{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:44:30Z","timestamp":1787615070061,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Siberian State Medical University\u2019s development program Priority 2030","award":["MK-4273.2021.1.4"],"award-info":[{"award-number":["MK-4273.2021.1.4"]}]},{"name":"the Grant of the President of the Russian Federation","award":["MK-4273.2021.1.4"],"award-info":[{"award-number":["MK-4273.2021.1.4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Bladder neck contracture (BNC) is a complication of the surgical treatment of benign and malignant prostate conditions and is associated with the partial or complete blockage of urination. Correction of this condition usually requires repeated surgical intervention, which does not guarantee recovery. Balloon dilation is a minimally invasive alternative to the surgical dissection of tissues; however, it significantly reduces the patient\u2019s quality of life. Additional local anti-inflammatory treatment may reduce the number of procedures requested and increase the attractiveness of this therapeutic strategy. Here, we report about an ultrathin biocompatible coating based on polylactic acid for Foley catheter balloons that can provide localized release of Prednol-L in the range of 56\u201399 \u00b5g in the BNC zone under conventional diagnostic ultrasound exposure. Note that the exposure of a transrectal probe with a conventional gray-scale ultrasound regimen with and without shear wave elastography (SWE) was comparably effective for Prednol-L release from the coating surface of a Foley catheter balloon. This strategy does not require additional manipulations by clinicians. The trigger for the drug release is the ultrasound exposure, which is applied for visualization of the balloon\u2019s location during the dilation process. In vivo experiments demonstrated the absence of negative effects of the usage of a coated Foley catheter for balloon dilation of the bladder neck and urethra.<\/jats:p>","DOI":"10.3390\/pharmaceutics14102186","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T22:21:11Z","timestamp":1665699671000},"page":"2186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound-Triggerable Coatings for Foley Catheter Balloons for Local Release of Anti-Inflammatory Drugs during Bladder Neck Dilation"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5288-4157","authenticated-orcid":false,"given":"Olga A.","family":"Sindeeva","sequence":"first","affiliation":[{"name":"A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-8364","authenticated-orcid":false,"given":"Arkady S.","family":"Abdurashitov","sequence":"additional","affiliation":[{"name":"A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-3265","authenticated-orcid":false,"given":"Pavel I.","family":"Proshin","sequence":"additional","affiliation":[{"name":"A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-8164","authenticated-orcid":false,"given":"Alexey V.","family":"Kadrev","sequence":"additional","affiliation":[{"name":"Ultrasound Diagnostics Department, Medical Research and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia"},{"name":"Diagnostic Ultrasound Division, Russian Medical Academy of Continuous Professional Education, 1 Barrikadnaya Str., 125445 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0739-3981","authenticated-orcid":false,"given":"Oleg A.","family":"Kulikov","sequence":"additional","affiliation":[{"name":"Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0232-1567","authenticated-orcid":false,"given":"Boris M.","family":"Shaparov","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay I.","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin P.","family":"Ageev","sequence":"additional","affiliation":[{"name":"Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay A.","family":"Pyataev","sequence":"additional","affiliation":[{"name":"Institute of Medicine, National Research Ogarev Mordovia State University, 68 Bolshevistskaya Str., 430005 Saransk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-7520","authenticated-orcid":false,"given":"Aleksandr","family":"Kritskiy","sequence":"additional","affiliation":[{"name":"LLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-7279","authenticated-orcid":false,"given":"Alexander","family":"Tishin","sequence":"additional","affiliation":[{"name":"LLC Magnetic Drug Delivery, AMT & C Group, 4 Promyshlennaya Str., Troitsk, 108840 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armais A.","family":"Kamalov","sequence":"additional","affiliation":[{"name":"Department of Urology and Andrology, Faculty of Fundamental Medicine, Medical Scientific and Educational Center, Lomonosov Moscow State University, 27 Lomonosovsky Ave., 119192 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gleb B.","family":"Sukhorukov","sequence":"additional","affiliation":[{"name":"A.V. Zelmann Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, 121205 Moscow, Russia"},{"name":"Siberian State Medical University, 2 Moskovskiy Trakt, 634050 Tomsk, Russia"},{"name":"School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,13]]},"reference":[{"key":"ref_1","first-page":"214","article-title":"Bladder neck contracture","volume":"3","author":"Simhan","year":"2014","journal-title":"Transl. Androl. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.23736\/S0393-2249.16.02777-6","article-title":"Bladder neck contracture after surgery for benign prostatic obstruction","volume":"69","author":"Cindolo","year":"2017","journal-title":"Minerva Urol. 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