{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:27:07Z","timestamp":1787740027344,"version":"build-2784847793"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-23-00793"],"award-info":[{"award-number":["22-23-00793"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Understanding of the nucleation process\u2019s fundamental principles in saturated solutions is an urgent task. To do this task, it is necessary to control the formation of polymorphic forms of biologically active compounds. In certain cases, a compound can exist in a single polymorphic form, but have several solvates which can appear in different crystal forms, depending on the medium and conditions of formation, and show different pharmaceutical activity. In the present paper, we report on the analysis of Arbidol conformational preferences in two solvents of different polarities\u2014deuterated chloroform and dimethyl sulfoxide\u2014at 25 \u00b0C, using the 2D NOESY method. The Arbidol molecule has various solvate forms depending on the molecular conformation. The method based on the nuclear Overhauser effect spectroscopy was shown to be efficient in the analysis of complex heterocyclic compounds possessing conformation-dependent pseudo-polymorphism. It is one of the types of polymorphism observed in compounds forming crystal solvates. Combined use of NMR methods and X-ray data allowed determining of conformer populations of Arbidol in CDCl3 and DMSO-d6 which were found to be 8\/92% and 37\/63%, respectively. The preferred conformation in solution is the same that appears in stable crystal solvates of Arbidol.<\/jats:p>","DOI":"10.3390\/pharmaceutics15010226","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T01:30:47Z","timestamp":1673314247000},"page":"226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Conformational Screening of Arbidol Solvates: Investigation via 2D NOESY"],"prefix":"10.3390","volume":"15","author":[{"given":"Varvara A.","family":"Eventova","sequence":"first","affiliation":[{"name":"Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia"},{"name":"Department of Inorganic Chemistry, Ivanovo State University of Chemistry and Technology, Ivanovo 153000, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5690-340X","authenticated-orcid":false,"given":"Konstantin V.","family":"Belov","sequence":"additional","affiliation":[{"name":"Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-8124","authenticated-orcid":false,"given":"Sergey V.","family":"Efimov","sequence":"additional","affiliation":[{"name":"Institute of Physics, Kazan Federal University, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-9290","authenticated-orcid":false,"given":"Ilya A.","family":"Khodov","sequence":"additional","affiliation":[{"name":"Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1021\/acschembio.1c00756","article-title":"Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein","volume":"16","author":"Shuster","year":"2021","journal-title":"ACS Chem. 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