{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:23:56Z","timestamp":1792099436861,"version":"4.4.0"},"reference-count":512,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21971212"],"award-info":[{"award-number":["21971212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SWU-XDZD22007"],"award-info":[{"award-number":["SWU-XDZD22007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Project of Innovation Research 2035 Pilot Plan of Southwest University","award":["21971212"],"award-info":[{"award-number":["21971212"]}]},{"name":"Key Project of Innovation Research 2035 Pilot Plan of Southwest University","award":["SWU-XDZD22007"],"award-info":[{"award-number":["SWU-XDZD22007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.<\/jats:p>","DOI":"10.3390\/pharmaceutics15051348","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:33:40Z","timestamp":1682645620000},"page":"1348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes"],"prefix":"10.3390","volume":"15","author":[{"given":"Shu-Rui","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Min","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Technology, Shijiazhuang University, Shijiazhuang 050035, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-5465","authenticated-orcid":false,"given":"Cheng-He","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic & Medicinal Chemistry, Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"key":"ref_1","first-page":"1587","article-title":"Supermolecules as Medicinal Drugs","volume":"Volume 2","author":"Liu","year":"2020","journal-title":"Handbook of Macrocyclic Supramolecular Assembly"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1039\/b926224p","article-title":"The uses of supramolecular chemistry in synthetic methodology development: Examples of anion and neutral molecular recognition","volume":"39","author":"Joyce","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1039\/C1CS15220C","article-title":"Supramolecular polymers constructed by crown ether-based molecular recog-nition","volume":"41","author":"Zheng","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1016\/j.ccr.2008.11.019","article-title":"Metallomicellar supramolecular systems and their applications in catalytic reac-tions","volume":"253","author":"Zhang","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6011","DOI":"10.1039\/C4CS00094C","article-title":"Applications of metal\u2013organic frameworks in heterogeneous supramolecular catalysis","volume":"43","author":"Liu","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1039\/D2SC01770A","article-title":"Supramolecular assembly confined purely organic room temperature phosphores-cence and its biological imaging","volume":"13","author":"Zhou","year":"2022","journal-title":"Chem. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1039\/C9CS00326F","article-title":"Assembly strategies of organic-based imaging agents for fluorescence and photoa-coustic bioimaging applications","volume":"49","author":"Cheng","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.ccr.2009.01.015","article-title":"Supramolecular aggregates containing lipophilic Gd(III) complex-es as contrast agents in MRI","volume":"253","author":"Accardo","year":"2009","journal-title":"Coord. Chem. Rev."},{"key":"ref_9","first-page":"208","article-title":"Research in supramolecular chemical drugs","volume":"39","author":"Zhou","year":"2009","journal-title":"Sci. China Ser. B Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11426-009-0103-2","article-title":"Review on supermolecules as chemical drugs","volume":"52","author":"Zhou","year":"2009","journal-title":"Sci. China Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.6023\/cjoc201509006","article-title":"Current researches and applications of azole-based supermolecules as medici-nal agents","volume":"36","author":"Cheng","year":"2016","journal-title":"Chin. J. Org. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1021\/acs.jmedchem.5b01678","article-title":"Novel 3-aminothiazolquinolones: Design, synthesis, bioactive evaluation, SARs, and pre-liminary antibacterial mechanism","volume":"59","author":"Cui","year":"2016","journal-title":"J. Med. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/9781608054961113020005","article-title":"Recent developments in organometallic supramolecular complexes as anticancer drugs","volume":"2","author":"Zhou","year":"2013","journal-title":"Adv. Anticancer. Agents Med. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.2174\/15680266113139990125","article-title":"Recent Developments in Azole Compounds as Antibacterial and Antifungal Agents","volume":"13","author":"Peng","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/1389557516666160630120725","article-title":"New Progress in Azole Compounds as Antimicrobial Agents","volume":"17","author":"Zhang","year":"2016","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.4155\/fmc-2016-0002","article-title":"Quinazolinone azolyl ethanols: Potential lead anti-bacterial agents with dual action modes targeting MRSA DNA","volume":"8","author":"Peng","year":"2016","journal-title":"Future Med. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/med.21290","article-title":"Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry","volume":"34","author":"Zhang","year":"2014","journal-title":"Med. Res. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1360\/N032018-00098","article-title":"Researches and applica-tions of nitroimidazole heterocycles in medicinal chemistry","volume":"49","author":"Li","year":"2019","journal-title":"Sci. Sin. Chim."},{"key":"ref_19","first-page":"404","article-title":"Progress in research of histamine H3 receptor ligands","volume":"42","author":"Wu","year":"2007","journal-title":"Chin. Pharm. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2174\/092986712803414213","article-title":"Recent researches in triazole compounds as medicinal drugs","volume":"19","author":"Zhou","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1360\/032010-843","article-title":"Recent advances in the researches of triazole compounds as medicinal drugs","volume":"41","author":"Wang","year":"2011","journal-title":"Sci. Sin. Chim."},{"key":"ref_22","first-page":"481","article-title":"Research progress of 1,2,3-triazole medicinal compounds","volume":"46","author":"Wei","year":"2011","journal-title":"Chin. Pharm. J."},{"key":"ref_23","first-page":"1970","article-title":"Recent advances in supramolecular chemistry and drugs of triazole","volume":"32","author":"Chang","year":"2011","journal-title":"Chem. J. Chin. Univ."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.6023\/cjoc201208036","article-title":"Recent Advances in the Synthesis and Application of Tetrazoles","volume":"33","author":"Dai","year":"2013","journal-title":"Chin. J. Org. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/C4MD00266K","article-title":"Synthesis of tetrazole compounds as a novel type of potential antimicrobial agents and their synergistic effects with clinical drugs and interactions with calf thymus DNA","volume":"6","author":"Dai","year":"2015","journal-title":"Med. Chem. Comm."},{"key":"ref_26","first-page":"1105","article-title":"Recent advances in application researches of thiazole compounds","volume":"42","author":"Cui","year":"2012","journal-title":"Sci. Sin. Chim."},{"key":"ref_27","first-page":"311","article-title":"Recent advances in the researches on thiazole compounds as enzyme and acceptor inhibitors","volume":"33","author":"Cui","year":"2012","journal-title":"Chin. J. Biochem. Pharm."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chen, J.-P., Battini, N., Ansari, M.F., and Zhou, C.-H. (2021). Membrane active 7-thiazoxime quinolones as novel DNA binding agents to decrease the genes expression and exert potent anti-methicillin-resistant Staphylococcus aureus activity. Eur. J. Med. Chem., 217.","DOI":"10.1016\/j.ejmech.2021.113340"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.ejmech.2017.12.044","article-title":"Recent advance in oxazole-based medicinal chemistry","volume":"144","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_30","first-page":"1963","article-title":"Recent advances in syntheses of oxazole compounds","volume":"31","author":"Zhang","year":"2011","journal-title":"Chin. J. Org. Chem."},{"key":"ref_31","first-page":"1505","article-title":"Advances in the research of benzimidazole drugs","volume":"18","author":"Meng","year":"2009","journal-title":"Chin. J. New Drugs"},{"key":"ref_32","first-page":"418","article-title":"Advances in the research of benzimidazole compounds as enzyme inhibitors","volume":"29","author":"Meng","year":"2008","journal-title":"Chin. J. Biochem. Pharm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4172\/2161-0444.1000207","article-title":"Recent Development of Benzotriazole-based Medicinal Drugs","volume":"4","author":"Ren","year":"2014","journal-title":"Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/cjoc.201600639","article-title":"Chalcone-Benzotriazole Conjugates as New Potential Antimicrobial Agents: Design, Synthesis, Biological Evaluation and Synergism with Clinical Drugs","volume":"35","author":"Liu","year":"2017","journal-title":"Chin. J. Chem."},{"key":"ref_35","first-page":"783","article-title":"New progress of researches in carbazole compounds","volume":"30","author":"Zhang","year":"2010","journal-title":"Chin. J. Org. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.ejmech.2018.06.022","article-title":"Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi","volume":"155","author":"Zhang","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/acs.jmedchem.2c00001","article-title":"Unique Carbazole-Oxadiazole Derivatives as New Potential Antibiotics for Combating Gram-Positive and -Negative Bacteria","volume":"65","author":"Xie","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1021\/acsmedchemlett.7b00514","article-title":"Potential Antimicrobial Isopropanol-Conjugated Carbazole Azoles as Dual Targeting Inhibitors of Enterococcus faecalis","volume":"9","author":"Zhang","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1360\/N032016-00029","article-title":"Recent advance in sulfonamide-based medicinal chemistry","volume":"46","author":"He","year":"2016","journal-title":"Sci. Sin. Chim."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1002\/anie.201610456","article-title":"Sulfonimidamides in Medicinal and Agricultural Chemistry","volume":"56","author":"Chinthakindi","year":"2017","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wan, Y., Fang, G., Chen, H., Deng, X., and Tang, Z. (2021). Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation. Eur. J. Med. Chem., 226.","DOI":"10.1016\/j.ejmech.2021.113837"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.2174\/1568026616666160506145943","article-title":"Heterocyclic naphthalimides as new skeleton structure of compounds with in-creasingly expanding relational medicinal applications","volume":"16","author":"Gong","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1021\/acsmedchemlett.7b00452","article-title":"Novel naphthalimide amino-thiazoles as potential multitargeting antimicrobial agents","volume":"8","author":"Chen","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.2174\/092986709787846659","article-title":"Naphthalimides and azonafides as promising anti-cancer agents","volume":"16","author":"Ingrassia","year":"2009","journal-title":"Curr. Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.2174\/1381612811319210013","article-title":"Current Developments of Coumarin Compounds in Medicinal Chemistry","volume":"19","author":"Peng","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Yang, X.-C., Zeng, C.-M., Avula, S.R., Peng, X.-M., Geng, R.-X., and Zhou, C.-H. (2023). Novel coumarin aminophosphonates as potential multitargeting antibacterial agents against Staphylococcus aureus. Eur. J. Med. Chem., 245.","DOI":"10.1016\/j.ejmech.2022.114891"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Patil, S.A., Kandathil, V., Sobha, A., Somappa, S.B., Feldman, M.R., Bugarin, A., and Patil, S.A. (2022). Comprehensive review on medic-inal applications of coumarin-derived imine-metal complexes. Molecules, 27.","DOI":"10.3390\/molecules27165220"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Qin, H.-L., Zhang, Z.-W., Ravindar, L., and Rakesh, K. (2020). Antibacterial activities with the structure-activity relationship of coumarin derivatives. Eur. J. Med. Chem., 207.","DOI":"10.1016\/j.ejmech.2020.112832"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.4155\/fmc-2017-0108","article-title":"Antimicrobial 2-aminothiazolyl quinolones: What is their potential in the clinic?","volume":"9","author":"Gao","year":"2017","journal-title":"Future Med. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1016\/j.bmcl.2013.03.118","article-title":"Synthesis and biological evaluation of a novel class of quinolone triazoles as potential antimicrobial agents and their interactions with calf thymus DNA","volume":"23","author":"Cui","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1021\/acs.jafc.2c08293","article-title":"New efforts toward aminothiazolylquinolones with multi-targeting antibacterial potential","volume":"71","author":"Zhang","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/cjoc.202000627","article-title":"Synthesis and Biological Evaluation of Quinazolonethiazoles as New Potential Conquerors towards Pseudomonas aeruginosa","volume":"39","author":"Wang","year":"2020","journal-title":"Chin. J. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/acs.jmedchem.1c00334","article-title":"Identification of Unique Quinazolone Thiazoles as Novel Structural Scaffolds for Potential Gram-Negative Bacterial Conquerors","volume":"64","author":"Wang","year":"2021","journal-title":"J. Med. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1360\/N032017-00026","article-title":"Design and synthesis of quinazolinone imid-azoles and their antibacterial and DNA-targeting investigation","volume":"47","author":"Cao","year":"2017","journal-title":"Sci. Sin. Chim."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1021\/acs.jmedchem.1c01592","article-title":"Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant Escherichia coli","volume":"65","author":"Sun","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s11426-017-9169-4","article-title":"Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli","volume":"61","author":"Zhang","year":"2018","journal-title":"Sci. China Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejmech.2018.01.038","article-title":"Discovery of 2-aminothiazolyl berberine derivatives as effectively antibacterial agents toward clinically drug-resistant Gram-negative Acinetobacter baumanii","volume":"146","author":"Gao","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/C8QO01180J","article-title":"Novel potential artificial MRSA DNA intercalators: Synthesis and biological evaluation of berberine-derived thiazolidinediones","volume":"6","author":"Sun","year":"2019","journal-title":"Org. Chem. Front."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Li, F.-F., Zhao, W.-H., Tangadanchu, V.K.R., Meng, J.-P., and Zhou, C.-H. (2022). Discovery of novel phenylhydrazone-based oxindole-thiolazoles as potent antibacterial agents toward Pseudomonas aeruginosa. Eur. J. Med. Chem., 239.","DOI":"10.1016\/j.ejmech.2022.114521"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Tangadanchu, V.K.R., Sui, Y.-F., and Zhou, C.-H. (2021). Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation. Bioorganic Med. Chem. Lett., 41.","DOI":"10.1016\/j.bmcl.2021.128030"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.3390\/molecules18066620","article-title":"Biomedical Importance of Indoles","volume":"18","author":"Kaushik","year":"2013","journal-title":"Molecules"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Sui, Y.-F., Ansari, M.F., Fang, B., Zhang, S.-L., and Zhou, C.-H. (2021). Discovery of novel purinylthiazolylethanone derivatives as anti-Candida albicans agents through possible multifaceted mechanisms. Eur. J. Med. Chem., 221.","DOI":"10.1016\/j.ejmech.2021.113557"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/cplu.201600293","article-title":"Luminescent Silver-Purine Double Helicate: Synthesis, Self-Assembly and Antibacterial Action","volume":"81","author":"Venkatesh","year":"2016","journal-title":"Chempluschem"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Deng, Z., Bheemanaboina, R.R.Y., Luo, Y., and Zhou, C.H. (2022). Aloe emodin-conjugated sulfonyl hydrazones as novel type of anti-bacterial modulators against S. aureus 25923 through multifaceted synergistic effects. Bioorg. Chem., 127.","DOI":"10.1016\/j.bioorg.2022.106035"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1039\/D0MD00429D","article-title":"Aloe-emodin derived azoles as a new structural type of potential antibacterial agents: Design, synthesis, and evaluation of the action on membrane, DNA, and MRSA DNA isomerase","volume":"12","author":"Liang","year":"2021","journal-title":"RSC Med. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Deng, Z., Sun, H., Bheemanaboina, R.R.Y., Luo, Y., and Zhou, C.H. (2022). Natural aloe emodin-hybridized sulfonamide aminophos-phates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis. Bioorg. Med. Chem. Lett., 64.","DOI":"10.1016\/j.bmcl.2022.128695"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Sui, Y.-F., Li, D., Wang, J., Bheemanaboina, R.R.Y., Ansari, M.F., Gan, L.-L., and Zhou, C.-H. (2020). Design and biological evaluation of a novel type of potential multi-targeting antimicrobial sulfanilamide hybrids in combination of pyrimidine and azoles. Bioorganic Med. Chem. Lett., 30.","DOI":"10.1016\/j.bmcl.2020.126982"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Tan, Y.-M., Li, D., Li, F.-F., Ansari, M.F., Fang, B., and Zhou, C.-H. (2022). Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents. Bioorganic Med. Chem. Lett., 73.","DOI":"10.1016\/j.bmcl.2022.128885"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Tolomeu, H.V., and Fraga, C.A.M. (2023). Imidazole: Synthesis, functionalization and physicochemical properties of a privileged struc-ture in medicinal chemistry. Molecules, 28.","DOI":"10.3390\/molecules28020838"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1021\/ic011291v","article-title":"Synthesis and structural, spectroscopic, and elec-trochemical characterization of new ruthenium dimethyl sulfoxide nitrosyls","volume":"41","author":"Serli","year":"2002","journal-title":"Inorg. Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1021\/cr4002935","article-title":"Man-Made Cytotoxic Steroids: Exemplary Agents for Cancer Therapy","volume":"114","author":"Bansal","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_72","first-page":"1281","article-title":"Research progress in antitumor drugs of nitrogen mustard","volume":"44","author":"Zhuang","year":"2008","journal-title":"Chin. Pharm. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1517\/13543776.17.9.1061","article-title":"Alkylating agents and cancer therapy","volume":"17","author":"Ralhan","year":"2007","journal-title":"Expert Opin. Ther. Patents"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/1871520611009050371","article-title":"Recent researches in metal supramolecular complexes as anti-cancer agents","volume":"10","author":"Zhou","year":"2010","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","article-title":"Novel metals and metal complexes as plat-forms for cancer therapy","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_76","first-page":"481","article-title":"Advances in macrocyclic drugs","volume":"43","author":"Yu","year":"2008","journal-title":"Chin. Pharm. J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1158\/0008-5472.CAN-14-2598","article-title":"Mechanisms of Hypoxia-Mediated Immune Escape in Cancer","volume":"74","author":"Barsoum","year":"2014","journal-title":"Cancer Res"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1002\/anie.201403036","article-title":"Engineered Nanoparticles for Drug Delivery in Cancer Therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"10241","DOI":"10.1021\/jm500865u","article-title":"DNA repair and redox activities and inhibitors of apurinic\/apyrimidinic endonuclease 1\/redox effector factor 1 (ape1\/ref-1): A comparative analysis and their scope and limitations toward anti-cancer drug development","volume":"57","author":"Kaur","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"272","DOI":"10.2174\/1389557516666151120120524","article-title":"Recent advances on dark and light-activated cytotoxity of imidazole-containing rutheni-um complexes","volume":"16","author":"Liu","year":"2016","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1039\/C2CS35314H","article-title":"Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs","volume":"42","author":"Liu","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.2174\/092986712800672067","article-title":"Recent Progress and Future Potential for Metal Complexes as Anticancer Drugs Targeting G-quadruplex DNA","volume":"19","author":"Zhang","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.2174\/0929867321666140216125721","article-title":"The combined therapeutical effect of metal-based drugs and radia-tion therapy: The present status of research","volume":"21","author":"Ceresa","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3184\/003685014X13904811808460","article-title":"Platinum Anticancer Drugs and Photochemotherapeutic Agents: Recent Advances and Future Developments","volume":"97","author":"Shaili","year":"2014","journal-title":"Sci. Prog."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1039\/C2CS35259A","article-title":"Targeting and delivery of platinum-based anticancer drugs","volume":"42","author":"Wang","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.bmc.2017.02.010","article-title":"In Vitro anticancer activity evaluation of new cationic platinum(II) complexes based on imidazole moiety","volume":"25","author":"Rimoldi","year":"2017","journal-title":"Bioorganic Med. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.poly.2018.05.062","article-title":"Plati-num(II)-azoimidazole drugs against TB and cancer: Structural studies, cytotoxicity and anti-mycobacterial activity","volume":"152","author":"Sen","year":"2018","journal-title":"Polyhedron"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1021\/acs.jmedchem.1c01248","article-title":"Pt(II)-NHC Complex Induces ROS-ERS-Related DAMP Balance to Harness Immunogenic Cell Death in Hepatocellular Carcinoma","volume":"65","author":"Bian","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Czarnomysy, R., Muszynska, A., Rok, J., Rzepka, Z., and Bielawski, K. (2021). Mechanism of anticancer action of novel imidazole plati-num(ii) complex conjugated with G2 PAMAM-OH dendrimer in breast cancer cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22115581"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"15390","DOI":"10.1039\/C6DT02350A","article-title":"Novel cis-[(NHC)1(NHC)2(L)Cl]platinum(ii) complexes synthesis, structures, and anticancer activities","volume":"45","author":"Rehm","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.saa.2011.11.024","article-title":"Molecular structure of 2-chloromethyl-1H-benzimidazole hydrochloride: Single crystal, spectral, biological studies, and DFT calculations","volume":"86","author":"Ghani","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3109\/14756360903282858","article-title":"Synthesis, characterization, cytotoxicity, and DNA binding of some new platinum(II) and platinum(IV) complexes with benzimidazole ligands","volume":"25","author":"Utku","year":"2010","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/14756366.2011.594046","article-title":"Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands","volume":"27","author":"Utku","year":"2012","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_94","first-page":"487","article-title":"Beyond platinums: Gold complexes as anticancer agents","volume":"34","author":"Nardon","year":"2014","journal-title":"Anticancer. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ejmech.2014.05.036","article-title":"Recent developments of metal N-heterocyclic carbenes as anti-cancer agents","volume":"81","author":"Aher","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1021\/jm901693m","article-title":"N-Heterocyclic Carbene-Amine Pt(II) Complexes, a New Chemical Space for the Development of Platinum-Based Anticancer Drugs","volume":"53","author":"Skander","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1021\/jm300428v","article-title":"Gold(I) carbene complexes caus-ing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents","volume":"55","author":"Schuh","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1002\/anie.201612583","article-title":"Cyclometalated gold(III) complexes con-taining N-heterocyclic carbene ligands engage multiple anti-cancer molecular targets","volume":"56","author":"Fung","year":"2017","journal-title":"Angew. Chem. Int. Edit."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.ejmech.2018.06.002","article-title":"In Vitro and In Vivo studies of gold(I) azolate\/phosphane complexes for the treatment of basal like breast cancer","volume":"155","author":"Gambini","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.1016\/j.tetlet.2018.06.040","article-title":"Synthesis and anticancer activity of novel NHC-gold(I)-sugar complexes","volume":"59","author":"Dada","year":"2018","journal-title":"Tetrahedron Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1039\/C7DT01377A","article-title":"Gold(I)-BODIPY-imidazole bimetallic complexes as new potential anti-inflammatory and anti-cancer trackable agents","volume":"46","author":"Trommenschlager","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/ic401731a","article-title":"Chemistry and Biology of Two Novel Gold(I) Carbene Complexes as Prospective Anticancer Agents","volume":"53","author":"Messori","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Xiao, Q.M., Liu, Y.H., and Zhang, Z.B. (2022). Heteroleptic Gold(I)-bisNHC complex with excellent activity In Vitro, ex vivo and In Vivo against endometrial cancer. Eur. J. Med. Chem., 236.","DOI":"10.1016\/j.ejmech.2022.114302"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1021\/acs.jmedchem.0c00257","article-title":"Halo and pseudohalo gold(I)-NHC complexes derived from 4,5-diarylimidazoles with excellent In Vitro and In Vivo anticancer activities against HCC","volume":"63","author":"Bian","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jinorgbio.2014.08.013","article-title":"Synthesis and biological assays on cancer cells of dinuclear gold complexes with novel functionalised di(N-heterocyclic carbene) ligands","volume":"141","author":"Baron","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"12421","DOI":"10.1039\/c3dt51071a","article-title":"Cationic gold(I) heteroleptic complexes bearing a pyrazole-derived N-heterocyclic car-bene: Syntheses, characterizations, and cytotoxic activities","volume":"42","author":"Sivaram","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2174\/0929867321666131217161849","article-title":"Metal-N-heterocyclic carbene complexes as anti-tumor agents","volume":"21","author":"Hu","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1021\/acs.organomet.0c00069","article-title":"Silver(I) N-Heterocyclic Carbene Complexes Derived from Clotrimazole: Antiproliferative Activity and Interaction with an Artificial Membrane-Based Biosensor","volume":"39","author":"Mohamed","year":"2020","journal-title":"Organometallics"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.inoche.2014.03.016","article-title":"Silver(I)-N-heterocyclic carbene complexes of nitrile-functionalized imidazol-2-ylidene ligands as anticancer agents","volume":"44","author":"Haque","year":"2014","journal-title":"Inorg. Chem. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jinorgbio.2013.09.011","article-title":"Synthesis and In Vitro antitumor activity of water-soluble sulfonate\u2014And ester-functionalized silver(I) N-heterocyclic carbene complexes","volume":"129","author":"Gandin","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1021\/ic3013188","article-title":"Synthesis and biological activity of ester\u2014And amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes","volume":"51","author":"Pellei","year":"2012","journal-title":"Inorg. Chem."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ica.2013.11.011","article-title":"Topology control in nitrile-functionalized silver(I)-N-heterocyclic carbene complexes: Synthesis, molecular structures, and In Vitro anticancer studies","volume":"411","author":"Zulikha","year":"2014","journal-title":"Inorg. Chim. Acta"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.inoche.2012.05.037","article-title":"Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and In Vitro anticancer studies","volume":"22","author":"Haque","year":"2012","journal-title":"Inorg. Chem. Commun."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1080\/00958972.2013.831406","article-title":"Synthesis, crystal structures, In Vitro anticancer, and In Vivo acute oral toxicity studies of bis-imidazolium\/benzimidazolium salts and respective dinu-clear Ag(I)-N-heterocyclic carbene complexes","volume":"66","author":"Haque","year":"2013","journal-title":"J. Coord. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e3819","DOI":"10.1002\/aoc.3819","article-title":"Non-symmetrically p -nitrobenzyl-substituted N -heterocyclic carbene-silver(I) complexes as metallopharmaceutical agents","volume":"31","author":"Shahini","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/cmdc.201800672","article-title":"A Fluorescent Silver(I) Carbene Complex with Anticancer Properties: Synthesis, Characterization, and Biological Studies","volume":"14","author":"Fabbrini","year":"2019","journal-title":"Chemmedchem"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Carrasco, C.J., Montilla, F., \u00c1lvarez, E., Calder\u00f3n-Monta\u00f1o, J.M., L\u00f3pez-L\u00e1zaro, M., and Galindo, A. (2022). Chirality influence on the cytotoxic properties of anionic chiral bis(N-heterocyclic carbene)silver complexes. J. Inorg. Biochem., 235.","DOI":"10.1016\/j.jinorgbio.2022.111924"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Stryjska, K., Radko, L., Ch\u0119ci\u0144ska, L., Kusz, J., Posyniak, A., and Ochocki, J. (2020). Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103629"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Kutlu, T., Yildirim, I., Karabiyik, H., Kilincli, A., Tekedereli, I., Gok, Y., Dikmen, M., and Aktas, A. (2021). Cytotoxic activity and apop-tosis induction by a series Ag(I)-NHC complexes on human breast cancer cells and non-tumorigenic epithelial cell line. J. Mol. Struct., 1228.","DOI":"10.1016\/j.molstruc.2020.129462"},{"key":"ref_120","first-page":"126987","article-title":"Synthesis, characterization, and investigation of antiproliferative activity of novel Ag (I)-N-Heterocyclic Carbene (NHC) compounds","volume":"1199","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1080\/00958972.2019.1697808","article-title":"Synthesis and antitumor activity of new silver(I)-N-heterocyclic carbene com-plexes","volume":"72","author":"Sahin","year":"2019","journal-title":"J. Coord. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jscs.2019.03.002","article-title":"Unsymmetrically substituted benzimid-azolium based Silver(I)-N-heterocyclic carbene complexes: Synthesis, characterization and In Vitro anticancer study against human breast cancer and colon cancer","volume":"23","author":"Habib","year":"2019","journal-title":"J. Saudi Chem. Soc."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1080\/00958972.2016.1230670","article-title":"Synthesis, crystal structure, In Vitro anticancer and In Vivo acute oral toxicity studies of tetramethylene linked bis-benzimidazolium salts and their respective dinuclear Ag(I)\u2013NHC complexes","volume":"69","author":"Fatima","year":"2016","journal-title":"J. Coord. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s00044-012-0240-6","article-title":"Synthesis and anticancer activity of para-xylyl linked bis-benzimidazolium salts and respective Ag(I) N-heterocyclic carbene complexes","volume":"22","author":"Iqbal","year":"2013","journal-title":"Med. Chem. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.1080\/00958972.2015.1084618","article-title":"New chiral \u03b1-ketoimine-Pd(II) complexes and their anticancer activity","volume":"68","author":"Portillo","year":"2015","journal-title":"J. Coord. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/00958972.2014.890717","article-title":"Synthesis, characterization, and antitumor activities of new palladium(II) complex-es with 1-(alkyldithiocarbonyl)imidazoles","volume":"67","author":"Hou","year":"2014","journal-title":"J. Coord. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Ramezanpour, A., Karami, K., Kharaziha, M., Zakariazadeh, M., Lipkowski, J., Shahpiri, A., Azizi, N., and Namazian, M. (2021). A mononuclear PdII complex with Naphcon; crystal structure, experimental and computational studies of the interaction with DNA\/BSA and evaluation of anticancer activity. Polyhedron, 206.","DOI":"10.1016\/j.poly.2021.115333"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1080\/00958972.2011.587004","article-title":"Synthesis and characterization of some potential antitumor palladium(II) complexes of 2-aminomethylbenzimidazole and amino acids","volume":"64","year":"2011","journal-title":"J. Coord. Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"14106","DOI":"10.1039\/D0DT02598D","article-title":"Macrocyclic NHC complexes of group 10 elements with enlarged aromaticity for biological studies","volume":"49","author":"Bernd","year":"2020","journal-title":"Dalton Trans."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cbpa.2014.02.003","article-title":"Metal-based anticancer chemotherapeutic agents","volume":"19","author":"Muhammad","year":"2014","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref_131","first-page":"107","article-title":"Progress on the study of non-platinum metallic drugs in antitumor","volume":"18","author":"Xu","year":"2006","journal-title":"Prog. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.drudis.2009.09.003","article-title":"Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs","volume":"14","author":"Sadler","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1039\/b706075k","article-title":"Developing new metal-based therapeutics: Challenges and opportunities","volume":"43","author":"Hambley","year":"2007","journal-title":"Dalton Trans."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1158\/1078-0432.CCR-03-0746","article-title":"A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent","volume":"10","author":"Pluim","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1002\/chem.201301389","article-title":"Ruthenium-arene-carboline complexes as potent inhibitors of cyclin-dependent kinase1: Synthesis, characterization and anticancer mechanism studies","volume":"19","author":"He","year":"2013","journal-title":"Chem. Eur. J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1039\/D0CC00472C","article-title":"Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives","volume":"56","author":"Acharya","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1002\/asia.201801058","article-title":"Imine-N-heterocyclic carbenes as versa-tile ligands in ruthenium(II) p-cymene anticancer complexes: A structure-activity relationship study","volume":"13","author":"Yang","year":"2018","journal-title":"Chem. Asian J."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jorganchem.2012.06.027","article-title":"Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands","volume":"717","author":"Huber","year":"2012","journal-title":"J. Organomet. Chem."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Morais, T.S., Marques, F., Madeira, P.J.A., Robalo, M.P., and Garcia, M.H. (2022). Design and Anticancer Properties of New Water-Soluble Ruthenium\u2013Cyclopentadienyl Complexes. Pharmaceuticals, 15.","DOI":"10.3390\/ph15070862"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bmcl.2013.11.013","article-title":"1,2,3-Triazole-derived naphthalimides as a novel type of potential antimicrobial agents: Synthesis, antimicrobial activity, interaction with calf thymus DNA and human serum albumin","volume":"24","author":"Lv","year":"2014","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1021\/om3007079","article-title":"Naphthalimide-Tagged Ruthenium\u2013Arene Anticancer Complexes: Combining Coordination with Intercalation","volume":"31","author":"Kilpin","year":"2012","journal-title":"Organometallics"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1039\/c3nj00542a","article-title":"Studies of ruthenium(II)-2,2\u2032-bisimidazole complexes on bind-ing to G-quadruplex DNA and inducing apoptosis in HeLa cells","volume":"37","author":"Xia","year":"2013","journal-title":"New J. Chem."},{"key":"ref_143","unstructured":"de Souza, A.E.C., Pires, A.D.R., Cardoso, C.R., Carlos, R.M., Cadena, S.M.S.C., and Acco, A. (2020). Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adeno-carcinoma (HeLa) cells. Heliyon, 5."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11243-018-0203-y","article-title":"A comparative study on In Vitro cytotoxicity, cellular uptake, localization and apoptosis-inducing mechanism of two ruthenium(II) complexes","volume":"43","author":"Chen","year":"2018","journal-title":"Transit. Met. Chem."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1021\/acs.inorgchem.8b00053","article-title":"A Cancer Cell-Selective and Low-Toxic Bifunctional Heterodinuclear Pt(IV)\u2013Ru(II) Anticancer Prodrug","volume":"57","author":"Ma","year":"2018","journal-title":"Inorg. Chem."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1002\/ejic.201601226","article-title":"Ruthenium(II)-arene metallacycles: Crystal structures, interaction with DNA, and cytotoxicity","volume":"12","author":"Wang","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jinorgbio.2018.02.004","article-title":"Bioactive ruthenium(II)-arene complexes containing modified 18\u03b2-glycyrrhetinic acid ligands","volume":"182","author":"Kong","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1039\/C1DT11950H","article-title":"Ruthenium complexes containing bis-benzimidazole derivatives as a new class of apoptosis inducers","volume":"41","author":"Li","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Xicheng, W., Wu, Q., Wang, X., Xie, Q., Tang, Y., Lan, Y., Zhang, S., and Mei, W. (2016). Microwave-Assisted Synthesis of Arene Ru(II) Complexes Induce Tumor Cell Apoptosis Through Selectively Binding and Stabilizing bcl-2 G-Quadruplex DNA. Materials, 9.","DOI":"10.3390\/ma9050386"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1039\/D0DT03107K","article-title":"DNA targeting half sandwich Ru(ii)-p-cymene-N^N complexes as cancer cell imaging and terminating agents: Influence of regioisomers in cytotoxicity","volume":"50","author":"Mondal","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5309","DOI":"10.1039\/D0NJ00311E","article-title":"Synthesis, characteriza-tion, biological determination and catalytic evaluation of ruthenium(II) complexes bearing benzimidazole-based NHC lig-ands in transfer hydrogenation catalysis","volume":"44","author":"Slimani","year":"2020","journal-title":"New J. Chem."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"9068","DOI":"10.1039\/D2CC03118C","article-title":"Rationally designed Ru(ii) metallacycles with tunable imidazole ligands for synergistical chemo-phototherapy of cancer","volume":"58","author":"Tu","year":"2022","journal-title":"Chem. Commun."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10847-021-01099-x","article-title":"Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells","volume":"102","author":"Orhan","year":"2021","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1002\/med.20174","article-title":"Copper in diseases and treatments, and copper-based anticancer strategies","volume":"30","author":"Tisato","year":"2010","journal-title":"Med. Res. Rev."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1021\/ja109413c","article-title":"Copper binding agents acting as copper lonophores lead to caspase inhibition and paraptotic cell death in human cancer cells","volume":"133","author":"Tardito","year":"2011","journal-title":"Am. Chem. Soc."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Li, Z.-Z., Liu, H., and Liu, J.-C. (2020). Copper (II) complexes modified with water-soluble porphyrin and various small molecules ligand for DNA binding and potential selectivity antitumor agents. Dye. Pigment., 173.","DOI":"10.1016\/j.dyepig.2019.107923"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wang, X.-D., Zhou, M., Liu, Y., and Si, Z.-Z. (2023). Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies. Cancer Lett., 561.","DOI":"10.1016\/j.canlet.2023.216157"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ejmech.2013.07.051","article-title":"DNA binding and cytotoxicity of copper (II) imidazole terpyridine complexes: Role of oxyanion, hydrogen bonding and \u03c0\u2013\u03c0 interaction","volume":"68","author":"Manikandamathavan","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ejmech.2013.12.046","article-title":"Synthesis and characterization of Cu(II)-based anticancer chemotherapeutic agent targeting topoisomerase I alpha: In Vitro DNA binding, pBR322 cleavage, molecular docking studies and cytotoxicity against human cancer cell lines","volume":"74","author":"Tabassum","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s11243-014-9842-9","article-title":"Mixed-ligand metal complexes containing an ONS Schiff base and imidazole\/benzimidazole ligands: Synthesis, characterization, crystallography and biological activity","volume":"39","author":"Mazlan","year":"2014","journal-title":"Transit. Met. Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1039\/c3dt32992e","article-title":"Copper(ii) complexes with 2NO and 3N donor ligands: Synthesis, structures and chemical nuclease and anticancer activities","volume":"42","author":"Rajarajeswari","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1080\/00958972.2020.1843160","article-title":"Cu(II) complexes of hydrazones-NSAID conjugates: Synthesis, characterization and anticancer activity","volume":"73","author":"Kaur","year":"2020","journal-title":"J. Coord. Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ica.2018.04.017","article-title":"DNA binding and cyto-toxicity of two Cu(II) complexes containing a Schiff base ligand along with 1,10-phenanthroline or imidazole as a coligand","volume":"478","author":"Koley","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"ref_164","doi-asserted-by":"crossref","unstructured":"Abdel-Rahman, L.H., Abdelhamid, A.A., Abu-Dief, A.M., Shehata, M.R., and Bakheet, M.A. (2020). Facile synthesis, X-Ray structure of new multi-substituted aryl imidazole ligand, biological screening and DNA binding of its Cr(III), Fe(III) and Cu(II) coordi-nation compounds as potential antibiotic and anticancer drugs. J. Mol. Struct., 1200.","DOI":"10.1016\/j.molstruc.2019.127034"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"36056","DOI":"10.1039\/C7RA05874H","article-title":"Coumarin centered copper(II) complex with ap-pended-imidazole as cancer chemotherapeutic agents against lung cancer: Molecular insight via DFT-based vibrational analysis","volume":"7","author":"Usman","year":"2017","journal-title":"RSC Adv."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ica.2016.02.046","article-title":"A dinuclear copper(II) complex with piperazine bridge ligand as a potential anticancer agent: DFT computation and biological evaluation","volume":"445","author":"Usman","year":"2016","journal-title":"Inorganica Chim. Acta"},{"key":"ref_167","first-page":"1153","article-title":"Synthesis, X-ray characterization and evaluation of potent anti-angiogenic activity of a novel copper(II)-imidazole-bipyridyl complex","volume":"521","author":"Kiyan","year":"2022","journal-title":"Inorg. Nano Metal Chem."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Mirzaahmadi, A., Hosseini-Yazdi, S.A., Safarzadeh, E., Baradaran, B., Samolova, E., and Dusek, M. (2019). New series of water-soluble thiosemicarbazones and their copper(II) complexes as potentially promising anticancer compounds. J. Mol. Liq., 293.","DOI":"10.1016\/j.molliq.2019.111412"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jinorgbio.2016.11.006","article-title":"Anticancer copper pyridine benzimidazole complexes: ROS gen-eration, biomolecule interactions, and cytotoxicity","volume":"167","author":"Prosser","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jinorgbio.2014.12.006","article-title":"Cu(II)-dipeptide complexes of 2-(4\u2032-thiazolyl)benzimidazole: Synthesis, DNA oxidative damage, antioxidant and In Vitro antitumor activity","volume":"143","author":"Fu","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.cclet.2017.03.025","article-title":"Synthesis, chemical nuclease activity, and In Vitro cytotoxicity of benzimidazole-based Cu(II)\/Co(II) complexes","volume":"28","author":"Zhao","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Cai, D.-H., Zhang, C.-L., Liu, Q.-Y., He, L., Liu, Y.-J., Xiong, Y.-H., and Le, X.-Y. (2021). Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper(II) complexes containing gluconate. Eur. J. Med. Chem., 213.","DOI":"10.1016\/j.ejmech.2021.113182"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Ismail, Z., Dam, J., Penny, C., de Koning, C.B., and Harmse, L. (2022). Copper-imidazo[1,2-a]pyridines differentially modulate pro- and anti-apoptotic protein and gene expression in HL-60 and K562 leukaemic cells to cause apoptotic cell death. Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1869.","DOI":"10.1016\/j.bbamcr.2021.119160"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1039\/D2DT00077F","article-title":"Sparfloxacin-Cu(II)-aromatic heterocyclic complexes: Synthesis, charac-terization and In Vitro anticancer evaluation","volume":"51","author":"Liu","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Sharma, S.A., Sudhindra, P., Roy, N., and Paira, P. (2020). Advances in novel iridium (III) based complexes for anticancer applications: A review. Inorg. Chim. Acta, 513.","DOI":"10.1016\/j.ica.2020.119925"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.biomaterials.2014.10.070","article-title":"Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents","volume":"39","author":"Li","year":"2015","journal-title":"Biomaterials"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1002\/ejic.201601129","article-title":"Cyclometalated IrIII complexes as mitochondria-targeted photo-dynamic anticancer agents","volume":"12","author":"Ouyang","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_178","first-page":"264","article-title":"Synthe-sis, physicochemical properties, thermal analysis and biological application of phosphorescent cationic iridium(III) com-plexes. Inorg","volume":"467","author":"Thamilarasan","year":"2017","journal-title":"Chim. Acta"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fchem.2020.00182","article-title":"Imidazole and benzimidazole modified half-sandwich iridium(III) N-heterocyclic car-bene complexes: Synthesis, anticancer application, and organelle targeting","volume":"8","author":"Liu","year":"2020","journal-title":"Front. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"15873","DOI":"10.1039\/C8DT02461H","article-title":"Alkyl chain-modified cyclometalated iridium com-plexes as tunable anticancer and imaging agents","volume":"47","author":"Laha","year":"2018","journal-title":"Dalton Trans."},{"key":"ref_181","first-page":"916","article-title":"Transferrin receptor 1 in cancer: A new sight for cancer therapy","volume":"8","author":"Shen","year":"2018","journal-title":"Am. J. Cancer Res."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1039\/c0dt00887g","article-title":"Thiophenolato-bridged dinuclear arene ruthenium complexes: A new family of highly cytotoxic anticancer agents","volume":"39","author":"Gras","year":"2010","journal-title":"Dalton Trans."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2013.07.033","article-title":"Important cytotoxicity of novel iron(II) cyclopentadienyl complexes with imidazole based ligands","volume":"129","author":"Morais","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Guo, J.L., Liu, G.Y., Wang, R.Y., and Sun, S.X. (2022). Synthesis and structure elucidation of two essential metal complexes: In-vitro stud-ies of their BSA\/HSA-binding properties, docking simulations, and anticancer activities. Molecules, 27.","DOI":"10.3390\/molecules27061886"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1016\/j.arabjc.2020.08.014","article-title":"Design, synthesis, characterization of zirconium (IV), cadmium (II) and iron (III) complexes derived from Schiff base 2-aminomethylbenzimidazole, 2-hydroxynaphtadehyde and evaluation of their biological activity","volume":"13","author":"Alminderej","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nature06917","article-title":"Imaging in the era of molecular oncology","volume":"452","author":"Weissleder","year":"2008","journal-title":"Nature"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1002\/chem.201701208","article-title":"Defining the anticancer activity of tricarbonyl rhenium complexes: Induction of G2\/M cell cycle arrest and blockade of aurora-a kinase phosphorylation","volume":"23","author":"Simpson","year":"2017","journal-title":"Chem. Eur. J."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/ejic.201301474","article-title":"Rhenium complexes with red-light-induced anticancer activity","volume":"2014","author":"Ludewig","year":"2014","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"827","DOI":"10.2174\/187152009789124646","article-title":"Titanium and vanadium complexes as anticancer agents","volume":"9","author":"Kostova","year":"2009","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"16682","DOI":"10.1039\/C7DT02903A","article-title":"Syntheses, crystal structures, DFT calculations, protein interaction and anticancer activities of water soluble dipicolinic acid-imidazole based oxidovanadium(iv) complexes","volume":"46","author":"Biswal","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Ghosh, N., Chatterjee, S., Biswal, D., Pramanik, N.R., Chakrabarti, S., and Sil, P.C. (2022). Oxidative stress imposed In Vivo anticancer therapeutic efficacy of novel imidazole-based oxidovanadium (IV) complex in solid tumor. Life Sci., 301.","DOI":"10.1016\/j.lfs.2022.120606"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1002\/ejic.201402001","article-title":"Mitochondria-targeted photoinduced anticancer activity of oxi-dovanadium(IV) complexes of curcumin in visible light","volume":"2014","author":"Prasad","year":"2014","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1080\/00958972.2016.1231921","article-title":"CO-releasing properties and anticancer activities of manganese complexes with imidazole\/benzimidazole ligands","volume":"69","author":"Ustun","year":"2016","journal-title":"J. Coord. Chem."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Mahdy, A.R.E., Abu Ali, O.A., Serag, W.M., Fayad, E., Elshaarawy, R.F.M., and Gad, E.M. (2022). Synthesis, characterization, and biolog-ical activity of Co(II) and Zn(II) complexes of imidazoles-based azo-functionalized Schiff bases. J. Mol. Struct., 1259.","DOI":"10.1016\/j.molstruc.2022.132726"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"16749","DOI":"10.1039\/c3dt51209f","article-title":"Chiral heterobimetallic complexes targeting human DNA-topoisomerase I\u03b1","volume":"42","author":"Tabassum","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_196","unstructured":"Sayed, F.N., and Mohamed, G.G. (2022). Ruthenium(II)-mercapto complexes with anticancer activity interact with topoisomerase IB. J. Organomet. Chem., 977."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.poly.2016.12.020","article-title":"Syn-thesis, characterization and biological activity of gallium(III) complexes with non-symmetrical N2O-donor Schiff bases","volume":"123","author":"Padilha","year":"2017","journal-title":"Polyhedron"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ejpb.2018.02.022","article-title":"Recent advances on antimicrobial wound dressing: A review","volume":"127","author":"Miguel","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_199","first-page":"401","article-title":"Extended-spectrum beta-lactamases: Implications for the clinical laboratory and therapy","volume":"28","author":"Harada","year":"2008","journal-title":"Korean J. Lab. Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1080\/07853890.2022.2085881","article-title":"Re-establishing the utility of tetracycline-class antibiotics for current challenges with antibiotic resistance","volume":"54","author":"LaPlante","year":"2022","journal-title":"Ann. Med."},{"key":"ref_201","first-page":"1154","article-title":"The supramolecular self-assembly of aminoglycoside anti-biotics and their applications","volume":"8","author":"Jadhav","year":"2019","journal-title":"Chem. Open"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S1369-5274(99)00002-8","article-title":"Recent developments in macrolides and ketolides","volume":"2","author":"Chu","year":"1999","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.tibs.2018.06.011","article-title":"How Macrolide Antibiotics Work","volume":"43","author":"Mankin","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1016\/j.bmcl.2011.05.042","article-title":"Synthesis and activities of naphthalimide azoles as a new type of antibacterial and antifungal agents","volume":"21","author":"Zhang","year":"2011","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Zhang, P.L., Gopala, L., Zhang, S.L., Cai, G.X., and Zhou, C.H. (2022). An unanticipated discovery towards novel naphthalimide cor-belled aminothiazoximes as potential anti-MRSA agents and allosteric modulators for PBP2a. Eur. J. Med. Chem., 229.","DOI":"10.1016\/j.ejmech.2021.114050"},{"key":"ref_206","doi-asserted-by":"crossref","unstructured":"Zhang, P.L., Laiche, M.H., Li, Y.L., Gao, W.W., Lin, J.M., and Zhou, C.H. (2022). An unanticipated discovery of novel naph-thalimidopropanediols as potential broad-spectrum antibacterial members. Eur. J. Med. Chem., 241.","DOI":"10.1016\/j.ejmech.2022.114657"},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1039\/C5MD00574D","article-title":"Synthesis and biological evaluation of Schiff base-linked imidazolyl naphthalimides as novel potential anti-MRSA agents","volume":"7","author":"Gong","year":"2016","journal-title":"Med. Chem. Comm."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Zhou, X.-M., Hu, Y.-Y., Fang, B., and Zhou, C.-H. (2023). Benzenesulfonyl thiazoloimines as unique multitargeting antibacterial agents towards Enterococcus faecalis. Eur. J. Med. Chem., 248.","DOI":"10.1016\/j.ejmech.2023.115088"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"5776","DOI":"10.1039\/C4NJ01932F","article-title":"Synthesis of novel sulfonamide azoles via C\u2013N cleavage of sulfona-mides by azole ring and relational antimicrobial study","volume":"39","author":"Zhang","year":"2015","journal-title":"New J. Chem."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1039\/C5MD00186B","article-title":"Design, synthesis, and antibacterial evaluation of novel azolylthioether quinolones as MRSA DNA intercalators","volume":"6","author":"Zhang","year":"2015","journal-title":"Med. Chem. Comm."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/bi5000564","article-title":"Mechanism of Quinolone Action and Resistance","volume":"53","author":"Aldred","year":"2014","journal-title":"Biochemistry"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s11426-015-0351-0","article-title":"Coumarin-derived azolyl ethanols: Synthesis, antimicrobial evaluation and preliminary action mechanism study","volume":"59","author":"Peng","year":"2016","journal-title":"Sci. China Chem."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1016\/j.bmcl.2014.05.029","article-title":"Synthesis and bioactive evaluation of a novel series of coumarinazoles","volume":"24","author":"Damu","year":"2014","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.bmcl.2010.12.059","article-title":"Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents","volume":"21","author":"Shi","year":"2011","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s11426-016-9009-6","article-title":"Design, synthesis and biological evaluation of amino organophosphorus imidazoles as a new type of potential antimicrobial agents","volume":"60","author":"Gao","year":"2017","journal-title":"Sci. China Chem."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejmech.2018.02.056","article-title":"Molecular interaction of nov-el benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicro-bial agents","volume":"150","author":"Maddili","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Xie, Y.-P., Ansari, M.F., Zhang, S.-L., and Zhou, C.-H. (2021). Novel carbazole-oxadiazoles as potential Staphylococcus aureus germicides. Pestic. Biochem. Physiol., 175.","DOI":"10.1016\/j.pestbp.2021.104849"},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Wang, J., Ansari, M.F., and Zhou, C.-H. (2021). Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus. Bioorganic Med. Chem. Lett., 41.","DOI":"10.1016\/j.bmcl.2021.127995"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"10976","DOI":"10.1021\/cr500252u","article-title":"Surface-initiated polymer brushes in the biomedical field: Ap-plications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings","volume":"114","author":"Krishnamoorthy","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ejmech.2019.01.072","article-title":"Design and synthesis of aminothiazolyl norfloxacin analogues as potential antimicrobial agents and their biological evaluation","volume":"167","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ejmech.2016.10.011","article-title":"Multi-targeting explora-tion of new 2-aminothiazolyl quinolones: Synthesis, antimicrobial evaluation, interaction with DNA, combination with topoisomerase IV and penetrability into cells","volume":"124","author":"Cheng","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1021\/cb5007135","article-title":"Bacterial Histidine Kinases as Novel Antibacterial Drug Targets","volume":"10","author":"Bem","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Henriksen, J.R., Etzerodt, T.P., Gjetting, T., and Andresen, T.L. (2014). Side Chain Hydrophobicity Modulates Therapeutic Activity and Membrane Selectivity of Antimicrobial Peptide Mastoparan-X. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0091007"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2174\/1573406414666181106124852","article-title":"Design and synthesis novel sulfonamide-derived triazoles and bioac-tivity exploration","volume":"16","author":"He","year":"2020","journal-title":"Med. Chem."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"11153","DOI":"10.3390\/molecules180911153","article-title":"Metal Complexes of Quinolone Antibiotics and Their Applications: An Update","volume":"18","author":"Uivarosi","year":"2013","journal-title":"Molecules"},{"key":"ref_226","first-page":"764085","article-title":"Antimicrobial Applications of Transition Metal Complexes of Benzothiazole Based Terpolymer: Synthesis, Characterization, and Effect on Bacterial and Fungal Strains","volume":"2014","author":"Ahamed","year":"2014","journal-title":"Bioinorg. Chem. Appl."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Siwach, A., and Verma, P.K. (2021). Synthesis and therapeutic potential of imidazole containing compounds. BMC Chem., 15.","DOI":"10.1186\/s13065-020-00730-1"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cclet.2015.12.014","article-title":"A green and convenient approach toward benzimidazole derivatives and their antimicrobial activity","volume":"27","author":"Wen","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.2174\/13895575113136660091","article-title":"Imidazoles as promising scaffolds for antibacterial activity: A review","volume":"13","author":"Rani","year":"2013","journal-title":"Mini Reviews Med. Chem."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/cbdd.12532","article-title":"Design, synthesis, and antimicrobial evaluation of novel quino-lone imidazoles and interactions with MRSA DNA","volume":"86","author":"Zhang","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ejmech.2013.03.049","article-title":"Design, synthesis and antimicrobial evaluation of novel benzimidazole type of Fluconazole analogues and their synergistic effects with Chloromycin, Norfloxacin and Fluconazole","volume":"64","author":"Zhang","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.bmcl.2012.12.036","article-title":"Novel berberine triazoles: Synthesis, antimicrobial evaluation and competitive interactions with metal ions to Human Serum Albumin","volume":"23","author":"Zhang","year":"2013","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.2174\/15680266113136660222","article-title":"Exploration of structure-based on imidazole core as antibacterial agents","volume":"13","author":"Duan","year":"2013","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bioorg.2018.06.008","article-title":"Design, synthesis of novel azolyl flavonoids and their protein tyrosine Phosphatase-1B inhibitory activities","volume":"80","author":"Zhang","year":"2018","journal-title":"Bioorg. Chem."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2174\/1389557520999201209213648","article-title":"Imidazole derivatives and their antibacterial activity\u2014A Mini-Review","volume":"21","author":"Andrei","year":"2021","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_236","doi-asserted-by":"crossref","unstructured":"Samanta, T., Roymahapatra, G., Porto, W.F., Seth, S., Ghorai, S., Saha, S., Sengupta, J., Franco, O.L., Dinda, J., and Mandal, S.M. (2013). N,N\u2032-Olefin Functionalized Bis-Imidazolium Gold(I) Salt Is an Efficient Candidate to Control Keratitis-Associated Eye Infection. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058346"},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10973-012-2333-3","article-title":"Chelating behavior, thermal studies and biocidal efficiency of tioconazole and its complexes with some transition metal ions","volume":"111","author":"Mohamed","year":"2013","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"4964","DOI":"10.1016\/j.bmcl.2017.10.020","article-title":"Novel potentially antifungal hybrids of 5-flucytosine and fluconazole: Design, synthesis and bioactive evaluation","volume":"27","author":"Fang","year":"2017","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.saa.2013.01.024","article-title":"Mixed ligand complexation of some transition metal ions in solution and solid state: Spectral characterization, antimicrobial, antioxidant, DNA cleavage activities and molecular modeling","volume":"107","author":"Shobana","year":"2013","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.saa.2014.01.089","article-title":"Morphological and pharmacological investigation on some biopo-tent materials derived from substituted pyrimidine and imidazole enzyme constituents","volume":"126","author":"Shobana","year":"2014","journal-title":"Spectrochim. Acta. Part A"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jorganchem.2012.07.006","article-title":"Novel symmetrically p-benzyl-substituted 4,5-diaryl-imidazole N-heterocyclic carbene-silver(I) acetate complexes\u2014Synthesis and biological evaluation","volume":"717","author":"Hackenberg","year":"2012","journal-title":"J. Organomet. Chem."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1080\/00958972.2014.974582","article-title":"Review: Antibacterial behavior of carboxylate silver(I) complexes","volume":"67","author":"Paez","year":"2014","journal-title":"J. Coord. Chem."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ica.2017.07.070","article-title":"Synthesis, structures and antimicrobial activities of silver(I) complexes de-rived from 2-propyl-1H-imidazole-4,5-dicarboxylic acid","volume":"467","author":"Li","year":"2017","journal-title":"Inorg. Chim. Acta"},{"key":"ref_244","first-page":"694","article-title":"Influence of selected inorganic counter-ions on the structure and antimicrobial properties of silver(i) complexes with imidazole-containing ligands","volume":"40","author":"Felczak","year":"2015","journal-title":"N. J. Chem."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.poly.2012.04.017","article-title":"Syntheses, characterization and antimicrobial activity of silver(I) complexes containing 2-hydroxymethyl-N-alkylimidazole ligands","volume":"41","author":"Kleyi","year":"2012","journal-title":"Polyhedron"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"12056","DOI":"10.1039\/D2DT01657E","article-title":"Antibacterial silver and gold complexes of imidazole and 1,2,4-triazole derived N-heterocyclic carbenes","volume":"51","author":"Mather","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Ghdhayeb, M.Z., Sabah, K.J., Salman, A.W., and Kadhim, M.M. (2021). New Ag(I) and Pd(II) complexes derived from symmetrical and asymmetrical NHC precursors: Synthesis, Characterization, Antibacterial activity, and Theoretical calculations. J. Mol. Struct., 1245.","DOI":"10.1016\/j.molstruc.2021.131254"},{"key":"ref_248","doi-asserted-by":"crossref","unstructured":"Stryjska, K., Korona-Glowniak, I., Checinska, L., Kusz, J., and Ochocki, J. (2021). Synthesis, spectroscopy, single-crystal structure analy-sis and antibacterial activity of two novel complexes of silver(I) with miconazole drug. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041510"},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1080\/00958972.2014.931575","article-title":"Synthesis and crystal structures of sterically tuned ether functionalized NHC-silver(I) complexes: Antibacterial and nucleic acid interaction studies","volume":"67","author":"Haque","year":"2014","journal-title":"J. Coord. Chem."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/hc.21160","article-title":"NHC-Silver(I) Complexes as Chemical Nucleases; Synthesis, Crystal Structures, and Antibacterial Studies","volume":"25","author":"Haque","year":"2014","journal-title":"Heteroat. Chem."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jorganchem.2012.10.040","article-title":"Silver(I) N-heterocyclic carbene complexes: Synthesis, characterization and antibacterial activity","volume":"725","author":"Napoli","year":"2013","journal-title":"J. Organomet. Chem."},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/chem.201604512","article-title":"Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects","volume":"23","author":"Schmidt","year":"2017","journal-title":"Chem. A Eur. J."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molstruc.2016.12.080","article-title":"Heteroleptic complexes of Zn(II) based on 1-(5-bromo-2-hydroxybenzylidene)-4-phenylthiosemicarbazide: Synthesis, structural characterization, theoretical studies and antibacterial activity","volume":"1134","author":"Azarkish","year":"2017","journal-title":"J. Mol. Struct."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"7011","DOI":"10.1016\/j.tet.2017.10.029","article-title":"Synthesis, crystal structure and spectroscopic characterizations of porphyrin-based Mg(II) complexes\u2014Potential application as antibacterial agent","volume":"73","author":"Amiri","year":"2017","journal-title":"Tetrahedron"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ica.2015.10.015","article-title":"Synthesis, crystal structure, spectroscopic and biological properties of mixed ligand complexes of cadmium(II), cobalt(II) and manganese(II) valproate with 1,10-phenanthroline and imidazole","volume":"439","author":"Tabrizi","year":"2016","journal-title":"Inorganica Chim. Acta"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1021\/acs.inorgchem.1c03032","article-title":"Nitroimidazole-based ruthenium(II) complexes: Playing with structural parameters to design pho-tostable and light-responsive antibacterial agents","volume":"61","author":"Giacomazzo","year":"2022","journal-title":"Inorg. Chem."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"17517","DOI":"10.1039\/D2NJ03063B","article-title":"A hemilabile 2-(2\u2032-pyridyl)-imidazole based nickel(II) complex: Proton-coupled-electron-transfer, bactericidal and cytotoxicity studies","volume":"46","author":"Paramanik","year":"2022","journal-title":"New J. Chem."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ica.2015.12.016","article-title":"Structural, spectroscopic, electrochemical and antibacterial studies of some new nickel(II) Schiff base complexes","volume":"443","author":"Salehi","year":"2016","journal-title":"Inorganica Chim. Acta"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"e3907","DOI":"10.1002\/aoc.3907","article-title":"A mixed-ligand quinazoline-based Ni(II) Schiff base complex: Synthesis, characterization, crystal structure, antimicrobial investigation and catalytic activity for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones","volume":"32","author":"Nejad","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"5962","DOI":"10.1080\/10406638.2021.1963790","article-title":"Spectroscopic studies and antimicrobial evaluation of new mixed ligand Mn(II), Ni(II), Cu(II) complexes synthesized from an ionic liquid-supported Schiff base and 1-methyl imidazole","volume":"42","author":"Sinha","year":"2022","journal-title":"Polycycl. Aromat. Compd."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ica.2017.01.015","article-title":"Synthesis, characterization and preliminary antimicrobial assays of copper(II) complexes with 2-(imidazole-2-yl)heteroaryl ligands","volume":"458","author":"Nakahata","year":"2017","journal-title":"Inorganica Chim. Acta"},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1134\/S1070363213030201","article-title":"Synthesis, structure, and antimicro-bial activity of copper(II) chelates containing imidazole and condensation products of alpha-amino acids with salicylaldehyde and its derivatives","volume":"83","author":"Gulya","year":"2013","journal-title":"Russ. J. Gen. Chem."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/00958972.2014.1000883","article-title":"Syntheses, characterizations, crystal struc-tures, and biological activities of two new mixed ligand Ni(II) and Cu(II) Schiff base complexes","volume":"68","author":"Ebrahimipour","year":"2015","journal-title":"J. Coord. Chem."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.arabjc.2010.08.011","article-title":"Synthesis, characterization and biological studies of Co(II), Ni(II),Cu(II) and Zn(II) complexes with pyr-ral-l-histidinate","volume":"5","author":"Arish","year":"2012","journal-title":"Arab. J. Chem."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/zaac.201300082","article-title":"Copper(II) complex with the tridentate ligand N,N-bis(2-ethyl-4-methyl-imidazol-5-ylmethyl)phenylethylamine (biaq). X-ray crystal structure and biological activity on bacillus subtilis of [Cu(biaq)Cl-2]","volume":"639","author":"Mendoza","year":"2013","journal-title":"Anorg. Allg. Chem."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.saa.2011.11.031","article-title":"Spectral, biological screening of metal chelates of chalcone based Schiff bases of N-(3-aminopropyl) imidazole","volume":"87","author":"Kalanithi","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/15533174.2015.1137057","article-title":"Synthesis, characterization, and biological activity of new mixed ligand transition metal complexes of glutamine, glutaric, and glutamic acid with nitrogen based ligands","volume":"47","author":"Ismail","year":"2017","journal-title":"Inorg. Nano-Metal Chem."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.15244\/pjoes\/68536","article-title":"Cytotoxi-city and antimicrobial activity of pivalic and benzoic acid-complexed cu and mn complexes","volume":"26","author":"Ali","year":"2017","journal-title":"Pol. J. Environ. Stud."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"e4576","DOI":"10.1002\/aoc.4576","article-title":"Structural characterizations, spectroscopic, electrochemical properties, and antibacterial activities of copper (II) and cobalt (II) complexes containing imidazole ring","volume":"32","author":"Chai","year":"2018","journal-title":"Appl. Organomet. Chem."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.micpath.2017.10.034","article-title":"A novel cationic cobalt(III) Schiff base complex: Preparation, crystal structure, Hirshfeld surface analysis, antimicrobial activities and molecular docking","volume":"113","author":"Ebrahimipour","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_271","doi-asserted-by":"crossref","unstructured":"Abu-Dief, A.M., Abdel-Rahman, L.H., Abdelhamid, A.A., Marzouk, A.A., Shehata, M.R., Bakheet, M.A., Almaghrabi, O.A., and Nafady, A. (2019). Synthesis and characterization of new Cr(III), Fe(III) and Cu(II) complexes incorporating multi-substituted aryl imidazole ligand: Structural, DFT, DNA binding, and biological implications. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 228.","DOI":"10.1016\/j.saa.2019.117700"},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1039\/D2DT00411A","article-title":"Clinically used antifungal azoles as ligands for gold(iii) complexes: The influence of the Au(iii) ion on the antimicrobial activity of the complex","volume":"51","author":"Kljun","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.poly.2012.03.007","article-title":"Mixed-ligand aroylhydrazone complexes of molybdenum: Synthesis, structure and biological activity","volume":"38","author":"Pasayat","year":"2012","journal-title":"Polyhedron"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ejmech.2014.08.063","article-title":"Novel hybrids of metronidazole and quinolones: Synthesis, bioactive evaluation, cytotoxicity, preliminary antimicrobial mechanism and effect of metal ions on their transpor-tation by human serum albumin","volume":"86","author":"Cui","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1016\/j.bmcl.2015.06.041","article-title":"Design and biological evaluation of novel quinolone-based metronidazole derivatives as potent Cu2+ mediated DNA-targeting antibacterial agents","volume":"25","author":"Zhang","year":"2015","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1039\/C4MD00281D","article-title":"Synthesis and biological evaluation of a new class of quinazolinone azoles as potential antimicrobial agents and their interactions with calf thymus DNA and human serum albumin","volume":"6","author":"Peng","year":"2015","journal-title":"Med. Chem. Comm."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1016\/j.bmc.2017.10.028","article-title":"Discovery of novel nitroimidazole enols as Pseudomonas aeruginosa DNA cleavage agents","volume":"25","author":"Li","year":"2017","journal-title":"Bioorganic Med. Chem."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ejmech.2019.06.093","article-title":"Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus","volume":"179","author":"Li","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_279","doi-asserted-by":"crossref","unstructured":"Li, F.-F., Zhang, P.-L., Tangadanchu, V.K.R., Li, S., and Zhou, C.-H. (2022). Novel metronidazole-derived three-component hybrids as promising broad-spectrum agents to combat oppressive bacterial resistance. Bioorganic Chem., 122.","DOI":"10.1016\/j.bioorg.2022.105718"},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/j.bmcl.2018.06.016","article-title":"Azoalkyl ether imidazo[2,1-b]benzothiazoles as potentially antimicrobial agents with novel structural skeleton","volume":"28","author":"Maddili","year":"2018","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_281","doi-asserted-by":"crossref","unstructured":"Yang, X., Sun, H., Maddili, S.K., Li, S., Yang, R.G., and Zhou, C.H. (2022). Dihydropyrimidinone imidazoles as unique structural anti-bacterial agents for drug-resistant gram-negative pathogens. Eur. J. Med. Chem., 232.","DOI":"10.1016\/j.ejmech.2022.114188"},{"key":"ref_282","doi-asserted-by":"crossref","unstructured":"Bheemanaboina, R.R.Y., Wang, J., Hu, Y.Y., Meng, J.P., Guan, Z., and Zhou, C.H. (2021). A facile reaction to access novel structural sul-fonyl-hybridized imidazolyl ethanols as potential DNA-targeting antibacterial agents. Bioorg. Med. Chem. Lett., 47.","DOI":"10.1016\/j.bmcl.2021.128198"},{"key":"ref_283","doi-asserted-by":"crossref","unstructured":"Hu, Y., Pan, G., Yang, Z., Li, T., Wang, J., Ansari, M.F., Hu, C., Bheemanaboina, R.R.Y., Cheng, Y., and Zhou, C. (2021). Novel Schiff base-bridged multi-component sulfonamide imidazole hybrids as potentially highly selective DNA-targeting membrane active repressors against methicillin-resistant Staphylococcus aureus. Bioorganic Chem., 107.","DOI":"10.1016\/j.bioorg.2020.104575"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/cjoc.202100165","article-title":"Design and synthesis of sulfanilamide aminophosphonates as novel antibacte-rial agents towards Escherichia coli","volume":"39","author":"Wang","year":"2021","journal-title":"Chin. J. Chem."},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1039\/C8MD00301G","article-title":"Novel organophosphorus aminopy-rimidines as unique structural DNA-targeting membrane active inhibitors towards drug-resistant MRSA","volume":"9","author":"Li","year":"2018","journal-title":"Med. Chem. Comm."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"711","DOI":"10.4155\/fmc-2017-0160","article-title":"Novel naphthalimide nitroimidazoles as multi-targeting antibacterial agents against resistant Acinetobacter baumanii","volume":"10","author":"Kang","year":"2018","journal-title":"Future Med. Chem."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.cclet.2017.04.002","article-title":"Novel potentially antibacterial naphthalimide-derived metronidazoles: Design, synthesis, biological evaluation and supramolecular interactions with DNA, human serum albumin and topoisomerase II","volume":"28","author":"Kang","year":"2017","journal-title":"Chin. Chem. Lett."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1016\/j.bmc.2013.05.007","article-title":"Synthesis and bioactive evaluation of novel hy-brids of metronidazole and berberine as new type of antimicrobial agents and their transportation behavior by human se-rum albumin","volume":"21","author":"Zhang","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.bmcl.2016.04.070","article-title":"Discovery of novel berberine imidazoles as safe antimicrobial agents by down regulating ROS generation","volume":"26","author":"Wen","year":"2016","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Ansari, M.F., Tan, Y.-M., Sun, H., Li, S., and Zhou, C.-H. (2022). Unique iminotetrahydroberberine-corbelled metronidazoles as potential membrane active broad-spectrum antibacterial agents. Bioorganic Med. Chem. Lett., 76.","DOI":"10.1016\/j.bmcl.2022.129012"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1021\/acs.molpharmaceut.8b01021","article-title":"Sulfonamide-derived four-component molecular hybrids as novel DNA-targeting membrane active potentiators against clinical Escherichia coil","volume":"16","author":"Hu","year":"2019","journal-title":"Mol. Pharmaceutics"},{"key":"ref_292","first-page":"1375","article-title":"Catalytic hydrolysis and supramolecular recognition by benzimidazoly macrocyclic polyamine Zn(II) complex","volume":"26","author":"Li","year":"2009","journal-title":"Chem. Res. Appl."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejmech.2017.11.027","article-title":"Novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents: Design, synthesis and biological evaluation","volume":"143","author":"Liu","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_294","first-page":"81","article-title":"Recent advance in research of benzimidazole containing compounds as antimicrobial drugs","volume":"36","author":"Meng","year":"2012","journal-title":"Chin. J. Antibiot."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1016\/j.tetlet.2014.05.113","article-title":"A unique one-pot reaction via C\u2013C cleavage from aminomethylene benzimidazoles to access benzimidazolones with wide potentiality","volume":"55","author":"Zhang","year":"2014","journal-title":"Tetrahedron Lett."},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.5012\/bkcs.2010.31.12.3684","article-title":"Synthesis of azole-containing piperazine derivatives and evaluation of their antibacterial, antifungal and cytotoxic activities","volume":"31","author":"Gan","year":"2010","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_297","first-page":"2050","article-title":"Advance in the research of antimicrobial drugs with sulfamide group","volume":"19","author":"Wang","year":"2010","journal-title":"Chin. J. New Drugs"},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.bmcl.2017.02.071","article-title":"Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration","volume":"27","author":"Jeyakkumar","year":"2017","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/cmdc.201300333","article-title":"Synthesis, Characterization, and Antimicrobial Activity of Silver(I) and Copper(II) Complexes of Phosphate Derivatives of Pyridine And Benzimidazole","volume":"9","author":"Szewczyk","year":"2014","journal-title":"Chemmedchem"},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Kalinowska-Lis, U., Felczak, A., Ch\u0119ci\u0144ska, L., Szab\u0142owska-Gadomska, I., Patyna, E., Ma\u0142ecki, M., Lisowska, K., and Ochocki, J. (2016). Antibacterial Activity and Cytotoxicity of Silver(I) Complexes of Pyridine and (Benz)Imidazole Derivatives. X-ray Crystal Structure of [Ag(2,6-di(CH2OH)py)2]NO3. Molecules, 21.","DOI":"10.3390\/molecules21020087"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1080\/00958972.2016.1276574","article-title":"Non-symmetrically pnitrobenzyl\u2014And pcyanobenzyl-substituted N-heterocyclic carbene-silver(I) complexes: Synthesis, characterization and antibacterial studies","volume":"70","author":"Prasad","year":"2016","journal-title":"J. Coord. Chem."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ica.2017.06.072","article-title":"Synthesis, structural investigation and antibacterial studies of non\u2013symmetrically p\u2013nitrobenzyl substituted benzimidazole N\u2013heterocyclic carbene\u2013silver(I) complexes","volume":"466","author":"Shahini","year":"2017","journal-title":"Inorg. Chim. Acta"},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"e3770","DOI":"10.1002\/aoc.3770","article-title":"Coumarin-tethered (benz)imidazolium salts and their silver(I) N-heterocyclic carbene complexes: Synthesis, characterization, crystal structure and antibacterial studies","volume":"31","author":"Achar","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.poly.2016.11.049","article-title":"Synthesis, characterization, crystal structure and biological studies of silver(I) complexes derived from coumarin-tethered N-heterocyclic carbene ligands","volume":"123","author":"Achar","year":"2017","journal-title":"Polyhedron"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jinorgbio.2018.02.012","article-title":"Sterically modulated silver(I) complexes of coumarin substituted benzimidazol-2-ylidenes: Synthesis, crystal structures and evaluation of their antimi-crobial and antilung cancer potentials","volume":"183","author":"Achar","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jorganchem.2017.01.024","article-title":"Synthesis, structural characterization, crystal structures and antibacterial potentials of coumarin-tethered N-heterocyclic carbene silver(I) complexes","volume":"833","author":"Achar","year":"2017","journal-title":"J. Organomet. Chem."},{"key":"ref_307","doi-asserted-by":"crossref","unstructured":"Yang, X.C., Zhang, P.L., Kumar, K.V., Li, S., Geng, R.X., and Zhou, C.H. (2022). Discovery of unique thiazolidinone-conjugated couma-rins as novel broad spectrum antibacterial agents. Eur. J. Med. Chem., 232.","DOI":"10.1016\/j.ejmech.2022.114192"},{"key":"ref_308","doi-asserted-by":"crossref","unstructured":"Zeng, C., Avula, S.R., Meng, J., and Zhou, C. (2023). Synthesis and Biological Evaluation of Piperazine Hybridized Coumarin Indolylcyanoenones with Antibacterial Potential. Molecules, 28.","DOI":"10.3390\/molecules28062511"},{"key":"ref_309","doi-asserted-by":"crossref","unstructured":"Yang, X.-C., Hu, C.-F., Zhang, P.-L., Li, S., Geng, R.-X., and Zhou, C.-H. (2022). Coumarin thiazoles as unique structural skeleton of potential antimicrobial agents. Bioorganic Chem., 124.","DOI":"10.1016\/j.bioorg.2022.105855"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Hu, C.-F., Zhang, P.-L., Sui, Y.-F., Lv, J.-S., Ansari, M.F., Battini, N., Li, S., Zhou, C.-H., and Geng, R.-X. (2020). Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus. Bioorganic Chem., 94.","DOI":"10.1016\/j.bioorg.2019.103434"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jorganchem.2017.11.005","article-title":"Ether and coumarinefunctionalized (benz) im-idazolium salts and their silver(I)-N-heterocyclic carbene complexes: Synthesis, characterization, crystal structures and an-timicrobial studies","volume":"854","author":"Achar","year":"2018","journal-title":"J. Organomet. Chem."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.molstruc.2019.06.102","article-title":"Synthesis, characterization, crystal structure and antibac-terial properties of N- and O-functionalized (benz)imidazolium salts and their N-heterocyclic carbene silver(I) complexes","volume":"1196","author":"Achar","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_313","doi-asserted-by":"crossref","unstructured":"Turker, D., Ustun, E., Gunal, S., Yildiz, H., Dusunceli, S.D., and Ozdemir, I. (2022). Cyanopropyl functionalized benzimidazolium salts and their silver N-heterocyclic carbene complexes: Synthesis, antimicrobial activity, and theoretical analysis. Arch. Pharm., 355.","DOI":"10.1002\/ardp.202200041"},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"e6891","DOI":"10.1002\/aoc.6891","article-title":"Antimicrobial and antibiofilm activities and bovine serum albumin binding prop-erties of benzimidazolium derivative NHC salts and their Ag(I)-NHC complexes","volume":"36","author":"Celik","year":"2022","journal-title":"Appl. Organomet. Chem."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1080\/00958972.2012.654469","article-title":"Synthesis and antimicrobial studies of 1-methyl-2-dimethylaminoethyl-substituted benzimidazolium salts and N-heterocyclic carbene\u2013silver complexes","volume":"65","year":"2012","journal-title":"J. Coord. Chem."},{"key":"ref_316","doi-asserted-by":"crossref","first-page":"11596","DOI":"10.1039\/D1DT02008K","article-title":"Water-soluble silver(i) complexes with N-donor benzimidazole ligands containing an imidazolium core: Stability and preliminary biological studies","volume":"50","author":"Ulukaya","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_317","doi-asserted-by":"crossref","unstructured":"Ashraf, R., Javed, M., Taskin-Tok, T., Nadeem, R., Javaid, M.K., El-Naggar, M., Alzahrani, O.M., and Mahmoud, S.F. (2021). Design, DFT studies, antimicrobial and antioxidant potential of Binuclear N-heterocyclic Carbene (NHCs) complexes, Probing the aspect of DNA interaction through In-vitro and In-silico approach. Comput. Biol. Chem., 95.","DOI":"10.1016\/j.compbiolchem.2021.107591"},{"key":"ref_318","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.3390\/molecules15042203","article-title":"Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity","volume":"15","author":"Ozdemir","year":"2010","journal-title":"Molecules"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.poly.2016.08.045","article-title":"Synthesis, X-ray structure, theoretical investigation, corrosion inhibition and antimicrobial activity of ben-zimidazole thioether and their metal complexes","volume":"119","author":"Bouchouit","year":"2016","journal-title":"Polyhedron"},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.ejmech.2014.07.075","article-title":"The synthesis and activities of novel mono-nuclear or dinuclear cyclen complexes bearing azole pendants as antibacterial and antifungal agents","volume":"84","author":"Li","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"9297","DOI":"10.1002\/chem.201300889","article-title":"Identifi-cation of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate","volume":"19","author":"Meier","year":"2013","journal-title":"Chem. Eur. J."},{"key":"ref_322","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.saa.2011.10.077","article-title":"Nucleic acid interaction and antibacterial behaviours of a ternary palladium(II) complexes","volume":"86","author":"Patel","year":"2012","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"973","DOI":"10.6023\/A1110252","article-title":"Structure, Antibacterial Activities and DNA Cleavage of a Copper(II) Complex with 2-(2\u2032-Pyridyl)benzimidazole and L-Alaninate","volume":"70","author":"Lu","year":"2012","journal-title":"Acta Chim. Sin."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1080\/00958972.2013.800195","article-title":"A copper(II) complex with 2-(2\u2032-pyridyl)benzimidazole and L-arginine: Synthesis, structure, antibacterial activities, and DNA interaction","volume":"66","author":"Ou","year":"2013","journal-title":"J. Coord. Chem."},{"key":"ref_325","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1080\/00958972.2010.493583","article-title":"Synthesis, characterization, thermal and redox behavior, and biological activity of Ni(II), Cu(II), and Zn(II) complexes containing pyridoxine and imidazole moieties","volume":"63","author":"Neelakantan","year":"2010","journal-title":"J. Coord. Chem."},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.molstruc.2013.12.009","article-title":"Newer mixed ligand Schiff base complexes from aquo-N-(2\u2032-hydroxy acetophenone) glycinatocopper(II) as synthon: DFT, antimicrobial activity and molecular docking study","volume":"1059","author":"Pramanik","year":"2014","journal-title":"J. Mol. Struct."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"e4126","DOI":"10.1002\/aoc.4126","article-title":"Three new mixed-ligand copper(II) complexes containing glycyl-L-valine and N,N-aromatic heterocyclic compounds: Synthesis, characterization, DNA interaction, cytotoxicity and antimicrobial activity","volume":"32","author":"Qi","year":"2017","journal-title":"Appl. Organomet. Chem."},{"key":"ref_328","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.msec.2016.08.069","article-title":"A treatise on benzimidazole based Schiff base metal(II) complexes accentuating their biological efficacy: Spectroscopic evaluation of DNA interactions, DNA cleavage and antimicrobial screening","volume":"70","author":"Kumaravel","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2019.06.046","article-title":"A new exploration towards aminothiazolquinolone oximes as potentially multi-targeting antibacterial agents: Design, synthesis and evaluation acting on microbes, DNA, HSA and topoisomerase IV","volume":"179","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_330","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/cjoc.201180257","article-title":"Antibacterial activities and nuclease properties of two new ternary copper(II) complexes with 2-(4\u2032-Thiazolyl)-benzimidazole and 2,2\u2032-bipyridine\/1,10-phenanthroline","volume":"29","author":"Ren","year":"2011","journal-title":"Chin. J. Chem."},{"key":"ref_331","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhang, P.-L., Ansari, M.F., Li, S., and Zhou, C.-H. (2021). Molecular design and preparation of 2-aminothiazole sulfanilamide oximes as membrane active antibacterial agents for drug resistant Acinetobacter baumannii. Bioorganic Chem., 113.","DOI":"10.1016\/j.bioorg.2021.105039"},{"key":"ref_332","first-page":"2052","article-title":"From Antibacterial to Antitumour Agents: A Brief Review on The Chemical and Medicinal Aspects of Sulfonamides","volume":"20","author":"Dias","year":"2021","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00958970903398069","article-title":"Studies on Cu(II)-mixed ligand complexes containing a sulfa drug and some enzyme constituents","volume":"63","author":"Nair","year":"2010","journal-title":"J. Coord. Chem."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1155\/2012\/969760","article-title":"3D-Metal Complexes Derived from Proton Pump Inhibitors-Synthesis, Characterization and Biological Studies","volume":"9","author":"Malik","year":"2012","journal-title":"E J. Chem."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3109\/14756366.2011.592646","article-title":"Investigation of DNA binding mechanism, photoinduced cleavage activity, electrochemical proper-ties and biological functions of mixed ligand copper(II) complexes with benzimidazole derivatives: Synthesis and spectral characterization","volume":"27","author":"Raman","year":"2012","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1007\/s10953-010-9593-y","article-title":"Synthesis, Solution Equilibria and Antibacterial Activity of Co(II) with 2-(Aminomethyl)-Benzimidazole and Dicarboxylic Acids","volume":"39","year":"2010","journal-title":"J. Solut. Chem."},{"key":"ref_337","doi-asserted-by":"crossref","first-page":"16691","DOI":"10.1039\/C9NJ03960K","article-title":"Antibacterial and aqueous dual-responsive sensing activi-ties of monomeric complexes with uncoordinated imidazole sites","volume":"43","author":"Liang","year":"2019","journal-title":"New J. Chem."},{"key":"ref_338","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.saa.2012.11.038","article-title":"Novel Ni(II) and Zn(II) complexes coordinated by 2-arylaminomethyl-1H-benzimidazole: Molecular structures, spectral, DFT studies and evaluation of biological activity","volume":"104","author":"Mansour","year":"2013","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_339","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.13005\/ojc\/280343","article-title":"Synthesis, Spectral, Cyclic Voltammetric and Antimicrobial Studies of Iron (III) Complexes with Tetradentate Bis-benzimidazole Based Diamide Ligand","volume":"28","author":"Sharma","year":"2012","journal-title":"Orient. J. Chem."},{"key":"ref_340","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1080\/00958972.2011.594886","article-title":"Synthesis, spectroscopic (IR, electronic, FAB-mass, and PXRD), magnetic, and antimi-crobial studies of new iron(III) complexes containing Schiff bases and substituted benzoxazole ligands","volume":"64","author":"Dubey","year":"2011","journal-title":"J. Coord. Chem."},{"key":"ref_341","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.molstruc.2012.12.062","article-title":"Spectroscopic, luminescence, electrochemical and antimi-crobial studies of lanthanide complexes of bis-benzimidazole derived ligands","volume":"1037","author":"Siddiqi","year":"2013","journal-title":"J. Mol. Struct."},{"key":"ref_342","doi-asserted-by":"crossref","unstructured":"Baartzes, N., Jordaan, A., Warner, D.F., Combrinck, J., Taylor, D., Chibale, K., and Smith, G.S. (2020). Antimicrobial evaluation of neu-tral and cationic iridium(III) and rhodium(III) aminoquinoline-benzimidazole hybrid complexes. Eur. J. Med. Chem., 206.","DOI":"10.1016\/j.ejmech.2020.112694"},{"key":"ref_343","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1080\/00958972.2012.673123","article-title":"Synthesis, characterization, and biological activities of zinc, cadmium, copper, and nickel complexes containing meta-aminophenyl benzimidazole","volume":"65","author":"Roopashree","year":"2012","journal-title":"J. Coord. Chem."},{"key":"ref_344","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1080\/00958972.2012.731050","article-title":"Syntheses, characterizations, and antimicrobial activities of binuclear ruthenium(III) complexes containing 2-substituted benzimidazole derivatives","volume":"65","author":"Roopashree","year":"2012","journal-title":"J. Coord. Chem."},{"key":"ref_345","doi-asserted-by":"crossref","unstructured":"Elaaraj, I., Raouan, S.E., Nakkabi, A., Es-Sounni, B., Koraichi, I., El Moualij, N., and Fahim, M. (2022). Synthesis, characterization and antioxidant, antibacterial activity Zn2+, Cu2+, Ni2+ and Co2+, complexes of ligand [2-(thiophen-2-yl)-1-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole]. J. Indian Chem. Soc., 99.","DOI":"10.1016\/j.jics.2022.100404"},{"key":"ref_346","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jphotobiol.2012.05.003","article-title":"Synthesis, characterization, biological studies (DNA binding, cleavage, antibac-terial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes","volume":"114","author":"Arjmand","year":"2012","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_347","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.saa.2009.11.035","article-title":"Studies on Cu(II) ternary complexes involving an aminopenicillin drug and imidazole containing ligands","volume":"75","author":"Regupathy","year":"2010","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_348","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1155\/2012\/287909","article-title":"Synthesis, characterization and antimicrobial activity of transition metal com-plexes of Schiff base ligand derived from 3-ethoxy salicylaldehyde and 2-(2-aminophenyl) 1-H-benzimidazole","volume":"9","author":"Sunitha","year":"2012","journal-title":"E-J. Chem."},{"key":"ref_349","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/cjoc.201100668","article-title":"Synthesis and Characterization of Thiophene-derived Amido Bis-nitrogen Mustard and Its Antimicrobial and Anticancer Activities","volume":"30","author":"Tang","year":"2012","journal-title":"Chin. J. Chem."},{"key":"ref_350","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1080\/00397911.2020.1777311","article-title":"Synthetic strategies and functional reactivity of versatile thiophene synthons","volume":"50","author":"Khalifa","year":"2020","journal-title":"Synth. Commun."},{"key":"ref_351","first-page":"723","article-title":"Furans, thiophenes and related heterocycles in drug discovery","volume":"8","author":"Sperry","year":"2005","journal-title":"Curr. Opin. drug Discov. Dev."},{"key":"ref_352","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1155\/2011\/604295","article-title":"Synthesis, Characterization and Antibacterial Studies of Some Transition Metal Complexes of a Schiff Base Derived from 2-(Aminomethyl)- benzimidazole and Thiophene-2-carbaxaldehyde","volume":"8","author":"Jogi","year":"2011","journal-title":"E-J. Chem."},{"key":"ref_353","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s11426-014-5087-x","article-title":"Design, synthesis, and biological evaluation of novel benzimidazole deriva-tives and their interaction with calf thymus DNA and synergistic effects with clinical drugs","volume":"57","author":"Zhang","year":"2014","journal-title":"Sci. China Chem."},{"key":"ref_354","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/cmdc.201700739","article-title":"Discovery of Benzimidazole-Quinolone Hybrids as New Cleaving Agents toward Drug-Resistant Pseudomonas aeruginosa DNA","volume":"13","author":"Wang","year":"2018","journal-title":"Chemmedchem"},{"key":"ref_355","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.bmcl.2018.03.046","article-title":"Novel purine benzimidazoles as antimicrobial agents by regulating ROS generation and targeting clinically resistant Staphylococcus aureus DNA groove","volume":"28","author":"Wang","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_356","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/j.bmcl.2016.04.036","article-title":"Design, synthesis and biological evaluation of 5-fluorouracil-derived benzimidazoles as novel type of potential antimicrobial agents","volume":"26","author":"Fang","year":"2016","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_357","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11426-014-5296-3","article-title":"Novel benzimidazole derived naphthalimide triazoles: Synthesis, antimicrobial activity and interactions with calf thymus DNA","volume":"58","author":"Luo","year":"2015","journal-title":"Sci. China Chem."},{"key":"ref_358","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1002\/cjoc.202200326","article-title":"A new discovery towards novel skeleton of benzimidazole conjugated pyrimidi-nones as unique effective antibacterial agents","volume":"40","author":"Yang","year":"2022","journal-title":"Chin. J. Chem."},{"key":"ref_359","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejmech.2017.04.077","article-title":"Design, synthesis and antimicrobial evaluation of novel benzimidazole-incorporated sulfonamide analogues","volume":"136","author":"Zhang","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"ref_360","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ejmech.2016.06.031","article-title":"Design, synthesis and biological evaluation of berberine-benzimidazole hybrids as new type of potentially DNA-targeting antimicrobial agents","volume":"122","author":"Jeyakkumar","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_361","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1021\/acs.jafc.2c03849","article-title":"A New Discovery of Unique 13-(Benzimidazolylmethyl)berberines as Promising Broad-Spectrum Antibacterial Agents","volume":"70","author":"Sun","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_362","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1021\/acs.jafc.1c02545","article-title":"Natural Berberine-Hybridized Benzimidazoles as Novel Unique Bactericides against Staphylococcus aureus","volume":"69","author":"Sun","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_363","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejmech.2016.01.052","article-title":"Discov-ery of membrane active benzimidazole quinolones-based topoisomerase inhibitors as potential DNA-binding antimicrobi-al agents","volume":"111","author":"Zhang","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_364","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejmech.2012.07.015","article-title":"Synthesis and biological evaluation of novel benzimidazole de-rivatives and their binding behavior with bovine serum albumin","volume":"55","author":"Zhang","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"ref_365","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1021\/acs.jmedchem.2c02042","article-title":"Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii","volume":"66","author":"Tan","year":"2023","journal-title":"J. Med. Chem."},{"key":"ref_366","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1039\/C7MD00112F","article-title":"Discovery of potential antifungal triazoles: Design, synthesis, biological evaluation, and preliminary antifungal mechanism exploration","volume":"8","author":"Zhang","year":"2017","journal-title":"Med. Chem. Comm."},{"key":"ref_367","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00044-014-1123-9","article-title":"Synthesis and biological evaluation of novel d-glucose-derived 1,2,3-triazoles as potential antibacterial and antifungal agents","volume":"24","author":"Zhang","year":"2015","journal-title":"Med. Chem. Res."},{"key":"ref_368","doi-asserted-by":"crossref","first-page":"4631","DOI":"10.1016\/j.ejmech.2010.07.031","article-title":"Synthesis of novel sulfanilamide-derived 1,2,3-triazoles and their evaluation for antibacte-rial and antifungal activities","volume":"45","author":"Wang","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"ref_369","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.2174\/0929867321666141011194825","article-title":"Recent Advances in Design of Potential Quinoxaline Anti-Infectives","volume":"21","author":"Jampilek","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_370","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/CMR.00046-13","article-title":"Tissue Penetration of Antifungal Agents","volume":"27","author":"Felton","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_371","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chembiol.2014.04.004","article-title":"Suppressive drug interactions between antifungals","volume":"21","author":"Vos","year":"2014","journal-title":"Chem. Biol."},{"key":"ref_372","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4155\/fmc-2021-0162","article-title":"Identification of a novel antifungal backbone of naphthalimide thia-zoles with synergistic potential for chemical and dynamic treatment","volume":"13","author":"Zhang","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_373","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12039-018-1574-5","article-title":"Synthesis, physicochemical and biological characterization of Ni(II) complex with imidazole-4-acetate anion as new anti-fungal agent","volume":"130","author":"Galczynska","year":"2018","journal-title":"J. Chem. Sci."},{"key":"ref_374","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jinorgbio.2005.07.018","article-title":"Copper complexes of imidazole-2-, pyr-role-2- and indol-3-carbaldehyde thiosemicarbazones: Inhibitory activity against fungi and bacteria","volume":"99","author":"Sanmartin","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"ref_375","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1002\/asia.202100146","article-title":"Pyrimidinetrione-imidazoles as a unique structural type of potential agents towards can-dida albicans: Design, synthesis and biological evaluation","volume":"16","author":"Sui","year":"2021","journal-title":"Chem. Asian J."},{"key":"ref_376","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ejmech.2019.05.047","article-title":"Design, synthesis, and structure-activity relationship studies of l-amino alcohol derivatives as broad-spectrum antifungal agents","volume":"177","author":"Zhao","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_377","doi-asserted-by":"crossref","first-page":"5939","DOI":"10.1021\/nn501073x","article-title":"Perylene-derived single-component organic nano-particles with tunable emission: Efficient anticancer drug carriers with real-time monitoring of drug release","volume":"8","author":"Jana","year":"2014","journal-title":"ACS Nano"},{"key":"ref_378","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.jconrel.2011.08.164","article-title":"Drug carriers based on cyclodextrin inclusion complexes for the controlled release of hydrophobic drugs","volume":"152","author":"Xiong","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_379","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s10847-010-9922-1","article-title":"Inclusion complexes of ketoconazole with beta-cyclodextrin: Physicochemical characteri-zation and In Vitro dissolution behaviour of its vaginal suppositories","volume":"70","author":"Demirel","year":"2011","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"ref_380","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.poly.2013.03.023","article-title":"Imidazole Schiff base ligands: Synthesis, coordination complexes and biological activities","volume":"55","author":"McGinley","year":"2013","journal-title":"Polyhedron"},{"key":"ref_381","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.poly.2013.03.057","article-title":"Synthesis, structure and bio-logical activity of silver(I) complexes of substituted imidazoles","volume":"56","author":"McCann","year":"2013","journal-title":"Polyhedron"},{"key":"ref_382","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1039\/c2dt12166b","article-title":"Silver(i) complexes of 9-anthracenecarboxylic acid and imidazoles: Synthesis, structure and antimicrobial activity","volume":"41","author":"McCann","year":"2012","journal-title":"Dalton Trans."},{"key":"ref_383","doi-asserted-by":"crossref","first-page":"309179","DOI":"10.1155\/2013\/309179","article-title":"Synthesis, Characterization, and Physicochemical Studies of Mixed Ligand Complexes of Inner Transition Metals with Lansoprazole and Cytosine","volume":"2013","author":"Verma","year":"2012","journal-title":"J. Chem."},{"key":"ref_384","doi-asserted-by":"crossref","first-page":"5363","DOI":"10.1016\/j.bmcl.2012.07.064","article-title":"Design, synthesis and evaluation of clinafloxacin tria-zole hybrids as a new type of antibacterial and antifungal agents","volume":"22","author":"Wang","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_385","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1007\/s11426-012-4602-1","article-title":"Synthesis and biological activities of thio-triazole derivatives as new potential antibacterial and antifungal agents","volume":"55","author":"Wang","year":"2012","journal-title":"Sci. China Chem."},{"key":"ref_386","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1016\/j.ejmech.2011.07.010","article-title":"Synthesis of novel fluconazoliums and their evaluation for antibacterial and antifungal activities","volume":"46","author":"Zhang","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"ref_387","doi-asserted-by":"crossref","unstructured":"Zhang, P., Tangadanchu, V.K.R., and Zhou, C. (2022). Identification of Novel Antifungal Skeleton of Hydroxyethyl Naphthalimides with Synergistic Potential for Chemical and Dynamic Treatments. Molecules, 27.","DOI":"10.3390\/molecules27238453"},{"key":"ref_388","doi-asserted-by":"crossref","unstructured":"Zala, A.R., Rajani, D.P., Ahmad, I., Patel, H., and Kumari, P. (2023). Synthesis, characterization, molecular dynamic simulation, and biological assessment of cinnamates linked to imidazole\/benzimidazole as a CYP51 inhibitor. J. Biomol. Struct. Dyn., 1\u201317.","DOI":"10.1080\/07391102.2023.2170918"},{"key":"ref_389","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1080\/00958972.2020.1812587","article-title":"Synthesis, antimicrobial properties, and theoretical analysis of benzimidazole-2-ylidene silver(I) complexes","volume":"73","author":"Ayaz","year":"2020","journal-title":"J. Coord. Chem."},{"key":"ref_390","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3109\/14756366.2015.1132210","article-title":"In Vitro antimicrobial studies of new benzimidazolium salts and silver N-heterocyclic carbene complexes","volume":"31","author":"Albayrak","year":"2016","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_391","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1007\/s00044-012-0220-x","article-title":"Synthesis, characterization, and antimicrobial activity of some new 2-diazo-benzimidazole derivatives and their Ni(II), Cu(II), and Ag(I) complexes","volume":"22","author":"Murthy","year":"2013","journal-title":"Med. Chem. Res."},{"key":"ref_392","doi-asserted-by":"crossref","unstructured":"Kalarani, R., Sankarganesh, M., Kumar, G.G.V., and Kalanithi, M. (2020). Synthesis, spectral, DFT calculation, sensor, antimicrobial and DNA binding studies of Co(II), Cu(II) and Zn(II) metal complexes with 2-amino benzimidazole Schiff base. J. Mol. Struct., 1206.","DOI":"10.1016\/j.molstruc.2020.127725"},{"key":"ref_393","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1002\/ejic.201900155","article-title":"Pyridylbenzimidazole-based gold(III) complexes: Lysozyme metalation, DNA binding studies, and biological activity","volume":"23","author":"Mansour","year":"2019","journal-title":"Eur. J. Inorg. Chem."},{"key":"ref_394","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40249-016-0159-0","article-title":"Major parasitic diseases of poverty in mainland China: Perspectives for better control","volume":"5","author":"Wang","year":"2016","journal-title":"Infect. Dis. Poverty"},{"key":"ref_395","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/DDDT.S146521","article-title":"Leishmaniasis in humans: Drug or vaccine therapy?","volume":"12","author":"Ghorbani","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_396","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.2174\/09298673113206660285","article-title":"Transition-state-guided drug design for treatment of parasitic neglected tropical diseases","volume":"21","author":"Murkin","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_397","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-pharmtox-011613-135915","article-title":"Antiparasitic Chemotherapy: From Genomes to Mechanisms","volume":"54","author":"Horn","year":"2014","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_398","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1021\/jm400443k","article-title":"Phenotypic Screening as a Strategic Component of Drug Discovery Programs Targeting Novel Antiparasitic and Antimycobacterial Agents: An Editorial","volume":"56","author":"Butera","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref_399","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1007\/s00436-020-06668-6","article-title":"Imidazole derivatives as antiparasitic agents and use of molecular modeling to investigate the structure-activity relationship","volume":"119","author":"Adeyemi","year":"2020","journal-title":"Parasitol. Res."},{"key":"ref_400","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/jm701179m","article-title":"Efficient Inhibition of Iron Superoxide Dismutase and of Trypanosoma cruzi Growth by Benzo[g]phthalazine Derivatives Functionalized with One or Two Imidazole Rings","volume":"51","author":"Sanz","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_401","doi-asserted-by":"crossref","unstructured":"Beltran-Hortelano, I., Alcolea, V., Font, M., and Perez-Silanes, S. (2020). The role of imidazole and benzimidazole heterocycles in Cha-gas disease: A review. Eur. J. Med. Chem., 206.","DOI":"10.1016\/j.ejmech.2020.112692"},{"key":"ref_402","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jinorgbio.2011.09.009","article-title":"Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae In Vitro","volume":"108","author":"Turner","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"ref_403","doi-asserted-by":"crossref","unstructured":"Rosa, L.B., Galuppo, C., Lima, R.L.A., Fontes, J.V., Siqueira, F.S., Judice, W.A.S., Abbehausen, C., and Miguel, D.C. (2022). Antileishma-nial activity and insights into the mechanisms of action of symmetric Au(I) benzyl and aryl-N-heterocyclic carbenes. J. Inorg. Biochem., 229.","DOI":"10.1016\/j.jinorgbio.2022.111726"},{"key":"ref_404","doi-asserted-by":"crossref","unstructured":"Koko, W.S., Jentzsch, J., Kalie, H., Schobert, R., Ersfeld, K., Al Nasr, I.S., Khan, T.A., and Biersack, B. (2020). Evaluation of the antipara-sitic activities of imidazol-2-ylidene-gold(I) complexes. Arch. Pharm., 353.","DOI":"10.1002\/ardp.201900363"},{"key":"ref_405","doi-asserted-by":"crossref","unstructured":"Huang, Q., Li, B.P., Yang, S., Ma, P.P., and Wang, Z.Z. (2013). Preparation and cyclodextrin solubilization of the antibacterial agent ben-zoyl metronidazole. Sci. World J., 306476.","DOI":"10.1155\/2013\/306476"},{"key":"ref_406","doi-asserted-by":"crossref","unstructured":"Celebioglu, A., and Uyar, T. (2019). Metronidazole\/Hydroxypropyl-beta-Cyclodextrin inclusion complex nanofibrous webs as fast-dissolving oral drug delivery system. Int. J. Pharm., 572.","DOI":"10.1016\/j.ijpharm.2019.118828"},{"key":"ref_407","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.bmc.2010.12.015","article-title":"Studies on 6-chloro-5-(1-naphthyloxy)-2-(trifluoromethyl)-1H-benzimidazole\/2-hydroxypropyl-\u03b2-cyclodextrin association: Characterization, molecular modeling studies, and In Vivo anthelminthic activity","volume":"19","author":"Castillo","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref_408","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10534-014-9703-1","article-title":"Gold complexes with benzimidazole derivatives: Synthesis, characterization and biological studies","volume":"27","author":"Mota","year":"2014","journal-title":"Biometals"},{"key":"ref_409","doi-asserted-by":"crossref","unstructured":"Mushtaq, A., Azam, U., Mehreen, S., and Naseer, M.M. (2023). Synthetic \u03b1-glucosidase inhibitors as promising anti-diabetic agents: Re-cent developments and future challenges. Eur. J. Med. Chem., 249.","DOI":"10.1016\/j.ejmech.2023.115119"},{"key":"ref_410","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.2174\/1568026614666141215151056","article-title":"Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs","volume":"14","author":"Alcantara","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_411","doi-asserted-by":"crossref","first-page":"4013","DOI":"10.2174\/0929867321666140915143309","article-title":"Sixteen-years of clinically relevant dipeptidyl peptidase-IV (DPP-IV) inhibitors for treatment of type-2 diabetes: A perspective","volume":"21","author":"Kushwaha","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_412","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/jm401780b","article-title":"Design, Synthesis, and Biological Evaluation of DeuteratedC-Aryl Glycoside as a Potent and Long-Acting Renal Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes","volume":"57","author":"Xu","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_413","doi-asserted-by":"crossref","unstructured":"Shaik, A., Kondaparthy, V., Aveli, R., and Das Manwal, D. (2022). Studies on the serum glucose reducing effect of vanadium metal complexes on Wistar rats. J. Mol. Struct., 1261.","DOI":"10.1016\/j.molstruc.2022.132825"},{"key":"ref_414","doi-asserted-by":"crossref","unstructured":"Patel, N., Prajapati, A.K., Jadeja, R.N., Patel, R.N., Patel, S.K., Tripathi, I.P., Dwivedi, N., Gupta, V.K., and Butcher, R.J. (2020). Dioxi-dovanadium(V) complexes of a tridentate ONO Schiff base ligand: Structural characterization, quantum chemical calcula-tions and In Vitro antidiabetic activity. Polyhedron, 180.","DOI":"10.1016\/j.poly.2020.114434"},{"key":"ref_415","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.poly.2018.12.021","article-title":"Synthesis, X-ray struc-tures and biological properties of palladium(II) complexes of 1,2-dimethylimidazole and benzimidazole","volume":"160","author":"Sadaf","year":"2019","journal-title":"Polyhedron"},{"key":"ref_416","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.poly.2019.06.025","article-title":"Synthesis, crystal structures and biological activities of palladium(II) complexes of benzimidazole and 2-methylbenzimidazole","volume":"170","author":"Sadaf","year":"2019","journal-title":"Polyhedron"},{"key":"ref_417","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2174\/0929867321666141106113018","article-title":"New Antihypertensive Drugs Under Development","volume":"22","author":"Tamargo","year":"2015","journal-title":"Curr. Med. Chem."},{"key":"ref_418","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.2174\/0929867321666140304093848","article-title":"Antihypertensive therapy in children: Differences in medical ap-proach between the unitedstates and europe","volume":"21","author":"Bassareo","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"ref_419","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1021\/ic500483p","article-title":"Antitumoral, Antihypertensive, Antimicrobial, and Antioxidant Effects of an Octanuclear Copper(II)-Telmisartan Complex with an Hydrophobic Nanometer Hole","volume":"53","author":"Islas","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_420","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.2147\/DDDT.S307113","article-title":"Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction","volume":"15","author":"Alghamdi","year":"2021","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_421","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1021\/jm5016044","article-title":"Recent Advances in the Discovery of Small Molecule Inhibitors of Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) as a Therapeutic Target for Inflammation and Oncology Disorders","volume":"58","author":"Chaudhary","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_422","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1021\/jm500907a","article-title":"Targeting Aldose Reductase for the Treatment of Diabetes Complications and Inflammatory Diseases: New Insights and Future Directions","volume":"58","author":"Maccari","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_423","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.2174\/0929867311320150006","article-title":"Recent developments of p38 alpha MAP kinase inhibitors as anti-inflammatory agents based on the imidazole scaffolds","volume":"20","author":"Kong","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_424","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.poly.2011.12.005","article-title":"Therapeutic properties, SOD and catecholase mimetic activities of novel ternary copper(II) complexes of the anti-inflammatory drug Fenoprofen with imid-azole and caffeine","volume":"34","author":"Agotegaray","year":"2012","journal-title":"Polyhedron"},{"key":"ref_425","doi-asserted-by":"crossref","unstructured":"Sasahara, G.L., Gouveia, F.S., Rodrigues, R.D., Zampieri, D.S., Fonseca, S.G.C., Goncalves, R.D.R., Athaydes, B.R., Kitagawa, R.R., Santos, F.A., and Sousa, E.H.S. (2020). Nitro-imidazole-based ruthenium complexes with antioxi-dant and anti-inflammatory activities. J. Inorg. Biochem., 206.","DOI":"10.1016\/j.jinorgbio.2020.111048"},{"key":"ref_426","doi-asserted-by":"crossref","first-page":"19475","DOI":"10.1039\/C5RA25071D","article-title":"In Vivo assessment of newly synthesized achiral copper(ii) and zinc(ii) complexes of a benzimidazole derived scaffold as a potential analgesic, antipyretic and anti-inflammatory","volume":"6","author":"AlAjmi","year":"2016","journal-title":"RSC Adv."},{"key":"ref_427","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.jorganchem.2010.02.009","article-title":"New di- and triorganotin(IV) complexes of tripodal Schiff base ligand containing three im-idazole arms: Synthesis, structural characterization, anti-inflammatory activity and thermal studies","volume":"695","author":"Nath","year":"2010","journal-title":"J. Organomet. Chem."},{"key":"ref_428","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.bmcl.2014.03.010","article-title":"Design, synthesis, and biological evaluation of dihydroartemisinin\u2013fluoroquinolone conjugates as a novel type of poten-tial antitubercular agents","volume":"24","author":"Zhou","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_429","doi-asserted-by":"crossref","unstructured":"Bekier, A., Kawka, M., Lach, J., Dziadek, J., Paneth, A., Gatkowska, J., Dzitko, K., and Dziadek, B. (2021). Imidazole-Thiosemicarbazide Derivatives as Potent Anti-Mycobacterium tuberculosis Compounds with Antibiofilm Activity. Cells, 10.","DOI":"10.3390\/cells10123476"},{"key":"ref_430","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.bmcl.2010.01.159","article-title":"Synthesis, antibacterial and antifungal activities of some carbazole derivatives","volume":"20","author":"Zhang","year":"2010","journal-title":"Bioorganic Med. Chem. Lett."},{"key":"ref_431","doi-asserted-by":"crossref","unstructured":"Kashyap, S., Singh, R., and Singh, U.P. (2020). Inorganic and organic anion sensing by azole family members. Coord. Chem. Rev., 417.","DOI":"10.1016\/j.ccr.2020.213369"},{"key":"ref_432","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1016\/j.tetlet.2016.06.016","article-title":"Pyrrole, imidazole, and triazole derivatives as ion-pair recognition receptors","volume":"57","author":"Alfonso","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"ref_433","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/cplu.202000484","article-title":"From Heteroditopic to Multitopic Receptors for Ion-Pair Recognition: Advances in Receptor Design and Applications","volume":"85","author":"McConnell","year":"2020","journal-title":"Chempluschem"},{"key":"ref_434","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1021\/ol902624h","article-title":"Novel Ratiometric Fluorescent Sensor for Silver Ions","volume":"12","author":"Wang","year":"2010","journal-title":"Org. Lett."},{"key":"ref_435","doi-asserted-by":"crossref","first-page":"15415","DOI":"10.1039\/C4CC06659F","article-title":"Graphitic carbon nitride solid nanofilms for selective and recyclable sensing of Cu2+ and Ag+ in water and serum","volume":"50","author":"Huang","year":"2014","journal-title":"Chem. Commun."},{"key":"ref_436","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1021\/ja807230c","article-title":"Selective Fluorogenic and Chromogenic Probe for Detection of Silver Ions and Silver Nanoparticles in Aqueous Media","volume":"131","author":"Chatterjee","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_437","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1021\/cr400546e","article-title":"Fluorescent Sensors for Measuring Metal Ions in Living Systems","volume":"114","author":"Carter","year":"2014","journal-title":"Chem. Rev."},{"key":"ref_438","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1039\/C2AY25769F","article-title":"Rhodamine and BODIPY chemodosimeters and chemosensors for the detection of Hg2+, based on fluorescence enhancement effects","volume":"5","author":"Culzoni","year":"2013","journal-title":"Anal. Methods"},{"key":"ref_439","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1016\/j.tetlet.2016.08.064","article-title":"Two \u2018turn-off\u2019 Schiff base fluorescence sensors based on phenan-thro [9,10-d]imidazole-coumarin derivatives for Fe3+ in aqueous solution","volume":"57","author":"Zhao","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"ref_440","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1039\/c3dt52424h","article-title":"Synthesis, structural characterization, and multichannel anion and cation sensing studies of a bifunctional Ru(II) polypyridyl-imidazole based receptor","volume":"43","author":"Das","year":"2014","journal-title":"Dalton Trans."},{"key":"ref_441","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ica.2016.02.041","article-title":"Polypyridyl-imidazole based smart Ru(II) complex mimicking advanced Boolean and Fuzzy logic functions","volume":"454","author":"Karmakar","year":"2017","journal-title":"Inorg. Chim. Acta"},{"key":"ref_442","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/acs.joc.8b02591","article-title":"Simultaneous detection of Cu2+ and Hg2+ via two mutually independent sensing pathways of biimidazole push\u2013pull dye","volume":"84","author":"Dey","year":"2019","journal-title":"J. Org. Chem."},{"key":"ref_443","doi-asserted-by":"crossref","unstructured":"Sun, J.L., Suo, Q.L., Hou, J.N., Ma, T., Gao, X.C., Lv, L., Gao, Y.Y., Jia, H.J., and Wang, Y.Q. (2021). 2-Ferrocenylimidazole-based multire-sponsive receptors for Al3+, Cu2+, and H2PO4\u2212 ions: Effect of structural modification on the ion sensing performance. Tetrahedron, 99.","DOI":"10.1016\/j.tet.2021.132434"},{"key":"ref_444","doi-asserted-by":"crossref","unstructured":"Joel, C., Livingston, D.J., Bennie, R.B., Jeyanthi, D., and Solomon, R.V. (2021). Designing bifunctional phenanthroimidazole chromo-phores for highly selective ratiometric chemosensing of Cu2+\/F- and Co2+\/F\u2014Ions in organic solvents. J. Photochem. Photobiol. A Chem., 423.","DOI":"10.1016\/j.jphotochem.2021.113612"},{"key":"ref_445","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jccs.201800200","article-title":"Sequential detection of Cu2+ and cysteine using an imid-azole-based chemosensor in aqueous solution","volume":"66","author":"Saha","year":"2019","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_446","doi-asserted-by":"crossref","unstructured":"Kumar, P., and Kumar, S. (2019). Copper ion luminescence on\/off sensing by a quinoline-appended ruthenium(II)-polypyridyl complex in aqueous media. J. Mol. Struct., 1202.","DOI":"10.1016\/j.molstruc.2019.127242"},{"key":"ref_447","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1021\/acs.inorgchem.2c02175","article-title":"Design of a highly selective benzimidazole-based de-rivative for optical and solid-state detection of zinc ion","volume":"61","author":"Honnappa","year":"2022","journal-title":"Inorg. Chem."},{"key":"ref_448","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.snb.2016.06.085","article-title":"Selective and sensitive colorimetric detection of Hg(II) in aqueous solution by quinone-diimidazole ensemble with mimicking YES-OR-INHIBIT logic gate operation","volume":"237","author":"Parthiban","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_449","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/1521-3773(20010202)40:3<486::AID-ANIE486>3.0.CO;2-P","article-title":"Anion recognition and sensing: The state of the art and future perspectives","volume":"40","author":"Beer","year":"2001","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_450","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1039\/D0CS00642D","article-title":"Revisiting imidazolium receptors for the recognition of anions: Highlighted research during 2010\u20132019","volume":"50","author":"Hu","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_451","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.snb.2016.03.106","article-title":"Colorimetric sensing of anions by Cu(II), Co(II), Ni(II) and Zn(II) com-plexes of naphthoquinone-imidazole hybrid\u2014Influence of complex formation on selectivity and sensing medium","volume":"231","author":"Parthiban","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_452","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1039\/C0NJ00478B","article-title":"Development of luminescent iridium(III) polypyridine complexes as chemical and bio-logical probes","volume":"35","author":"Lo","year":"2011","journal-title":"New J. Chem."},{"key":"ref_453","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.1021\/ic500999k","article-title":"Iridium(III) complexes with phe-nyl-tetrazoles as cyclometalating ligands","volume":"53","author":"Monti","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_454","doi-asserted-by":"crossref","first-page":"11882","DOI":"10.1021\/ic501032t","article-title":"Tuning the Emission Lifetime in Bis-cyclometalated Iridium(III) Complexes Bearing Iminopyrene Ligands","volume":"53","author":"Howarth","year":"2014","journal-title":"Inorg. Chem."},{"key":"ref_455","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.snb.2017.02.022","article-title":"A water\u2013soluble cationic Ir(III) complex for turn\u2013on sensing of ClO4-, based on aggregation\u2013induced emission","volume":"245","author":"Chao","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_456","doi-asserted-by":"crossref","first-page":"8495","DOI":"10.1021\/ic400478d","article-title":"Mono- and dinuclear cationic Iridium(III) complexes bear-ing a 2,5-dipyridylpyrazine (2,5-dpp) ligand","volume":"52","author":"Donato","year":"2013","journal-title":"Inorg. Chem."},{"key":"ref_457","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.1039\/C6DT04813G","article-title":"A highly sensitive and selective visible-light excitable luminescent probe for singlet oxygen based on a dinuclear ruthenium complex","volume":"46","author":"Yin","year":"2017","journal-title":"Dalton Trans."},{"key":"ref_458","doi-asserted-by":"crossref","unstructured":"Paul, A., Bar, M., Ahmed, T., and Baitalik, S. (2020). Anion-sensitive photophysics of luminescent trimetallic complexes of Fe(II), Ru(II), and Os(II) with polarized NH motifs. Polyhedron, 190.","DOI":"10.1016\/j.poly.2020.114772"},{"key":"ref_459","doi-asserted-by":"crossref","first-page":"10459","DOI":"10.1002\/chem.201600209","article-title":"Cadmium(II)-Triazole Framework as a Luminescent Probe for Ca2+ and Cyano Complexes","volume":"22","author":"Wang","year":"2016","journal-title":"Chem. A Eur. J."},{"key":"ref_460","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.snb.2016.08.047","article-title":"Smart ruthenium and osmium complexes mimic the complicated func-tions of traffic signal and memory device","volume":"239","author":"Mardanya","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_461","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.snb.2017.01.153","article-title":"Selective colorimetric sensing of fluoride ion via H-bonding in 80% aqueous solution by transi-tion metal chelates","volume":"245","author":"Parthiban","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_462","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.snb.2017.03.028","article-title":"A phenanthroimidazole based effective colorimetric chemosensor for copper(II) and fluoride ions","volume":"247","author":"Beneto","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_463","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jlumin.2016.06.024","article-title":"Establishing the anion recognition correlation of the 2-(2-methoxyphenyl)-1H-imidazo [4, 5-f][1,10] phenanthroline and its Ru(bipy) 2 2+ complex via fluorimetry","volume":"179","author":"Alreja","year":"2016","journal-title":"J. Lumin"},{"key":"ref_464","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.snb.2016.11.058","article-title":"Anthraquinone-biimidazole based ruthenium(II) complexes as selective multichannel anion sensors and multi-readout molecular logic gates and memory devices: Combined experimental and DFT\/TD-DFT study","volume":"242","author":"Mondal","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_465","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.snb.2017.05.025","article-title":"Asymmetric bimetallic ruthenium(II) complexes selectively sense cyanide in water through significant modulation of their ground and excited state properties","volume":"251","author":"Bar","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_466","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1021\/acs.inorgchem.6b03058","article-title":"Technetium(I) Complexes of Bathophenanthrolinedisulfonic Acid","volume":"56","author":"Yazdani","year":"2017","journal-title":"Inorg. Chem."},{"key":"ref_467","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1039\/C5SC04458H","article-title":"Stable luminescent iridium(iii) complexes with bis(N-heterocyclic carbene) ligands: Photo-stability, excited state properties, visible-light-driven radical cyclization and CO2 reduction, and cellular imaging","volume":"7","author":"Yang","year":"2016","journal-title":"Chem. Sci."},{"key":"ref_468","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1039\/C7TB00731K","article-title":"Two-photon photodynamic ablation of tumor cells by mitochondria-targeted iridium(iii) complexes in aggregate states","volume":"5","author":"Qiu","year":"2017","journal-title":"J. Mater. Chem. B"},{"key":"ref_469","doi-asserted-by":"crossref","unstructured":"Rizvi, S.F.A., Zhang, H.X., Mehmood, S., and Sanad, M. (2020). Synthesis of 99mTc-labeled 2-Mercaptobenzimidazole as a novel radio-tracer to diagnose tumor hypoxia. Transl. Oncol., 13.","DOI":"10.1016\/j.tranon.2020.100854"},{"key":"ref_470","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jinorgbio.2015.12.010","article-title":"Synthesis, characterization and biological evaluation of 99mTc\/Re-tricarbonyl quinolone complexes","volume":"160","author":"Kydonaki","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_471","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.talanta.2016.08.061","article-title":"Simultaneous bioimaging recognition of Al3+ and Cu2+ in living-cell, and further detection of F\u2212 and S2\u2212 by a simple fluorogenic benzimidazole-based chemosensor","volume":"161","author":"Liu","year":"2016","journal-title":"Talanta"},{"key":"ref_472","doi-asserted-by":"crossref","unstructured":"Ganesan, J.S., Sepperumal, M., and Ayyanar, S. (2020). A novel pyrazole bearing imidazole frame as ratiometric fluorescent chemosen-sor for Al3+\/Fe3+ ions and its application in HeLa cell imaging. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 230.","DOI":"10.1016\/j.saa.2019.117993"},{"key":"ref_473","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.snb.2017.02.079","article-title":"A new selective chemosensor based on phenan-thro[9,10-d]imidazole-coumarin with sequential \u201con-off-on\u201d fluorescence response to Fe3+ and phosphate anions and its ap-plication in live cell","volume":"246","author":"Zhao","year":"2017","journal-title":"Sens. Actuator B Chem."},{"key":"ref_474","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1111\/php.12789","article-title":"A boron 2-(2\u2032-pyridyl) imidazole fluorescence probe for bovine serum al-bumin: Discrimination over other proteins and identification of its denaturation","volume":"93","author":"Liu","year":"2017","journal-title":"Photochem. Photobiol."},{"key":"ref_475","doi-asserted-by":"crossref","unstructured":"Chen, X.H., Chen, Z.W., Hu, B.H., Cai, P.Q., Wang, S., Xiao, S.Z., Wu, Y.L., and Chen, X.D. (2018). Synergistic lysosomal activatable pol-ymeric nanoprobe encapsulating ph sensitive imidazole derivative for tumor diagnosis. Small, 14.","DOI":"10.1002\/smll.201703164"},{"key":"ref_476","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1021\/acsabm.0c00712","article-title":"pH-Sensitive Near-IR emitting dinuclear ruthenium com-plex for recognition, two-photon luminescent imaging, and subcellular localization of cancer cells","volume":"3","author":"Liu","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_477","doi-asserted-by":"crossref","first-page":"32632","DOI":"10.1039\/C7RA03312E","article-title":"Luminescent detection of the lipopolysaccharide endotoxin and rapid discrimination of bacterial pathogens using cationic platinum(ii) complexes","volume":"7","author":"Zhu","year":"2017","journal-title":"RSC Adv."},{"key":"ref_478","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ccr.2018.03.021","article-title":"Recent progress on the development of glutathione (GSH) selective fluorescent and colorimetric probes","volume":"366","author":"Lee","year":"2018","journal-title":"Coord. Chem. Rev."},{"key":"ref_479","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.dyepig.2018.05.069","article-title":"4-(4,5-Diphenyl-1H-imidazole-2-yl)-N,N-dimethylaniline-Cu(II) complex, a highly selective probe for glutathione sensing in water-acetonitrile mixtures","volume":"159","author":"Okda","year":"2018","journal-title":"Dye. Pigment."},{"key":"ref_480","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1039\/D0AN00164C","article-title":"An anthraquinone-imidazole-based colorimetric and fluorescent sensor for the sequential detection of Ag+ and biothiols in living cells","volume":"145","author":"Zhao","year":"2020","journal-title":"Analyst"},{"key":"ref_481","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.saa.2017.02.048","article-title":"Design and synthesis of novel adenine fluorescence probe based on Eu(III) complexes with dtpa-bis(guanine) ligand","volume":"179","author":"Tian","year":"2017","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_482","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1872-2040(18)61094-1","article-title":"Progress on Detection of Metals Ions by Functional Nucleic Acids Biosensor","volume":"46","author":"DU","year":"2018","journal-title":"Chin. J. Anal. Chem."},{"key":"ref_483","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.snb.2015.02.122","article-title":"A review on detection of heavy metal ions in water\u2014An electrochemical approach","volume":"213","author":"Gumpu","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_484","doi-asserted-by":"crossref","unstructured":"Zhu, Y.Y., Sun, Q., Shi, J.W., Xia, H.Y., Wang, J.L., Chen, H.Y., He, H.F., Shen, L., Zhao, F., and Zhong, J. (2020). A novel triple substituted imidazole fluorescent sensor for Ag plus and its imaging in living cell and zebrafish. J. Photochem. Photobiol. A Chem., 389.","DOI":"10.1016\/j.jphotochem.2019.112244"},{"key":"ref_485","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.snb.2017.10.087","article-title":"Ratiometric detection of Cu+ in aqueous buffered solutions and in live cells using fluorescent peptidyl probe to mimic the binding site of the metalloprotein for Cu+","volume":"256","author":"Mehta","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_486","doi-asserted-by":"crossref","unstructured":"Suresh, S., Bhuvanesh, N., Raman, A., Sugumar, P., Padmanabhan, D., Easwaramoorthi, S., Ponnuswamy, M.N., Kavitha, S., and Nandhakumar, R. (2019). Experimental and theoretical studies of imidazole based chemosensor for Palladium and their biological applications. J. Photochem. Photobiol. A Chem., 385.","DOI":"10.1016\/j.jphotochem.2019.112092"},{"key":"ref_487","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1002\/bio.4232","article-title":"Application of 2,4,5-tris(2-pyridyl)imidazole as \u2018turn-off\u2019 fluorescence sensor for Cu(II) and Hg(II) ions and In Vitro cell imaging","volume":"37","author":"Bhattacharya","year":"2022","journal-title":"Luminescence"},{"key":"ref_488","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1039\/C8QI01127C","article-title":"An imidazole derivative-based chemodosimeter for Zn2+ and Cu2+ ions through \u201cON\u2013OFF\u2013ON\u201d switching with intracellular Zn2+ detection","volume":"6","author":"Ansari","year":"2019","journal-title":"Inorg. Chem. Front."},{"key":"ref_489","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.snb.2017.01.154","article-title":"Ratiometric fluorescent probe based on symmetric peptidyl receptor with picomolar affinity for Zn2+ in aqueous solution","volume":"245","author":"Mehta","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_490","doi-asserted-by":"crossref","unstructured":"Zhang, L., Zhao, Q., Jiang, Z., Shen, J., Wu, W., Liu, X., Fan, Q., and Huang, W. (2021). Recent Progress of SERS Nanoprobe for pH Detecting and Its Application in Biological Imaging. Biosensors, 11.","DOI":"10.20944\/preprints202107.0031.v1"},{"key":"ref_491","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1080\/00958972.2019.1678031","article-title":"Preparation, characterization, pH titration, and electro-chemical properties of an anthracene-bridged binuclear ruthenium complex containing imidazole","volume":"72","author":"Yin","year":"2019","journal-title":"J. Coord. Chem."},{"key":"ref_492","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7150\/thno.9860","article-title":"Fluorescent Sensing of Fluoride in Cellular System","volume":"5","author":"Jiao","year":"2015","journal-title":"Theranostics"},{"key":"ref_493","doi-asserted-by":"crossref","unstructured":"Niu, L.C., Liu, J., Gao, S.Y., Gao, J.J., Zhou, Y., Liu, S.Z., Ma, C., and Zhao, Y.Z. (2023). Fluoride ions detection in aqueous media by un-precedented ring opening of fluorescein dye: A novel multimodal sensor for fluoride ions and its utilization in live cell imaging. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 287.","DOI":"10.1016\/j.saa.2022.122001"},{"key":"ref_494","first-page":"123","article-title":"Detection of hydrogen sulfide in water samples with 2-(4-hydroxyphenyl)-4,5-di(2-pyridyl)imidazole-copper(II) complex using environmentally green microplate fluorescence assay method","volume":"1057","author":"Watanabe","year":"2019","journal-title":"Anal. Chim. Acta"},{"key":"ref_495","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11705-021-2050-1","article-title":"Recent advances of small-molecule fluorescent probes for detecting biological hydrogen sulfide","volume":"16","author":"Zhou","year":"2021","journal-title":"Front. Chem. Sci. Eng."},{"key":"ref_496","doi-asserted-by":"crossref","first-page":"17075","DOI":"10.1039\/D1DT02489B","article-title":"Imidazo-pyridine-based zinc(ii) complexes as fluorescent hydrogen sulfide probes","volume":"50","author":"Strianese","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_497","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1039\/C4CS00353E","article-title":"Fluorescent and colorimetric chemosensors for pyrophosphate","volume":"44","author":"Lee","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_498","doi-asserted-by":"crossref","first-page":"11372","DOI":"10.1039\/D2DT01634F","article-title":"Cyclometalated iridium(iii) complex of a 1,2,3-triazole-based ligand for highly selective sensing of pyrophosphate ion","volume":"51","author":"Rabha","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_499","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/etc.5620180112","article-title":"Bioaccumulation and toxicity of silver compounds: A review","volume":"18","author":"Ratte","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_500","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s11164-018-3678-4","article-title":"Phenanthrene-imidazole-based fluorescent sensor for selective detection of Ag+ and F\u2212 ions: Real sample application and live cell imaging","volume":"45","author":"Asaithambi","year":"2019","journal-title":"Res. Chem. Intermed."},{"key":"ref_501","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1039\/C8OB02482K","article-title":"Triazole-imidazole (TA-IM) derivatives as ultra-fast fluorescent probes for selective Ag+ detection","volume":"16","author":"Lai","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_502","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bios.2015.09.003","article-title":"Development of mercury (II) ion biosen-sors based on mercury-specific oligonucleotide probes","volume":"75","author":"Li","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_503","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/bio.3063","article-title":"Two new reversible naphthalimide-based fluorescent chemosensors for Hg2+","volume":"31","author":"Li","year":"2015","journal-title":"Luminescence"},{"key":"ref_504","doi-asserted-by":"crossref","unstructured":"Wang, F., Wang, K.J., Kong, Q., Wang, J., Xi, D.Z., Gu, B.W., Lu, S., Wei, T.W., and Chen, X.Q. (2021). Recent studies focusing on the de-velopment of fluorescence probes for zinc ion. Coord. Chem. Rev., 429.","DOI":"10.1016\/j.ccr.2020.213636"},{"key":"ref_505","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10895-021-02839-5","article-title":"A Novel Imidazole Bound Schiff Base as Highly Selective \u201cTurn-on\u201d Fluorescence Sensor for Zn2+ and Colorimetric Kit for Co2+","volume":"32","author":"Gopalakrishnan","year":"2022","journal-title":"J. Fluoresc."},{"key":"ref_506","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.snb.2017.03.112","article-title":"Highly selective imidazole-appended 9,10-N,N\u2032-diaminomethylanthracene fluorescent probe for switch-on Zn2+ detection and switch-off H2PO4\u2212 and CN\u2212 detection in 80% aqueous DMSO, and applica-tions to sequential logic gate operations","volume":"247","author":"Pandith","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"ref_507","doi-asserted-by":"crossref","first-page":"5992","DOI":"10.1002\/aoc.5992","article-title":"Tridentate benzimidazole ligand and its metal complexes: Synthesis, characterization, photo physical and sensor properties","volume":"34","author":"Kose","year":"2020","journal-title":"Appl. Organomet. Chem."},{"key":"ref_508","doi-asserted-by":"crossref","unstructured":"Mahnashi, M.H., Mahmoud, A.M., Alkahtani, S.A., Ali, R., and El-Wekil, M.M. (2020). A novel imidazole derived colorimetric and fluo-rometric chemosensor for bifunctional detection of copper (II) and sulphide ions in environmental water samples. Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 228.","DOI":"10.1016\/j.saa.2019.117846"},{"key":"ref_509","doi-asserted-by":"crossref","unstructured":"Pan, J., Yu, J., Qiu, S., Zhu, A., Liu, Y., Ban, X., Li, W., Yu, H., and Li, L. (2020). A novel dibenzimidazole-based fluorescent probe with high sensitivity and selectivity for copper ions. J. Photochem. Photobiol. A Chem., 406.","DOI":"10.1016\/j.jphotochem.2020.113018"},{"key":"ref_510","doi-asserted-by":"crossref","first-page":"6297","DOI":"10.1007\/s11696-021-01795-5","article-title":"A novel tetraphenylethylene-functionalized arylimidazole AIEgen for detections of picric acid and Cu2+","volume":"75","author":"Yin","year":"2021","journal-title":"Chem. Pap."},{"key":"ref_511","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1039\/c2cs35152h","article-title":"Iron(iii) selective molecular and supramolecular fluorescent probes","volume":"41","author":"Sahoo","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref_512","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s40242-019-8244-0","article-title":"A New Tetrasubstituted Imidazole Based Difunctional Probe for UV-spectrophotometric and Fluorometric Detecting of Fe3+ Ion in Aqueous Solution","volume":"35","author":"Shi","year":"2019","journal-title":"Chem. Res. Chin. Univ."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/5\/1348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:24:38Z","timestamp":1760124278000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/5\/1348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":512,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["pharmaceutics15051348"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15051348","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,27]]}}}