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This work reports the preparation of organic-inorganic nanophases aiming for the development of drug delivery systems based on NAC intercalation into layered double hydroxides (LDH) of zinc\u2013aluminum (Zn2Al\u2013NAC) and magnesium\u2013aluminum (Mg2Al\u2013NAC) compositions. A detailed characterization of the synthesized hybrid materials was performed, including X-ray diffraction (XRD) and pair distribution function (PDF) analysis, infrared and Raman spectroscopies, solid-state 13carbon and 27aluminum nuclear magnetic resonance (NMR), simultaneous thermogravimetric and differential scanning calorimetry coupled to mass spectrometry (TG\/DSC\u2013MS), scanning electron microscopy (SEM), and elemental chemical analysis to assess both chemical composition and structure of the samples. The experimental conditions allowed to isolate Zn2Al\u2013NAC nanomaterial with good crystallinity and a loading capacity of 27.3 (m\/m)%. On the other hand, NAC intercalation was not successful into Mg2Al\u2013LDH, being oxidized instead. In vitro drug delivery kinetic studies were performed using cylindrical tablets of Zn2Al\u2013NAC in a simulated physiological solution (extracellular matrix) to investigate the release profile. After 96 h, the tablet was analyzed by micro-Raman spectroscopy. NAC was replaced by anions such as hydrogen phosphate by a slow diffusion-controlled ion exchange process. Zn2Al\u2013NAC fulfil basic requirements to be employed as a drug delivery system with a defined microscopic structure, appreciable loading capacity, and allowing a controlled release of NAC.<\/jats:p>","DOI":"10.3390\/pharmaceutics15030955","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T06:36:36Z","timestamp":1678862196000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of Dipeptide N\u2013acetyl\u2013L\u2013cysteine Loaded Nanostructured Carriers Based on Inorganic Layered Hydroxides"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-2494","authenticated-orcid":false,"given":"Denise","family":"Eul\u00e1lio","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo\u2014USP, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9389-2057","authenticated-orcid":false,"given":"Mariana","family":"Pires Figueiredo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo\u2014USP, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-2684","authenticated-orcid":false,"given":"Christine","family":"Taviot-Gueho","sequence":"additional","affiliation":[{"name":"Institut de Chimie de Clermont-Ferrand, Universit\u00e9 Clermont Auvergne, BP 10448, F-63000 Clermont-Ferrand, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 6296, Institut de Chimie de Clermont-Ferrand (ICCF), F-63178 Aubiere, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-9630","authenticated-orcid":false,"given":"Fabrice","family":"Leroux","sequence":"additional","affiliation":[{"name":"Institut de Chimie de Clermont-Ferrand, Universit\u00e9 Clermont Auvergne, BP 10448, F-63000 Clermont-Ferrand, France"},{"name":"Centre National de la Recherche Scientifique (CNRS), UMR 6296, Institut de Chimie de Clermont-Ferrand (ICCF), F-63178 Aubiere, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4250-6603","authenticated-orcid":false,"given":"Cristina Helena","family":"dos Reis Serra","sequence":"additional","affiliation":[{"name":"Departamento de Farm\u00e1cia, Faculdade de Ci\u00eancias Farmac\u00eauticas, Universidade de S\u00e3o Paulo\u2014USP, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-6522","authenticated-orcid":false,"given":"Dalva L\u00facia Ara\u00fajo de","family":"Faria","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo\u2014USP, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-7329","authenticated-orcid":false,"given":"Vera Regina Leopoldo","family":"Constantino","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Fundamental, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo\u2014USP, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1515\/jbcpp-2020-0099","article-title":"An Insight on Safety, Efficacy, and Molecular Docking Study Reports of N-Acetylcysteine and Its Compound Formulations","volume":"33","author":"Rind","year":"2022","journal-title":"J. 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