{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:37:55Z","timestamp":1760233075792,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministerio de Economia y Competitividad (MINECO) Spain","award":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"],"award-info":[{"award-number":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"]}]},{"name":"Universitat de Girona","award":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"],"award-info":[{"award-number":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"]}]},{"name":"Generalitat de Catalunya","award":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"],"award-info":[{"award-number":["BIO2013-43517","MPCUdG2016-18","MPCUdG2016\/048","SGR2014-70","2017 SGR 1720"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>A family of dinuclear iron (II) compounds with iminopyridine-based ligands displays selective cytotoxic activity against cancer cell lines. All compounds have IC50 values 2\u20136 fold lower than that of cisplatin, and 30\u201390 fold lower than that of carboplatin for the tumor cell lines assayed. Comparing the IC50 values between tumor and non-tumor cell lines, the selectivity indexes range from 3.2 to 34, compound 10, [Fe2(4)2(CH3CN)4](BF4)4, showing the highest selectivity. Those compounds carrying substituents on the iminopyridine ring show the same cytotoxicity as those without substituents. However, the electronic effects of the substituents on position 6 may be important for the cytotoxicity of the complexes, and consequently for their selectivity. All compounds act over DNA, promoting cuts on both strands in the presence of reactive oxygen species. Since compound 10 presented the highest selectivity, its cytotoxic effect was further characterized. It induces apoptosis, affects cell cycle phase distribution in a cell-dependent manner, and its cytotoxic effect is linked to reactive oxygen species generation. In addition, it decreases tumor cell migration, showing potential antimetastatic effects. These properties make compound 10 a good lead antitumor agent among all compounds studied here.<\/jats:p>","DOI":"10.3390\/pharmaceutics14122801","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:20:57Z","timestamp":1671070857000},"page":"2801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dinuclear Iron Complexes of Iminopyridine-Based Ligands as Selective Cytotoxins for Tumor Cells and Inhibitors of Cancer Cell Migration"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4766-2311","authenticated-orcid":false,"given":"Jessica","family":"Castro","sequence":"first","affiliation":[{"name":"Laboratori d\u2019Enginyeria de Prote\u00efnes, Departament de Biologia, Facultat de Ci\u00e8ncies, Universitat de Girona, Campus de Montilivi, C\/Maria Aur\u00e8lia Capmany, 40, 17003 Girona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Biom\u00e8dica de Girona Dr. Josep Trueta, Parc Hospitalari Mart\u00ed i Juli\u00e0\u2014Edifici M2 C\/Dr. Castany s\/n, 17190 Salt Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-9812","authenticated-orcid":false,"given":"Marlon","family":"Bravo","sequence":"additional","affiliation":[{"name":"Laboratori d\u2019Enginyeria de Prote\u00efnes, Departament de Biologia, Facultat de Ci\u00e8ncies, Universitat de Girona, Campus de Montilivi, C\/Maria Aur\u00e8lia Capmany, 40, 17003 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4639-815X","authenticated-orcid":false,"given":"Meritxell","family":"Albert\u00ed","sequence":"additional","affiliation":[{"name":"Laboratori d\u2019Enginyeria de Prote\u00efnes, Departament de Biologia, Facultat de Ci\u00e8ncies, Universitat de Girona, Campus de Montilivi, C\/Maria Aur\u00e8lia Capmany, 40, 17003 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u00eds","family":"Marsal","sequence":"additional","affiliation":[{"name":"Laboratori d\u2019Enginyeria de Prote\u00efnes, Departament de Biologia, Facultat de Ci\u00e8ncies, Universitat de Girona, Campus de Montilivi, C\/Maria Aur\u00e8lia Capmany, 40, 17003 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Alonso-De Gennaro","sequence":"additional","affiliation":[{"name":"Laboratori d\u2019Enginyeria de Prote\u00efnes, Departament de Biologia, Facultat de Ci\u00e8ncies, Universitat de Girona, Campus de Montilivi, C\/Maria Aur\u00e8lia Capmany, 40, 17003 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriol","family":"Mart\u00ednez-Ferrat\u00e9","sequence":"additional","affiliation":[{"name":"Departament de Quimica F\u00edsica e Inorg\u00e0nica, Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain"},{"name":"Institut Catal\u00e0 d\u2019Investigaci\u00f3 Qu\u00edmica (ICIQ), Avinguda dels Pa\u00efsos Catalans, 16, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Claver","sequence":"additional","affiliation":[{"name":"Departament de Quimica F\u00edsica e Inorg\u00e0nica, Universitat Rovira i Virgili, Campus Sescelades, 43007 Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2165-7090","authenticated-orcid":false,"given":"Piet W. 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