{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:28:36Z","timestamp":1792160916268,"version":"4.4.0"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Econom\u00eda y Competitividad, Gobierno de Espa\u00f1a","award":["Grant RTC-2016-4983-1"],"award-info":[{"award-number":["Grant RTC-2016-4983-1"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad, Gobierno de Espa\u00f1a","award":["Grant PI19\/01577"],"award-info":[{"award-number":["Grant PI19\/01577"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad, Gobierno de Espa\u00f1a","award":["Grant PI19\/00343"],"award-info":[{"award-number":["Grant PI19\/00343"]}]},{"name":"Ministerio de Econom\u00eda y Competitividad, Gobierno de Espa\u00f1a","award":["Grant P18-TP-5194"],"award-info":[{"award-number":["Grant P18-TP-5194"]}]},{"name":"U-ERDF-Instituto de Salud Carlos III","award":["Grant RTC-2016-4983-1"],"award-info":[{"award-number":["Grant RTC-2016-4983-1"]}]},{"name":"U-ERDF-Instituto de Salud Carlos III","award":["Grant PI19\/01577"],"award-info":[{"award-number":["Grant PI19\/01577"]}]},{"name":"U-ERDF-Instituto de Salud Carlos III","award":["Grant PI19\/00343"],"award-info":[{"award-number":["Grant PI19\/00343"]}]},{"name":"U-ERDF-Instituto de Salud Carlos III","award":["Grant P18-TP-5194"],"award-info":[{"award-number":["Grant P18-TP-5194"]}]},{"name":"FIS-Instituto de Salud Carlos III","award":["Grant RTC-2016-4983-1"],"award-info":[{"award-number":["Grant RTC-2016-4983-1"]}]},{"name":"FIS-Instituto de Salud Carlos III","award":["Grant PI19\/01577"],"award-info":[{"award-number":["Grant PI19\/01577"]}]},{"name":"FIS-Instituto de Salud Carlos III","award":["Grant PI19\/00343"],"award-info":[{"award-number":["Grant PI19\/00343"]}]},{"name":"FIS-Instituto de Salud Carlos III","award":["Grant P18-TP-5194"],"award-info":[{"award-number":["Grant P18-TP-5194"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento y Universidad, Junta de Andaluc\u00eda","award":["Grant RTC-2016-4983-1"],"award-info":[{"award-number":["Grant RTC-2016-4983-1"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento y Universidad, Junta de Andaluc\u00eda","award":["Grant PI19\/01577"],"award-info":[{"award-number":["Grant PI19\/01577"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento y Universidad, Junta de Andaluc\u00eda","award":["Grant PI19\/00343"],"award-info":[{"award-number":["Grant PI19\/00343"]}]},{"name":"Consejer\u00eda de Econom\u00eda, Conocimiento y Universidad, Junta de Andaluc\u00eda","award":["Grant P18-TP-5194"],"award-info":[{"award-number":["Grant P18-TP-5194"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The widespread use of added sugars or non-nutritive sweeteners in processed foods is a challenge for addressing the therapeutics of obesity and diabetes. Both types of sweeteners generate health problems, and both are being blamed for multiple complications associated with these prevalent diseases. As an example, fructose is proven to contribute to obesity and liver steatosis, while non-nutritive sweeteners generate gut dysbiosis that complicates the metabolic control exerted by the liver. The present work explores an alternative approach for sweetening through the use of a simple carob-pod-derived syrup. This sweetener consists of a balanced mixture of fructose (47%) and glucose (45%), as sweetening sugars, and a functional natural ingredient (D-Pinitol) at a concentration (3%) capable of producing active metabolic effects. The administration of this syrup to healthy volunteers (50 g of total carbohydrates) resulted in less persistent glucose excursions, a lower insulin response to the hyperglycemia produced by its ingestion, and an enhanced glucagon\/insulin ratio, compared to that observed after the ingestion of 50 g of glucose. Daily administration of the syrup to Wistar rats for 10 days lowered fat depots in the liver, reduced liver glycogen, promoted fat oxidation, and was devoid of toxic effects. In addition, this repeated administration of the syrup improved glucose handling after a glucose (2 g\/kg) load. Overall, this alternative functional sweetener retains the natural palatability of a glucose\/fructose syrup while displaying beneficial metabolic effects that might serve to protect against the progression towards complicated obesity, especially the development of liver steatosis.<\/jats:p>","DOI":"10.3390\/pharmaceutics14081594","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T04:04:00Z","timestamp":1659326640000},"page":"1594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endocrine and Metabolic Impact of Oral Ingestion of a Carob-Pod-Derived Natural-Syrup-Containing D-Pinitol: Potential Use as a Novel Sweetener in Diabetes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-0983","authenticated-orcid":false,"given":"Juan A.","family":"Navarro","sequence":"first","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Facultad de Medicina, Campus de Teatinos s\/n, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-015X","authenticated-orcid":false,"given":"Juan","family":"Decara","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0342-1287","authenticated-orcid":false,"given":"Dina","family":"Medina-Vera","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Facultad de Medicina, Campus de Teatinos s\/n, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n del Coraz\u00f3n, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"},{"name":"Facultad de Ciencias, Campus de Teatinos s\/n, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Tovar","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Facultad de Medicina, Campus de Teatinos s\/n, Universidad de 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Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Departamento de Anatom\u00eda Humana, Medicina Legal e Historia de la Ciencia, Universidad de M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-8904","authenticated-orcid":false,"given":"Francisco Javier","family":"Pav\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n Cl\u00ednica de Salud Mental, Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga-IBIMA, Hospital Regional Universitario de M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unidad de Gesti\u00f3n del Coraz\u00f3n, Hospital Universitario Virgen de la Victoria, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Serrano","sequence":"additional","affiliation":[{"name":"Laboratorio de Medicina Regenerativa, Unidad de Gesti\u00f3n 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