{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:26:15Z","timestamp":1783463175458,"version":"3.55.0"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"QUESPER R&amp;D"},{"name":"INNCORPORA-TU-2011-1886 subprogram"},{"name":"programme for the Reinforcement of Research Activity in the Clinical Management Units of the Andalusian Health Service"},{"name":"Noventure, Ferrer company group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive\u00ae (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm2\/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G\u2032\/G\u2033 ratio, the lowest viscous modulus, G\u2033, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance.<\/jats:p>","DOI":"10.3390\/pharmaceutics15071925","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T02:05:21Z","timestamp":1689041121000},"page":"1925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract\u2014Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-7323","authenticated-orcid":false,"given":"Jos\u00e9","family":"Verd\u00fa-Soriano","sequence":"first","affiliation":[{"name":"Department of Community Nursing, Preventive Medicine, Public Health and History of Science, Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"de Cristino-Espinar","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Reina Sofia University Hospital, 14004 C\u00f3rdoba, Spain"},{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Luna-Morales","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Occidente Health Center, C\u00f3rdoba and Guadalquivir Health Management Area, 14005 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caridad","family":"Dios-Guerra","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Occidente Health Center, C\u00f3rdoba and Guadalquivir Health Management Area, 14005 C\u00f3rdoba, Spain"},{"name":"Department of Nursing, Faculty of Medicine and Nursing, University of Cordoba, 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8278","authenticated-orcid":false,"given":"Antonio","family":"Casado-D\u00edaz","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Endocrinology and Nutrition Unit, Reina Sofia University Hospital, 14004 Cordoba, Spain"},{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Quesada-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sof\u00eda University Hospital, University of C\u00f3rdoba, 14004 C\u00f3rdoba, Spain"},{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Dorado","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Dep. Bioqu\u00edmica y Biolog\u00eda Molecular, Campus Rabanales C6-1-E17, Campus de Excelencia Internacional Agroalimentario (ceiA3), Universidad de C\u00f3rdoba, 14071 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Berenguer-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Community Nursing, Preventive Medicine, Public Health and History of Science, Faculty of Health Sciences, University of Alicante, 03690 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"V\u00edlchez","sequence":"additional","affiliation":[{"name":"Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cient\u00edficas (IQAC-CSIC), 08034 Barcelona, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-5259","authenticated-orcid":false,"given":"Jordi","family":"Esquena","sequence":"additional","affiliation":[{"name":"Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cient\u00edficas (IQAC-CSIC), 08034 Barcelona, Spain"},{"name":"Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6551-1333","authenticated-orcid":false,"given":"Leocadio","family":"Rodr\u00edguez-Ma\u00f1as","sequence":"additional","affiliation":[{"name":"Consortium for Biomedical Research in Frailty & Healthy Ageing (CIBERFES), Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Geriatric Research Group, Biomedical Research Foundation at Getafe University Hospital, 28905 Getafe, Spain"},{"name":"Department of Geriatrics, University Hospital of Getafe, 28905 Getafe, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6110-0265","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"L\u00e1zaro-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Diabetic Foot Unit, University Podiatry Clinic, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1038\/d41586-018-07429-3","article-title":"Superpowered skin","volume":"563","author":"Gould","year":"2018","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fbioe.2020.00146","article-title":"Extracellular Vesicles Derived From Mesenchymal Stem Cells (MSC) in Regenerative Medicine: Applications in Skin Wound Healing","volume":"8","author":"Dorado","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.fsc.2011.06.009","article-title":"Skin: Histology and physiology of wound healing","volume":"19","author":"Gantwerker","year":"2011","journal-title":"Facial Plast. Surg. Clin. N. Am."},{"key":"ref_4","unstructured":"Neligan, P. (2017). Neligan Plastic Surgery: Volume One, Elsevier."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0002-9610(03)00303-9","article-title":"A specialized wound-healing center concept: Importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds","volume":"187","author":"Gottrup","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human Wounds and Its Burden: An Updated Compendium of Estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv. Wound Care"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Rani Raju, N., Silina, E., Stupin, V., Manturova, N., Chidambaram, S.B., and Achar, R.R. (2022). Multifunctional and Smart Wound Dressings\u2014A Review on Recent Research Advancements in Skin Regenerative Medicine. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081574"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eurpolymj.2017.12.046","article-title":"Hydrogel wound dressings for bioactive treatment of acute and chronic wounds","volume":"100","author":"Koehler","year":"2018","journal-title":"Eur. Polym. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"B\u00eerc\u0103, A.C., Chircov, C., Niculescu, A.G., Hildegard, H., Balt\u0103, C., Ro\u0219u, M., Mladin, B., Gherasim, O., Mihaiescu, D.E., and Vasile, B.\u0218. (2023). H2O2-PLA-(Alg)2Ca Hydrogel Enriched in Matrigel\u00ae Promotes Diabetic Wound Healing. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030857"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tavakoli, S., and Klar, A.S. (2020). Advanced Hydrogels as Wound Dressings. Biomolecules, 10.","DOI":"10.3390\/biom10081169"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"718377","DOI":"10.3389\/fbioe.2021.718377","article-title":"Biomimetic Hydrogels to Promote Wound Healing","volume":"9","author":"Fan","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Casado-D\u00edaz, A., La Torre, M., Priego-Capote, F., Verd\u00fa-Soriano, J., L\u00e1zaro-Mart\u00ednez, J.L., Rodr\u00edguez-Ma\u00f1as, L., Berenguer P\u00e9rez, M., and Tunez, I. (2022). EHO-85: A Multifunctional Amorphous Hydrogel for Wound Healing Containing Olea europaea Leaf Extract: Effects on Wound Microenvironment and Preclinical Evaluation. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051229"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Casado-Diaz, A., Moreno-Rojas, J.M., Verd\u00fa-Soriano, J., L\u00e1zaro-Mart\u00ednez, J.L., Rodr\u00edguez-Ma\u00f1as, L., Tunez, I., Torre, M.L., P\u00e9rez, M.B., Priego-Capote, F., and Pereira-Caro, G. (2022). Evaluation of Antioxidant and Wound-Healing Properties of EHO-85, a Novel Multifunctional Amorphous Hydrogel Containing Olea europaea Leaf Extract. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020349"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Verd\u00fa-soriano, J., de Cristino-Espinar, M., Luna-morales, S., Dios-guerra, C., Caballero-villarraso, J., Moreno-moreno, P., Casado-d\u00edaz, A., Berenguer-p\u00e9rez, M., Guler-caama\u00f1o, I., and Laosa-zafra, O. (2022). Superiority of a Novel Multifunctional Amorphous Hydrogel Containing Olea europaea Leaf Extract (EHO-85) for the Treatment of Skin Ulcers: A Randomized, Active-Controlled Clinical Trial. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051260"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1039\/dc9786500065","article-title":"Structure and stability of concentrated boehmite sols","volume":"65","author":"Ramsay","year":"1978","journal-title":"Faraday Discuss. Chem. Soc."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tadros, T.F. (2012). Dispersion of Powders in Liquids and Stabilization of Suspensions, Wiley-VCH.","DOI":"10.1002\/9783527656592"},{"key":"ref_17","unstructured":"Haesler, E. (2014). Prevention and Treatment of Pressure Ulcers: Quick Reference Guide, Cambridge Media. [2014th ed.]."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/107110078100200202","article-title":"The Dysvascular Foot: A System for Diagnosis and Treatment","volume":"2","author":"Wagner","year":"1981","journal-title":"Foot Ankle Int."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1023\/B:PHAM.0000033006.11619.07","article-title":"Rheological characterization of topical carbomer gels neutralized to different pH","volume":"21","author":"Islam","year":"2004","journal-title":"Pharm. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1208\/s12249-017-0937-4","article-title":"Hydrogels Containing Antibiofilm and Antimicrobial Agents Beneficial for Biofilm-Associated Wound Infection: Formulation Characterizations and In vitro Study","volume":"19","author":"Anjum","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_21","first-page":"113","article-title":"Physical Properties of Glycerine","volume":"Volume 1","author":"Jungermann","year":"2018","journal-title":"Glycerin: A Key Cosmetic Ingredient"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0753-3322(03)00031-3","article-title":"Studies on skin aging. Preparation and properties of fucose-rich oligo- and polysaccharides. Effect on fibroblast proliferation and survival","volume":"57","author":"Isnard","year":"2003","journal-title":"Biomed. Pharmacother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0002-9343(00)00379-X","article-title":"Which venous leg ulcers will heal with limb compression bandages?","volume":"109","author":"Margolis","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1111\/wrr.12587","article-title":"Reliability and measurement error of digital planimetry for the measurement of chronic venous leg ulcers","volume":"25","author":"Stacey","year":"2017","journal-title":"Wound Repair Regen."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mezger, T. (2020). The Rheology Handbook: For Users of Rotational and Oscillatory Rheometers, Vincentz Network.","DOI":"10.1515\/9783748603702"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1515\/revce-2020-0016","article-title":"Carbomer microgels as model yield-stress fluids","volume":"38","author":"Jaworski","year":"2022","journal-title":"Rev. Chem. Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00396-002-0808-7","article-title":"Rheological properties and microstructures of Carbopol gel network system","volume":"281","author":"Kim","year":"2003","journal-title":"Colloid Polym. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jval.2017.07.007","article-title":"An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds","volume":"21","author":"Nussbaum","year":"2018","journal-title":"Value Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/jocn.13870","article-title":"The quality of life of people who have chronic wounds and who self-treat","volume":"27","author":"Kapp","year":"2018","journal-title":"J. Clin. Nurs."},{"key":"ref_30","first-page":"CD011226","article-title":"Hydrogel dressings for treating pressure ulcers","volume":"2015","author":"Dumville","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S2213-8587(17)30438-2","article-title":"Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): An international, multicentre, double-blind, randomised, controlled trial","volume":"6","author":"Edmonds","year":"2018","journal-title":"Lancet. Diabetes Endocrinol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1524-475X.2012.00797.x","article-title":"A randomized, controlled, double-blind prospective trial with a Lipido-Colloid Technology-Nano-OligoSaccharide Factor wound dressing in the local management of venous leg ulcers","volume":"20","author":"Meaume","year":"2012","journal-title":"Wound Repair Regen."},{"key":"ref_33","first-page":"CD010738","article-title":"Hydrogel dressings for venous leg ulcers","volume":"8","author":"Ribeiro","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_34","first-page":"339","article-title":"The pH of varicose ulcer surfaces and its relationship to healing","volume":"8","author":"Wilson","year":"1979","journal-title":"Vasa"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00403-006-0713-x","article-title":"Influence of pH on wound-healing: A new perspective for wound-therapy?","volume":"298","author":"Schneider","year":"2007","journal-title":"Arch. Dermatol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","article-title":"Oxidative stress in normal and impaired wound repair","volume":"58","author":"Werner","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e1901502","DOI":"10.1002\/adhm.201901502","article-title":"Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing","volume":"9","author":"Xu","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"ref_38","first-page":"38","article-title":"A cut above the rest: Oxidative stress in chronic wounds and the potential role of polyphenols as therapeutics","volume":"3","author":"Johnson","year":"2021","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1002\/jps.24610","article-title":"Advanced Therapeutic Dressings for Effective Wound Healing\u2014A Review","volume":"104","author":"Boateng","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1089\/wound.2012.0412","article-title":"Clinical Impact Upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments","volume":"2","author":"Junker","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Brumberg, V., Astrelina, T., Malivanova, T., and Samoilov, A. (2021). Modern Wound Dressings: Hydrogel Dressings. Biomedicines, 9.","DOI":"10.3390\/biomedicines9091235"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/ten.teb.2019.0281","article-title":"Design Considerations for Hydrogel Wound Dressings: Strategic and Molecular Advances","volume":"26","author":"Walboomers","year":"2020","journal-title":"Tissue Eng.-Part B Rev."},{"key":"ref_43","first-page":"5","article-title":"Acidic environment and wound healing: A review","volume":"27","author":"Nagoba","year":"2015","journal-title":"Wounds"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0168-1605(93)90199-Q","article-title":"Effect of three preservatives on the growth of Bacillus cereus, Vero cytotoxigenic Escherichia coli and Staphylococcus aureus, on plates with gradients of pH and sodium chloride concentration","volume":"17","author":"Thomas","year":"1993","journal-title":"Int. J. Food Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/000155500300012819","article-title":"Experimental Candida albicans lesions in healthy humans: Dependence on skin pH","volume":"80","author":"Runeman","year":"2000","journal-title":"Acta Derm. Venereol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Sim, P., Song, Y., Yang, G.N., Cowin, A.J., and Garg, S. (2022). In Vitro Wound Healing Properties of Novel Acidic Treatment Regimen in Enhancing Metabolic Activity and Migration of Skin Cells. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23137188"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/00000658-197312000-00011","article-title":"Chemical acidification of wounds. An adjuvant to healing and the unfavorable action of alkalinity and ammonia","volume":"178","author":"Leveen","year":"1973","journal-title":"Ann. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sim, P., Strudwick, X.L., Song, Y.M., Cowin, A.J., and Garg, S. (2022). Influence of Acidic pH on Wound Healing In Vivo: A Novel Perspective for Wound Treatment. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113655"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4103\/0970-0358.155263","article-title":"Effects of limited access dressing in chronic wounds: A biochemical and histological study","volume":"48","author":"Honnegowda","year":"2015","journal-title":"Indian J. Plast. Surg."},{"key":"ref_50","first-page":"16","article-title":"The pH changes of pressure ulcers related headling process of wound","volume":"4","author":"Tsukada","year":"1992","journal-title":"Wounds"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/iwj.12557","article-title":"Reactive oxygen species (ROS) and wound healing: The functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process","volume":"14","author":"Dunnill","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/14786419.2011.582842","article-title":"Phenolic compounds and antioxidant activity of olive leaf extracts","volume":"26","author":"Kontogianni","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1016\/j.biortech.2009.12.052","article-title":"Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract","volume":"101","author":"Lee","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_54","first-page":"25","article-title":"Evaluation of effect of oleuropein on skin wound healing in aged male BALB\/c mice","volume":"16","author":"Mehraein","year":"2014","journal-title":"Cell J."},{"key":"ref_55","first-page":"83","article-title":"Therapeutic effects of oleuropein on wounded skin in young male Balb\/c mice","volume":"26","author":"Mehraein","year":"2014","journal-title":"Wounds"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3923\/ijp.2018.963.972","article-title":"Biological activity of olive leaf extract and regulation of tissue transglutaminase expression in diabetic wound healing","volume":"14","year":"2018","journal-title":"Int. J. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.7326\/0003-4819-142-12_Part_2-200506211-00002","article-title":"Better information for better health care: The Evidence-based Practice Center program and the Agency for Healthcare Research and Quality","volume":"142","author":"Atkins","year":"2005","journal-title":"Ann. Intern. 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