{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:36Z","timestamp":1791235176016,"version":"4.1.0"},"reference-count":127,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Khalifa University","award":["FSU 8474000442"],"award-info":[{"award-number":["FSU 8474000442"]}]},{"name":"Khalifa University","award":["FSU-2022-022"],"award-info":[{"award-number":["FSU-2022-022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release\/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.<\/jats:p>","DOI":"10.3390\/pharmaceutics14102244","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T08:19:06Z","timestamp":1666599546000},"page":"2244","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications"],"prefix":"10.3390","volume":"14","author":[{"given":"Zahra","family":"Rezaei","sequence":"first","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"},{"name":"Chemical Engineering Department, Sharif University of Technology, Azadi Ave, Tehran 11365-11155, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2287-2585","authenticated-orcid":false,"given":"Dilara","family":"Yilmaz-Aykut","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"},{"name":"Department of Chemical Engineering, Faculty of Engineering, Istanbul University-Cerrahpa\u015fa, 34320 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Mumtaza","family":"Tourk","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"},{"name":"Department of Mechanical Engineering, Northeastern University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bassous","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6211-3367","authenticated-orcid":false,"given":"Margot","family":"Barroso-Zuppa","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"},{"name":"School of Medicine and Health Sciences, Tecnologico de Monterrey, Mexico City 14380, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif Iqbal","family":"Shawl","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4961-5527","authenticated-orcid":false,"given":"Syed Salman","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts and Sciences, Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"},{"name":"Center for Biotechnology (BTC), Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"},{"name":"Center for Catalysis and Separation (CeCas), SAN Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"},{"name":"Advanced Materials Chemistry Centre (AMCC), SAN Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-1963","authenticated-orcid":false,"given":"Huseyin","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Metallurgical and Materials Engineering, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey"},{"name":"Cellular Therapy and Stem Cell Research Center, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey"},{"name":"Translational Medicine Research and Clinical Center, Eskisehir Osmangazi University, 26040 Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-9508","authenticated-orcid":false,"given":"Shabir","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Engineering in Medicine, Brigham and Women\u2019s Hospital, Department of Medicine, Harvard Medical School, Cambridge, MA 02139, USA"},{"name":"Department of Biology, College of Arts and Sciences, Main Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"},{"name":"Advanced Materials Chemistry Centre (AMCC), SAN Campus, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7906","DOI":"10.7150\/thno.38425","article-title":"Recent advances and challenges of repurposing nanoparticle-based drug delivery systems to enhance cancer immunotherapy","volume":"9","author":"Lim","year":"2019","journal-title":"Theranostics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid\u2013bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. 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