{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:28:33Z","timestamp":1792664913546,"version":"4.5.0"},"reference-count":102,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Laser-assisted drug delivery (LADD) is an increasingly studied and applied methodology for drug delivery. It has been used in a wide variety of clinical applications. Given the relatively low barrier to entry for clinicians as well as ongoing research in this area, the authors aimed to review outcomes relating to safety in laser-assisted drug delivery. A systematic review was conducted, with the databases PubMed, Medline and Embase searched in September 2022. Included articles were those that mentioned laser-assisted drug delivery in human subjects that also reported adverse effects or safety outcomes. There were no language-based exclusions. Conference abstracts and literature reviews were excluded. The results were then tabulated and categorized according to the application of LADD. In total, 501 articles were obtained. Following deduplication, screening, and full text review 70 articles of various study designs were included. Common findings were erythema, oedema, pain, and crusting following LADD. Several notably more severe adverse effects such as generalized urticaria, infection, scarring and dyspigmentation were noted. However, these events were varied depending on the clinical use of LADD. Relevant negatives were also noted whereby no studies reported life-threatening adverse effects. Limitations included limited details regarding the adverse effects within the full texts, lack of follow-up, and risk of bias. In conclusion, there were multiple adverse effects that clinicians should consider prior to carrying out LADD, where treatment goals and patient tolerability should be considered. Further evidence is needed to quantitatively determine these risks.<\/jats:p>","DOI":"10.3390\/pharmaceutics14122738","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T06:22:18Z","timestamp":1670394138000},"page":"2738","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6508-9427","authenticated-orcid":false,"given":"William Hao Syuen","family":"Ng","sequence":"first","affiliation":[{"name":"Greenslopes Private Hospital, Brisbane, QLD 4120, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saxon D.","family":"Smith","sequence":"additional","affiliation":[{"name":"ANU Medical School, ANU College of Health and Medicine, Australian National University, Canberra, ACT 2601, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.addr.2019.10.003","article-title":"Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation","volume":"153","author":"Wenande","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/jamadermatol.2022.3234","article-title":"Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery","volume":"158","author":"Labadie","year":"2022","journal-title":"JAMA Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/lsm.23198","article-title":"Multi-Factors Associated With Efficacy and Adverse Events of Fractional Erbium:YAG Laser-Assisted Delivery of Topical Betamethasone for Stable Vitiligo: A Retrospective Analysis","volume":"52","author":"Huang","year":"2020","journal-title":"Lasers Surg. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/IOP.0000000000000948","article-title":"Ablative Fractional Laser Resurfacing with Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring","volume":"34","author":"Lee","year":"2018","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/1523-1747.ep12465112","article-title":"Controlled removal of human stratum corneum by pulsed laser","volume":"88","author":"Jacques","year":"1987","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1590\/s1984-82502016000300018","article-title":"Evaluation of skin absorption of drugs from topical and transdermal formulations","volume":"52","author":"Ruela","year":"2016","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/17425247.2021.1856071","article-title":"Dermato-pharmacokinetic: Assessment tools for topically applied dosage forms","volume":"18","author":"Rapalli","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e29314","DOI":"10.1097\/MD.0000000000029314","article-title":"How physical techniques improve the transdermal permeation of therapeutics: A review","volume":"101","author":"Gao","year":"2022","journal-title":"Medicine"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.ad.2018.07.008","article-title":"Laser-Assisted Drug Delivery. Vehiculizaci\u00f3n de f\u00e1rmacos asistida por l\u00e1ser","volume":"109","author":"Boixeda","year":"2018","journal-title":"Actas Dermosifiliogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/lsm.20860","article-title":"Fractional CO(2) laser-assisted drug delivery","volume":"42","author":"Haedersdal","year":"2010","journal-title":"Lasers Surg. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ejpb.2011.03.006","article-title":"Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications","volume":"78","author":"Bachhav","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/lsm.22227","article-title":"Laser assisted drug delivery: A review of an evolving technology","volume":"46","author":"Sklar","year":"2014","journal-title":"Lasers Surg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s10103-015-1853-z","article-title":"Laser-assisted drug delivery in dermatology: From animal models to clinical practice","volume":"31","author":"Ali","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10103-021-03296-z","article-title":"A systematic review of randomised controlled trials investigating laser assisted drug delivery for the treatment of keloid and hypertrophic scars","volume":"37","author":"Truong","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.jaad.2018.09.021","article-title":"Laser-assisted photodynamic therapy for actinic keratosis: A systematic review and meta-analysis","volume":"80","author":"Steeb","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ng, W.H.S., and Smith, S.D. (2022). Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events, OSF.","DOI":"10.3390\/pharmaceutics14122738"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_18","first-page":"501","article-title":"Photodynamic therapy with topical aminolevulinic acid and pulsed dye laser irradiation for sebaceous hyperplasia","volume":"2","author":"Alster","year":"2003","journal-title":"J. Drugs Dermatol."},{"key":"ref_19","first-page":"329","article-title":"Laser-Assisted Photodynamic Therapy: Two Novel Protocols for Enhanced Treatment Results","volume":"16","author":"Stevenson","year":"2017","journal-title":"J. Drugs Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"adv00694","DOI":"10.2340\/actadv.v102.1057","article-title":"Ablative Fractional Laser-assisted Low-irradiance Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients: A Prospective, Randomized, Intraindividual Controlled Trial","volume":"102","author":"Lonsdorf","year":"2022","journal-title":"Acta Derm. Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/lsm.23497","article-title":"Efficacy and safety of laser-assisted combination chemotherapy: A follow-up study of treatment with 5-fluorouracil and cisplatin for basal cell carcinoma","volume":"54","author":"Fredman","year":"2022","journal-title":"Lasers Surg. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"425","DOI":"10.36849\/JDD.2020.4589","article-title":"Treating Field Cancerization by Ablative Fractional Laser and Indoor Daylight: Assessment of Efficacy and Tolerability","volume":"19","author":"Paasch","year":"2020","journal-title":"J. Drugs Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/lsm.23323","article-title":"Efficacy and Safety of Laser-Assisted Combination Chemotherapy: An Explorative Imaging-Guided Treatment With 5-Fluorouracil and Cisplatin for Basal Cell Carcinoma","volume":"53","author":"Wenande","year":"2021","journal-title":"Lasers Surg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pdpdt.2019.08.034","article-title":"Laser-assisted MAL-PDT associated with acoustic pressure wave ultrasound with short incubation time for field cancerization treatment: A left-right comparison","volume":"28","author":"Pires","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/ced.13936","article-title":"Localized mycosis fungoides treated with laser-assisted photodynamic therapy: A case series","volume":"44","author":"Dairi","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jaad.2018.05.034","article-title":"Ablative fractional laser-assisted photodynamic therapy provides superior long-term efficacy compared with standard methyl aminolevulinate photodynamic therapy for lower extremity Bowen disease","volume":"79","author":"Kim","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/jdv.15109","article-title":"Short incubation fractional CO2 laser-assisted photodynamic therapy vs. conventional photodynamic therapy in field-cancerized skin: 12-month follow-up results of a randomized intraindividual comparison study","volume":"33","author":"Vrani","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1097\/DSS.0000000000000814","article-title":"Ablative Fractional Laser-Assisted Topical Fluorouracil for the Treatment of Superficial Basal Cell Carcinoma and Squamous Cell Carcinoma In Situ: A Follow-Up Study","volume":"42","author":"Hsu","year":"2016","journal-title":"Dermatol. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/1721727X16674219","article-title":"Ablative fractional laser improves treatment of actinic keratoses with Ingenol Mebutate","volume":"14","author":"Sannino","year":"2016","journal-title":"Eur. J. Inflamm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jaad.2014.09.055","article-title":"Laser-assisted drug delivery: Enhanced response to ingenol mebutate after ablative fractional laser treatment","volume":"72","author":"Braun","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/bjd.13542","article-title":"Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomized, comparative trial","volume":"173","author":"Choi","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1111\/jdv.12953","article-title":"Efficacy of ablative fractional laser-assisted photodynamic therapy with short-incubation time for the treatment of facial and scalp actinic keratosis: 12-month follow-up results of a randomized, prospective, comparative trial","volume":"29","author":"Choi","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/bjd.12507","article-title":"Intensified fractional CO2 laser-assisted photodynamic therapy vs. laser alone for organ transplant recipients with multiple actinic keratoses and wart-like lesions: A randomized half-side comparative trial on dorsal hands","volume":"169","author":"Helsing","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1111\/jdv.12334","article-title":"Fractional erbium: YAG laser-assisted photodynamic therapy for facial actinic keratoses: A randomized, comparative, prospective study","volume":"28","author":"Ko","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1007\/s00266-021-02232-4","article-title":"Treatment of Scars with Laser-Assisted Delivery of Growth Factors and Vitamin C: A Comparative, Randomised, Double-blind, Early Clinical Trial","volume":"45","author":"Machado","year":"2021","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"adv00416","DOI":"10.2340\/00015555-3781","article-title":"Hypertrophic Scar Outcomes in Fractional Laser Monotherapy Versus Fractional Laser-Assisted Topical Corticosteroid Delivery: A Randomized Clinical Trial","volume":"101","author":"Manuskiatti","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/jocd.13521","article-title":"Laser-assisted topical steroid application versus steroid injection for treating keloids: A split side study","volume":"20","author":"Nada","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e14488","DOI":"10.1111\/dth.14488","article-title":"Fractional carbon dioxide laser-assisted delivery of lyophilized-growth factors is a promising treatment modality of post-acne scars","volume":"33","author":"Neinaa","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e13980","DOI":"10.1111\/dth.13980","article-title":"Assessment of laser-assisted delivery vs intralesional injection of botulinum toxin A in treatment of hypertrophic scars and keloids","volume":"33","author":"Sabry","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e14359","DOI":"10.1111\/dth.14359","article-title":"Combination therapy of refractory keloid with ultrapulse fractional carbon dioxide (CO2) laser and topical triamcinolone in Asians-long-term prevention of keloid recurrence","volume":"33","author":"Wang","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/DSS.0000000000001678","article-title":"Treatment of Hypertrophic Scars Using Laser-Assisted Corticosteroid Versus Laser-Assisted 5-Fluorouracil Delivery","volume":"45","author":"Waibel","year":"2019","journal-title":"Dermatol. Surg."},{"key":"ref_42","first-page":"925","article-title":"Successful Treatment of Keloid with Fractionated Carbon Dioxide (CO2) Laser and Laser-Assisted Drug Delivery of Triamcinolone Acetonide Ointment in an African-American Man","volume":"16","author":"Kraeva","year":"2017","journal-title":"J. Drugs Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s10103-017-2154-5","article-title":"Laser-assisted topical corticosteroid delivery for the treatment of keloids","volume":"32","author":"Park","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/dth.12187","article-title":"Treatment of keloids with laser-assisted topical steroid delivery: A retrospective study of 23 cases","volume":"28","author":"Sillard","year":"2015","journal-title":"Dermatol. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1007\/s10103-022-03547-7","article-title":"Comparison of fractional erbium:YAG laser-assisted tranexamic acid delivery alone and in combination with oral tranexamic acid in melasma","volume":"37","author":"Botsali","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1007\/s10103-022-03566-4","article-title":"Efficacy and safety of 755-nm picosecond alexandrite laser with topical tranexamic acid versus laser monotherapy for melasma and facial rejuvenation: A multicenter, randomized, double-blinded, split-face study in Chinese patients","volume":"37","author":"Li","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e15287","DOI":"10.1111\/dth.15287","article-title":"Evaluating the tolerance and efficacy of laser-assisted delivery of tranexamic acid, niacinamide, and kojic acid for melasma: A single center, prospective, split-face trial","volume":"35","author":"Park","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/jocd.13817","article-title":"Laser-assisted delivery of tranexamic acid for melasma: Pilot study using a novel 1927 nm fractional thulium fiber laser","volume":"20","author":"Wang","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10103-020-03045-8","article-title":"The efficacy in treatment of facial melasma with thulium 1927-nm fractional laser-assisted topical tranexamic acid delivery: A split-face, double-blind, randomized controlled pilot study","volume":"35","author":"Wanitphakdeedecha","year":"2020","journal-title":"Lasers Med. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jocd.13134","article-title":"Study the effect of erbium:YAG laser plus topical 5-flurouracil in stable vitiligo resistant to NB-UVB phototherapy","volume":"19","author":"Doghaim","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/CCID.S147413","article-title":"Fractional erbium-doped yttrium aluminum garnet laser-assisted drug delivery of hydroquinone in the treatment of melasma","volume":"11","author":"Badawi","year":"2018","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1007\/s10103-017-2282-y","article-title":"Fractional Er:YAG laser assisting topical betamethasone solution in combination with NB-UVB for resistant non-segmental vitiligo","volume":"32","author":"Yan","year":"2017","journal-title":"Lasers Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1007\/s10103-021-03496-7","article-title":"A study to assess the efficacy of fractional carbon dioxide laser with topical platelet-rich plasma in the treatment of androgenetic alopecia","volume":"37","author":"Hanthavichai","year":"2022","journal-title":"Lasers Med. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/jewd.jewd_63_20","article-title":"Fractional carbon dioxide laser-assisted topical steroid delivery versus intralesional steroid in the treatment of alopecia areata","volume":"18","author":"Soror","year":"2021","journal-title":"J. Egypt. Women\u2019s Dermatol. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"217","DOI":"10.4103\/JCAS.JCAS_96_18","article-title":"Fractional Carbon Dioxide Laser in Combination with Topical Corticosteroid Application in Resistant Alopecia Areata: A Case Series","volume":"11","author":"Majid","year":"2018","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1080\/14764172.2017.1418516","article-title":"Fractional non-ablative laser-assisted drug delivery leads to improvement in male and female pattern hair loss","volume":"20","author":"Bertin","year":"2018","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/phpp.12312","article-title":"Nonablative fractional laser-assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study","volume":"33","author":"Kim","year":"2017","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaad.2011.08.031","article-title":"Prospective randomized controlled clinical and histopathological study of acne vulgaris treated with dual mode of quasi-long pulse and Q-switched 1064-nm Nd:YAG laser assisted with a topically applied carbon suspension","volume":"66","author":"Jung","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jaad.2007.11.027","article-title":"Long-pulsed dye laser versus long-pulsed dye laser-assisted photodynamic therapy for acne vulgaris: A randomized controlled trial","volume":"58","author":"Haedersdal","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1553-2712.2006.tb01021.x","article-title":"Laser-assisted anesthesia reduces the pain of venous cannulation in children and adults: A randomized controlled trial","volume":"13","author":"Singer","year":"2006","journal-title":"Acad. Emerg. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1197\/j.aem.2005.04.011","article-title":"Laser-assisted anesthesia prior to intravenous cannulation in volunteers: A randomized, controlled trial","volume":"12","author":"Singer","year":"2005","journal-title":"Acad. Emerg. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/archderm.139.10.1288","article-title":"Laser-assisted penetration of topical anesthetic in adults","volume":"139","author":"Baron","year":"2003","journal-title":"Arch. Dermatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1080\/09546634.2020.1771252","article-title":"Fractional CO2-assisted photodynamic therapy improves the clinical outcome and patient\u2019s satisfaction in toenail onychomycosis treatment: An intra-patient comparative single-center study","volume":"33","author":"Abdallah","year":"2022","journal-title":"J. Dermatol. Treat."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2340\/00015555-2874","article-title":"Laser-assisted Photodynamic Therapy or Laser-assisted Amorolfine Lacquer Delivery for Treatment of Toenail Onychomycosis: An Open-label Comparative Study","volume":"98","author":"Koren","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jaad.2015.12.002","article-title":"Fractional carbon-dioxide (CO2) laser-assisted topical therapy for the treatment of onychomycosis","volume":"74","author":"Bhatta","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s40261-020-00914-6","article-title":"Comparative Study of Traditional Ablative CO2 Laser-Assisted Topical Antifungal with only Topical Antifungal for Treating Onychomycosis: A Multicenter Study","volume":"40","author":"Rajbanshi","year":"2020","journal-title":"Clin. Drug Investig."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1097\/DSS.0000000000002901","article-title":"Fractional CO2 Laser for Transcutaneous Drug Delivery of Onabotulinum Toxin in Palmar Hyperhidrosis","volume":"47","author":"Agamia","year":"2021","journal-title":"Dermatol. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/14764172.2022.2049312","article-title":"Safety profile of laser-assisted drug delivery of vitamin C, E, and ferulic acid serum following ablative fractional resurfacing: A retrospective chart review","volume":"23","author":"Johnson","year":"2021","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/DSS.0000000000003333","article-title":"Fractional Ablative Laser-Assisted Delivery of Topical Poly-l-lactic Acid: A 2.5-Year Safety Review","volume":"48","author":"Wang","year":"2022","journal-title":"Dermatol. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"712511","DOI":"10.3389\/fmed.2021.712511","article-title":"Phase I Study to Assess Safety of Laser-Assisted Topical Administration of an Anti-TNF Biologic in Patients with Chronic Plaque-Type Psoriasis","volume":"8","author":"Bauer","year":"2021","journal-title":"Front. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1111\/jocd.14536","article-title":"Efficacy of combined fractional carbon dioxide laser and topical tazarotene in nail psoriasis treatment: A randomized intrapatient left-to-right study","volume":"21","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1111\/jocd.14595","article-title":"Efficacy of the topical cyclosporine cream assisted by fractional carbon dioxide laser vs topical clobetasol cream for the treatment of plaque psoriasis: Randomized comparative study","volume":"21","author":"Helmy","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1080\/09546634.2020.1729330","article-title":"Fractional 2940-nm Er:YAG laser-assisted drug delivery of timolol maleate for the treatment of deep infantile hemangioma","volume":"32","author":"Sun","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10103-020-03064-5","article-title":"Fractional CO2 laser-assisted Botulinum toxin type A delivery for the treatment of primary palmar hyperhidrosis","volume":"36","author":"Junsuwan","year":"2021","journal-title":"Lasers Med. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1097\/DSS.0000000000002835","article-title":"Pulse-Dye Laser Followed by Betamethasone-Calcipotriol and Fractional Ablative CO2-Laser-Assisted Delivery for Nail Psoriasis","volume":"47","author":"Shehadeh","year":"2021","journal-title":"Dermatol. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s10103-018-2457-1","article-title":"Comparative study of fractional CO2 laser and fractional CO2 laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis","volume":"33","author":"Sobhi","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1097\/DSS.0000000000000885","article-title":"Fractional Laser-Assisted Topical Imiquimod 5% Cream Treatment for Recalcitrant Common Warts in Children: A Pilot Study","volume":"42","author":"Park","year":"2016","journal-title":"Dermatol. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/pde.12299","article-title":"Fractional carbon dioxide laser-assisted drug delivery of topical timolol solution for the treatment of deep infantile hemangioma: A pilot study","volume":"31","author":"Ma","year":"2014","journal-title":"Pediatr. Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2310\/6620.2006.05023","article-title":"Laser-assisted penetration of allergens for patch testing","volume":"17","author":"Ramirez","year":"2006","journal-title":"Dermatitis"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1002\/lsm.23403","article-title":"Laser-Assisted Hyaluronic Acid Delivery by Fractional Carbon Dioxide Laser in Facial Skin Remodeling: A Prospective Randomized Split-Face Study in France","volume":"53","author":"Benzaquen","year":"2021","journal-title":"Lasers Surg. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s00266-020-02035-z","article-title":"Comparative Study on the Outcome of Periorbital Wrinkles Treated with Laser-Assisted Delivery of Vitamin C or Vitamin C Plus Growth Factors: A Randomized, Double-blind, Clinical Trial","volume":"45","author":"Machado","year":"2021","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Widianingsih, N.P., Setyaningrum, T., and Prakoeswa, C.R. (2019). The efficacy and safety of fractional erbium YAG laser combined with topical amniotic membrane stem cell (AMSC) metabolite product for facial rejuvenation: A controlled, Split-Face Study. Dermatol. Rep.","DOI":"10.4081\/dr.2019.8036"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10103-009-0709-9","article-title":"Topical imiquimod in conjunction with Nd:YAG laser for tattoo removal","volume":"24","author":"Elsaie","year":"2009","journal-title":"Lasers Med. Sci."},{"key":"ref_84","first-page":"1082","article-title":"Laser-assisted tattoo removal with topical 5% imiquimod cream","volume":"33","author":"Ricotti","year":"2007","journal-title":"Dermatol. Surg."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/lsm.22610","article-title":"Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery","volume":"49","author":"Banzhaf","year":"2017","journal-title":"Lasers Surg. Med."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1177\/1090820X13496248","article-title":"Topical lidocaine enhanced by laser pretreatment: A safe and effective method of analgesia for facial rejuvenation","volume":"33","author":"Oni","year":"2013","journal-title":"Aesthet. Surg. J."},{"key":"ref_87","unstructured":"Prohaska, J., and Hohman, M.H. (2022). Laser Complications. StatPearls, StatPearls Publishing."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1529-8019.2012.01476.x","article-title":"Complications of lasers and light treatments","volume":"24","author":"Alam","year":"2011","journal-title":"Dermatol. Ther."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.clindermatol.2005.10.027","article-title":"Laser-mediated photodynamic therapy","volume":"24","year":"2006","journal-title":"Clin. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/bjd.17131","article-title":"Adverse effects of topical photodynamic therapy: A consensus review and approach to management","volume":"180","author":"Ibbotson","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Piaserico, S., Mazzetto, R., Sartor, E., and Bortoletti, C. (2022). Combination-Based Strategies for the Treatment of Actinic Keratoses with Photodynamic Therapy: An Evidence-Based Review. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081726"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/lsm.22024","article-title":"Urticaria induced by laser epilation: A clinical and histopathological study with extended follow-up in 36 patients","volume":"44","author":"Landa","year":"2012","journal-title":"Lasers Surg. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1081-1206(10)61942-4","article-title":"Immediate cutaneous hypersensitivity after treatment of tattoo with nd:YAG laser: A case report and review of the literature","volume":"89","author":"England","year":"2002","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/0974-2077.155072","article-title":"Complications of Tattoos and Tattoo Removal: Stop and Think Before you ink","volume":"8","author":"Khunger","year":"2015","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_95","first-page":"303","article-title":"Intraoperative localized urticarial reaction during Q-switched Nd:YAG laser tattoo removal","volume":"14","author":"Wilken","year":"2015","journal-title":"J. Drugs Dermatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jdcr.2015.01.005","article-title":"A case of delayed anaphylaxis after laser tattoo removal","volume":"1","author":"Hibler","year":"2015","journal-title":"JAAD Case Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/pcmr.12404","article-title":"Recent progress in melasma pathogenesis","volume":"28","author":"Lee","year":"2015","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/pcmr.12949","article-title":"An update on Vitiligo pathogenesis","volume":"34","author":"Seneschal","year":"2021","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1111\/j.1524-4725.2010.01672.x","article-title":"Review of the literature: Treatment of dyspigmentation with fractionated resurfacing","volume":"36","author":"Tierney","year":"2010","journal-title":"Dermatol. Surg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1055\/s-0032-1329413","article-title":"Current Laser Resurfacing Technologies: A Review that Delves Beneath the Surface","volume":"26","author":"Preissig","year":"2012","journal-title":"Semin. Plast. Surg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1001\/archdermatol.2009.291","article-title":"Topical imiquimod or fluorouracil therapy for basal and squamous cell carcinoma: A systematic review","volume":"145","author":"Love","year":"2009","journal-title":"Arch. Dermatol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0781.2010.00560.x","article-title":"Adverse effects of topical photodynamic therapy","volume":"27","author":"Ibbotson","year":"2011","journal-title":"Photodermatol. Photoimmunol. Photomed."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/12\/2738\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:35:44Z","timestamp":1760146544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/12\/2738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":102,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["pharmaceutics14122738"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14122738","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]}}}