{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:10Z","timestamp":1792806190008,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cukurova University Scientific Research Council","award":["CU-BAP-2022-1550"],"award-info":[{"award-number":["CU-BAP-2022-1550"]}],"id":[{"id":"https:\/\/ror.org\/05wxkj555","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>DNA has become the target of metal complexes in cancer drug discovery. Due to the side effects of widely known cisplatin and its derivative compounds, alternative metal-based drug discovery studies are still ongoing. In this study, the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines are investigated by using in silico analyses. Phosphorus Schiff base-Pd(II) complexes encoded as B1 and B2 with the best DNA-binding potential are synthesized and characterized. The DNA-binding potentials of these two new Pd(II) complexes are also investigated experimentally, and their antitumor properties are demonstrated in vitro in A549, MCF7, HuH7, and HCT116 cancer cells. The mechanisms of these metal complexes that kill the cells mentioned above in different activities are elucidated by flow cytometry apoptosis analysis and colony formation analysis The in silico binding energies of these two new palladium complexes \u0394G (B1): \u22124.51 and \u0394G (B2): \u22126.04 kcal\/mol, and their experimental DNA-binding constants were found as Kb (B1): 4.24 \u00d7 105, Kb (B2): 4.98 \u00d7 105). The new complexes, which show different antitumor effects in different cells, are the least effective in HuH7 liver cells, while they showed the best antitumor properties in HCT116 colon cancer cells.<\/jats:p>","DOI":"10.3390\/pharmaceutics14112409","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T08:17:12Z","timestamp":1667895432000},"page":"2409","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["DNA Binding and Anticancer Properties of New Pd(II)-Phosphorus Schiff Base Metal Complexes"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-0522","authenticated-orcid":false,"given":"Burcu","family":"Sayg\u0131de\u011fer Demir","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Adana 01330, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9941-7281","authenticated-orcid":false,"given":"Simay","family":"\u0130nce","sequence":"additional","affiliation":[{"name":"Department of Nanotechnology and Advanced Materials, Institute of Science and Technology, Mersin University, Mersin 33343, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-3956","authenticated-orcid":false,"given":"Mustafa Kemal","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Nanotechnology and Advanced Materials, Institute of Science and Technology, Mersin University, Mersin 33343, Turkey"},{"name":"Department of Chemistry, Science Faculty, Mersin University, Mersin 33343, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aycan","family":"Sezan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Adana 01330, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi","family":"Derin\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Adana 01330, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-8400","authenticated-orcid":false,"given":"Tugba","family":"Taskin-Tok","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Arts and Science, Gaziantep University, Gaziantep 27410, Turkey"},{"name":"Department of Bioinformatics and Computational Biology, Institute of Health Sciences, Gaziantep University, Gaziantep 27410, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-373X","authenticated-orcid":false,"given":"Yasemin","family":"Saygideger","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Adana 01330, Turkey"},{"name":"Department of Pulmonary, School of Medicine, Cukurova University, Adana 01330, Turkey"},{"name":"Department of Translational Medicine, Institute of Health Sciences, \u00c7ukurova University, Adana 01330, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.2174\/156802661511150408111252","article-title":"Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 3\/4-Bromo benzohydrazide derivatives","volume":"15","author":"Kumar","year":"2015","journal-title":"Curr. 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