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Taiwan","award":["TCRD-TPE-111-07"],"award-info":[{"award-number":["TCRD-TPE-111-07"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCRD-TPE-MOST-110-02"],"award-info":[{"award-number":["TCRD-TPE-MOST-110-02"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCRD-TPE-MOST-111-02"],"award-info":[{"award-number":["TCRD-TPE-MOST-111-02"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCRD-TPE-MOST-109-03"],"award-info":[{"award-number":["TCRD-TPE-MOST-109-03"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCAS-110-02"],"award-info":[{"award-number":["TCAS-110-02"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCMFA 107-01-13(112)"],"award-info":[{"award-number":["TCMFA 107-01-13(112)"]}]},{"name":"Buddhist Tzu Chi Medical Foundation, Taiwan","award":["TCMF-JCT 111-17"],"award-info":[{"award-number":["TCMF-JCT 111-17"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>(1) Background: Increasing attention has been given to applying nanosized iron oxide nanoparticles (IOPs) to treat iron deficiency anemia (IDA). Chronic kidney disease (CKD) patients who suffer from IDA often need long-term iron supplements. We aim to evaluate the safety and therapeutic effect of MPB-1523, a novel IOPs, in anemic CKD mice and to monitor iron storage by magnetic resonance (MR) imaging. (2) Methods: MPB-1523 was intraperitoneally delivered to the CKD and sham mice, and blood were collected for hematocrit, iron storage, cytokine assays, and MR imaging throughout the study. (3) Results: The hematocrit levels of CKD and sham mice dropped initially but increased gradually to reach a steady value 60 days after IOP injection. The body iron storage indicator, ferritin gradually rose and total iron-binding capacity stabilized 30 days after IOP injection. No significant inflammation or oxidative stress were observed in both groups. By T2-weighted MR imaging, the liver signal intensity gradually increased in both groups but was more pronounced in the CKD group, indicating aggressive utilization of MPB-1523. MR imaging, histology and electron microscopy showed MPB-1523 is liver-specific. (4) Conclusions: MPB-1523 can serve as a long-term iron supplement and is monitored by MR imaging. Our results have strong translatability to the clinic.<\/jats:p>","DOI":"10.3390\/pharmaceutics15061714","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T01:35:30Z","timestamp":1686620130000},"page":"1714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Theranostic Role of Iron Oxide Nanoparticle for Treating Renal Anemia: Evidence of Efficacy and Significance by MRI, Histology and Biomarkers"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5249-1679","authenticated-orcid":false,"given":"Jong-Kai","family":"Hsiao","sequence":"first","affiliation":[{"name":"Department of Medical Imaging, Taipei Tzu Chi Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City 23142, Taiwan"},{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Lung","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, MegaPro, Ltd., Hsinchu 30204, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yuan","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Translational Medicine, MegaPro, Ltd., Hsinchu 30204, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-0388","authenticated-orcid":false,"given":"Ko-Lin","family":"Kuo","sequence":"additional","affiliation":[{"name":"School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"},{"name":"Division of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan"},{"name":"School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97048, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1056\/NEJMra1401038","article-title":"Iron-Deficiency Anemia","volume":"372","author":"Camaschella","year":"2015","journal-title":"N. 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