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Available treatment modalities show limited efficacy in more severe cases. Hence, the search for new treatment modalities, including immunotherapies, for curing, mitigating, and\/or preventing cancer is important and urgently needed. Carbon nanoparticles associated with some plant materials, such as Aloe vera, have shown appealing antineoplastic activity, derived mainly from the compounds aloin, aloe-emodin, barbaloin acemannan, and octapeptide, thus representing new possibilities as antitumor agents. This systematic review aims to arouse interest and present the possibilities of using Aloe vera combined with carbon-based nanomaterials as an antineoplastic agent in the treatment and prevention of melanoma. Limitations and advances in melanoma treatment using functionalized carbon nanomaterials are discussed here. Moreover, this review provides the basis for further studies designed to fully explore the potential of carbon nanomaterials associated with Aloe vera in the treatment of various cancers, with a focus on melanoma.<\/jats:p>","DOI":"10.3390\/pharmaceutics14102004","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T05:33:14Z","timestamp":1663824794000},"page":"2004","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of Carbon Nanomaterials and Aloe vera on Melanomas\u2014Where Are We? Recent Updates"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5906-1076","authenticated-orcid":false,"given":"Elidamar Nunes","family":"de Carvalho Lima","sequence":"first","affiliation":[{"name":"Telecommunication and Control Engineering Department, Polytechnic School of the University of S\u00e3o Paulo, Avenida Prof. Luciano Gualberto, Travessa 3, 158, S\u00e3o Paulo 05508-010, Brazil"},{"name":"Infectious Diseases Division, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"},{"name":"Electronic Systems Engineering Department, Polytechnic School of the University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-4011","authenticated-orcid":false,"given":"Guilherme Le\u00e3o","family":"Barros Martins","sequence":"additional","affiliation":[{"name":"Telecommunication and Control Engineering Department, Polytechnic School of the University of S\u00e3o Paulo, Avenida Prof. Luciano Gualberto, Travessa 3, 158, S\u00e3o Paulo 05508-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8395-7304","authenticated-orcid":false,"given":"Ricardo Sobhie","family":"Diaz","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Schechter","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023-062, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-6686","authenticated-orcid":false,"given":"Jos\u00e9 Roberto Castilho","family":"Piqueira","sequence":"additional","affiliation":[{"name":"Telecommunication and Control Engineering Department, Polytechnic School of the University of S\u00e3o Paulo, Avenida Prof. Luciano Gualberto, Travessa 3, 158, S\u00e3o Paulo 05508-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Francisco","family":"Justo","sequence":"additional","affiliation":[{"name":"Electronic Systems Engineering Department, Polytechnic School of the University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current Cancer Epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J. 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