{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:03:46Z","timestamp":1770141826321,"version":"3.49.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u0420eoples\u2019 Friendship University of Russia (RUDN University)","award":["RUDN University"],"award-info":[{"award-number":["RUDN University"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>In the present work, the methods of dynamic light scattering and fluorescence spectroscopy were applied to study the optical properties of aqueous dilutions of the humic substances complex (HC) as a potential drug delivery system. The supramolecular structures in the humate solution were characterized as monodisperse systems of the submicron range with a tendency to decrease in particle size with a decrease in the dry matter concentration. The slightly alkaline medium (8.3) of the studied aqueous dilutions of HC causes the absence of a pronounced fluorescence maximum in the region from 400 to 500 nm. However, the presence of an analytically significant, inversely proportional to the concentration second-order scattering (SOS) signal at 2\u03bbex = \u03bbem was shown. In the examples of the antiviral substances mangiferin and favipiravir, it was shown that the use of the humic complex as a drug carrier makes it possible to increase the solubility by several times and simultaneously obtain a system with a smaller particle size of the dispersed phase. It has been shown that HC can interact with mangiferin and favipiravir to form stable structures, which lead to a significant decrease in SOS intensities on HC SOS spectra. The scattering wavelengths, \u03bbex\/\u03bbem, were registered at 350 nm\/750 nm for mangiferin and 365 nm\/730 nm for favipiravir, respectively. The increments of the scattering intensities (I0\/I) turned out to be proportional to the concentration of antiviral components in a certain range of concentrations.<\/jats:p>","DOI":"10.3390\/pharmaceutics14040767","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:34:29Z","timestamp":1648762469000},"page":"767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Second-Order Scattering Quenching in Fluorescence Spectra of Natural Humates as a Tracer of Formation Stable Supramolecular System for the Delivery of Poorly Soluble Antiviral Drugs on the Example of Mangiferin and Favipiravir"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-2183","authenticated-orcid":false,"given":"Mariya A.","family":"Morozova","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir N.","family":"Tumasov","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaha V.","family":"Kazimova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana V.","family":"Maksimova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-8348","authenticated-orcid":false,"given":"Elena V.","family":"Uspenskaya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton V.","family":"Syroeshkin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Toxicological Chemistry, Medical Institute, Peoples\u2019 Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.addr.2012.10.003","article-title":"Advanced materials and processing for drug delivery: The past and the future","volume":"65","author":"Zhang","year":"2013","journal-title":"Adv. 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