{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:45:52Z","timestamp":1782276352558,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The purpose of this study was to investigate the applicability of the Gastrointestinal Simulator (GIS), a multi-compartmental dissolution model, to predict the in vivo performance of Biopharmaceutics Classification System (BCS) Class IIa compounds. As the bioavailability enhancement of poorly soluble drugs requires a thorough understanding of the desired formulation, the appropriate in vitro modelling of the absorption mechanism is essential. Four immediate release ibuprofen 200 mg formulations were tested in the GIS using fasted biorelevant media. In addition to the free acid form, ibuprofen was present as sodium and lysine salts in tablets and as a solution in soft-gelatin capsules. In the case of rapid-dissolving formulations, the dissolution results indicated supersaturation in the gastric compartment, which affected the resulting concentrations in the duodenum and the jejunum as well. In addition, a Level A in vitro\u2013in vivo correlation (IVIVC) model was established using published in vivo data, and then the plasma concentration profiles of each formulation were simulated. The predicted pharmacokinetic parameters were consistent with the statistical output of the published clinical study. In conclusion, the GIS method was found to be superior compared to the traditional USP method. In the future, the method can be useful for formulation technologists to find the optimal technique to enhance the bioavailability of poorly soluble acidic drugs.<\/jats:p>","DOI":"10.3390\/pharmaceutics15030753","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T03:01:01Z","timestamp":1677207661000},"page":"753","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multi-Compartmental Dissolution Method, an Efficient Tool for the Development of Enhanced Bioavailability Formulations Containing Poorly Soluble Acidic Drugs"],"prefix":"10.3390","volume":"15","author":[{"given":"Mikl\u00f3s Tam\u00e1s","family":"Katona","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Semmelweis University, 7 H\u0151gyes Endre Street, H-1092 Budapest, Hungary"},{"name":"Egis Pharmaceuticals PLC, 116-120 B\u00f6k\u00e9nyf\u00f6ldi Street, H-1165 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Nagy-Katona","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 3 M\u0171egyetem rakpart, H-1111 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Egis Pharmaceuticals PLC, 116-120 B\u00f6k\u00e9nyf\u00f6ldi Street, H-1165 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enik\u0151","family":"Borb\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 3 M\u0171egyetem rakpart, H-1111 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Tonka-Nagy","sequence":"additional","affiliation":[{"name":"Egis Pharmaceuticals PLC, 116-120 B\u00f6k\u00e9nyf\u00f6ldi Street, H-1165 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krisztina","family":"Tak\u00e1cs-Nov\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Semmelweis University, 7 H\u0151gyes Endre Street, H-1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ejps.2007.05.110","article-title":"When poor solubility becomes an issue: From early stage to proof of concept","volume":"31","author":"Stegemann","year":"2007","journal-title":"Eur. 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