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A Memnoniella dichroa CF-080171 extract was identified to exhibit potent activity against Plasmodium falciparum 3D7 and Trypanosoma cruzi Tulahuen whole parasites in a high-throughput screening (HTS) campaign of microbial extracts from the Fundaci\u00f3n MEDINA\u2019s collection. Bioassay-guided isolation of the active metabolites from this extract afforded eight new meroterpenoids of varying potencies, namely, memnobotrins C-E (1\u20133), a glycosylated isobenzofuranone (4), a tricyclic isobenzofuranone (5), a tetracyclic benzopyrane (6), a tetracyclic isobenzofuranone (7), and a pentacyclic isobenzofuranone (8). The structures of the isolated compounds were established by (+)-ESI-TOF high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy. Compounds 1, 2, and 4 exhibited potent antiparasitic activity against P. falciparum 3D7 (EC50 0.04\u20130.243 \u03bcM) and T. cruzi Tulahuen (EC50 0.266\u20131.37 \u03bcM) parasites, as well as cytotoxic activity against HepG2 tumoral liver cells (EC50 1.20\u20134.84 \u03bcM). The remaining compounds (3, 5\u20138) showed moderate or no activity against the above-mentioned parasites and cells.<\/jats:p>","DOI":"10.3390\/pharmaceutics15020492","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T03:24:49Z","timestamp":1675308289000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antiparasitic Meroterpenoids Isolated from Memnoniella dichroa CF-080171"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3014-2750","authenticated-orcid":false,"given":"Frederick Boye","family":"Annang","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Centro de Excelencia en Investigaci\u00f3n de Medicamentos Innovadores de Andaluc\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud, Avda. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiomar","family":"P\u00e9rez-Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina \u201cL\u00f3pez-Neyra\u201d, Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Bosch-Navarrete","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina \u201cL\u00f3pez-Neyra\u201d, Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-6284","authenticated-orcid":false,"given":"Victor","family":"Gonz\u00e1lez-Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Centro de Excelencia en Investigaci\u00f3n de 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-615X","authenticated-orcid":false,"given":"Maria C.","family":"Ramos","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Centro de Excelencia en Investigaci\u00f3n de Medicamentos Innovadores de Andaluc\u00eda, Parque Tecnol\u00f3gico de Ciencias de la Salud, Avda. del Conocimiento 34, 18016 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Ruiz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina \u201cL\u00f3pez-Neyra\u201d, Consejo Superior de Investigaciones Cient\u00edficas (CSIC) Avda. del Conocimiento 17, Armilla, 18016 Granada, 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2023, January 24). 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