{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:30:50Z","timestamp":1784784650167,"version":"3.55.0"},"reference-count":44,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONICET and The National University of C\u00f3rdoba (UNC, Argentina)","award":["Agencia Nacional de I+D+i PICT-2020-SERIEA-02037\u2014RAICES"],"award-info":[{"award-number":["Agencia Nacional de I+D+i PICT-2020-SERIEA-02037\u2014RAICES"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Domperidone (DOM) is a drug commonly used to treat nausea and vomiting, as well as gastrointestinal disorders. However, its low solubility and extensive metabolism pose significant administration challenges. In this study, we aimed to improve DOM solubility and avoid its metabolism by developing nanocrystals (NC) of DOM through a 3D printing technology\u2014melting solidification printing process (MESO-PP)\u2014to be delivered via a solid dosage form (SDF) that can be administered sublingually. We obtained DOM-NCs using the wet milling process and designed an ultra-rapid release ink (composed of PEG 1500, propylene glycol, sodium starch glycolate, croscarmellose sodium, and sodium citrate) for the 3D printing process. The results demonstrated an increase in the saturation solubility of DOM in both water and simulated saliva without any physicochemical changes in the ink as observed by DSC, TGA, DRX, and FT-IR. The combination of nanotechnology and 3D printing technology enabled us to produce a rapidly disintegrating SDF with an improved drug-release profile. This study demonstrates the potential of developing sublingual dosage forms for drugs with low aqueous solubility using nanotechnology and 3D printing technology, providing a feasible solution to the challenges associated with the administration of drugs with low solubility and extensive metabolism in pharmacology.<\/jats:p>","DOI":"10.3390\/pharmaceutics15051459","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T01:37:09Z","timestamp":1683769029000},"page":"1459","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Design and Development of Sublingual Printlets Containing Domperidone Nanocrystals Using 3D Melting Solidification Printing Process (MESO-PP)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-2028","authenticated-orcid":false,"given":"Luc\u00eda","family":"Lopez-Vidal","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET, Haya de la Torre y Medina Allemde, C\u00f3rdoba X5000HUA, Argentina"},{"name":"Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la torre y Medina Allende, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-8972","authenticated-orcid":false,"given":"Alejandro J.","family":"Paredes","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Medical Biology Centre, Queen\u2019s University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Daniel","family":"Palma","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET, Haya de la Torre y Medina Allemde, C\u00f3rdoba X5000HUA, Argentina"},{"name":"Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la torre y Medina Allende, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-8294","authenticated-orcid":false,"given":"Juan Pablo","family":"Real","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA), CONICET, Haya de la Torre y Medina Allemde, C\u00f3rdoba X5000HUA, Argentina"},{"name":"Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, Haya de la torre y Medina Allende, C\u00f3rdoba X5000HUA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"ref_1","unstructured":"Enna, S.J., and Bylund, D.B. 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