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They are effective in vitro in a wide range of human diseases, particularly those mediated by free radicals, such as cancer, atherosclerosis, AIDS, or neuronal diseases. However, their applications have been reduced due to their low solubility, poor absorption, and rapid metabolism. Flavonoid encapsulation in nanocarriers significantly improves their oral absorption, protects the drug against degradation, decreases the first-pass hepatic effect, and makes absorption through the lymphatic system easier. In this work, carbon nanotubes were used as nanocarriers of 7-hydroxyflavone, 7-HF. The encapsulation of 7-HF into pristine single- and multi-walled carbon nanotubes, and into -COOH functionalized single-walled carbon nanotubes has been investigated. The equilibrium association constants were estimated. The structural backbone of 7-HF, two benzene rings linked through three carbon atoms that form a pyran heterocyclic ring containing a keto group, seems to play a key role in the 7-HF\/CNT interactions, although other types of interactions are also at work. The in vitro release of 7-HF was studied at three pHs, 2.0, 7.4, and 9.2, mimicking the different biological barriers of the human organism.<\/jats:p>","DOI":"10.3390\/pharmaceutics14122806","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T02:20:57Z","timestamp":1671070857000},"page":"2806","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Single -and Multi-Walled Carbon Nanotubes as Nanocarriers for the Delivery of 7-Hydroxyflavone"],"prefix":"10.3390","volume":"14","author":[{"given":"Cecilia","family":"Esp\u00edndola","sequence":"first","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Javier","family":"Correa","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9060-9554","authenticated-orcid":false,"given":"Manuel","family":"L\u00f3pez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Physical Chemistry and Material Sciences, Campus de El Carmen, Avda. de las Fuerzas Armadas s\/n, 21071 Huelva, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-9483","authenticated-orcid":false,"given":"Pilar","family":"L\u00f3pez-Cornejo","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bernal","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-3690","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Lebr\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6583-6974","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Ostos","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"},{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital, CSIC, University of Seville, 41013 Seville, Spain"},{"name":"Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Rafii-El-Idrissi","family":"Benhnia","sequence":"additional","affiliation":[{"name":"Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville (IBiS), Virgen del Roc\u00edo University Hospital, CSIC, University of Seville, 41013 Seville, Spain"},{"name":"Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2736-9348","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Moy\u00e1","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Seville, C\/Profesor Garc\u00eda Gonz\u00e1lez 1, 41012 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.3390\/12092228","article-title":"Flavonoids: Hemysinthesis, reactivity, characterization and free radical scavenging activity","volume":"12","author":"Ghidouche","year":"2007","journal-title":"Molecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sabino, R.K., Ranjit, A., Sharma, K., Prada\u2019s, P., and Shang, X. 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