{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:40:11Z","timestamp":1785519611648,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["06919"],"award-info":[{"award-number":["06919"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Courtois Foundation, Canada","award":["06919"],"award-info":[{"award-number":["06919"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in aqueous phase were evaluated with the aim to identify materials and procedures which would generate multifunctional excipients providing gastro-protection for controlled drug delivery. Chemical, structural and thermal characteristics of anionic and ampholytic High Amylose Starch (HAS) derivatives under powder (P), tablet (T) and film (F) forms were evaluated by X-ray Diffraction (XRD), Fourier Transformed Infrared (FTIR) and thermogravimetric analysis (TGA) methods and correlated with the behavior of tablets and films in simulated gastric and intestinal media. At low DS, the HAS carboxymethylation (CMHAS) in aqueous phase, generated tablets and films that were insoluble at ambient conditions. The CMHAS filmogenic solutions, with a lower viscosity, were easier to cast and gave smooth films without the use of plasticizer. Correlations were found between structural parameters and the properties of starch excipients. Compared to other starch modification procedures, the aqueous modification of HAS generated tunable multifunctional excipients that may be recommended for tablets and functional coatings for colon-targeted formulations.<\/jats:p>","DOI":"10.3390\/pharmaceutics15030834","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T06:29:06Z","timestamp":1678084146000},"page":"834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and Biopharmaceutical Applications: Structure-Properties Correlations"],"prefix":"10.3390","volume":"15","author":[{"given":"Marc-Andr\u00e9","family":"Labelle","sequence":"first","affiliation":[{"name":"Department of Chemistry, Research Chair on Enteric Dysfunctions \u2018Allerdys\u2019, CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC 3PC 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-9804","authenticated-orcid":false,"given":"Pompilia","family":"Ispas-Szabo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Research Chair on Enteric Dysfunctions \u2018Allerdys\u2019, CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC 3PC 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Tajer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Research Chair on Enteric Dysfunctions \u2018Allerdys\u2019, CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC 3PC 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences & CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC H3C 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7186-9756","authenticated-orcid":false,"given":"Beno\u00eet","family":"Barbeau","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences & CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC H3C 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5922-4701","authenticated-orcid":false,"given":"Mircea Alexandru","family":"Mateescu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Research Chair on Enteric Dysfunctions \u2018Allerdys\u2019, CERMO-FC Center, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C.P. 8888, Succursale Centre-Ville, Montr\u00e9al, QC 3PC 3P8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"ref_1","unstructured":"Mateescu, M.A., Ispas-Szabo, P., and Assaad, E. 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