{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:02:39Z","timestamp":1787029359065,"version":"build-2736575974"},"reference-count":39,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004616","name":"CNCS-UEFISCDI","doi-asserted-by":"publisher","award":["348PED\/03.08.2020"],"award-info":[{"award-number":["348PED\/03.08.2020"]}],"id":[{"id":"10.13039\/501100004616","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004616","name":"CNCS-UEFISCDI","doi-asserted-by":"publisher","award":["24905\/08.11.2021"],"award-info":[{"award-number":["24905\/08.11.2021"]}],"id":[{"id":"10.13039\/501100004616","id-type":"DOI","asserted-by":"publisher"}]},{"name":"USAMV CN","award":["348PED\/03.08.2020"],"award-info":[{"award-number":["348PED\/03.08.2020"]}]},{"name":"USAMV CN","award":["24905\/08.11.2021"],"award-info":[{"award-number":["24905\/08.11.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The immunomodulatory effect of a novel biomaterial obtained through electrospinning, based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP), loaded with doxycycline (doxy) was evaluated in an animal model. The treatment capabilities as a local non-surgical treatment of periodontitis was investigated on the lower incisors of Wistar rats, after the induction of localized periodontitis using the ligature technique. Following the induction of the disease, the non-surgical treatment of scaling and root planing was applied, in conjunction with the application of the new material. The results of the treatment were evaluated clinically, using the tooth mobility and gingival index scores, as well as histologically. The salivary concentrations of matrix metalloproteinase 8 (MMP-8) and plasmatic concentrations of interleukin 1 (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-\u03b1) were also monitored. Two weeks after the ligature application, the periodontal disease was successfully induced in rats. The application of the novel biomaterial obtained through electrospinning was proven to be more effective in improving the clinical parameters, while decreasing the salivary MMP-8 and plasmatic IL-1 and TNF-\u03b1 concentrations, compared to the simple scaling and root planing. Thus, the novel electrospun biomaterial could be a strong candidate as an adjuvant to the non-surgical periodontal therapy.<\/jats:p>","DOI":"10.3390\/pharmaceutics15020707","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T05:27:01Z","timestamp":1676870821000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immunomodulatory Effect of Novel Electrospun Nanofibers Loaded with Doxycycline as an Adjuvant Treatment in Periodontitis"],"prefix":"10.3390","volume":"15","author":[{"given":"Vlad","family":"Andrei","sequence":"first","affiliation":[{"name":"Department of Oral Rehabilitation, Faculty of Dentistry, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-0963","authenticated-orcid":false,"given":"Sanda","family":"Andrei","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5967-4438","authenticated-orcid":false,"given":"Adrian Florin","family":"Gal","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Histology and Embryology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, 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Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-0259","authenticated-orcid":false,"given":"Mihaela","family":"Niculae","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka","family":"Barabas","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Engineering of Hungarian Line of Study, Faculty of Chemistry and Chemical Engineering, Babe\u0219-Bolyai University, 400028 Cluj-Napoca, 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and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmin Petru","family":"Pe\u0219tean","sequence":"additional","affiliation":[{"name":"Department of Surgery and Intensive Care, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hora\u021biu","family":"Rotar","sequence":"additional","affiliation":[{"name":"Department of Cranio-Maxillofacial Surgery, Faculty of Dentistry, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Boca","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Faculty of Dentistry, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, 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