{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:43:55Z","timestamp":1766159035733,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T00:00:00Z","timestamp":1668816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades (Micinn) of Spain","award":["PID2019-109371GB-I00","MAT2016-77345-C3-2-P","PP2021\/00000658"],"award-info":[{"award-number":["PID2019-109371GB-I00","MAT2016-77345-C3-2-P","PP2021\/00000658"]}]},{"DOI":"10.13039\/100009042","name":"Universidad de Sevilla","doi-asserted-by":"publisher","award":["PID2019-109371GB-I00","MAT2016-77345-C3-2-P","PP2021\/00000658"],"award-info":[{"award-number":["PID2019-109371GB-I00","MAT2016-77345-C3-2-P","PP2021\/00000658"]}],"id":[{"id":"10.13039\/100009042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>One of the most important threats to public health is the appearance of multidrug-resistant pathogenic bacteria, since they are the cause of a high number of deaths worldwide. Consequently, the preparation of new effective antibacterial agents that do not generate antimicrobial resistance is urgently required. We report on the synthesis of new linear cationic antibacterial polytriazoles that could be a potential source of new antibacterial compounds. These polymers were prepared by thermal- or copper-catalyzed click reactions of azide and alkyne functions. The antibacterial activity of these materials can be modulated by varying the size or nature of their side chains, as this alters the hydrophilic\/hydrophobic balance. Antibacterial activity was tested against pathogens of the ESKAPE group. The P3TD polymer, which has butylated side chains, was found to have the highest bactericidal activity. The toxicity of selected polytriazoles was investigated using human red blood cells and a human gingival fibroblast cell line. The propensity of prepared polytriazoles to induce resistance in certain bacteria was studied. Some of them were found to not produce resistance in methicillin-resistant Staphylococcus aureus or Pseudomonas aeruginosa. The interaction of these polytriazoles with the Escherichia coli membrane produces both depolarization and disruption of the membrane.<\/jats:p>","DOI":"10.3390\/pharmaceutics14112518","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T03:09:30Z","timestamp":1669000170000},"page":"2518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tackling Antibiotic Resistance: Influence of Aliphatic Branches on Broad-Spectrum Antibacterial Polytriazoles against ESKAPE Group Pathogens"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5681-0131","authenticated-orcid":false,"given":"Cristian","family":"Rangel-N\u00fa\u00f1ez","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Facultad de Farmacia, Universidad de Sevilla, C\/Profesor Garc\u00eda Gonz\u00e1lez 2, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Molina-Pinilla","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Facultad de Farmacia, Universidad de Sevilla, C\/Profesor Garc\u00eda Gonz\u00e1lez 2, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Ram\u00edrez-Trujillo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Facultad de Farmacia, Universidad de Sevilla, C\/Profesor Garc\u00eda Gonz\u00e1lez 2, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-6427","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Su\u00e1rez-Cruz","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Facultad de Farmacia, Universidad de Sevilla, C\/Profesor Garc\u00eda Gonz\u00e1lez 2, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Bernal","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Virgen de Valme, 41014 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7656-4847","authenticated-orcid":false,"given":"Manuel","family":"Bueno-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica y Farmac\u00e9utica, Facultad de Farmacia, Universidad de Sevilla, C\/Profesor Garc\u00eda Gonz\u00e1lez 2, 41012 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1134\/S0003683813080024","article-title":"Antibiotic Resistance: Origins, Mechanisms, Approaches to Counter","volume":"49","author":"Debabov","year":"2013","journal-title":"Appl. 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