{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T01:38:14Z","timestamp":1792892294879,"version":"4.5.0"},"reference-count":224,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council under ERC-2015-AdG Proposal","doi-asserted-by":"publisher","award":["694160"],"award-info":[{"award-number":["694160"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council under ERC-2015-AdG Proposal","doi-asserted-by":"publisher","award":["814410"],"award-info":[{"award-number":["814410"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council under ERC-2015-AdG Proposal","doi-asserted-by":"publisher","award":["PID2020-117091RB-I00"],"award-info":[{"award-number":["PID2020-117091RB-I00"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council under ERC-2015-AdG Proposal","doi-asserted-by":"publisher","award":["PID2019-106436RB-I00"],"award-info":[{"award-number":["PID2019-106436RB-I00"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["694160"],"award-info":[{"award-number":["694160"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["814410"],"award-info":[{"award-number":["814410"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["PID2020-117091RB-I00"],"award-info":[{"award-number":["PID2020-117091RB-I00"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["PID2019-106436RB-I00"],"award-info":[{"award-number":["PID2019-106436RB-I00"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["694160"],"award-info":[{"award-number":["694160"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["814410"],"award-info":[{"award-number":["814410"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["PID2020-117091RB-I00"],"award-info":[{"award-number":["PID2020-117091RB-I00"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n","award":["PID2019-106436RB-I00"],"award-info":[{"award-number":["PID2019-106436RB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Nowadays, mesoporous bioactive glasses (MBGs) are envisaged as promising candidates in the field of bioceramics for bone tissue regeneration. This is ascribed to their singular chemical composition, structural and textural properties and easy-to-functionalize surface, giving rise to accelerated bioactive responses and capacity for local drug delivery. Since their discovery at the beginning of the 21st century, pioneering research efforts focused on the design and fabrication of MBGs with optimal compositional, textural and structural properties to elicit superior bioactive behavior. The current trends conceive MBGs as multitherapy systems for the treatment of bone-related pathologies, emphasizing the need of fine-tuning surface functionalization. Herein, we focus on the recent developments in MBGs for biomedical applications. First, the role of MBGs in the design and fabrication of three-dimensional scaffolds that fulfil the highly demanding requirements for bone tissue engineering is outlined. The different approaches for developing multifunctional MBGs are overviewed, including the incorporation of therapeutic ions in the glass composition and the surface functionalization with zwitterionic moieties to prevent bacterial adhesion. The bourgeoning scientific literature on MBGs as local delivery systems of diverse therapeutic cargoes (osteogenic\/antiosteoporotic, angiogenic, antibacterial, anti-inflammatory and antitumor agents) is addressed. Finally, the current challenges and future directions for the clinical translation of MBGs are discussed.<\/jats:p>","DOI":"10.3390\/pharmaceutics14122636","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T01:42:02Z","timestamp":1669686122000},"page":"2636","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Achievements in Mesoporous Bioactive Glasses for Biomedical Applications"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6104-4889","authenticated-orcid":false,"given":"Mar\u00eda","family":"Vallet-Reg\u00ed","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina CIBER-BBN, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1961-4160","authenticated-orcid":false,"given":"Montserrat","family":"Colilla","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina CIBER-BBN, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4139-4646","authenticated-orcid":false,"given":"Isabel","family":"Izquierdo-Barba","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica en Ciencias Farmac\u00e9uticas, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre i+12, 28040 Madrid, Spain"},{"name":"CIBER de Bioingenier\u00eda Biomateriales y Nanomedicina CIBER-BBN, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vitale-Brovarone","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Fiorilli","sequence":"additional","affiliation":[{"name":"Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","first-page":"174","article-title":"Evolution of Bioceramics within the Field of Biomaterials","volume":"13","year":"2010","journal-title":"Comptes Rendus Chim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1246\/bcsj.63.988","article-title":"The Preparation of Alkyltrimethylammonium-Kanemite Complexes and Their Conversion to Microporous Materials","volume":"63","author":"Yanagisawa","year":"1990","journal-title":"Bull. 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