{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:48:06Z","timestamp":1792806486090,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ivanovo State University","award":["\u2116 60-20G"],"award-info":[{"award-number":["\u2116 60-20G"]}],"id":[{"id":"https:\/\/ror.org\/03rqm8n56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Ivanovo State University","award":["122040500044-4"],"award-info":[{"award-number":["122040500044-4"]}],"id":[{"id":"https:\/\/ror.org\/03rqm8n56","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Program of the Ministry of Science and Higher Education","award":["\u2116 60-20G"],"award-info":[{"award-number":["\u2116 60-20G"]}],"id":[{"id":"https:\/\/ror.org\/05dwvd537","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Program of the Ministry of Science and Higher Education","award":["122040500044-4"],"award-info":[{"award-number":["122040500044-4"]}],"id":[{"id":"https:\/\/ror.org\/05dwvd537","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Metal-organic frameworks based on cyclodextrins (CDs) have been proposed as promising drug delivery systems due to their large surface area, variable pore size, and biocompatibility. In the current work, we investigated an incorporation of tolfenamic acid (TA), a representative of non-steroidal anti-inflammatory drugs (NSAIDs), in a metal-organic framework based on \u03b3-cyclodextrin and potassium cations (\u03b3CD-MOF). Composites \u03b3CD-MOF\/TA obtained by absorption and co-crystallization methods were characterized using powder X-ray diffraction, low temperature nitrogen adsorption\/desorption, scanning electron microscopy, and FTIR spectroscopy. It was demonstrated that TA loaded in \u03b3CD-MOF has an improved dissolution profile. However, the inclusion of TA in \u03b3-CD reduces the membrane permeability of the drug. A comparative analysis of the encapsulation of different NSAIDs in \u03b3CD-MOF was performed. The impact of NSAID structure on the loading capacity was considered for the first time. It was revealed that the presence of heterocycles in the structure and drug lipophilicity influence the loading efficiency of NSAIDs in \u03b3CD-MOF.<\/jats:p>","DOI":"10.3390\/pharmaceutics15010071","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T07:30:06Z","timestamp":1672126206000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Regularities of Encapsulation of Tolfenamic Acid and Some Other Non-Steroidal Anti-Inflammatory Drugs in Metal-Organic Framework Based on \u03b3-Cyclodextrin"],"prefix":"10.3390","volume":"15","author":[{"given":"Ekaterina","family":"Delyagina","sequence":"first","affiliation":[{"name":"Institute of Mathematics, Information Technology and Natural Sciences, Ivanovo State University, 153025 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Garibyan","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of RAS, 153045 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-7036","authenticated-orcid":false,"given":"Mikhail","family":"Agafonov","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of RAS, 153045 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Terekhova","sequence":"additional","affiliation":[{"name":"G.A. Krestov Institute of Solution Chemistry of RAS, 153045 Ivanovo, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120301","DOI":"10.1016\/j.lfs.2022.120301","article-title":"Overview of nanoparticulate strategies for solubility enhancement of poorly soluble drugs","volume":"291","author":"Khan","year":"2022","journal-title":"Life Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/j.apsb.2021.05.014","article-title":"Overview of milling techniques for improving the solubility of poorly water-soluble drugs","volume":"11","author":"Bhujbal","year":"2021","journal-title":"Acta Pharm. Sin. 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