{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:41:04Z","timestamp":1792050064982,"version":"4.4.0"},"reference-count":202,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund (ERDF\/FEDER)","award":["AGL2017-82987"],"award-info":[{"award-number":["AGL2017-82987"]}]},{"name":"Spanish Ministry of Economy, Industry and Competitiveness and the European Regional Development Fund (ERDF\/FEDER)","award":["A20_23R"],"award-info":[{"award-number":["A20_23R"]}]},{"name":"European Social Found (ESF)","award":["AGL2017-82987"],"award-info":[{"award-number":["AGL2017-82987"]}]},{"name":"European Social Found (ESF)","award":["A20_23R"],"award-info":[{"award-number":["A20_23R"]}]},{"name":"Aragon Regional Government","award":["AGL2017-82987"],"award-info":[{"award-number":["AGL2017-82987"]}]},{"name":"Aragon Regional Government","award":["A20_23R"],"award-info":[{"award-number":["A20_23R"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The intestine represents one of the first barriers where microorganisms and environmental antigens come into tight contact with the host immune system. A healthy intestine is essential for the well-being of humans and animals. The period after birth is a very important phase of development, as the infant moves from a protected environment in the uterus to one with many of unknown antigens and pathogens. In that period, mother\u2019s milk plays an important role, as it contains an abundance of biologically active components. Among these components, the iron-binding glycoprotein, lactoferrin (LF), has demonstrated a variety of important benefits in infants and adults, including the promotion of intestinal health. This review article aims to provide a compilation of all the information related to LF and intestinal health, in infants and adults.<\/jats:p>","DOI":"10.3390\/pharmaceutics15061569","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T07:00:02Z","timestamp":1684825202000},"page":"1569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["The Role of Lactoferrin in Intestinal Health"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0862-9893","authenticated-orcid":false,"given":"Celia","family":"Conesa","sequence":"first","affiliation":[{"name":"Departamento de Producci\u00f3n Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bell\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Fisiolog\u00eda y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n IA2 (UNIZAR-CITA), 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5306-9365","authenticated-orcid":false,"given":"Laura","family":"Grasa","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Fisiolog\u00eda y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n IA2 (UNIZAR-CITA), 50013 Zaragoza, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Arag\u00f3n (IIS Arag\u00f3n), 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5964-823X","authenticated-orcid":false,"given":"Lourdes","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Producci\u00f3n Animal y Ciencia de los Alimentos, Facultad de Veterinaria, Universidad de Zaragoza, 50013 Zaragoza, Spain"},{"name":"Instituto Agroalimentario de Arag\u00f3n IA2 (UNIZAR-CITA), 50013 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"759507","DOI":"10.3389\/fnut.2021.759507","article-title":"The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease","volume":"8","author":"Liu","year":"2021","journal-title":"Front. 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