{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:16:19Z","timestamp":1778609779278,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T00:00:00Z","timestamp":1672358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NCBiR","award":["MAZOWSZE\/0023\/19"],"award-info":[{"award-number":["MAZOWSZE\/0023\/19"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Modern dental therapy makes use of prosthetic implant reconstructions, which are supported or retained on dental implants. The most frequent, long-term complications associated with these prosthetic implants include mucositis and peri-implantitis. Since mucositis is the initial inflammation of tissues supporting the dental implant, the management of this condition is thus crucial. The aim of the present study was to assess the effects of the placement of bioactive healing abutment for 48 h, in patients diagnosed with peri-implant mucositis. Moreover, the quantitative and qualitative shift in the bacterial profile of the biofilm present in the peri-implant pockets, was assessed by means of RT-PCR genotyping. Each patient was examined using a commercially available PET test protocol: the first sample was taken upon diagnosis (after which the bioactive healing abutment, with clindamycin at a dose of 30 mg, was used for 48 h and replaced with the prosthetic superstructure used so far by a patient); the second sample was taken two weeks after removal of the bioactive healing abutment. The effects of the intervention were clinically assessed using the PET test after the two weeks. A significant reduction in mucositis was observed following treatment, as measured by periodontal indices: modified Sulcus Bleeding Index\u2014mBI (p &lt; 0.001), modified Plaque Index\u2014PLI (r = 0.69, Z= \u22124.43; p &lt; 0.001) and probing depth\u2014PD (Z = \u22124.61; p &lt; 0.001). Significant differences in the occurrence of periopathogenic bacteria were also observed: Aggregatibacter actinomycetemcomitans (p &lt; 0.014; Z = \u22122.45; r = 0.38), Treponema denticola (p &lt; 0.005; Z = \u22122.83; r = 0.44), Tannerella forsythia (p &lt; 0.001; Z = \u22124.47; r = 0.69) and Porphyromonas gingivalis (p &lt; 0.132; Z = \u22121.51).<\/jats:p>","DOI":"10.3390\/pharmaceutics15010138","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T02:23:06Z","timestamp":1672626186000},"page":"138","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Effectiveness of a Bioactive Healing Abutment as a Local Drug Delivery System to Impact Peri-Implant Mucositis: A Prospective Case Series Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-5697","authenticated-orcid":false,"given":"Piotr","family":"Wychowa\u0144ski","sequence":"first","affiliation":[{"name":"Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the \u201cSacred Heart\u201d, 00168 Rome, Italy"},{"name":"Department of Oral Surgery, Medical University of Gda\u0144sk, 7 D\u0119binki Street, 80-211 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-2509","authenticated-orcid":false,"given":"Maciej","family":"Nowak","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Diseases, Medical University of Warsaw, 6 Binieckiego Street, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1361-1487","authenticated-orcid":false,"given":"Andrzej","family":"Miskiewicz","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Diseases, Medical University of Warsaw, 6 Binieckiego Street, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadeusz","family":"Morawiec","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Pl. Akademicki 17, 41-902 Bytom, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaros\u0142aw","family":"Woli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 3 Instytucka Street, 05-110 Jab\u0142onna, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew","family":"Kucharski","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Medical University of Warsaw, 6 St. Binieckiego Street, 02-097 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Carmine","family":"Passarelli","sequence":"additional","affiliation":[{"name":"Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the \u201cSacred Heart\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Bodnarenko","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Mucosa Diseases, E. Orzeszkowej 18, 80-208 Gda\u0144sk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8914-3590","authenticated-orcid":false,"given":"Michele Antonio","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the \u201cSacred Heart\u201d, 00168 Rome, Italy"},{"name":"Unit of Otolaryngology, University Campus Bio-Medico, Via \u00c1lvaro del Portillo, 21, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.morpho.2016.02.002","article-title":"Dental implants: A review","volume":"100","author":"Guillaume","year":"2016","journal-title":"Morphologie"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/prd.12335","article-title":"Breaking the wave of peri-implantitis","volume":"84","author":"Fu","year":"2020","journal-title":"Periodontology 2000"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ijom.2014.10.023","article-title":"Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: A systematic review","volume":"44","author":"Moraschini","year":"2015","journal-title":"Int. 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