{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:48:43Z","timestamp":1793116123385,"version":"4.5.0"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Research Project \u201cNanomate-riales funcionalizados para su aplicaci\u00f3n en procesos de desalaci\u00f3n y depuraci\u00f3n de aguas","doi-asserted-by":"publisher","award":["P18-RT-4193"],"award-info":[{"award-number":["P18-RT-4193"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The use of nanomaterials for the controlled release of drugs aims to enhance their effectiveness, especially when poorly soluble in water, and achieve their rapid, localized, and effective administration. The present study focuses on the use of a Zeolitic Imidazolate Framework-8 (ZIF-8) as vehicle for the transport and controlled release of the antibiotic ciprofloxacin (CIP) as model due to its favorable physicochemical characteristics. The objective is to synthesize the ZIF-8 material loaded with CIP through encapsulation for subsequent release of the drug in neutral and acid physiological media. In addition, functionalization of the CIP\/ZIF compound with magnetic nanoparticles (NP) was sought to increase its traceability through the possible use of magnetic fields. Characterizations by XRD, FT-IR, SEM-EDX, and TGA showed a satisfactory synthesis of both pure ZIF-8 and ciprofloxacin-loaded ZIF-8, with high crystallinity and thermal stability. The release profiles showed an abrupt initial release that stabilized over time. A much higher release (20\u201380% greater) was obtained in acid versus neutral pH in all cases, attributable to the collapse of the ZIF-8 structure in acid media. In addition, functionalization of the material with iron NPs did not affect the behavior of the system during drug release. Antimicrobial activity tests against E. coli and S. aureus showed that ZIF-8 per se exerts antimicrobial activity, while the compounds CIP\/ZIF and magnetic CIP\/ZIF increased the antimicrobial capacity of pure CIP by 10\u201320%. The ZIF-8 system has high potential as a drug carrier and release agent for the treatment of diseases, especially those that cause acidification of the cellular environment, achieving a rapid, localized, and targeted action with the possibility of achieving traceability of the system after its magnetic functionalization.<\/jats:p>","DOI":"10.3390\/pharmaceutics14112546","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T03:04:20Z","timestamp":1669086260000},"page":"2546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["ZIF-8 and Its Magnetic Functionalization as Vehicle for the Transport and Release of Ciprofloxacin"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-960X","authenticated-orcid":false,"given":"Ventura Castillo","family":"Ramos","sequence":"first","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-8235","authenticated-orcid":false,"given":"Cinthia Berenice Garc\u00eda","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain"},{"name":"Faculty of Chemical Sciences, Nuevo Le\u00f3n Autonomous University, San Nicol\u00e1s de los Garza 66455, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo Mangas","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-3954","authenticated-orcid":false,"given":"Mar\u00eda Inmaculada Sampedro","family":"Quesada","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-5071","authenticated-orcid":false,"given":"Fernando Jos\u00e9 Mart\u00ednez-Checa","family":"Barrero","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Josafat Salazar","family":"R\u00e1bago","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Sciences, Nuevo Le\u00f3n Autonomous University, San Nicol\u00e1s de los Garza 66455, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-6505","authenticated-orcid":false,"given":"Manuel S\u00e1nchez","family":"Polo","sequence":"additional","affiliation":[{"name":"Department of Inorganic Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,21]]},"reference":[{"key":"ref_1","unstructured":"Beledo, J.F., Mart\u00ednez, A.M., and Armijo, J. (2013). Farmacolog\u00eda Humana, Elsevier. [6th ed.]. Available online: https:\/\/www.elsevier.com\/books\/farmacologia-humana\/florez-beledo\/978-84-458-2316-3."},{"key":"ref_2","first-page":"568","article-title":"Ciprofloxacin","volume":"21","author":"Terp","year":"1987","journal-title":"Drug Intell. Clin. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ejmech.2018.01.078","article-title":"Ciprofloxacin derivatives and their antibacterial activities","volume":"146","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_4","unstructured":"Thai, T., Salisbury, B.H., Zito, P.M., and Ciprofloxacin (2022, January 20). StatPearls, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK535454\/."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2165\/00019053-199303050-00007","article-title":"Oral Ciprofloxacin","volume":"3","author":"Balfour","year":"1993","journal-title":"Pharmacoeconomics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/00325481.1990.11704677","article-title":"Ciprofloxacin","volume":"87","author":"Fass","year":"1990","journal-title":"Postgrad. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/jmm.0.000873","article-title":"Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: New approaches to an old problem","volume":"68","author":"Rehman","year":"2019","journal-title":"J. Med. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/clinids\/10.3.516","article-title":"Ciprofloxacin: In Vitro Activity, Mechanism of Action, and Resistance","volume":"10","author":"Sanders","year":"1988","journal-title":"Clin. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/jac\/43.suppl_1.31","article-title":"The global epidemiology of resistance to ciprofloxacin and the changing nature of antibiotic resistance: A 10 year perspective","volume":"43","author":"Thomson","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2174\/2211738507666191021102256","article-title":"Chitosan-induced Synergy for Extended Antimicrobial Potency and Enhanced In Vitro Drug Release of Free Base Ciprofloxacin Nanoplexes","volume":"8","author":"Abioye","year":"2020","journal-title":"Pharm. Nanotechnol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1021\/mp0600182","article-title":"A Provisional Biopharmaceutical Classification of the Top 200 Oral Drug Products in the United States, Great Britain, Spain, and Japan","volume":"3","author":"Takagi","year":"2006","journal-title":"Mol. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2011.08.032","article-title":"Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications","volume":"420","author":"Kawabata","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jconrel.2015.06.004","article-title":"Probing the mechanisms of drug release from amorphous solid dispersions in medium-soluble and medium-insoluble carriers","volume":"211","author":"Sun","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ijantimicag.2003.12.005","article-title":"Extended-release ciprofloxacin (Cipro XR) for treatment of urinary tract infections","volume":"23","author":"Talan","year":"2004","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s10934-015-0027-5","article-title":"In vitro bioactivity and drug release kinetics studies of mesoporous silica-biopolymer composites","volume":"22","author":"Reddy","year":"2015","journal-title":"J. Porous Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2015.10.005","article-title":"Controlled Drug Delivery: Historical perspective for the next generation","volume":"219","author":"Yun","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8","DOI":"10.29105\/qh11.02-289","article-title":"Nanomateriales para el transporte y liberaci\u00f3n controlada de ciprofloxacino en aplicaciones biom\u00e9dicas","volume":"11","author":"Reyes","year":"2022","journal-title":"Quim. Hoy."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Reyes, C.B., Salazar-R\u00e1bago, J.J., S\u00e1nchez-Polo, M., Loredo-Cancino, M., and Leyva-Ramos, R. (2021). Ciprofloxacin, ranitidine, and chlorphenamine removal from aqueous solution by adsorption. Mechanistic and regeneration analysis. Environ. Technol. Innov., 24.","DOI":"10.1016\/j.eti.2021.102060"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ramos, V.C., Han, W., and Yeung, K.L. (2022). Functionalization of metal organic frameworks by [BMIM][CH3COO] ionic liquid for toluene capture. Environ. Res., 215.","DOI":"10.1016\/j.envres.2022.114341"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1517\/17425247.2013.741583","article-title":"Metal-organic frameworks as potential drug delivery systems","volume":"10","author":"Sun","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Hasan, M.N., Bera, A., Maji, T.K., and Pal, S.K. (2021). Sensitization of nontoxic MOF for their potential drug delivery application against microbial infection. Inorg. Chim Acta, 523.","DOI":"10.1016\/j.ica.2021.120381"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1039\/C7NJ00606C","article-title":"Synthesis and characterization of nanoscale zeolitic imidazolate frameworks with ciprofloxacin and their applications as antimicrobial agents","volume":"41","author":"Nabipour","year":"2017","journal-title":"New J. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jddst.2017.07.004","article-title":"Synthesis and characterization of ZIF-8 nanoparticles for controlled release of 6-mercaptopurine drug","volume":"41","author":"Kaur","year":"2017","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jcis.2014.03.014","article-title":"Influence of the solvent in the synthesis of zeolitic imidazolate framework-8 (ZIF-8) nanocrystals at room temperature","volume":"424","author":"Bustamante","year":"2014","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"44329","DOI":"10.1021\/acsami.1c11815","article-title":"Magnetic ZIF-8-Based Mimic Multi-enzyme System as a Colorimetric Biosensor for Detection of Aryloxyphenoxypropionate Herbicides","volume":"13","author":"Ma","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_26","unstructured":"Bruschi, M.L., and Strategies to Modify the Drug Release from Pharmaceutical Systems (2022, June 24). Strategies to Modify the Drug Release from Pharmaceutical Systems. Available online: http:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780081000922000060."},{"key":"ref_27","unstructured":"Wayne, P.A. (2011). Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19914","DOI":"10.1039\/D1RA02856A","article-title":"Different view of solvent effect on the synthesis methods of zeolitic imidazolate framework-8 to tuning the crystal structure and properties","volume":"11","author":"Tezerjani","year":"2021","journal-title":"RSC Adv."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/11\/2546\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:23:10Z","timestamp":1760145790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/11\/2546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,21]]},"references-count":28,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["pharmaceutics14112546"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14112546","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,21]]}}}