{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:56:20Z","timestamp":1790589380225,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Junta de Extremadura","award":["GR21042"],"award-info":[{"award-number":["GR21042"]}]},{"name":"Junta de Extremadura","award":["GR21075"],"award-info":[{"award-number":["GR21075"]}]},{"name":"Junta de Extremadura","award":["IB18013"],"award-info":[{"award-number":["IB18013"]}]},{"name":"Junta de Extremadura","award":["TA18002"],"award-info":[{"award-number":["TA18002"]}]},{"name":"Junta de Extremadura","award":["PD18020"],"award-info":[{"award-number":["PD18020"]}]},{"name":"European Social Fund","award":["GR21042"],"award-info":[{"award-number":["GR21042"]}]},{"name":"European Social Fund","award":["GR21075"],"award-info":[{"award-number":["GR21075"]}]},{"name":"European Social Fund","award":["IB18013"],"award-info":[{"award-number":["IB18013"]}]},{"name":"European Social Fund","award":["TA18002"],"award-info":[{"award-number":["TA18002"]}]},{"name":"European Social Fund","award":["PD18020"],"award-info":[{"award-number":["PD18020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The synthesis of analogs of cisplatin, which is a widely used chemotherapeutic agent, using other metal centers could be an alternative for cancer treatment. Pd(II) could be a substitute for Pt(II) due to its coordination chemistry similarity. For that reason, six squared-planar Pd(II) complexes with thiazine and thiazoline ligands and formula [PdCl2(L)] were synthesized and characterized in this work. The potential anticarcinogenic ability of the compounds was studied via cytotoxicity assay in three different human tumor cell lines, i.e., epithelial cervix carcinoma (HeLa), promyelocytic leukemia (HL-60), and histiocytic lymphoma (U-937). Data obtained showed that complexes with methyl substitutions did not modify cell viability, while no-methyl substituted compounds had a moderate cytotoxic effect on all three cell lines. The complexes with phenyl substitutions displayed the lowest IC50 values, which ranged between 46.39 \u00b1 3.99 \u03bcM and 62.74 \u00b1 6.45 \u03bcM. Moreover, Pd accumulation inside the cell was observed after incubation with any of the four complexes mentioned, and the two complexes with phenyl rings were found to induce an increase in the percentage of apoptotic cells. These results suggested that the presence of bulky substitutions on the ligands such as phenyl groups may influence the cytotoxicity of the chemotherapeutic agents synthesized.<\/jats:p>","DOI":"10.3390\/pharmaceutics15020696","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:27:01Z","timestamp":1676870821000},"page":"696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cytotoxic Effects of New Palladium(II) Complexes with Thiazine or Thiazoline Derivative Ligands in Tumor Cell Lines"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-6586","authenticated-orcid":false,"given":"Elena","family":"Fern\u00e1ndez-Delgado","sequence":"first","affiliation":[{"name":"Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-1463","authenticated-orcid":false,"given":"Samuel","family":"Estirado","sequence":"additional","affiliation":[{"name":"Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6063-0504","authenticated-orcid":false,"given":"Ana B.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-1449","authenticated-orcid":false,"given":"Francisco","family":"Luna-Giles","sequence":"additional","affiliation":[{"name":"Coordination Chemistry Research Group, Department of Organic and Inorganic Chemistry, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0634-1829","authenticated-orcid":false,"given":"Emilio","family":"Vi\u00f1uelas-Zah\u00ednos","sequence":"additional","affiliation":[{"name":"Coordination Chemistry Research Group, Department of Organic and Inorganic Chemistry, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8549-9343","authenticated-orcid":false,"given":"Javier","family":"Espino","sequence":"additional","affiliation":[{"name":"Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-9943","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Pariente","sequence":"additional","affiliation":[{"name":"Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Science, University of Extremadura, 06006 Badajoz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,18]]},"reference":[{"key":"ref_1","unstructured":"WHO Cancer (2022, November 25). 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