{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:54:13Z","timestamp":1790628853370,"version":"4.1.0"},"reference-count":201,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["20ZR1448700"],"award-info":[{"award-number":["20ZR1448700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["KQYJXK2020"],"award-info":[{"award-number":["KQYJXK2020"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Discipline fund from the Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, and the College of Stomatology, Shanghai Jiao Tong University","award":["20ZR1448700"],"award-info":[{"award-number":["20ZR1448700"]}]},{"name":"Research Discipline fund from the Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, and the College of Stomatology, Shanghai Jiao Tong University","award":["KQYJXK2020"],"award-info":[{"award-number":["KQYJXK2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Dental pulp and periapical diseases make patients suffer from acute pain and economic loss. Although root canal therapies, as demonstrated through evidence-based medicine, can relieve symptoms and are commonly employed by dentists, it is still difficult to fully restore a dental pulp\u2019s nutrition, sensory, and immune-regulation functions. In recent years, researchers have made significant progress in tissue engineering to regenerate dental pulp in a desired microenvironment. With breakthroughs in regenerative medicine and material science, bioactive scaffolds play a pivotal role in creating a suitable microenvironment for cell survival, proliferation, and differentiation, following dental restoration and regeneration. This article focuses on current challenges and novel perspectives about bioactive scaffolds in creating a microenvironment to promote dental pulp regeneration. We hope our readers will gain a deeper understanding and new inspiration of dental pulp regeneration through our summary.<\/jats:p>","DOI":"10.3390\/pharmaceutics15010158","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T02:51:39Z","timestamp":1672714299000},"page":"158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Creating a Microenvironment to Give Wings to Dental Pulp Regeneration\u2014Bioactive Scaffolds"],"prefix":"10.3390","volume":"15","author":[{"given":"Nan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Endodontics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1263-3791","authenticated-orcid":false,"given":"Weiping","family":"Li","sequence":"additional","affiliation":[{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Oral and Maxillofacial Head & Neck Oncology, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-2622","authenticated-orcid":false,"given":"Wentao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wen","sequence":"additional","affiliation":[{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China"},{"name":"Department of Prosthodontics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, Shanghai 200125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shensheng","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China"},{"name":"National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gulabivala, K., and Ng, Y.-L. 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