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It is used in folk medicine to treat kidney diseases, skin diseases, infections, rheumatism, gastrointestinal diseases, and respiratory diseases. It is also used as an abortifacient. To evaluate the effects of the ethanolic extract of Gomphrena celosioides (EEGc) on reproductive performance, embryo development, and chromosome stability, Swiss mice were randomly divided into experimental groups (n = 10). The animals in the control group received the vehicle Tween 80\u20131% in the proportion of 0.1 mL\/10 g of body weight orally, from the first to the 18th gestational day. The animals in the treatment groups received the EEGc (100, 1000, and 2000 mg\/kg) from the first to the 18th gestational day. The animals underwent evaluations of their reproductive performance and embryofetal development. The results showed that the EEGc did not change the animals\u2019 final weight, weight gain, uterine weight, or net weight gain. The evaluation showed that the absolute and relative organs\u2019 weights did not vary between the different experimental groups. In addition, the EEGc did not change the numbers of implants, live fetuses, dead fetuses, or fetal resorptions. There were no differences in post-operative loss rates, implantations, or resorptions, nor were there differences in fetal viability or sex ratio. The use of the EEGc did not result in different frequencies of malformations. In addition, the EEGc did not alter the frequency of chromosomal damage or frequency of micronuclei. Based on our findings, we considered the extract of Gomphrena celosioides to be safe for use during pregnancy, although some parameters indicated caution in its use.<\/jats:p>","DOI":"10.3390\/pharmaceutics14112369","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T04:49:20Z","timestamp":1667450960000},"page":"2369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Ethanolic Extract of Gomphrena celosioides Mart. Does Not Alter Reproductive Performance or Embryo-Fetal Development, nor Does It Cause Chromosomal Damage"],"prefix":"10.3390","volume":"14","author":[{"given":"Fabricia Rodrigues","family":"Salustriano","sequence":"first","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, Terapia Celular e Gen\u00e9tica Toxicol\u00f3gica (CeTroGen), Campo Grande 79070-900, MS, Brazil"},{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Carlos Duenhas","family":"Monreal","sequence":"additional","affiliation":[{"name":"Campus II de Tr\u00eas Lagoas, Universidade Federal de Mato Grosso do Sul, Tr\u00eas Lagoas 79602-070, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Cordeiro","family":"das Neves","sequence":"additional","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-8942","authenticated-orcid":false,"given":"Diego Duarte Marques","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, Terapia Celular e Gen\u00e9tica Toxicol\u00f3gica (CeTroGen), Campo Grande 79070-900, MS, Brazil"},{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Sa\u00fade e Desenvolvimento da Regi\u00e3o Centro-Oeste, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Luiz Brand\u00e3o","family":"Vilela","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, 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58102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-7068","authenticated-orcid":false,"given":"Arunachalam","family":"Karuppusamy","sequence":"additional","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, Terapia Celular e Gen\u00e9tica Toxicol\u00f3gica (CeTroGen), Campo Grande 79070-900, MS, Brazil"},{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Sa\u00fade e Desenvolvimento da Regi\u00e3o Centro-Oeste, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-6510","authenticated-orcid":false,"given":"Henrique Rodrigues Scherer","family":"Coelho","sequence":"additional","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, Terapia Celular e Gen\u00e9tica Toxicol\u00f3gica (CeTroGen), Campo Grande 79070-900, MS, Brazil"},{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-9219","authenticated-orcid":false,"given":"Candida Aparecida Leite","family":"Kassuya","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Sa\u00fade, Universidade Federal da Grande Dourados (UFGD), Dourados 79804-970, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-2126","authenticated-orcid":false,"given":"Dayanna Isabel Araque","family":"Gelves","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-862, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3839-5445","authenticated-orcid":false,"given":"Marcos Jos\u00e9","family":"Salvador","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Departamento de Biologia Vegetal, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-862, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-3346","authenticated-orcid":false,"given":"Rodrigo Juliano","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centro de Estudos em C\u00e9lulas Tronco, Terapia Celular e Gen\u00e9tica Toxicol\u00f3gica (CeTroGen), Campo Grande 79070-900, MS, Brazil"},{"name":"Faculdade de Medicina Dr. H\u00e9lio Mandetta (FAMED), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande 79070-900, MS, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Sa\u00fade e Desenvolvimento da Regi\u00e3o Centro-Oeste, Campo Grande 79070-900, MS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8075-9716","authenticated-orcid":false,"given":"Roberto da Silva","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, North Dakota State University, Fargo, ND 58102, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/35002501","article-title":"Biodiversity hotspots for conservation priorities","volume":"403","author":"Myers","year":"2000","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jep.2018.05.036","article-title":"Diuretic herb Gomphrena celosioides Mart. 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