{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:26:47Z","timestamp":1787066807453,"version":"build-2736575974"},"reference-count":53,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T00:00:00Z","timestamp":1677715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of Taiwan","award":["MOST 108-2628-E-027-003-MY3"],"award-info":[{"award-number":["MOST 108-2628-E-027-003-MY3"]}]},{"name":"Ministry of Science and Technology of Taiwan","award":["MOST 111-2221-E-027-105"],"award-info":[{"award-number":["MOST 111-2221-E-027-105"]}]},{"name":"Ministry of Science and Technology of Taiwan","award":["NTUT-Tohoku-110-02"],"award-info":[{"award-number":["NTUT-Tohoku-110-02"]}]},{"name":"National Taipei University of Technology\u2014Tohoku University Joint Research Program","award":["MOST 108-2628-E-027-003-MY3"],"award-info":[{"award-number":["MOST 108-2628-E-027-003-MY3"]}]},{"name":"National Taipei University of Technology\u2014Tohoku University Joint Research Program","award":["MOST 111-2221-E-027-105"],"award-info":[{"award-number":["MOST 111-2221-E-027-105"]}]},{"name":"National Taipei University of Technology\u2014Tohoku University Joint Research Program","award":["NTUT-Tohoku-110-02"],"award-info":[{"award-number":["NTUT-Tohoku-110-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Herein, we present a one-pot hydrothermal approach for synthesizing metal\u2013organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.32% after PDA coating and exhibited good photothermal stability. Moreover, NWs with a suitable T1 relaxivity coefficient (r1 = 3.01 mg\u22121 s\u22121) can be effectively used as magnetic resonance imaging (MRI) contrast agents. By increasing concentrations, cellular uptake studies showed a greater uptake of Cu-BTC@PDA NWs into cancer cells. Further, in vitro studies showed PDA-coated Cu-BTC NWs possess exceptional therapeutic performance by 808 nm laser irradiation, destroying 58% of cancer cells compared with the absence of laser irradiation. This promising performance is anticipated to advance the research and implementation of copper-based NWs as theranostic agents for cancer treatment.<\/jats:p>","DOI":"10.3390\/pharmaceutics15030822","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T02:56:50Z","timestamp":1677812210000},"page":"822","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy"],"prefix":"10.3390","volume":"15","author":[{"given":"Senthilkumar","family":"Thirumurugan","sequence":"first","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayalvizhi","family":"Samuvel Muthiah","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalakshmi","family":"Sakthivel","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Yi","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry, National Pingtung University, Pingtung 90003, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kasai","sequence":"additional","affiliation":[{"name":"Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai 980-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-3680","authenticated-orcid":false,"given":"Ren-Jei","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Biotechnology, National Taipei University of Technology (Taipei Tech), Taipei 10608, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1053\/j.gastro.2004.09.011","article-title":"Primary Liver Cancer: Worldwide Incidence and Trends","volume":"127","author":"Bosch","year":"2004","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"2019","article-title":"Anatomic versus Non-Anatomic Liver Resection for Hepatocellular Carcinoma: A Systematic Review","volume":"60","author":"Tang","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"ref_3","first-page":"1847","article-title":"Factors Affecting Recurrence and Survival after Living Donor Liver Transplantation for Hepatocellular Carcinoma","volume":"60","author":"Sultan","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1067\/msy.2000.104746","article-title":"Aggressive Surgical Approach to Recurrent Tumors after Hepatectomy for Metastatic Spread of Colorectal Cancer to the Liver","volume":"127","author":"Imamura","year":"2000","journal-title":"Surgery"},{"key":"ref_5","first-page":"2039","article-title":"Expanded Criteria for Hepatocellular Carcinoma after Liver Transplantation: A 20-Year Evolution","volume":"60","author":"Lai","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1002\/lt.20034","article-title":"The Barcelona Approach: Diagnosis, Staging, and Treatment of Hepatocellular Carcinoma","volume":"10","author":"Llovet","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.2147\/IJN.S257142","article-title":"Magnetite Nanoparticles and Spheres for Chemo-and Photothermal Therapy of Hepatocellular Carcinoma in Vitro","volume":"15","author":"Golba","year":"2020","journal-title":"Int. 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