{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:09:30Z","timestamp":1774562970308,"version":"3.50.1"},"reference-count":137,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,6]],"date-time":"2022-08-06T00:00:00Z","timestamp":1659744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Spanish MICINN","doi-asserted-by":"publisher","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish MICINN","doi-asserted-by":"publisher","award":["202180E048"],"award-info":[{"award-number":["202180E048"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CIBER-BBN, ISCIII, Spain","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}]},{"name":"CIBER-BBN, ISCIII, Spain","award":["202180E048"],"award-info":[{"award-number":["202180E048"]}]},{"name":"The Interdisciplinary Platform SusPlast+, CSIC","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}]},{"name":"The Interdisciplinary Platform SusPlast+, CSIC","award":["202180E048"],"award-info":[{"award-number":["202180E048"]}]},{"name":"The Nanomedicine CSIC HUB","award":["PID2020-114086RB-100"],"award-info":[{"award-number":["PID2020-114086RB-100"]}]},{"name":"The Nanomedicine CSIC HUB","award":["202180E048"],"award-info":[{"award-number":["202180E048"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Osteoarthritis is a high-prevalence joint disease characterized by the degradation of cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self-repair, regenerative medicine strategies have become highly relevant in the management of osteoarthritis. Despite the great advances in medical and pharmaceutical sciences, current therapies stay unfulfilled, due to the inability of cartilage to repair itself. Additionally, the multifactorial etiology of the disease, including endogenous genetic dysfunctions and exogenous factors in many cases, also limits the formation of new cartilage extracellular matrix or impairs the regular recruiting of chondroprogenitor cells. Hence, current strategies for osteoarthritis management involve not only analgesics, anti-inflammatory drugs, and\/or viscosupplementation but also polymeric biomaterials that are able to drive native cells to heal and repair the damaged cartilage. This review updates the most relevant research on osteoarthritis management that employs polymeric biomaterials capable of restoring the viscoelastic properties of cartilage, reducing the symptomatology, and favoring adequate cartilage regeneration properties.<\/jats:p>","DOI":"10.3390\/pharmaceutics14081644","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T04:16:55Z","timestamp":1660018615000},"page":"1644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Role of Polymeric Biomaterials in the Treatment of Articular Osteoarthritis"],"prefix":"10.3390","volume":"14","author":[{"given":"Carmen","family":"Velasco-Salgado","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica y Bioqu\u00edmica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28925 Alcorcon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Mar\u00eda","family":"Pontes-Quero","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros (ICTP), CSIC, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingiener\u00eda, Biomateriales y Biotecnolog\u00eda CIBER-BBN, Instituto de Salud Carlos III, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4179-2556","authenticated-orcid":false,"given":"Luis","family":"Garc\u00eda-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingiener\u00eda, Biomateriales y Biotecnolog\u00eda CIBER-BBN, Instituto de Salud Carlos III, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-5754","authenticated-orcid":false,"given":"Mar\u00eda Rosa","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros (ICTP), CSIC, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingiener\u00eda, Biomateriales y Biotecnolog\u00eda CIBER-BBN, Instituto de Salud Carlos III, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra","family":"de Wit","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros (ICTP), CSIC, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5539-8026","authenticated-orcid":false,"given":"Blanca","family":"V\u00e1zquez-Lasa","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros (ICTP), CSIC, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingiener\u00eda, Biomateriales y Biotecnolog\u00eda CIBER-BBN, Instituto de Salud Carlos III, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-6736","authenticated-orcid":false,"given":"Luis","family":"Rojo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencia y Tecnolog\u00eda de Pol\u00edmeros (ICTP), CSIC, Calle Juan de la Cierva, 3, 28006 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Bioingiener\u00eda, Biomateriales y Biotecnolog\u00eda CIBER-BBN, Instituto de Salud Carlos III, Calle Monforte de Lemos S\/N, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Abradelo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica y Bioqu\u00edmica, Facultad de Farmacia, Universidad San Pablo-CEU, CEU Universities, Urbanizaci\u00f3n Montepr\u00edncipe, 28925 Alcorcon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,6]]},"reference":[{"key":"ref_1","first-page":"465","article-title":"Articular cartilage and osteoarthritis","volume":"54","author":"Buckwalter","year":"2005","journal-title":"Instr. Course Lect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.maturitas.2019.01.005","article-title":"A systematic review of osteoarthritis prevention and management with dietary phytochemicals from foods","volume":"122","author":"Guan","year":"2019","journal-title":"Maturitas"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The role of metabolism in the pathogenesis of osteoarthritis","volume":"13","author":"Mobasheri","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Palmer","year":"2015","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.joca.2013.03.018","article-title":"The epidemiology and impact of pain in osteoarthritis","volume":"21","author":"Neogi","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.semarthrit.2013.07.003","article-title":"Health economics in the field of osteoarthritis: An expert\u2019s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"43","author":"Hiligsmann","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jddst.2017.04.032","article-title":"Towards the antioxidant therapy in Osteoarthritis: Contribution of nanotechnology","volume":"42","author":"Rabasco","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12937-015-0115-z","article-title":"Benefits of antioxidant supplements for knee osteoarthritis: Rationale and reality","volume":"15","author":"Grover","year":"2015","journal-title":"Nutr. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.2147\/DDDT.S295224","article-title":"The development of disease-modifying therapies for osteoarthritis (DMOADs): The evidence to date","volume":"15","author":"Oo","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3390\/polym6030799","article-title":"Drugs and polymers for delivery systems in OA joints: Clinical needs and opportunities","volume":"6","author":"Janssen","year":"2014","journal-title":"Polymers"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.tips.2021.12.004","article-title":"Overcoming barriers for intra-articular delivery of disease-modifying osteoarthritis drugs","volume":"43","author":"Gao","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.semarthrit.2019.02.008","article-title":"Active viscosupplements for osteoarthritis treatment","volume":"49","author":"Aguilar","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s12325-018-0688-y","article-title":"A comparison between rheological properties of intra-articular hyaluronic acid preparations and reported human synovial fluid","volume":"35","author":"Nicholls","year":"2018","journal-title":"Adv. Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4328219","DOI":"10.1155\/2019\/4328219","article-title":"Novel hybrid gels made of high and low molecular weight hyaluronic acid induce proliferation and reduce inflammation in an osteoarthritis in vitro model based on human synoviocytes and chondrocytes","volume":"2019","author":"Stellavato","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0142-9612(00)00121-6","article-title":"Scaffolds in tissue engineering bone and cartilage","volume":"21","author":"Hutmacher","year":"2000","journal-title":"Biomaterials"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jbm.a.35698","article-title":"Thermo-responsive hydrogels from cellulose-based polyelectrolytes and catanionic vesicles for biomedical application","volume":"104","author":"Milcovich","year":"2016","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ijbiomac.2017.04.079","article-title":"Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages","volume":"102","author":"Milcovich","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1007\/s00167-013-2438-7","article-title":"Intra-articular hylastan versus steroid for knee osteoarthritis","volume":"22","author":"Housman","year":"2014","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.colsurfb.2017.03.003","article-title":"An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis","volume":"154","author":"He","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8010","DOI":"10.1039\/C5TB00981B","article-title":"Sustained small molecule delivery from injectable hyaluronic acid hydrogels through host\u2013guest mediated retention","volume":"3","author":"Mealy","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijbiomac.2019.02.031","article-title":"Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: Development, characterization and in-vivo evaluation","volume":"129","author":"Ahmad","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Wei, X., Gao, J., Zhao, Y., Zhao, Y., Guo, L., Chen, C., Duan, Z., Li, P., and Wei, L. (2016). Intra-articular injection of cross-linked hyaluronic acid-dexamethasone hydrogel attenuates osteoarthritis: An experimental study in a rat model of osteoarthritis. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17040411"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41467-018-03691-1","article-title":"Towards an arthritis flare-responsive drug delivery system","volume":"9","author":"Joshi","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.15171\/apb.2018.002","article-title":"Hybrid scaffolds of hyaluronic acid and collagen loaded with prednisolone: An interesting system for osteoarthritis","volume":"8","author":"Mohammadi","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"812949","DOI":"10.1155\/2015\/812949","article-title":"Analgesic effect of intra-articular injection of temperature-responsive hydrogel containing bupivacaine on osteoarthritic pain in rats","volume":"2015","author":"Kim","year":"2015","journal-title":"BioMed Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.ijbiomac.2018.06.152","article-title":"Controlled-release in-situ gel forming formulation of tramadol containing chitosan-based pro-nanogels","volume":"118","author":"Barati","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_27","first-page":"2391","article-title":"Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: Sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation","volume":"10","author":"Akkari","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9904","DOI":"10.1016\/j.biomaterials.2014.08.041","article-title":"Intra-articular administration of gelatin hydrogels incorporating rapamycin\u2013micelles reduces the development of experimental osteoarthritis in a murine model","volume":"35","author":"Matsuzaki","year":"2014","journal-title":"Biomaterials"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.biomaterials.2017.10.055","article-title":"An injectable, electrostatically interacting drug depot for the treatment of rheumatoid arthritis","volume":"154","author":"Park","year":"2018","journal-title":"Biomaterials"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"110702","DOI":"10.1016\/j.msec.2020.110702","article-title":"Injectable hydrogel-based drug delivery system for cartilage regeneration","volume":"110","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s13233-015-3006-4","article-title":"Injectable in situ forming chitosan-based hydrogels for curcumin delivery","volume":"23","author":"Songkroh","year":"2015","journal-title":"Macromol. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1177\/1947603518796550","article-title":"Intra-articular delivery of quercetin using thermosensitive hydrogel attenuate cartilage degradation in an osteoarthritis rat model","volume":"11","author":"Mok","year":"2020","journal-title":"Cartilage"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.carbpol.2018.11.050","article-title":"A novel injectable in situ forming gel based on carboxymethyl hexanoyl chitosan\/hyaluronic acid polymer blending for sustained release of berberine","volume":"206","author":"Lu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_34","first-page":"6603","article-title":"Methotrexate-loaded lipid-core nanocapsules are highly effective in the control of inflammation in synovial cells and a chronic arthritis model","volume":"10","author":"Boechat","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.5530\/jyp.2016.4.7","article-title":"Formulation and evaluation of chitosan nanospheres containing methotrexate targeted drug delivery system","volume":"8","author":"Dhanaraj","year":"2016","journal-title":"J. Young Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3109\/1061186X.2014.928714","article-title":"Aceclofenac-loaded chondroitin sulfate conjugated SLNs for effective management of osteoarthritis","volume":"22","author":"Bishnoi","year":"2014","journal-title":"J. Drug Target."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejpb.2019.02.008","article-title":"Silk fibroin nanoparticles for celecoxib and curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis","volume":"137","author":"Crivelli","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1039\/C8TB00672E","article-title":"Bergenin loaded gum xanthan stabilized silver nanoparticles suppress synovial inflammation through modulation of the immune response and oxidative stress in adjuvant induced arthritic rats","volume":"6","author":"Rao","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"ref_39","first-page":"2604","article-title":"Therapeutic potential of hyaluronic acid\/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"119378","DOI":"10.1016\/j.ijpharm.2020.119378","article-title":"Intra-articular multifunctional celecoxib loaded hyaluronan nanocapsules for the suppression of inflammation in an osteoarthritic rat model","volume":"583","author":"Khattab","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"128147","DOI":"10.1016\/j.cej.2020.128147","article-title":"Reactive oxygen species-responsive and scavenging polyurethane nanoparticles for treatment of osteoarthritis in vivo","volume":"409","author":"Zhang","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Pontes-Quero, G.M., Benito-Garz\u00f3n, L., P\u00e9rez Cano, J., Aguilar, M.R., and V\u00e1zquez-Lasa, B. (2021). Modulation of inflammatory mediators by polymeric nanoparticles loaded with anti-inflammatory drugs. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020290"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"111793","DOI":"10.1016\/j.msec.2020.111793","article-title":"Amphiphilic polymeric nanoparticles encapsulating curcumin: Antioxidant, anti-inflammatory and biocompatibility studies","volume":"121","author":"Cano","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"102104","DOI":"10.1016\/j.nano.2019.102104","article-title":"Acid-activatable polymeric curcumin nanoparticles as therapeutic agents for osteoarthritis","volume":"23","author":"Kang","year":"2020","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.carbpol.2016.04.096","article-title":"Injectable long acting chitosan\/tripolyphosphate microspheres for the intra-articular delivery of lornoxicam: Optimization and in vivo evaluation","volume":"149","author":"Kamel","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.msec.2016.11.092","article-title":"Polymer based microspheres of aceclofenac as sustained release parenterals for prolonged anti-inflammatory effect","volume":"72","author":"Kaur","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1080\/09205063.2015.1125564","article-title":"Synthesis, characterizations, in vitro and in vivo evaluation of Etoricoxib-loaded Poly (Caprolactone) microparticles\u2013a potential Intra-articular drug delivery system for the treatment of Osteoarthritis","volume":"27","author":"Arunkumar","year":"2016","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.colsurfb.2013.06.015","article-title":"Celecoxib-loaded PLGA\/cyclodextrin microspheres: Characterization and evaluation of anti-inflammatory activity on human chondrocyte cultures","volume":"111","author":"Tommasini","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jconrel.2016.11.003","article-title":"Celecoxib-loaded PEA microspheres as an auto regulatory drug-delivery system after intra-articular injection","volume":"244","author":"Janssen","year":"2016","journal-title":"J. Control. Release"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jconrel.2017.03.014","article-title":"Prolonged inhibition of inflammation in osteoarthritis by triamcinolone acetonide released from a polyester amide microsphere platform","volume":"253","author":"Colen","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.carbpol.2016.06.039","article-title":"Rutin-loaded chitosan microspheres: Characterization and evaluation of the anti-inflammatory activity","volume":"152","author":"Cosco","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ajps.2017.12.007","article-title":"Intra-articular delivery of tetramethylpyrazine microspheres with enhanced articular cavity retention for treating osteoarthritis","volume":"13","author":"Zhang","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10787-017-0318-3","article-title":"Localized delivery of curcumin from injectable gelatin\/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model","volume":"25","author":"Ratanavaraporn","year":"2017","journal-title":"Inflammopharmacology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4186\/ej.2017.21.4.139","article-title":"Development of Thai Silk Fibroin\/Hyaluronic Acid Microspheres and the Application on Controlled Release of Curcumin","volume":"21","author":"Sungkhaphan","year":"2017","journal-title":"Eng. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.ijpharm.2015.09.040","article-title":"Leflunomide biodegradable microspheres intended for intra-articular administration: Development, anti-inflammatory activity and histopathological studies","volume":"495","author":"Abdelmalak","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s40265-019-01083-3","article-title":"Triamcinolone acetonide extended-release: A review in osteoarthritis pain of the knee","volume":"79","author":"Paik","year":"2019","journal-title":"Drugs"},{"key":"ref_57","first-page":"3596","article-title":"Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis","volume":"6","author":"Han","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.biomaterials.2018.07.051","article-title":"Long-acting hydrogel\/microsphere composite sequentially releases dexmedetomidine and bupivacaine for prolonged synergistic analgesia","volume":"181","author":"Zhang","year":"2018","journal-title":"Biomaterials"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.actbio.2018.05.038","article-title":"Injectable nanocomposite analgesic delivery system for musculoskeletal pain management","volume":"74","author":"Khanal","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/jbm.a.36401","article-title":"Simultaneous release of melatonin and methylprednisolone from an injectable in situ self-crosslinked hydrogel\/microparticle system for cartilage tissue engineering","volume":"106","author":"Naghizadeh","year":"2018","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.xphs.2015.11.019","article-title":"Intra-articular administration of chitosan thermosensitive in situ hydrogels combined with diclofenac sodium\u2013loaded alginate microspheres","volume":"105","author":"Qi","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"11587","DOI":"10.1021\/acsami.8b20372","article-title":"Drug delivery system based on near-infrared light-responsive molybdenum disulfide nanosheets controls the high-efficiency release of dexamethasone to inhibit inflammation and treat osteoarthritis","volume":"11","author":"Zhao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.ijbiomac.2016.04.034","article-title":"Drug release characteristics of quercetin-loaded TiO2 nanotubes coated with chitosan","volume":"93","author":"Mohan","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2018.05.037","article-title":"Injectable liquid polymers extend the delivery of corticosteroids for the treatment of osteoarthritis","volume":"284","author":"Djuhadi","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13075-016-0971-8","article-title":"Novel hyaluronic acid\u2013methotrexate conjugate suppresses joint inflammation in the rat knee: Efficacy and safety evaluation in two rat arthritis models","volume":"18","author":"Tamura","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijbiomac.2018.03.059","article-title":"Attenuation of inflammation and cartilage degradation by sulfasalazine-containing hyaluronic acid on osteoarthritis rat model","volume":"114","author":"Kim","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11969","DOI":"10.1039\/C8NR01521J","article-title":"Morphological and mechanical determinants of cellular uptake of deformable nanoparticles","volume":"10","author":"Chen","year":"2018","journal-title":"Nanoscale"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.progpolymsci.2007.04.001","article-title":"Polymeric protein delivery systems","volume":"32","author":"Lee","year":"2007","journal-title":"Prog. Polym. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1139\/cjpp-2017-0795","article-title":"Nanodrug delivery platform for glucocorticoid use in skeletal muscle injury","volume":"96","author":"Sutariya","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1286-935X(16)79140-4","article-title":"Cart\u00edlago articular normal: Anatom\u00eda, fisiolog\u00eda, metabolismo y envejecimiento","volume":"49","author":"Roux","year":"2016","journal-title":"EMC-Apar. Locomot."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Luna-Preitschopf, A.D., Zwickl, H., Nehrer, S., Hengstschl\u00e4ger, M., and Mikula, M. (2017). Rapamycin maintains the chondrocytic phenotype and interferes with inflammatory cytokine induced processes. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18071494"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/s13075-014-0482-4","article-title":"Local intra-articular injection of rapamycin delays articular cartilage degeneration in a murine model of osteoarthritis","volume":"16","author":"Takayama","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/1091581817741840","article-title":"Toxicology evaluation of drugs administered via uncommon routes: Intranasal, intraocular, intrathecal\/intraspinal, and intra-articular","volume":"37","author":"Emami","year":"2018","journal-title":"Int. J. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/rheumatology\/key131","article-title":"Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: A meta-analysis of randomized controlled trials","volume":"57","author":"Persson","year":"2018","journal-title":"Rheumatology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2005513","DOI":"10.1002\/adma.202005513","article-title":"Recent progress in cartilage lubrication","volume":"33","author":"Lin","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/pola.29290","article-title":"In situ photocrosslinkable hyaluronic acid-based surgical glue with tunable mechanical properties and high adhesive strength","volume":"57","author":"Chandrasekharan","year":"2019","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.ijbiomac.2018.11.186","article-title":"Evaluation of modified hyaluronic acid in terms of rheology, enzymatic degradation and mucoadhesion","volume":"123","author":"Laffleur","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.carbpol.2018.09.014","article-title":"Facile strategy involving low-temperature chemical cross-linking to enhance the physical and biological properties of hyaluronic acid hydrogel","volume":"202","author":"Baek","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bej.2017.06.003","article-title":"Hyaluronic acid gels with tunable properties by conjugating with a synthetic copolymer","volume":"125","author":"Diaconu","year":"2017","journal-title":"Biochem. Eng. J."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/14658011.2018.1447340","article-title":"Bacterial cellulose\/hyaluronic acid composite hydrogels with improved viscoelastic properties and good thermodynamic stability","volume":"47","author":"Jia","year":"2018","journal-title":"Plast. Rubber Compos."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1021\/acsmacrolett.5b00544","article-title":"Injectable degradation-resistant hyaluronic acid hydrogels cross-linked via the oxidative coupling of green tea catechin","volume":"4","author":"Lee","year":"2015","journal-title":"ACS Macro Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.carbpol.2018.01.056","article-title":"Enhancement of bio-stability and mechanical properties of hyaluronic acid hydrogels by tannic acid treatment","volume":"186","author":"Lee","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1021\/acs.biomac.7b00788","article-title":"Thiol-mediated synthesis of hyaluronic acid\u2013epigallocatechin-3-O-gallate conjugates for the formation of injectable hydrogels with free radical scavenging property and degradation resistance","volume":"18","author":"Liu","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"109670","DOI":"10.1016\/j.msec.2019.04.049","article-title":"The effect of oxidation degree and volume ratio of components on properties and applications of in situ cross-linking hydrogels based on chitosan and hyaluronic acid","volume":"103","author":"Nguyen","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3390\/polym6071948","article-title":"Effect of mannitol on hyaluronic acid stability in two in vitro models of oxidative stress","volume":"6","author":"Rinaudo","year":"2014","journal-title":"Polymers"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijpharm.2019.01.017","article-title":"Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis","volume":"559","author":"Mota","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Doench, I., Torres-Ramos, M.E., Montembault, A., Nunes de Oliveira, P., Halimi, C., Viguier, E., Heux, L., Siadous, R., Thir\u00e9, R.M., and Osorio-Madrazo, A. (2018). Injectable and gellable chitosan formulations filled with cellulose nanofibers for intervertebral disc tissue engineering. Polymers, 10.","DOI":"10.3390\/polym10111202"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"511","DOI":"10.15255\/CABEQ.2014.2148","article-title":"Rheological studies dedicated to the development of a novel injectable polymeric blend for viscosupplementation treatment","volume":"29","author":"Lapasin","year":"2015","journal-title":"Chem. Biochem. Eng. Q."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/BIR-14013","article-title":"Viscosupplementation of synovial fluid with xanthan gum for treatment of osteoarthritis and its clearance kinetics in the rabbit knee joint","volume":"51","author":"Shao","year":"2014","journal-title":"Biorheology"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.biomaterials.2018.08.009","article-title":"A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model","volume":"182","author":"Wathier","year":"2018","journal-title":"Biomaterials"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jmbbm.2019.04.020","article-title":"Mechanical and tribological assessment of silica nanoparticle-alginate-polyacrylamide nanocomposite hydrogels as a cartilage replacement","volume":"95","author":"Arjmandi","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.wear.2018.04.013","article-title":"Experimental study on friction and wear properties of interpenetrating polymer network alginate-polyacrylamide hydrogels for use in minimally-invasive joint implants","volume":"406","author":"Arjmandi","year":"2018","journal-title":"Wear"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.joca.2018.01.001","article-title":"Functional effects of an interpenetrating polymer network on articular cartilage mechanical properties","volume":"26","author":"Cooper","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.msec.2018.07.016","article-title":"Interpenetrating polymer network hydrogels composed of chitosan and photocrosslinkable gelatin with enhanced mechanical properties for tissue engineering","volume":"92","author":"Suo","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.3233\/BME-171643","article-title":"Chitosan: A promising polymer for cartilage repair and viscosupplementation","volume":"28","author":"Comblain","year":"2017","journal-title":"Bio-Med. Mater. Eng."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijbiomac.2018.10.049","article-title":"Modified hyaluronic acid based materials for biomedical applications","volume":"121","author":"Tiwari","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/acs.biomac.9b00964","article-title":"Bioinspired hyaluronic acid\/phosphorylcholine polymer with enhanced lubrication and anti-inflammation","volume":"20","author":"Zheng","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.knee.2016.05.015","article-title":"Safety and efficacy of intra-articular injections of a combination of hyaluronic acid and mannitol (HAnOX-M) in patients with symptomatic knee osteoarthritis: Results of a double-blind, controlled, multicenter, randomized trial","volume":"23","author":"Conrozier","year":"2016","journal-title":"Knee"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"112254","DOI":"10.1016\/j.msec.2021.112254","article-title":"Targeting joint inflammation for osteoarthritis management through stimulus-sensitive hyaluronic acid based intra-articular hydrogels","volume":"128","author":"Marino","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e10245","DOI":"10.1002\/btm2.10245","article-title":"Injectable hyaluronic acid hydrogels encapsulating drug nanocrystals for long-term treatment of inflammatory arthritis","volume":"7","author":"Gao","year":"2022","journal-title":"Bioeng. Transl. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"111096","DOI":"10.1016\/j.msec.2020.111096","article-title":"Injectable anti-inflammatory hyaluronic acid hydrogel for osteoarthritic cartilage repair","volume":"115","author":"Jin","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fbioe.2019.00045","article-title":"Cellulose biomaterials for tissue engineering","volume":"7","author":"Hickey","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"736213","DOI":"10.3389\/fbioe.2021.736213","article-title":"Nanocellulose-Based Scaffolds for Chondrogenic Differentiation and Expansion","volume":"9","author":"Szustak","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fbioe.2020.00023","article-title":"A self-setting hydrogel of silylated chitosan and cellulose for the repair of osteochondral defects: From in vitro characterization to preclinical evaluation in dogs","volume":"8","author":"Boyer","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.joca.2017.03.001","article-title":"Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support","volume":"25","author":"Cooper","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"115347","DOI":"10.1016\/j.carbpol.2019.115347","article-title":"Enriched Gellan Gum hydrogel as visco-supplement","volume":"227","author":"Leone","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"116787","DOI":"10.1016\/j.carbpol.2020.116787","article-title":"A hydrogel system based on a lactose-modified chitosan for viscosupplementation in osteoarthritis","volume":"248","author":"Scognamiglio","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/jor.24259","article-title":"Effects of intra-articular hyaluronic acid associated to Chitlac (arty-duo\u00ae) in a rat knee osteoarthritis model","volume":"37","author":"Salamanna","year":"2019","journal-title":"J. Orthop. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/00914037.2020.1848831","article-title":"Calcium ions hyaluronan\/gellan gum protective shell for delivery of oleuropein in the knee","volume":"71","author":"Consumi","year":"2022","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/jbm.a.36449","article-title":"Injectable hydrogels and nanocomposite hydrogels for cartilage regeneration","volume":"106","author":"Jeznach","year":"2018","journal-title":"J. Biomed. Mater. Res. Part. A"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cis.2017.07.012","article-title":"Toward the development of biomimetic injectable and macroporous biohydrogels for regenerative medicine","volume":"247","author":"Pace","year":"2017","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1700939","DOI":"10.1002\/adhm.201700939","article-title":"Exploiting advanced hydrogel technologies to address key challenges in regenerative medicine","volume":"7","author":"Foyt","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"19715","DOI":"10.1039\/C4RA16411C","article-title":"Injectable in situ forming hydrogels based on natural and synthetic polymers for potential application in cartilage repair","volume":"5","author":"Fiorica","year":"2015","journal-title":"RSC Adv."},{"key":"ref_114","first-page":"5411","article-title":"Effects of different concentrations of type-I collagen hydrogel on the growth and differentiation of chondrocytes","volume":"14","author":"Hu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s13346-013-0188-1","article-title":"An injectable, in situ forming type II collagen\/hyaluronic acid hydrogel vehicle for chondrocyte delivery in cartilage tissue engineering","volume":"4","author":"Kontturi","year":"2014","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.apmt.2017.12.002","article-title":"Self-crosslinking and injectable chondroitin sulfate\/pullulan hydrogel for cartilage tissue engineering","volume":"10","author":"Li","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3390\/jfb5030197","article-title":"The effect of chondroitin sulphate and hyaluronic acid on chondrocytes cultured within a fibrin-alginate hydrogel","volume":"5","author":"Little","year":"2014","journal-title":"J. Funct. Biomater."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.carbpol.2018.10.109","article-title":"Alginate\/chondroitin sulfate based hybrid hydrogel with different molecular weight and its capacity to regulate chondrocytes activity","volume":"206","author":"Ma","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s13770-016-0059-1","article-title":"Alginate-hyaluronic acid-collagen composite hydrogel favorable for the culture of chondrocytes and their phenotype maintenance","volume":"13","author":"Mahapatra","year":"2016","journal-title":"Tissue Eng. Regen. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.msec.2017.02.130","article-title":"Promoting chondrocyte cell clustering through tuning of a poly (ethylene glycol)-poly (peptide) thermosensitive hydrogel with distinctive microarchitecture","volume":"76","author":"Peng","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.carbpol.2017.07.063","article-title":"Injectable glycosaminoglycan\u2013protein nano-complex in semi-interpenetrating networks: A biphasic hydrogel for hyaline cartilage regeneration","volume":"175","author":"Radhakrishnan","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.biomaterials.2017.02.010","article-title":"Elastin-like protein-hyaluronic acid (ELP-HA) hydrogels with decoupled mechanical and biochemical cues for cartilage regeneration","volume":"127","author":"Zhu","year":"2017","journal-title":"Biomaterials"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ijbiomac.2018.11.226","article-title":"The chondrocyte cell proliferation of a chitosan\/silk fibroin\/egg shell membrane hydrogels","volume":"124","author":"Adali","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/adhm.201500093","article-title":"Rapid self-integrating, injectable hydrogel for tissue complex regeneration","volume":"4","author":"Hou","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.msec.2019.01.115","article-title":"Repair of osteochondral defects using injectable chitosan-based hydrogel encapsulated synovial fluid-derived mesenchymal stem cells in a rabbit model","volume":"99","author":"Jia","year":"2019","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/0363546518808012","article-title":"Photopolymerizable injectable cartilage mimetic hydrogel for the treatment of focal chondral lesions: A proof of concept study in a rabbit animal model","volume":"47","author":"Aisenbrey","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/tcmj.tcmj_87_18","article-title":"Transplanting human umbilical cord mesenchymal stem cells and hyaluronate hydrogel repairs cartilage of osteoarthritis in the minipig model","volume":"31","author":"Wu","year":"2019","journal-title":"Tzu-Chi Med. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.actbio.2014.10.013","article-title":"Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells","volume":"12","author":"Choi","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.actbio.2018.11.022","article-title":"Enhancing chondrogenesis and mechanical strength retention in physiologically relevant hydrogels with incorporation of hyaluronic acid and direct loading of TGF-\u03b2","volume":"83","author":"Deng","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.carbpol.2018.09.010","article-title":"The three dimensional cues-integrated-biomaterial potentiates differentiation of human mesenchymal stem cells","volume":"202","author":"Park","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.msec.2017.05.043","article-title":"Glucosamine-modified polyethylene glycol hydrogel-mediated chondrogenic differentiation of human mesenchymal stem cells","volume":"79","author":"Yao","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/jbm.b.33760","article-title":"Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels","volume":"105","author":"Zhu","year":"2017","journal-title":"J. Biomed. Mater. Res. Part B Appl. Biomater."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1080\/10601325.2016.1189284","article-title":"Development of injectable high molecular weight hyaluronic acid hydrogels for cartilage regeneration","volume":"53","author":"Mondal","year":"2016","journal-title":"J. Macromol. Sci. Part A"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.actbio.2018.01.025","article-title":"Interplay between stiffness and degradation of architectured gelatin hydrogels leads to differential modulation of chondrogenesis in vitro and in vivo","volume":"69","author":"Sarem","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.actbio.2017.06.016","article-title":"Chondrogenesis of human bone marrow mesenchymal stem cells in 3-dimensional, photocrosslinked hydrogel constructs: Effect of cell seeding density and material stiffness","volume":"58","author":"Sun","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1166\/jbt.2017.1672","article-title":"Influence of fibrinogen concentration on mesenchymal stem cells and chondrocytes chondrogenesis in fibrin hydrogels","volume":"7","author":"Yang","year":"2017","journal-title":"J. Biomater. Tissue Eng."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12717\/DR.2017.21.1.001","article-title":"Usage of human mesenchymal stem cells in cell-based therapy: Advantages and disadvantages","volume":"21","author":"Kim","year":"2017","journal-title":"Dev. Reprod."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/8\/1644\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:05:15Z","timestamp":1760141115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/8\/1644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,6]]},"references-count":137,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["pharmaceutics14081644"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14081644","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,6]]}}}