{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:59:17Z","timestamp":1791813557522,"version":"4.3.4"},"reference-count":172,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:00:00Z","timestamp":1679011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Innovation Strategy (RIS)","award":["2021RIS-001"],"award-info":[{"award-number":["2021RIS-001"]}]},{"name":"Regional Innovation Strategy (RIS)","award":["NRF-2020R1A2C1102831"],"award-info":[{"award-number":["NRF-2020R1A2C1102831"]}]},{"name":"Regional Innovation Strategy (RIS)","award":["NRF-2021R1A2C2095113"],"award-info":[{"award-number":["NRF-2021R1A2C2095113"]}]},{"name":"Regional Innovation Strategy (RIS)","award":["2021R1A6A1A03046418"],"award-info":[{"award-number":["2021R1A6A1A03046418"]}]},{"name":"Regional Innovation Strategy (RIS)","award":["NRF-2022R1A4A3034038"],"award-info":[{"award-number":["NRF-2022R1A4A3034038"]}]},{"name":"Ministry of Science and ICT","award":["2021RIS-001"],"award-info":[{"award-number":["2021RIS-001"]}]},{"name":"Ministry of Science and ICT","award":["NRF-2020R1A2C1102831"],"award-info":[{"award-number":["NRF-2020R1A2C1102831"]}]},{"name":"Ministry of Science and ICT","award":["NRF-2021R1A2C2095113"],"award-info":[{"award-number":["NRF-2021R1A2C2095113"]}]},{"name":"Ministry of Science and ICT","award":["2021R1A6A1A03046418"],"award-info":[{"award-number":["2021R1A6A1A03046418"]}]},{"name":"Ministry of Science and ICT","award":["NRF-2022R1A4A3034038"],"award-info":[{"award-number":["NRF-2022R1A4A3034038"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, and it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, and functional, molecularly modified radiolabelled peptides have been used to produce biomolecules and therapeutics that are vastly utilised in the field of radio medicine. Since the 1990s, they have smoothly transitioned into clinical application, and as of today, a wide variety of radiolabelled radionuclide derivatives have been examined and evaluated in various studies. Advanced technologies, such as conjugation of functional peptides or incorporation of radionuclides into chelating ligands, have been developed for advanced radiopharmaceutical cancer therapy. New radiolabelled conjugates for targeted radiotherapy have been designed to deliver radiation directly to cancer cells with improved specificity and minimal damage to the surrounding normal tissue. The development of new theragnostic radionuclides, which can be used for both imaging and therapy purposes, allows for more precise targeting and monitoring of the treatment response. The increased use of peptide receptor radionuclide therapy (PRRT) is also important in the targeting of specific receptors which are overexpressed in cancer cells. In this review, we provide insights into the development of radionuclides and functional radiolabelled peptides, give a brief background, and describe their transition into clinical application.<\/jats:p>","DOI":"10.3390\/pharmaceutics15030971","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T04:10:48Z","timestamp":1679026248000},"page":"971","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1368-484X","authenticated-orcid":false,"given":"Kushal","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of IT and Energy Convergence (BK21 FOUR), Korea National University of Transportation, Chungju 27469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagannath","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Green Bio Engineering, Graduate School, Korea National University of Transportation, Chungju 27469, Republic of Korea"},{"name":"4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Man","family":"An","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, College of Engineering, Hanyang University, Seoul 04763, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6332-3278","authenticated-orcid":false,"given":"Jooho","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Applied Life Science, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Republic of Korea"},{"name":"Research Institute for Biomedical & Health Science, Konkuk University, Chungju 27478, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Kyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Green Bio Engineering, Graduate School, Korea National University of Transportation, Chungju 27469, Republic of Korea"},{"name":"4D Convergence Technology Institute, Korea National University of Transportation, Jeungpyeong 27909, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sim\u00f3n, M., J\u00f8rgensen, J.T., Khare, H.A., Christensen, C., Nielsen, C.H., and Kjaer, A. 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