{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:14:27Z","timestamp":1792822467656,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T00:00:00Z","timestamp":1688774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation","award":["2013\/04151-3"],"award-info":[{"award-number":["2013\/04151-3"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["2014\/24518-1"],"award-info":[{"award-number":["2014\/24518-1"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["2019\/14051-2"],"award-info":[{"award-number":["2019\/14051-2"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["2017\/16409-6"],"award-info":[{"award-number":["2017\/16409-6"]}]},{"name":"S\u00e3o Paulo Research Foundation","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["2013\/04151-3"],"award-info":[{"award-number":["2013\/04151-3"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["2014\/24518-1"],"award-info":[{"award-number":["2014\/24518-1"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["2019\/14051-2"],"award-info":[{"award-number":["2019\/14051-2"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["2017\/16409-6"],"award-info":[{"award-number":["2017\/16409-6"]}]},{"name":"Brazilian National Council for Scientific and Technological Development","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["2013\/04151-3"],"award-info":[{"award-number":["2013\/04151-3"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["2014\/24518-1"],"award-info":[{"award-number":["2014\/24518-1"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["2019\/14051-2"],"award-info":[{"award-number":["2019\/14051-2"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["2017\/16409-6"],"award-info":[{"award-number":["2017\/16409-6"]}]},{"name":"Coordination for the Improvement of Higher Education Personnel","award":["001"],"award-info":[{"award-number":["001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Hydrogen sulfide (H2S) is particularly produced in the skin, where it participates in the regulation of inflammation, pruritus, cytoprotection, scarring, and angiogenesis. In this study, we compared the effects of dexamethasone (Dex) with two H2S-releasing Dex derivatives in a murine model of atopic dermatitis (AD) induced by topical application of 2,4-dinitrochlorobenzene (DNCB). After sensitization with DNCB, the animals were topically treated for five consecutive days with either the H2S-releasing compounds 4-hydroxy-thiobenzamide (TBZ) and 5-(p-hydroxyphenyl)-1,2-dithione-3-thione (ADT-OH), Dex, or the derivatives Dex-TBZ or Dex-ADT. Topical treatment with equimolar doses of either Dex, Dex-TBZ, or Dex-ADT resulted in similar reductions in dermatitis score, scratching behavior, edema, eosinophilia, splenomegaly, and histological changes. In contrast with Dex, the H2S-releasing derivatives prevented IL-4 elevation and oxidative modification of skin proteins. On an equimolar dose basis, Dex-TBZ, but not Dex-ADT, promoted the elevation of endogenous H2S production and GPx activity. Neither Dex-TBZ nor Dex-ADT decreased GR activity or caused hyperglycemia, as observed with Dex treatment. We conclude that the presence of H2S-releasing moieties in the Dex structure does not interfere with the anti-inflammatory effects of this corticosteroid and adds beneficial therapeutical actions to the parent compound.<\/jats:p>","DOI":"10.3390\/pharmaceutics15071907","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:45:37Z","timestamp":1688949937000},"page":"1907","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Beneficial Effects of Two Hydrogen Sulfide (H2S)-Releasing Derivatives of Dexamethasone with Antioxidant Activity on Atopic Dermatitis in Mice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-8915","authenticated-orcid":false,"given":"Silvia Abigail","family":"Coavoy-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7057-2563","authenticated-orcid":false,"given":"Anderson Rom\u00e9rio Azevedo","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-5030","authenticated-orcid":false,"given":"Simone Aparecida","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Santagada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Andreozzi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-156X","authenticated-orcid":false,"given":"Angela","family":"Corvino","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-2788","authenticated-orcid":false,"given":"Antonia","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Sparaco","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Caliendo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3887-8869","authenticated-orcid":false,"given":"Beatrice","family":"Severino","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medicine, Universit\u00e0 degli Studi di Napoli \u201cFederico II\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-4490","authenticated-orcid":false,"given":"Soraia Katia Pereira","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-542X","authenticated-orcid":false,"given":"Luis Carlos","family":"Spolidorio","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, School of Dentistry, S\u00e3o Paulo State University, Araraquara 14801-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8342-5586","authenticated-orcid":false,"given":"Marcelo Nicol\u00e1s","family":"Muscar\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-000, SP, Brazil"},{"name":"Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/1346-8138.15664","article-title":"Basics and Recent Advances in the Pathophysiology of Atopic Dermatitis","volume":"48","author":"Nakahara","year":"2020","journal-title":"J. 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