{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:41:23Z","timestamp":1785897683044,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015690","name":"Academic Leadership Grant, Universitas Padjadjaran","doi-asserted-by":"publisher","award":["2203\/UN6.3.1\/PT.00\/2022"],"award-info":[{"award-number":["2203\/UN6.3.1\/PT.00\/2022"]}],"id":[{"id":"10.13039\/501100015690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Recurrent aphthous stomatitis (RAS) is a prevalent clinical disorder that causes mouth ulcers. Furthermore, corticosteroid treatment has been widely utilized for RAS therapy; however, it has side effects on the oral mucosa that limit its application. This study aimed to develop a novel RAS therapy with the natural ingredient \u03b1-mangostin, delivered by alginate and chitosan polymers-based hydrogel film (\u03b1-M Alg\/Chi-HF). To prepare \u03b1-M Alg\/Chi-HF, the solvent evaporation and casting methods were used, then characterized by using SEM, FTIR, and XRD. Based on the characterization studies, the \u03b1-M in \u03b1-M\/EtOH Alg\/Chi-HF with ethanol (EtOH) was found to be more homogenous compared to \u03b1-M in Alg\/Chi-HF with distilled water (H2O) as a casting solvent. The in vitro viability study using NIH3T3 cells showed 100% viability of \u03b1-M Alg\/Chi-HF (EtOH) and Alg\/Chi-HF after 24 h incubation, indicating well tolerability of these hydrogel films. Interestingly, the in vivo studies using male white rats (Rattus norvegicus Berkenhout) proved that \u03b1-M\/EtOH Alg\/Chi-HF with a recovery of 81.47 \u00b1 0.09% in seven days significantly more effective RAS therapy compared to control. These results suggest that \u03b1-M\/EtOH Alg\/Chi-HF has the potential as an alternative for RAS therapy.<\/jats:p>","DOI":"10.3390\/pharmaceutics14081709","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T03:15:27Z","timestamp":1660706127000},"page":"1709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Alginate\/Chitosan-Based Hydrogel Film Containing \u03b1-Mangostin for Recurrent Aphthous Stomatitis Therapy in Rats"],"prefix":"10.3390","volume":"14","author":[{"given":"Tiana","family":"Milanda","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faradila Ratu","family":"Cindana Mo\u2019o","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3368-0340","authenticated-orcid":false,"given":"Ahmed Fouad Abdelwahab","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Phaculty of Pharmacy, Minia University, Minia 61519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9555-1814","authenticated-orcid":false,"given":"Khaled M.","family":"Elamin","sequence":"additional","affiliation":[{"name":"Global Center for Natural Resources Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0904-3117","authenticated-orcid":false,"given":"Gofarana","family":"Wilar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-9294","authenticated-orcid":false,"given":"Ine","family":"Suharyani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia"},{"name":"Department of Pharmaceutics, School of Pharmacy Muhammadiyah Cirebon, Cirebon 45153, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-6909","authenticated-orcid":false,"given":"Nasrul","family":"Wathoni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Bandung 45363, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3389\/fimmu.2019.00208","article-title":"Oral mucosal epithelial cells","volume":"10","author":"Groeger","year":"2019","journal-title":"Front. 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