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Copper(I)-catalyzed alkyne\u2013azide cycloaddition (CuAAC) click chemistry under microwave irradiation was used to obtain the target compounds with yields up to 99%. The classical ethylenediamine (EDA) core present in PAMAM dendrimers was replaced by an EDTA core, obtaining platforms that increase the water solubility at least 80 times compared with native \u03b2CD. The synthetic methodology presented here represents a convenient alternative for the rapid and efficient construction of PAMAM analogs. These molecules are envisaged for future applications as drug carriers.<\/jats:p>","DOI":"10.3390\/pharmaceutics14112363","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T03:53:07Z","timestamp":1667447587000},"page":"2363","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synthesis of \u03b2-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: A New Class of PAMAM Dendrimer Analogs"],"prefix":"10.3390","volume":"14","author":[{"given":"Israel","family":"Gonz\u00e1lez-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Escolar, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Loera-Loera","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Escolar, Ciudad Universitaria, Mexico City CP 04510, Mexico"},{"name":"Escuela de Ciencias de la Salud, Campus Coyoac\u00e1n, Universidad del Valle de M\u00e9xico, Calzada de Tlalpan 3000, Coyoac\u00e1n, Mexico City CP 04910, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra","family":"Sorroza-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3467-9678","authenticated-orcid":false,"given":"Mireille","family":"Vonlanthen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7920-1176","authenticated-orcid":false,"given":"Fabi\u00e1n","family":"Cu\u00e9tara-Guadarrama","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Josefa","family":"Bernad-Bernad","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Escolar, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Rivera","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Materiales, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8067-1215","authenticated-orcid":false,"given":"Jes\u00fas","family":"Gracia-Mora","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica y Nuclear, Facultad de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Escolar, Ciudad Universitaria, Mexico City CP 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/1556-276X-9-247","article-title":"Dendrimers: Synthesis, Applications, and Properties","volume":"9","author":"Abbasi","year":"2014","journal-title":"Nanoscale Res. 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