{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:00:04Z","timestamp":1784581204305,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Topical photodynamic therapy (PDT) is a non-invasive treatment modality frequently used in dermatology to treat superficial skin cancers but also some inflammatory or infectious dermatoses. PDT appears a more and more promising therapeutic option also for cutaneous lymphomas, either of T- or B-cell origin. It is a well-tolerated treatment and has excellent cosmetic outcomes, less side effects compared to other therapies (steroids, surgery, radiotherapy, and so on), no particular contraindications, and is easily repeatable in case of relapses. However, how PDT works in the treatment of cutaneous lymphoproliferative diseases is poorly understood and the literature data are still controversial. Further randomized, controlled clinical trials involving a greater number of patients and centers with a long follow-up are necessary to assess the efficacy of PDT and establish a unique standardized treatment protocol in relation to the lymphomatous disease and the type, thickness, and location of the lesions.<\/jats:p>","DOI":"10.3390\/pharmaceutics15010047","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T04:24:53Z","timestamp":1671769493000},"page":"47","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Photodynamic Therapy as an Effective Treatment for Cutaneous Lymphomas"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-9283","authenticated-orcid":false,"given":"Stefano","family":"Caccavale","sequence":"first","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Tancredi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Sica","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ronchi","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Franco","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-7295","authenticated-orcid":false,"given":"Francesco","family":"Pastore","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-8214","authenticated-orcid":false,"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Via Sergio Pansini 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.pdpdt.2019.04.008","article-title":"Curettage\u2009+\u2009microneedling\u2009+\u2009topical ALA-PDT for the treatment of acral resistant warts: Our experience","volume":"27","author":"Caccavale","year":"2019","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kessel, D. (2019). Photodynamic Therapy: A Brief History. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101581"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/ced.14084","article-title":"Combination of photodynamic therapy with 5-aminolaevulinic acid and microneedling in the treatment of alopecia areata resistant to conventional therapies: Our experience with 41 patients","volume":"45","author":"Giorgio","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112244","DOI":"10.1016\/j.jphotobiol.2021.112244","article-title":"Photodynamic therapy of cutaneous T-cell lymphoma cell lines mediated by 5-aminolevulinic acid and derivatives","volume":"221","author":"Vallecorsa","year":"2021","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_5","unstructured":"Saurat, J.H., Lachapelle, J.M., Lipsker, D., and Thomas, L. (2017). Dermatologie et Infections Sexuellement Transmisibles, Elsevier. [6th ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/phpp.12698","article-title":"Photodynamic therapy of mycosis fungoides: A systematic review of case studies","volume":"37","author":"Hooper","year":"2021","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.jid.2019.07.712","article-title":"Overall Survival in Mycosis fungoides. A Systematic review and Meta-Analysis","volume":"140","author":"Mourad","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_8","first-page":"e2020069","article-title":"Dermoscopy of Syringotropic and Folliculotropic Mycosis Fungoides","volume":"10","author":"Caccavale","year":"2020","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1111\/ijd.14490","article-title":"Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs","volume":"58","author":"Caccavale","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5826\/dpc.0804a17","article-title":"Early dermoscopic sign of folliculotropism in patients with mycosis fungoides","volume":"8","author":"Toncic","year":"2018","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.3892\/etm.2022.11304","article-title":"Dermoscopy in the diagnosis of cutaneous lymphoma (Review)","volume":"23","author":"Ungureanu","year":"2022","journal-title":"Exp. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/ced.13936","article-title":"Localized mycosis fungoides treated with laser-assisted photodynamic therapy: A case series","volume":"44","author":"Dairi","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/bjd.12064","article-title":"Photodynamic therapy with methyl aminolaevulinate for cervical and\/or facial lesions of folliculotropic mycosis fungoides: Interest and limits","volume":"168","author":"Debu","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pdpdt.2017.09.004","article-title":"Photodynamic therapy: An option in mycosis fungoides","volume":"20","author":"Pileri","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/ced.12528","article-title":"A case of pagetoid reticulosis treated with fractional laser-assisted photodynamic therapy","volume":"40","author":"Jung","year":"2015","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_16","first-page":"58","article-title":"A case of unilesional mycosis fungoides treated with photodynamic therapy using methyl-Aminolevulinate","volume":"53","author":"Jang","year":"2015","journal-title":"Korean J. Dermatol."},{"key":"ref_17","first-page":"158","article-title":"A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: Oncologic and infectious indications","volume":"12","author":"Rossi","year":"2013","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.jaad.2013.07.047","article-title":"Photodynamic therapy with methyl-aminolevulinic acid for paucilesional mycosis fungoides: A prospective open study and review of the literature","volume":"69","author":"Brocard","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pdpdt.2016.07.011","article-title":"Observation of clinical efficacy of photodynamic therapy in 3 patients with refractory plaque-stage mycosis fungoides","volume":"16","author":"Han","year":"2016","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/00015555-1261","article-title":"Photodynamic therapy with methyl-aminolaevulinic acid for mycosis fungoides","volume":"92","author":"Kim","year":"2012","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/jdv.14160","article-title":"Unilesional plantar mycosis fungoides treated with topical photodynamic therapy\u2014Case report and review of the literature","volume":"31","author":"Kaufmann","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/j.1365-4632.2011.05427.x","article-title":"Topical photodynamic therapy with 5-aminolevulinate for the treatment of tumor-stage mycosis fungoides: A case report","volume":"52","author":"Hasson","year":"2013","journal-title":"Int. J. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/ddg.14403","article-title":"Successful treatment of palmoplantar dyshidrotic lesions of mycosis fungoides with conventional and daylight photodynamic therapy","volume":"19","year":"2021","journal-title":"J. Dtsch. Dermatol. Ges."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/S0190-9622(08)81742-2","article-title":"Photodynamic therapy for mycosis fungoides after topical photosensitization with 5-aminolevulinic acid","volume":"31","author":"Wolf","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_25","first-page":"827","article-title":"Photodynamic therapy as an alternative treatment for mycosis fungoides: A systemic review and meta-analysis","volume":"153","author":"Cazzaniga","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.pdpdt.2016.11.010","article-title":"Photodynamic therapy as an alternative treatment for relapsed or refractory mycosis fungoides: A systemic review","volume":"17","author":"Xue","year":"2017","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1751-1097.1995.tb02356.x","article-title":"The role of transferrin receptor (CD71) in photodynamic therapy of activated and malignant lymphocytes using the heme precursor delta-aminolevulinic acid (ALA)","volume":"61","author":"Morgan","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/120347540100500103","article-title":"Photodynamic therapy with 5-aminolevulinic acid induces apoptosis and caspase activation in malignant T cells","volume":"5","author":"Gad","year":"2001","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3389\/fonc.2020.00651","article-title":"Primary Cutaneous B-Cell Lymphomas: An Update","volume":"10","author":"Vitiello","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.hoc.2018.08.006","article-title":"Cutaneous B-Cell Lymphoma","volume":"33","author":"Goyal","year":"2019","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.5858\/arpa.2018-0215-RA","article-title":"Primary Cutaneous Follicle Center Lymphoma","volume":"142","author":"Skala","year":"2018","journal-title":"Arch. Pathol. Lab Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.beha.2017.01.001","article-title":"Bacteria associated with marginal zone lymphomas","volume":"30","author":"Ponzoni","year":"2017","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.critrevonc.2009.09.003","article-title":"Primary cutaneous marginal zone lymphoma","volume":"74","author":"Dalle","year":"2010","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/ajh.25224","article-title":"Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management","volume":"93","author":"Wilcox","year":"2018","journal-title":"Am. J. Hematol."},{"key":"ref_35","first-page":"292","article-title":"Treatment of primary cutaneous B-cell lymphoma with radiotherapy","volume":"23","author":"Ulutin","year":"2005","journal-title":"Radiat. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.det.2019.05.004","article-title":"Diagnosis and Management of Cutaneous B-Cell Lymphomas","volume":"37","author":"Malachowski","year":"2019","journal-title":"Dermatol. Clin."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/pir.35.12.500","article-title":"Borrelia burgdorferi (Lyme disease)","volume":"35","author":"Shapiro","year":"2014","journal-title":"Pediatr Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jaad.2005.10.016","article-title":"Topical photodynamic therapy for primary cutaneous B-cell lymphoma: A pilot study","volume":"54","author":"Mori","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/j.semdp.2016.11.006","article-title":"Primary cutaneous B-cell lymphomas with large cell predominance-primary cutaneous follicle center lymphoma, diffuse large B-cell lymphoma, leg type and intravascular large B-cell lymphoma","volume":"34","author":"Hope","year":"2017","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cup.13532","article-title":"Cutaneous pseudolymphoma-A review on the spectrum and a proposal for a new classification","volume":"47","author":"Mitteldorf","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_41","first-page":"640","article-title":"Cutaneous Pseudolymphomas","volume":"107","year":"2016","journal-title":"Actas Dermosifiliogr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2340\/00015555-2841","article-title":"Treatment of Cutaneous Pseudolymphoma: A Systematic Review","volume":"98","author":"Miguel","year":"2018","journal-title":"Acta Dermatol. Venereol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1159\/000087021","article-title":"Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid","volume":"211","author":"Takeda","year":"2005","journal-title":"Dermatology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.jaad.2005.05.016","article-title":"Topical 5-aminolevulinic acid-based photodynamic therapy for the treatment of a patient with cutaneous pseudolymphoma","volume":"53","author":"Mikasa","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_45","first-page":"50","article-title":"Successful treatment of cutaneous pseudolymphoma with topical methylaminolevulinate photodynamic therapy","volume":"156","author":"Caccavale","year":"2020","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e13938","DOI":"10.1111\/dth.13938","article-title":"Efficacy of chlorine photodynamic therapy in cutaneous lymphoid hyperplasia","volume":"33","author":"Olisova","year":"2020","journal-title":"Dermatol. Ther."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/1\/47\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:49:05Z","timestamp":1760147345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/1\/47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,23]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["pharmaceutics15010047"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15010047","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,23]]}}}