","family":"Rosiak","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Szymanowska","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego Street, 60-627 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Rajewski","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Poznan University of Medical Sciences, 33 Polna Street, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Wender-Ozegowska","sequence":"additional","affiliation":[{"name":"Department of Reproduction, Poznan University of Medical Sciences, 33 Polna Street, 60-535 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5419","authenticated-orcid":false,"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Poznan University of Medical Sciences, 3 Rokietnicka Street, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Abdul-Aziz, M., Mahdy, M.A.K., Abdul-Ghani, R., Alhilali, N.A., Al-Mujahed, L.K.A., Alabsi, S.A., Al-Shawish, F.A.M., Alsarari, N.J.M., Bamashmos, W., and Abdulwali, S.J.H. (2019). Bacterial Vaginosis, Vulvovaginal Candidiasis and Trichomonal Vaginitis among Reproductive-Aged Women Seeking Primary Healthcare in Sana\u2019a City, Yemen. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-4549-3"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"120.e1","DOI":"10.1016\/j.ajog.2010.05.023","article-title":"Efficacy of Vaginal Probiotic Capsules for Recurrent Bacterial Vaginosis: A Double-Blind, Randomized, Placebo-Controlled Study","volume":"203","author":"Ya","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4919404","DOI":"10.1155\/2017\/4919404","article-title":"Prevalence of Bacterial Vaginosis and Associated Risk Factors among Women Complaining of Genital Tract Infection","volume":"2017","author":"Bitew","year":"2017","journal-title":"Int. J. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/1040841X.2017.1306688","article-title":"Defence Factors of Vaginal Lactobacilli","volume":"44","author":"Kovachev","year":"2018","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e9703754","DOI":"10.1155\/2018\/9703754","article-title":"Risk Factors of Vulvovaginal Candidiasis among Women of Reproductive Age in Xi\u2019an: A Cross-Sectional Study","volume":"2018","author":"Zeng","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal Candidiasis: Epidemiology, Microbiology and Risk Factors","volume":"42","author":"Ferreira","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.nurpra.2019.03.010","article-title":"Bacterial Vaginosis: A Review of Treatment, Recurrence, and Disparities","volume":"15","author":"Jones","year":"2019","journal-title":"J. Nurse Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ajog.2020.10.019","article-title":"Bacterial Vaginosis and Its Association with Infertility, Endometritis, and Pelvic Inflammatory Disease","volume":"224","author":"Ravel","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajog.2019.09.002","article-title":"Bacterial Vaginosis and Surgical Site Infections","volume":"222","author":"Soper","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1089\/jwh.2018.7383","article-title":"Characterization and Treatment of Recurrent Bacterial Vaginosis","volume":"28","author":"Faught","year":"2019","journal-title":"J. Women\u2019s Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1093\/infdis\/jiw159","article-title":"Current Treatment of Bacterial Vaginosis\u2014Limitations and Need for Innovation","volume":"214","author":"Bradshaw","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rosati, D., Bruno, M., Jaeger, M., Ten Oever, J., and Netea, M.G. (2020). Recurrent Vulvovaginal Candidiasis: An Immunological Perspective. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020144"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/cid\/civ353","article-title":"Biofilms: An Underappreciated Mechanism of Treatment Failure and Recurrence in Vaginal Infections","volume":"61","author":"Muzny","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Vodstrcil, L.A., Muzny, C.A., Plummer, E.L., Sobel, J.D., and Bradshaw, C.S. (2021). Bacterial Vaginosis: Drivers of Recurrence and Challenges and Opportunities in Partner Treatment. BMC Med., 19.","DOI":"10.1186\/s12916-021-02077-3"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e01067","DOI":"10.1016\/j.heliyon.2018.e01067","article-title":"Bacterial Biofilm Formation on Implantable Devices and Approaches to Its Treatment and Prevention","volume":"4","author":"Khatoon","year":"2018","journal-title":"Heliyon"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3389\/fmicb.2018.01636","article-title":"Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation","volume":"9","author":"Costa","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e02192","DOI":"10.1016\/j.heliyon.2019.e02192","article-title":"Challenges of Intervention, Treatment, and Antibiotic Resistance of Biofilm-Forming Microorganisms","volume":"5","author":"Gebreyohannes","year":"2019","journal-title":"Heliyon"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Samrot, A.V., Abubakar Mohamed, A., Faradjeva, E., Si Jie, L., Hooi Sze, C., Arif, A., Chuan Sean, T., Norbert Michael, E., Yeok Mun, C., and Xiao Qi, N. (2021). Mechanisms and Impact of Biofilms and Targeting of Biofilms Using Bioactive Compounds\u2014A Review. Medicina, 57.","DOI":"10.3390\/medicina57080839"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e02508-16","DOI":"10.1128\/AEM.02508-16","article-title":"Control of Biofilm Formation: Antibiotics and Beyond","volume":"83","author":"Algburi","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13756-019-0533-3","article-title":"Antibiotics versus Biofilm: An Emerging Battleground in Microbial Communities","volume":"8","author":"Sharma","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"170.e1","DOI":"10.1016\/j.ajog.2007.02.027","article-title":"Effect of Biofilm Phenotype on Resistance of Gardnerella Vaginalis to Hydrogen Peroxide and Lactic Acid","volume":"197","author":"Patterson","year":"2007","journal-title":"Am. J. Obs. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1542-2011.2012.00246.x","article-title":"Vaginal Infections Update","volume":"57","author":"Mashburn","year":"2012","journal-title":"J. Midwifery Women\u2019s Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jep.2015.03.046","article-title":"The Traditional Use of Plants to Manage Candidiasis and Related Infections in Venda, South Africa","volume":"168","author":"Masevhe","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.3389\/fmicb.2018.01351","article-title":"Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents","volume":"9","author":"Vasconcelos","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"931","DOI":"10.31925\/farmacia.2019.6.1","article-title":"Herbal Medicines against Bacterial Vaginosis in Women of Reproductive Age: A Systematic Review","volume":"67","author":"Najafi","year":"2019","journal-title":"Farmacia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/03630242.2016.1263272","article-title":"Comparing the Effects of Calendula Officinalis and Clotrimazole on Vaginal Candidiasis: A Randomized Controlled Trial","volume":"57","author":"Saffari","year":"2017","journal-title":"Women Health"},{"key":"ref_27","first-page":"47","article-title":"Efficacy and Safety of Three Plant Extracts Based Formulations of Vagitories in the Treatment of Vaginitis: A Randomized Controlled Trial","volume":"18","year":"2021","journal-title":"Med. Glas."},{"key":"ref_28","first-page":"175","article-title":"Antibiotic Effect of Heat-Clearing Medicinals on Vaginal Microorganisms","volume":"19","author":"Cho","year":"2006","journal-title":"J. Korean Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1038\/s41598-019-38916-w","article-title":"Antifungal Activity and Mechanism of Action of Ou-Gon (Scutellaria Root Extract) Components against Pathogenic Fungi","volume":"9","author":"Da","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1002\/ptr.1216","article-title":"Main Flavonoids in the Root of Scutellaria Baicalensis Cultivated in Europe and Their Comparative Antiradical Properties","volume":"17","author":"Slanina","year":"2003","journal-title":"Phytother. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.fitote.2009.06.004","article-title":"Baicalin Suppresses Expression of Chlamydia Protease-like Activity Factor in Hep-2 Cells Infected by Chlamydia Trachomatis","volume":"7","author":"Hao","year":"2009","journal-title":"Fitoterapia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-0773.1999.tb01496.x","article-title":"Inhibitory Effects of Baicalein and Wogonin on Lipopolysaccharide-Induced Nitric Oxide Production in Macrophages","volume":"84","author":"Wakabayashi","year":"1999","journal-title":"Pharmacol. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/BF02975846","article-title":"Neuroprotective Effect of Wogonin: Potential Roles of Inflammatory Cytokines","volume":"27","author":"Piao","year":"2004","journal-title":"Arch. Pharm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.mad.2006.05.002","article-title":"Short-Term Feeding of Baicalin Inhibits Age-Associated NF-\u039aB Activation","volume":"127","author":"Kim","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1476-7961-5-5","article-title":"Baicalein Inhibits IL-1\u03b2- and TNF-\u03b1-Induced Inflammatory Cytokine Production from Human Mast Cells via Regulation of the NF-\u039aB Pathway","volume":"5","author":"Hsieh","year":"2007","journal-title":"Clin. Mol. Allergy"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.pupt.2010.05.004","article-title":"Baicalin Attenuates Inflammation by Inhibiting NF-\u039aB Activation in Cigarette Smoke Induced Inflammatory Models","volume":"23","author":"Lixuan","year":"2010","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jep.2014.02.010","article-title":"Baicalein, an Active Component of Scutellaria Baicalensis, Protects against Lipopolysaccharide-Induced Acute Lung Injury in Rats","volume":"153","author":"Tsai","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jinorgbio.2011.02.003","article-title":"In Vitro Analysis of Iron Chelating Activity of Flavonoids","volume":"105","author":"Bovicelli","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejphar.2004.11.060","article-title":"Effects of Dietary Baicalin Supplementation on Iron Overload-Induced Mouse Liver Oxidative Injury","volume":"509","author":"Zhao","year":"2005","journal-title":"Eur. J. Pharm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/1541-4337.12204","article-title":"Flavonoids as Potent Scavengers of Hydroxyl Radicals","volume":"15","author":"Treml","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fmicb.2018.01204","article-title":"Enhanced Biofilm Formation by Ferrous and Ferric Iron through Oxidative Stress in Campylobacter Jejuni","volume":"9","author":"Oh","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Chen, T., Dong, G., Zhang, S., Zhang, X., Zhao, Y., Cao, J., Zhou, T., and Wu, Q. (2020). Effects of Iron on the Growth, Biofilm Formation and Virulence of Klebsiella Pneumoniae Causing Liver Abscess. BMC Microbiol., 20.","DOI":"10.1186\/s12866-020-01727-5"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.1073\/pnas.0504266102","article-title":"Iron and Pseudomonas Aeruginosa Biofilm Formation","volume":"102","author":"Banin","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lin, M.-H., Shu, J.-C., Huang, H.-Y., and Cheng, Y.-C. (2012). Involvement of Iron in Biofilm Formation by Staphylococcus Aureus. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0034388"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S529","DOI":"10.1093\/cid\/ciz825","article-title":"The Role of Iron and Siderophores in Infection, and the Development of Siderophore Antibiotics","volume":"69","author":"Page","year":"2019","journal-title":"Clin. Infect Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijbiomac.2018.10.049","article-title":"Modified Hyaluronic Acid Based Materials for Biomedical Applications","volume":"121","author":"Tiwari","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","first-page":"102","article-title":"Hyaluronic Acid and Its Biomedical Applications: A Review","volume":"1","author":"Dovedytis","year":"2020","journal-title":"Eng. Regen."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"116364","DOI":"10.1016\/j.carbpol.2020.116364","article-title":"Hyaluronic Acid\u2014Based Wound Dressings: A Review","volume":"241","author":"Miguel","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/art.1780310110","article-title":"Antioxidant Activity of Synovial Fluid, Hyaluronic Acid, and Two Subcomponents of Hyaluronic Acid. Synovial Fluid Scavenging Effect Is Enhanced in Rheumatoid Arthritis Patients","volume":"31","author":"Sato","year":"1988","journal-title":"Arthritis Rheum."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7150\/jbji.17705","article-title":"Hyaluronic Acid and Its Composites as a Local Antimicrobial\/Antiadhesive Barrier","volume":"2","author":"Bortolin","year":"2017","journal-title":"J. Bone Jt. Infect."},{"key":"ref_51","first-page":"212","article-title":"Clinical Evaluation of Low-Molecular-Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial","volume":"42","author":"Delia","year":"2019","journal-title":"ORT"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1080\/07853890.2021.1974083","article-title":"Efficacy and Safety of Prolonged-Release Hyaluronic Acid Derivative Vaginal Application in the Postpartum Period: A Prospective Randomised Clinical Trial","volume":"53","author":"Gustavino","year":"2021","journal-title":"Ann. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jsxm.2020.10.016","article-title":"Hyaluronic Acid in Postmenopause Vaginal Atrophy: A Systematic Review","volume":"18","author":"Uggioni","year":"2021","journal-title":"J. Sex. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2165\/00137696-200301010-00004","article-title":"The Role of Chitosan in Drug Delivery","volume":"1","author":"Fini","year":"2003","journal-title":"Am. J. Drug Deliv."},{"key":"ref_55","first-page":"e527549","article-title":"Effects of Chitosan on Candida Albicans: Conditions for Its Antifungal Activity","volume":"2013","author":"Calahorra","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_56","first-page":"27","article-title":"Chitosan Based Scaffolds and Their Applications in Wound Healing","volume":"10","author":"Ahmed","year":"2016","journal-title":"Achiev. Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"109984","DOI":"10.1016\/j.eurpolymj.2020.109984","article-title":"Antibacterial Activity of Chitosan and Its Derivatives and Their Interaction Mechanism with Bacteria: Current State and Perspectives","volume":"138","author":"Li","year":"2020","journal-title":"Eur. Polym. J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"116002","DOI":"10.1016\/j.carbpol.2020.116002","article-title":"Cationic Chitosan Derivatives as Potential Antifungals: A Review of Structural Optimization and Applications","volume":"236","author":"Qin","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Ke, C.-L., Deng, F.-S., Chuang, C.-Y., and Lin, C.-H. (2021). Antimicrobial Actions and Applications of Chitosan. Polymers, 13.","DOI":"10.3390\/polym13060904"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"117919","DOI":"10.1016\/j.carbpol.2021.117919","article-title":"Chitosan-Based Systems Aimed at Local Application for Vaginal Infections","volume":"261","author":"Araujo","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Ways, T.M., Lau, W.M., and Khutoryanskiy, V.V. (2018). Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems. Polymers, 10.","DOI":"10.3390\/polym10030267"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-5173(98)00245-2","article-title":"Effect of Chitosan and Chitosan Glutamate Enhancing the Dissolution Properties of the Poorly Water Soluble Drug Nifedipine","volume":"175","author":"Portero","year":"1998","journal-title":"Int. J. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"6164","DOI":"10.1016\/j.biomaterials.2011.03.056","article-title":"Mechanism and Consequence of Chitosan-Mediated Reversible Epithelial Tight Junction Opening","volume":"32","author":"Yeh","year":"2011","journal-title":"Biomaterials"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Chanaj-Kaczmarek, J., Osma\u0142ek, T., Szyma\u0144ska, E., Winnicka, K., Karpi\u0144ski, T.M., Dyba, M., Bekalarska-D\u0119bek, M., and Cielecka-Piontek, J. (2021). Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae Baicalensis Radix Extract and Chitosan for Periodontal Diseases Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222111319"},{"key":"ref_65","unstructured":"ICH (2003). Stability Testing Guidelines: Stability Testing of New Drug Substances and Products, ICH Steering Committee. Available online: https:\/\/www.ema.europa.eu\/en\/ich-q1a-r2-stability-testing-new-drug-substances-drug-products."},{"key":"ref_66","first-page":"215","article-title":"Gaussian 09, Revision C. 01, Gaussian, Inc., Wallingford CT, 2009 Search PubMed;(b) Y. Zhao and DG Truhlar","volume":"120","author":"Frisch","year":"2008","journal-title":"Theor. Chem. Acc."},{"key":"ref_67","unstructured":"Dennington, R., Keith, T., and Millam, J. (2009). GaussView, Semichem Inc.. Version 5."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0010-7824(99)00010-4","article-title":"A Vaginal Fluid Simulant","volume":"59","author":"Owen","year":"1999","journal-title":"Contraception"},{"key":"ref_69","unstructured":"(2020). Dissolution test for solid dosage forms. European Pharmacopoeia, Council of Europe. [10th ed.]. Chapter 2.9.3."},{"key":"ref_70","first-page":"64","article-title":"Mathematical Comparison of Dissolution Profiles","volume":"20","author":"Moore","year":"1996","journal-title":"Pharm. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/abbi.1994.1485","article-title":"Action of Phenolic Derivatives (Acetaminophen, Salicylate, and 5-Aminosalicylate) as Inhibitors of Membrane Lipid Peroxidation and as Peroxyl Radical Scavengers","volume":"315","author":"Dinis","year":"1994","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Studzi\u0144ska-Sroka, E., Dudek-Makuch, M., Chanaj-Kaczmarek, J., Czepulis, N., Korybalska, K., Rutkowski, R., \u0141uczak, J., Grabowska, K., Bylka, W., and Witowski, J. (2018). Anti-Inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav. Molecules, 23.","DOI":"10.3390\/molecules23092133"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1080\/13880209.2017.1285321","article-title":"Comparative Research on Stability of Baicalin and Baicalein Administrated in Monomer and Total Flavonoid Fraction Form of Radix Scutellariae in Biological Fluids in Vitro","volume":"55","author":"Feng","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_74","unstructured":"DeNoyer, L.K., and Dodd, J.G. (2006). Smoothing and Derivatives in Spectroscopy. Handbook of Vibrational Spectroscopy, John Wiley & Sons, Ltd."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1055\/s-0032-1328764","article-title":"Unveiling Ontogenesis of Herbal Medicine in Plant Chemical Profiles by Infrared Macro-Fingerprinting","volume":"79","author":"Xu","year":"2013","journal-title":"Planta Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Sip, S., Paczkowska-Walendowska, M., Rosiak, N., Miklaszewski, A., Graba\u0144ska-Marty\u0144ska, K., Samarzewska, K., and Cielecka-Piontek, J. (2021). Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems. Pharmaceuticals, 14.","DOI":"10.3390\/ph14080712"},{"key":"ref_77","first-page":"1286","article-title":"Analysis of the 4th generation Scutellaria baicalensis Georgi with space mutagenesis via FTIR spectroscopy","volume":"29","author":"Ding","year":"2009","journal-title":"Guang Pu Xue Yu Guang Pu Fen Xi"},{"key":"ref_78","first-page":"1774","article-title":"Study on the identification of radix scutellariae and extract using Fourier transform infrared spectroscopy and two-dimensional IR correlation spectroscopy","volume":"30","author":"Zhang","year":"2010","journal-title":"Guang Pu Xue Yu Guang Pu Fen Xi"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.9734\/AIR\/2016\/22742","article-title":"Effect of Biological Control Antagonists Adsorbed on Chitosan Immobilized Silica Nanocomposite on Ralstonia Solanacearum and Growth of Tomato Seedlings","volume":"6","author":"Dennis","year":"2016","journal-title":"Adv. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s10876-018-1342-1","article-title":"Single Step Fabrication of Chitosan Nanocrystals Using Penaeus Semisulcatus: Potential as New Insecticides, Antimicrobials and Plant Growth Promoters","volume":"29","author":"Thamilarasan","year":"2018","journal-title":"J. Clust. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Zhao, L., Duan, X., Cao, W., Ren, X., Ren, G., Liu, P., and Chen, J. (2021). Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles. Foods, 10.","DOI":"10.3390\/foods10102470"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.carbpol.2005.02.022","article-title":"Thermal Analysis of Chitosan Based Networks","volume":"62","author":"Neto","year":"2005","journal-title":"Carbohydr. Polym."},{"key":"ref_83","first-page":"52","article-title":"Preparation, Characterization and Performance Evaluation Of Chitosan As An Adsorbent For Remazol Red","volume":"2","author":"Dey","year":"2016","journal-title":"Int. J. Latest Res. Eng. Technol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF03218428","article-title":"A Kinetic Study of Thermal Degradations of Chitosan\/Polycaprolactam Blends","volume":"12","author":"Liao","year":"2004","journal-title":"Macromol. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Perinelli, D.R., Campana, R., Skouras, A., Bonacucina, G., Cespi, M., Mastrotto, F., Baffone, W., and Casettari, L. (2018). Chitosan Loaded into a Hydrogel Delivery System as a Strategy to Treat Vaginal Co-Infection. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10010023"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"120375","DOI":"10.1016\/j.ijpharm.2021.120375","article-title":"Development and Microbiological Evaluation of Chitosan and Chitosan-Alginate Microspheres for Vaginal Administration of Metronidazole","volume":"598","author":"Cirri","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A.D., Selvanathan, V., Sonsudin, F., and Abouloula, C.N. (2017). PH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications. Polymers, 9.","DOI":"10.3390\/polym9040137"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jconrel.2004.01.025","article-title":"Controlled Release of Clozapine through Chitosan Microparticles Prepared by a Novel Method","volume":"96","author":"Agnihotri","year":"2004","journal-title":"J. Control. Release"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/wound.2014.0577","article-title":"EDTA: An Antimicrobial and Antibiofilm Agent for Use in Wound Care","volume":"4","author":"Finnegan","year":"2015","journal-title":"Adv. Wound Care"},{"key":"ref_90","unstructured":"Donelli, G. (2018). The Efficacy of Tetrasodium EDTA on Biofilms. Advances in Microbiology, Infectious Diseases and Public Health: Volume 9, Springer International Publishing. Advances in Experimental Medicine and Biology."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ijantimicag.2016.05.008","article-title":"Synergistic Antibiofilm Efficacy of Various Commercial Antiseptics, Enzymes and EDTA: A Study of Pseudomonas Aeruginosa and Staphylococcus Aureus Biofilms","volume":"48","author":"Lefebvre","year":"2016","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1128\/AAC.47.11.3580-3585.2003","article-title":"In Vitro and Ex Vivo Activities of Minocycline and EDTA against Microorganisms Embedded in Biofilm on Catheter Surfaces","volume":"47","author":"Raad","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","article-title":"Strategies for Combating Bacterial Biofilms: A Focus on Anti-Biofilm Agents and Their Mechanisms of Action","volume":"9","author":"Roy","year":"2018","journal-title":"Virulence"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00430-013-0311-4","article-title":"Anti-Biofilm Activity of Low-Molecular Weight Chitosan Hydrogel against Candida Species","volume":"203","author":"Miranda","year":"2014","journal-title":"Med. Microbiol. Immunol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijbiomac.2018.12.159","article-title":"Chitosan Disrupts Biofilm Formation and Promotes Biofilm Eradication in Staphylococcus Species Isolated from Bovine Mastitis","volume":"126","author":"Felipe","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_96","first-page":"78","article-title":"Hyaluronic Acid in Inflammation and Tissue Regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/1947603517749919","article-title":"Anti-Inflammatory Effects of Intra-Articular Hyaluronic Acid: A Systematic Review","volume":"10","author":"Altman","year":"2019","journal-title":"Cartilage"},{"key":"ref_98","first-page":"460","article-title":"Characterization of Biopolymer \u201cChitosan\u201d from the Shell of Donacid Clam Donax Scortum (Linnaeus, 1758) and Its Antioxidant Activity","volume":"4","author":"Shanmugam","year":"2012","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chandrasekharan, A., Hwang, Y.J., Seong, K.-Y., Park, S., Kim, S., and Yang, S.Y. (2019). Acid-Treated Water-Soluble Chitosan Suitable for Microneedle-Assisted Intracutaneous Drug Delivery. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11050209"},{"key":"ref_100","first-page":"47","article-title":"Interactions between Chitosan and Glycosaminoglycans (Chondroitin Sulfate and Hyaluronic Acid): Physicochemical and Biological Studies","volume":"58","author":"Ferrier","year":"2000","journal-title":"Ann. Pharm. Fr."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s11046-010-9341-2","article-title":"Antifungal Activity of Baicalein Against Candidakrusei Does Not Involve Apoptosis","volume":"170","author":"Kang","year":"2010","journal-title":"Mycopathologia"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1099\/jmm.0.047852-0","article-title":"2012 In Vitro Antifungal Activity of the Flavonoid Baicalein against Candida Species","volume":"61","author":"Serpa","year":"2012","journal-title":"J. Med. Microbiol."},{"key":"ref_103","first-page":"803","article-title":"Baicalein Induces Programmed Cell Death in Candida Albicans","volume":"19","author":"Dai","year":"2009","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ijantimicag.2008.01.026","article-title":"In Vitro Activity of Baicalein against Candida Albicans Biofilms","volume":"32","author":"Cao","year":"2008","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1248\/bpb.31.2234","article-title":"In Vitro Synergism of Fluconazole and Baicalein against Clinical Isolates of Candida Albicans Resistant to Fluconazole","volume":"31","author":"Huang","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1248\/bpb.34.214","article-title":"Combination of Baicalein and Amphotericin B Accelerates Candida Albicans Apoptosis","volume":"34","author":"Fu","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.bbrc.2014.07.040","article-title":"Baicalin Prevents Candida Albicans Infections via Increasing Its Apoptosis Rate","volume":"451","author":"Yang","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"fyab020","DOI":"10.1093\/fqsafe\/fyab020","article-title":"A Review: Antimicrobial Properties of Several Medicinal Plants Widely Used in Traditional Chinese Medicine","volume":"5","author":"Chen","year":"2021","journal-title":"Food Qual. Saf."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liu, T., Wang, K., Hou, C., Cai, S., Huang, Y., Du, Z., Huang, H., Kong, J., and Chen, Y. (2016). Baicalein Inhibits Staphylococcus Aureus Biofilm Formation and the Quorum Sensing System In Vitro. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153468"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00404-013-3064-9","article-title":"The Role of Lactobacilli and Probiotics in Maintaining Vaginal Health","volume":"289","author":"Borges","year":"2014","journal-title":"Arch. Gynecol. Obs."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1089\/jop.2000.16.261","article-title":"Chitosan as Tear Substitute: A Wetting Agent Endowed with Antimicrobial Efficacy","volume":"16","author":"Felt","year":"2000","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1021\/bm034130m","article-title":"Chitosan as Antimicrobial Agent:\u2009 Applications and Mode of Action","volume":"4","author":"Rabea","year":"2003","journal-title":"Biomacromolecules"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.eurpolymj.2004.02.015","article-title":"Diethylmethyl Chitosan as an Antimicrobial Agent: Synthesis, Characterization and Antibacterial Effects","volume":"40","author":"Avadi","year":"2004","journal-title":"Eur. Polym. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00289-005-0414-1","article-title":"Chitosan- Metal Complexes as Antimicrobial Agent: Synthesis, Characterization and Structure-Activity Study","volume":"55","author":"Wang","year":"2005","journal-title":"Polym. Bull."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/jbm.a.31871","article-title":"Self-Aggregation of Water-Soluble Chitosan and Solubilization of Thymol as an Antimicrobial Agent","volume":"90","author":"Hu","year":"2009","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1751-7915.2008.00080.x","article-title":"Chitosan and Its Antimicrobial Potential--a Critical Literature Survey","volume":"2","author":"Raafat","year":"2009","journal-title":"Microb. Biotechnol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.fm.2010.05.012","article-title":"Biodegradable Gelatin\u2013Chitosan Films Incorporated with Essential Oils as Antimicrobial Agents for Fish Preservation","volume":"27","author":"Montero","year":"2010","journal-title":"Food Microbiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijfoodmicro.2010.09.012","article-title":"Antimicrobial Properties of Chitosan and Mode of Action: A State of the Art Review","volume":"144","author":"Kong","year":"2010","journal-title":"Int. J. Food Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fmicb.2019.00602","article-title":"A Potential Antifungal Effect of Chitosan Against Candida Albicans Is Mediated via the Inhibition of SAGA Complex Component Expression and the Subsequent Alteration of Cell Surface Integrity","volume":"10","author":"Shih","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Lo, W.-H., Deng, F.-S., Chang, C.-J., and Lin, C.-H. (2020). Synergistic Antifungal Activity of Chitosan with Fluconazole against Candida Albicans, Candida Tropicalis, and Fluconazole-Resistant Strains. Molecules, 25.","DOI":"10.3390\/molecules25215114"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Shafer, W.M. (2006). Molecular Mechanisms of Bacterial Resistance to Antimicrobial Peptides. Antimicrobial Peptides and Human Disease, Springer. Current Topics in Microbiology and Immunology.","DOI":"10.1007\/3-540-29916-5"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.carbpol.2010.11.049","article-title":"Advances in Chitin\/Chitosan Science and Their Applications","volume":"84","author":"Chen","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7.3.10","DOI":"10.1128\/microbiolspec.GPP3-0044-2018","article-title":"The Gram-Positive Bacterial Cell Wall","volume":"7","author":"Rohde","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1128\/AEM.00453-08","article-title":"Insights into the Mode of Action of Chitosan as an Antibacterial Compound","volume":"74","author":"Raafat","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Kravanja, G., Primo\u017ei\u010d, M., Knez, \u017d., and Leitgeb, M. (2019). Chitosan-Based (Nano)Materials for Novel Biomedical Applications. Molecules, 24.","DOI":"10.3390\/molecules24101960"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2334\/josnusd.16-0295","article-title":"In Vivo Study of Antifungal Effects of Low-Molecular-Weight Chitosan against Candida Albicans","volume":"59","author":"Atai","year":"2017","journal-title":"J. Oral Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/j.1365-2958.2009.07039.x","article-title":"Membrane Fluidity Determines Sensitivity of Filamentous Fungi to Chitosan","volume":"75","author":"Huang","year":"2010","journal-title":"Mol. Microbiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.bbamem.2015.03.007","article-title":"Increased Membrane Surface Positive Charge and Altered Membrane Fluidity Leads to Cationic Antimicrobial Peptide Resistance in Enterococcus Faecalis","volume":"1848","author":"Kumariya","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Ganan, M., Lorentzen, S.B., Aam, B.B., Eijsink, V.G.H., Gaustad, P., and S\u00f8rlie, M. (2019). Antibiotic Saving Effect of Combination Therapy through Synergistic Interactions between Well-Characterized Chito-Oligosaccharides and Commercial Antifungals against Medically Relevant Yeasts. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0227098"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bjp.2015.09.010","article-title":"Evaluation of the Antimicrobial Activity of Chitosan and Its Quaternized Derivative on E. Coli and S. Aureus Growth","volume":"26","author":"Goy","year":"2016","journal-title":"Rev. Bras. De Farmacogn."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"12411","DOI":"10.1021\/jf203165k","article-title":"Synergistic Antimicrobial Activities of Natural Essential Oils with Chitosan Films","volume":"59","author":"Wang","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Kim, J.-H., Yu, D., Eom, S.-H., Kim, S.-H., Oh, J., Jung, W.-K., and Kim, Y.-M. (2017). Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic-Resistant Acne-Related Bacteria. Mar. Drugs, 15.","DOI":"10.20944\/preprints201704.0076.v1"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"100861","DOI":"10.1016\/j.nmni.2021.100861","article-title":"The Synergistic Effect of Turmeric Aqueous Extract and Chitosan against Multidrug-Resistant Bacteria","volume":"41","author":"Etemadi","year":"2021","journal-title":"New Microbes New Infect."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/4\/740\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:46:07Z","timestamp":1760136367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/4\/740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":133,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["pharmaceutics14040740"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14040740","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]}}}