{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:50:32Z","timestamp":1787784632740,"version":"build-2784847793"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T00:00:00Z","timestamp":1690156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2022-BS-154"],"award-info":[{"award-number":["2022-BS-154"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010018","name":"Doctoral Start-up Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["S202110163045"],"award-info":[{"award-number":["S202110163045"]}],"id":[{"id":"10.13039\/501100010018","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shenyang Pharmaceutical University","award":["2022-BS-154"],"award-info":[{"award-number":["2022-BS-154"]}]},{"name":"Shenyang Pharmaceutical University","award":["S202110163045"],"award-info":[{"award-number":["S202110163045"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Hydroxy-\u03b1-Sanshool (HAS) possesses various pharmacological properties, such as analgesia and regulating gastrointestinal function. However, the low oral bioavailability of HAS has limited its oral delivery in clinical application. Methods and Results: To enhance its oral bioavailability, a nanocomposite delivery system based on chitosan (CH, as the polycation) and sodium alginate (SA, as the polyanion) was prepared using a layer-by-layer coating technique. The morphology, thermal behavior and Fourier transform infrared spectrum (FTIR) showed that the obtained sodium alginate\/chitosan-coated HAS-loaded liposomes (SA\/CH-HAS-LIP) with core-shell structures have been successfully covered with polymers. When compared with HAS-loaded liposomes (HAS-LIP), SA\/CH-HAS-LIP displayed obvious pH sensitivity and a sustained-release behavior in in vitro studies, which fitted well to Weibull model. In vivo, the half-life of HAS from SA\/CH-HAS-LIP remarkably extended after oral administration compared to the free drug. Additionally, it allowed a 4.6-fold and 4.2-fold increase in oral bioavailability, respectively, compared with free HAS and HAS-LIP. Conclusions: SA\/CH-HAS-LIP could be a promising release vehicle for the oral delivery of HAS to increase its oral bioavailability.<\/jats:p>","DOI":"10.3390\/pharmaceutics15072010","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T03:03:25Z","timestamp":1690167805000},"page":"2010","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sodium Alginate\/Chitosan-Coated Liposomes for Oral Delivery of Hydroxy-\u03b1-Sanshool: In Vitro and In Vivo Evaluation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-2459","authenticated-orcid":false,"given":"Fengming","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-2772","authenticated-orcid":false,"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Faculty of Functional Food and Wine, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.3748\/wjg.v24.i35.4036","article-title":"Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel","volume":"24","author":"Hiraishi","year":"2018","journal-title":"World J. 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