{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T01:30:09Z","timestamp":1784683809839,"version":"3.55.0"},"reference-count":55,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UEFISCDI","award":["81TE\/2022"],"award-info":[{"award-number":["81TE\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>A new series of nanostructured materials was obtained by functionalization of SBA-15 mesoporous silica with Ru(II) and Ru(III) complexes bearing Schiff base ligands derived from salicylaldehyde and various amines (1,2-diaminocyclohexane, 1,2-phenylenediamine, ethylenediamine, 1,3-diamino-2-propanol, N,N-dimethylethylenediamine, 2-aminomethyl-pyridine, and 2-(2-aminoethyl)-pyridine). The incorporation of ruthenium complexes into the porous structure of SBA-15 and the structural, morphological, and textural features of the resulting nanostructured materials were investigated by FTIR, XPS, TG\/DTA, zeta potential, SEM, and N2 physisorption. The ruthenium complex-loaded SBA-15 silica samples were tested against A549 lung tumor cells and MRC-5 normal lung fibroblasts. A dose-dependent effect was observed, with the highest antitumoral efficiency being recorded for the material containing [Ru(Salen)(PPh3)Cl] (50%\/90% decrease in the A549 cells\u2019 viability at a concentration of 70 \u03bcg\/mL\/200 \u03bcg\/mL after 24 h incubation). The other hybrid materials have also shown good cytotoxicity against cancer cells, depending on the ligand included in the ruthenium complex. The antibacterial assay revealed an inhibitory effect for all samples, the most active being those containing [Ru(Salen)(PPh3)Cl], [Ru(Saldiam)(PPh3)Cl], and [Ru(Salaepy)(PPh3)Cl], especially against Staphylococcus aureus and Enterococcus faecalis Gram-positive strains. In conclusion, these nanostructured hybrid materials could represent valuable tools for the development of multi-pharmacologically active compounds with antiproliferative, antibacterial, and antibiofilm activity.<\/jats:p>","DOI":"10.3390\/pharmaceutics15051458","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:37:09Z","timestamp":1683769029000},"page":"1458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New Nanostructured Materials Based on Mesoporous Silica Loaded with Ru(II)\/Ru(III) Complexes with Anticancer and Antimicrobial Properties"],"prefix":"10.3390","volume":"15","author":[{"given":"Gabriela","family":"Marinescu","sequence":"first","affiliation":[{"name":"Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-5443","authenticated-orcid":false,"given":"Daniela C.","family":"Culita","sequence":"additional","affiliation":[{"name":"Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-4696","authenticated-orcid":false,"given":"Teodora","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul-Augustin","family":"Mitran","sequence":"additional","affiliation":[{"name":"Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Ilie Murgulescu Institute of Physical Chemistry, 202 Splaiul Independentei, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-8540","authenticated-orcid":false,"given":"Miruna S.","family":"Stan","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6098-1857","authenticated-orcid":false,"given":"Mariana C.","family":"Chifiriuc","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Popa","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Bucharest, 90 Panduri Street, 050663 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.1039\/C8DT02392A","article-title":"Mesoporous Silica Nanoparticles Functionalised with a Photoactive Ruthenium(ii) Complex: Exploring the Formulation of a Metal-Based Photodynamic Therapy Photosensitiser","volume":"48","author":"Ellahioui","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8011","DOI":"10.1021\/acs.inorgchem.1c00527","article-title":"Triazole-Based Half-Sandwich Ruthenium(II) Compounds: From In Vitro Antiproliferative Potential to In Vivo Toxicity Evaluation","volume":"60","author":"Cabral","year":"2021","journal-title":"Inorg. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1039\/D1DT00185J","article-title":"A New Bis-Pyrazolylpyridine Ruthenium (iii) Complex as a Potential Anticancer Drug: In Vitro and in Vivo Activity in Murine Colon Cancer","volume":"50","author":"Scheurer","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1039\/D1DT00777G","article-title":"UCNP@BSA@Ru Nanoparticles with Tumor-Specific and NIR-Triggered Efficient PACT Activity in Vivo","volume":"50","author":"Zhang","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"111963","DOI":"10.1016\/j.jinorgbio.2022.111963","article-title":"Synthesis and Characterization of Polypyridine Ruthenium(II) Complexes and Anticancer Efficacy Studies in Vivo and in Vitro","volume":"236","author":"Liang","year":"2022","journal-title":"J. Inorg. Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cbdv.200890195","article-title":"KP1019, A New Redox-Active Anticancer Agent\u2014Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients","volume":"5","author":"Hartinger","year":"2008","journal-title":"Chem. Biodivers."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7817","DOI":"10.1039\/c0dt01816c","article-title":"Ruthenium Anticancer Compounds: Myths and Realities of the Emerging Metal-Based Drugs","volume":"40","author":"Bergamo","year":"2011","journal-title":"Dalton Trans."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1039\/C3SC53243G","article-title":"NKP-1339, the First Ruthenium-Based Anticancer Drug on the Edge to Clinical Application","volume":"5","author":"Trondl","year":"2014","journal-title":"Chem. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1039\/C1DT11950H","article-title":"Ruthenium Complexes Containing Bis-Benzimidazole Derivatives as a New Class of Apoptosis Inducers","volume":"41","author":"Li","year":"2012","journal-title":"Dalton Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"214656","DOI":"10.1016\/j.ccr.2022.214656","article-title":"Combination of Light and Ru(II) Polypyridyl Complexes: Recent Advances in the Development of New Anticancer Drugs","volume":"469","author":"Conti","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s00775-020-01772-5","article-title":"An Unusual Bidentate Methionine Ruthenium(II) Complex: Photo-Uncaging and Antimicrobial Activity","volume":"25","author":"Gondim","year":"2020","journal-title":"J. Biol. Inorg. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Munteanu, A.-C., and Uivarosi, V. (2021). Ruthenium Complexes in the Fight against Pathogenic Microorganisms. An Extensive Review. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13060874"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"10275","DOI":"10.1021\/acs.inorgchem.0c01436","article-title":"Amino-Functionalized Mesoporous Silica Nanoparticle-Encapsulated Octahedral Organoruthenium Complex as an Efficient Platform for Combatting Cancer","volume":"59","author":"Ho","year":"2020","journal-title":"Inorg. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ccr.2016.01.001","article-title":"Nanostructured Materials Functionalized with Metal Complexes: In Search of Alternatives for Administering Anticancer Metallodrugs","volume":"312","author":"Wani","year":"2016","journal-title":"Coord. Chem. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41392-017-0004-3","article-title":"Controlled Drug Delivery Vehicles for Cancer Treatment and Their Performance","volume":"3","author":"Senapati","year":"2018","journal-title":"Signal Transduct. Target Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/cm0011559","article-title":"A New Property of MCM-41: Drug Delivery System","volume":"13","year":"2001","journal-title":"Chem. Mater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micromeso.2005.12.004","article-title":"Controlled Release of Captopril by Regulating the Pore Size and Morphology of Ordered Mesoporous Silica","volume":"92","author":"Qu","year":"2006","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1039\/B510101H","article-title":"Functionalization of Mesoporous Materials with Long Alkyl Chains as a Strategy for Controlling Drug Delivery Pattern","volume":"16","author":"Doadrio","year":"2006","journal-title":"J. Mater. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1021\/ja028650l","article-title":"A Mesoporous Silica Nanosphere-Based Carrier System with Chemically Removable CdS Nanoparticle Caps for Stimuli-Responsive Controlled Release of Neurotransmitters and Drug Molecules","volume":"125","author":"Lai","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1002\/chem.200900151","article-title":"A New Generation of Anticancer Drugs: Mesoporous Materials Modified with Titanocene Complexes","volume":"15","author":"Sierra","year":"2009","journal-title":"Chem. Eur. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jinorgbio.2016.11.004","article-title":"Inorganic Mesoporous Silicas as Vehicles of Two Novel Anthracene-Based Ruthenium Metalloarenes","volume":"166","author":"Rojas","year":"2017","journal-title":"J. Inorg. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jinorgbio.2017.12.011","article-title":"Delivery of [Ru(H6-p-Cymene)Cl2{Ph2P(CH2)3SPh-\u039aP}] Using Unfunctionalized and Mercapto Functionalized SBA-15 Mesoporous Silica: Preparation, Characterization and in Vitro Study","volume":"180","author":"Edeler","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s11426-016-0409-4","article-title":"Mesoporous Silica Nanoparticles-Assisted Ruthenium(II) Complexes for Live Cell Staining","volume":"60","author":"Wen","year":"2017","journal-title":"Sci. China Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18147","DOI":"10.1039\/C6DT03783F","article-title":"PH Sensitive Chitosan-Mesoporous Silica Nanoparticles for Targeted Delivery of a Ruthenium Complex with Enhanced Anticancer Effects","volume":"45","author":"Lv","year":"2016","journal-title":"Dalton Trans."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1021\/ja405058y","article-title":"Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles","volume":"135","author":"Frasconi","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1039\/C4CC07489K","article-title":"Ultralow-Intensity near-Infrared Light Induces Drug Delivery by Upconverting Nanoparticles","volume":"51","author":"He","year":"2015","journal-title":"Chem. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.actbio.2017.12.041","article-title":"Mesoporous Silica Nanoparticles Decorated with Polycationic Dendrimers for Infection Treatment","volume":"68","author":"Colilla","year":"2018","journal-title":"Acta Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"38364","DOI":"10.1021\/acsami.7b14642","article-title":"Modified Mesoporous Silica Nanoparticles with a Dual Synergetic Antibacterial Effect","volume":"9","author":"Michailidis","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"D\u00edaz-Garc\u00eda, D., Ardiles, P., Prashar, S., Rodr\u00edguez-Di\u00e9guez, A., P\u00e1ez, P., and G\u00f3mez-Ruiz, S. (2019). Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11010030"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1002\/adfm.201303533","article-title":"Cancer-Targeted Monodisperse Mesoporous Silica Nanoparticles as Carrier of Ruthenium Polypyridyl Complexes to Enhance Theranostic Effects","volume":"24","author":"He","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12951-021-00848-x","article-title":"Ruthenium-Loaded Mesoporous Silica as Tumor Microenvironment-Response Nano-Fenton Reactors for Precise Cancer Therapy","volume":"19","author":"Sun","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Harun, S.N., Ahmad, H., Lim, H.N., Chia, S.L., and Gill, M.R. (2021). Synthesis and Optimization of Mesoporous Silica Nanoparticles for Ruthenium Polypyridyl Drug Delivery. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13020150"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"146379","DOI":"10.1016\/j.apsusc.2020.146379","article-title":"Novel Hybrid Materials Based on Heteroleptic Ru(III) Complexes Immobilized on SBA-15 Mesoporous Silica as Highly Potent Antimicrobial and Cytotoxic Agents","volume":"520","author":"Marinescu","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/00958972.2014.997721","article-title":"New Heterometallic Coordination Polymers Based on Zinc(II) Complexes with Schiff-Base Ligands and Dicyanometallates: Synthesis, Crystal Structures, and Luminescent Properties","volume":"68","author":"Marinescu","year":"2015","journal-title":"J. Coord. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.poly.2011.01.001","article-title":"New D10 Heterometallic Coordination Polymers Based on Compartmental Schiff-Base Ligands. Synthesis, Structure and Luminescence","volume":"30","author":"Marinescu","year":"2011","journal-title":"Polyhedron"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1039\/c3nj00199g","article-title":"A New Synthetic Route towards Binuclear 3d\u20134f Complexes, Using Non-Compartmental Ligands Derived from o-Vanillin. Syntheses, Crystal Structures, Magnetic and Luminescent Properties","volume":"37","author":"Sarwar","year":"2013","journal-title":"New J. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/0022-1902(66)80191-4","article-title":"New Complexes of Ruthenium (II) and (III) with Triphenylphosphine, Triphenylarsine, Trichlorostannate, Pyridine and Other Ligands","volume":"28","author":"Stephenson","year":"1966","journal-title":"J. Inorg. Nucl. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1071\/CH9780203","article-title":"Ruthenium Complexes with a Tetradentate Salicylaldimine Schiff Base","volume":"31","author":"Murray","year":"1978","journal-title":"Aust. J. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1021\/ja974025i","article-title":"Nonionic Triblock and Star Diblock Copolymer and Oligomeric Surfactant Syntheses of Highly Ordered, Hydrothermally Stable, Mesoporous Silica Structures","volume":"120","author":"Zhao","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.ica.2018.03.017","article-title":"Synthesis, Structure and Catalytic Alcohol Oxidation by Ruthenium(III) Supported by Schiff Base and Triphenylphosphine Ligands","volume":"477","author":"Tang","year":"2018","journal-title":"Inorg. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.inoche.2005.08.004","article-title":"Ruthenium(III) Schiff Base Complexes of [ONNO]-Type Mediated Transfer Hydrogenation of Ketones","volume":"8","author":"Venkatachalam","year":"2005","journal-title":"Inorg. Chem. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.inoche.2003.11.020","article-title":"Spectral and Catalytic Studies of Ruthenium(III) Schiff Base Complexes","volume":"7","author":"Ramesh","year":"2004","journal-title":"Inorg. Chem. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/zaac.200400063","article-title":"A Novel Ruthenium(III) and Lithium Complex: Synthesis, Crystal Structure, and Magnetic Properties","volume":"630","author":"Bai","year":"2004","journal-title":"Z. Anorg. Allg. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Das, A.K., Peng, S.-M., and Bhattacharya, S. (2000). Ruthenium-Mediated Reduction of Oximes to Imines. Synthesis, Characterization and Redox Properties of Imine Complexes of Ruthenium. J. Chem. Soc. Dalton Trans., 181\u2013184.","DOI":"10.1039\/a907021d"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1039\/c3nj00415e","article-title":"A New Family of Ru(Ii) Complexes with a Tridentate Pyridine Schiff-Base Ligand and Bidentate Co-Ligands: Synthesis, Characterization, Structure and in Vitro Cytotoxicity Studies","volume":"37","author":"Siegler","year":"2013","journal-title":"New J. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.colsurfb.2018.02.019","article-title":"Mesoporous Silica Nanoparticles Functionalized with Hyaluronic Acid. Effect of the Biopolymer Chain Length on Cell Internalization","volume":"168","author":"Nairi","year":"2018","journal-title":"Colloids Surf. Biointerfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"108187","DOI":"10.1016\/j.matdes.2019.108187","article-title":"Functionalised Mesoporous Silica Nanoparticles with Excellent Cytotoxicity against Various Cancer Cells for PH-Responsive and Controlled Drug Delivery","volume":"184","author":"Park","year":"2019","journal-title":"Mater. Des."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1515\/pac-2014-1117","article-title":"Physisorption of Gases, with Special Reference to the Evaluation of Surface Area and Pore Size Distribution (IUPAC Technical Report)","volume":"87","author":"Thommes","year":"2015","journal-title":"Pure Appl. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"26466","DOI":"10.18632\/oncotarget.25470","article-title":"Folic Acid-Conjugated Mesoporous Silica Particles as Nanocarriers of Natural Prodrugs for Cancer Targeting and Antioxidant Action","volume":"9","author":"AbouAitah","year":"2018","journal-title":"Oncotarget"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"16339","DOI":"10.1039\/D2NR02994D","article-title":"Ruthenium-Based Antitumor Drugs and Delivery Systems from Monotherapy to Combination Therapy","volume":"14","author":"Lu","year":"2022","journal-title":"Nanoscale"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Mahmud, K.M., Niloy, M.S., Shakil, M.S., and Islam, M.A. (2021). Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081295"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"A186","DOI":"10.1136\/esmoopen-2018-EACR25.442","article-title":"PO-416 Cytotoxicity of Ru (II) and Ru (III) Salen Complexes against Breast and Colorectal Cancer Cell Lines","volume":"3","author":"Santos","year":"2018","journal-title":"ESMO Open"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ctrv.2016.01.003","article-title":"Cisplatin in the modern era: The backbone of first-line chemotherapy for non-small cell lung cancer","volume":"44","author":"Fennell","year":"2016","journal-title":"Cancer Treat. Rev."},{"key":"ref_54","first-page":"656","article-title":"In vitro and in silico assessment of antiproliferative activity of new acetamides bearing 1,3,4-oxadiazole and pyrimidine cores via COX inhibition","volume":"24","author":"Sever","year":"2020","journal-title":"J. Res. Pharm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1021\/tx050283e","article-title":"Threshold Effects of Nitric Oxide-Induced Toxicity and Cellular Responses in Wild-Type and P53-Null Human Lymphoblastoid Cells","volume":"19","author":"Li","year":"2006","journal-title":"Chem. Res. Toxicol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/5\/1458\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:32:23Z","timestamp":1760124743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/5\/1458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":55,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["pharmaceutics15051458"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15051458","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]}}}