{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:40:55Z","timestamp":1792597255946,"version":"4.5.0"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009573","name":"National University of Rosario (Argentina)","doi-asserted-by":"publisher","award":["PID 2019"],"award-info":[{"award-number":["PID 2019"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009573","name":"National University of Rosario (Argentina)","doi-asserted-by":"publisher","award":["PIP 3179"],"award-info":[{"award-number":["PIP 3179"]}],"id":[{"id":"10.13039\/100009573","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Scientific and Technical Research Council (Argentina)","award":["PID 2019"],"award-info":[{"award-number":["PID 2019"]}]},{"name":"National Scientific and Technical Research Council (Argentina)","award":["PIP 3179"],"award-info":[{"award-number":["PIP 3179"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5\u201310 mg\/kg), which since it is only available as tablets, hinders its administration to pediatric patients. Praziquantel is a poorly water-soluble drug which represents a challenge for its formulation in solution, particularly for the pediatric population. Thus, this study aimed to develop a palatable solution for praziquantel using pharmaceutical-accepted co-solvent systems. A design of experiments approach was applied to identify the optimal conditions for achieving a suitable amount of praziquantel in solution using co-solvent mixtures. Thus, praziquantel solubility increased from 0.38 up to 43.50 mg\/mL in the optimized system. A taste masking assay in healthy human volunteers confirmed a successful reduction of drug bitterness after the addition of selected flavors and a sweetener. Stability studies were also conducted at different temperatures (4, 25, and 40 \u00b0C) for 12 months Even though the presence of the three known impurities of praziquantel was observed, their amounts never exceeded the acceptance criteria of the USP. Thus, this novel approach should be considered a valuable alternative for further preclinical studies considering the high prevalence of this infection worldwide.<\/jats:p>","DOI":"10.3390\/pharmaceutics15082050","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T01:39:32Z","timestamp":1690767572000},"page":"2050","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery"],"prefix":"10.3390","volume":"15","author":[{"given":"Giselle","family":"Bedogni","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Rosario, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IQUIR-CONICET), Suipacha 531, Rosario 2000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Garcia","sequence":"additional","affiliation":[{"name":"Planta Piloto de Producci\u00f3n de Medicamentos, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Universidad Nacional de Rosario, Suipacha 570, Rosario 2000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-7073","authenticated-orcid":false,"given":"Katia","family":"Seremeta","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Procesos Tecnol\u00f3gicos Avanzados, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Universidad Nacional del Chaco Austral (INIPTA-CONICET-UNCAUS), Cte. Fern\u00e1ndez 755, Presidencia Roque S\u00e1enz Pe\u00f1a 3700, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Okulik","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Procesos Tecnol\u00f3gicos Avanzados, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Universidad Nacional del Chaco Austral (INIPTA-CONICET-UNCAUS), Cte. Fern\u00e1ndez 755, Presidencia Roque S\u00e1enz Pe\u00f1a 3700, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Salomon","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Rosario, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (IQUIR-CONICET), Suipacha 531, Rosario 2000, Argentina"},{"name":"\u00c1rea T\u00e9cnica Farmac\u00e9utica, Departamento de Farmacia, Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas, Suipacha 531, Universidad Nacional de Rosario, Rosario 2000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105075","DOI":"10.1016\/j.actatropica.2019.105075","article-title":"Taeniasis and cysticercosis in Asia: A review with emphasis on molecular approaches and local lifestyles","volume":"198","author":"Ito","year":"2019","journal-title":"Acta Trop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105133","DOI":"10.1016\/j.actatropica.2019.105133","article-title":"High prevalence of taeniasis and Taenia solium cysticercosis in children in western Sichuan, China","volume":"199","author":"Li","year":"2019","journal-title":"Acta Trop."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.tmaid.2017.12.006","article-title":"Mapping the residual incidence of taeniasis and cysticercosis in Colombia, 2009\u20132013, using geographical information systems: Implications for public health and travel medicine","volume":"22","author":"Flisser","year":"2018","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0891-5520(05)70220-8","article-title":"Taenia solium cisticercosis","volume":"14","author":"Garcia","year":"2000","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_5","first-page":"406","article-title":"Human taeniasis\/cysticercosis: A potentially emerging parasitic disease in Europe","volume":"31","author":"Symeonidou","year":"2018","journal-title":"Ann. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1017\/S0031182013001303","article-title":"Advances in diagnosis and spatial analysis of cysticercosis and taeniasis","volume":"140","author":"Raoul","year":"2013","journal-title":"Parasitology"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Carabin, H., Ndimubanzi, P.C., Budke, C.M., Nguyen, H., Qian, L.D., Cowan, Y., Stoner, J.A., Rainwater, E., and Dickey, M. (2011). Clinical manifestations associated with neurocysticercosis: A systematic review. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001152"},{"key":"ref_8","unstructured":"(2022, April 24). World Health Organization Model List of Essential Medicines\u201422nd List. Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-MHP-HPS-EML-2021.02."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/tmi.12152","article-title":"Practical dosing of praziquantel for schistosomiasis in preschool-aged children","volume":"18","author":"Olliaro","year":"2013","journal-title":"Trop. Med. Int. Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ijpharm.2015.05.013","article-title":"Formulation factors affecting acceptability of oral medicines in children","volume":"492","author":"Liu","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12247-018-9323-3","article-title":"Subdivision of tablets containing modified delivery technology: The case of orally disintegrating tablets","volume":"13","author":"Temer","year":"2018","journal-title":"J. Pharm. Innov."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Meyer, T., Sekljic, H., Fuchs, S., Bothe, H., Schollmeyer, D., and Miculka, C. (2009). Taste, a new incentive to switch to (R)-praziquantel in schistosomiasis treatment. PLoS Negl. Trop. Dis., 3.","DOI":"10.1371\/journal.pntd.0000357"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actatropica.2012.12.003","article-title":"Safety and efficacy of praziquantel syrup (Epiquantel\u00ae) against Schistosoma haematobium and Schistosoma mansoni in preschool-aged children in Niger","volume":"128","author":"Garba","year":"2013","journal-title":"Acta Trop."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.01.033","article-title":"In vitro characterization of some biopharmaceutical properties of praziquantel","volume":"295","author":"Rivera","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jddst.2018.03.009","article-title":"Solid dispersion of praziquantel enhanced solubility and improve the efficacy of the schistosomiasis treatment","volume":"45","author":"Rezende","year":"2018","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Borrego-S\u00e1nchez, A., S\u00e1nchez-Espejo, R., Garc\u00eda-Vill\u00e9n, F., Viseras, C., and Sainz-D\u00edaz, I. (2020). Praziquantel\u2013clays as accelerated release systems to enhance the low solubility of the drug. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12100914"},{"key":"ref_17","unstructured":"(2022, April 24). The Pediatric Praziquantel Consortium. Available online: https:\/\/www.pediatricpraziquantelconsortium.org\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1208\/s12249-019-1548-z","article-title":"Orphan formulations in pediatric Schistosomiasis treatment: Development and characterization of praziquantel nanoparticle-loaded powders for reconstitution","volume":"20","author":"Gonzalez","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ejps.2017.08.034","article-title":"Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel","volume":"109","author":"Schoch","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Albertini, B., Perissutti, B., Bertoni, S., Zanolla, D., Franceschinis, E., Voinovich, D., Lombardo, F., Keise, J., and Passerini, N. (2019). Combining mechanochemistry and spray congealing for new praziquantel pediatric formulations in schistosomiasis treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051233"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Boniatti, J., Januskaite, P., da Fonseca, L.B., Vi\u00e7osa, A.L., Amendoeira, F.C., Tuleu, C., Basit, A.W., Goyanes, A., and R\u00e9, M.I. (2021). Direct powder extrusion 3d printing of praziquantel to overcome neglected disease formulation challenges in paediatric populations. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081114"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s40249-017-0336-9","article-title":"Developing a comprehensive response for treatment of children under 6 years of age with schistosomiasis: Research and development of a pediatric formulation of praziquantel","volume":"6","author":"Klohe","year":"2017","journal-title":"Infect. Dis. Poverty"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.xphs.2020.12.036","article-title":"Paediatric medicines\u2014Regulatory drivers, restraints, opportunities and challenges","volume":"110","author":"Vieira","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/jps.21060","article-title":"Physical and biological considerations for the use of nonaqueous solvents in oral bioavailability enhancement","volume":"97","author":"Pole","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2005.05.006","article-title":"Paediatric formulations\u2014Getting to the heart of the problem","volume":"300","author":"Standing","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jps.22325","article-title":"Development of quality-by-design analytical methods","volume":"100","author":"Vogt","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1208\/s12248-014-9598-3","article-title":"Understanding pharmaceutical quality by design","volume":"16","author":"Yu","year":"2014","journal-title":"AAPS J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"101684","DOI":"10.1016\/j.jddst.2020.101684","article-title":"QbD based approach for formulation development of spray dried microparticles of erlotinib hydrochloride for sustained release","volume":"57","author":"Soni","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rouaz, K., Chiclana-Rodr\u00edguez, B., Nardi-Ricart, A., Su\u00f1\u00e9-Pou, M., Mercad\u00e9-Frutos, D., Su\u00f1\u00e9-Negre, J.M., P\u00e9rez-Lozano, P., and Garc\u00eda-Montoya, E. (2021). Excipients in the paediatric population: A review. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13030387"},{"key":"ref_30","unstructured":"(2022, April 24). Drug Bank-Praziquantel. Available online: https:\/\/go.drugbank.com\/drugs\/DB01058."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1542\/peds.73.3.405","article-title":"Ethanol in liquid preparations intended for children","volume":"73","author":"Pruitt","year":"1984","journal-title":"Pediatrics"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.curtheres.2014.09.002","article-title":"Ethanol pharmacokinetics in neonates and infants","volume":"76","author":"Marek","year":"2014","journal-title":"Curr. Ther. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHAM.0000016235.32639.23","article-title":"Solubilizing excipients in oral and injectable formulations","volume":"21","author":"Strickley","year":"2004","journal-title":"Pharm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1208\/s12249-008-9112-2","article-title":"Development and chemical stability studies of alcohol-free phenobarbital solution for use in pediatrics: A technical note","volume":"9","author":"Jelveghari","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/tmi.12980","article-title":"Development and in vitro\/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach","volume":"22","author":"Real","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1248\/bpb.31.1045","article-title":"Transdermal delivery of praziquantel: Effects of solvents on permeation across rabbit skin","volume":"31","author":"Zheng","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1021\/acs.jced.9b01051","article-title":"Solubility of d-Histidine in aqueous cosolvent mixtures of N,N-dimethylformamide, ethanol, dimethyl sulfoxide, and N-methyl-2-pyrrolidone: Determination, preferential solvation, and solvent effect","volume":"65","author":"Li","year":"2020","journal-title":"J. Chem. Eng. Data"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3109\/03639045.2014.886695","article-title":"Formulation of solid self-nanoemulsifying drug delivery systems using N-methyl pyrrolidone as cosolvent","volume":"41","author":"Agrawal","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113859","DOI":"10.1016\/j.molliq.2020.113859","article-title":"Solubility of codeine phosphate in N-methyl-2-pyrrolidone + 2-propanol mixture at different temperatures","volume":"316","author":"Rezaei","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.molliq.2019.02.038","article-title":"Solubility of ketoconazole in N-methyl-2-pyrrolidone + water mixtures at T = (293.2 to 313.2) K","volume":"281","author":"Hatefi","year":"2019","journal-title":"J. Mol. Liq."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"115287","DOI":"10.1016\/j.molliq.2021.115287","article-title":"Solubility study of ketoconazole in the mixtures of N-methyl-2-pyrrolidone and ethanol at different temperatures","volume":"326","author":"Moradi","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2015.11.015","article-title":"Polyethylene glycols in oral and parenteral formulations\u2014A critical review","volume":"496","author":"Gullapalli","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1002\/cphc.201500146","article-title":"Controlling the formation of ionic-liquid-based aqueous biphasic systems by changing the hydrogen-bonding ability of polyethylene glycol end groups","volume":"16","author":"Pereira","year":"2015","journal-title":"Chem. Phys. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1208\/s12249-008-9050-z","article-title":"Solubility improvement of drugs using N-methyl pyrrolidone","volume":"9","author":"Sanghvi","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijpharm.2013.07.049","article-title":"Assessing the impact of nimodipine devitrification in the ternary cosolvent system through quality by design approach","volume":"455","author":"Rahman","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Haby, M.M., Sosa Leon, L.A., Lucia\u00f1ez, A., Nicholls, R.S., Reveiz, L., and Donadeu, M. (2020). Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007873"},{"key":"ref_47","unstructured":"Clayton, G.D., and Clayton, F.E. (1982). Industrial Hygiene and Toxicology, Wiley & Sons."},{"key":"ref_48","unstructured":"(2022, April 24). Scientific Panel on Food Additives FPA and M in C with F. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission Related to an Application on the Use of Polyethylene Glycol (PEG) as a Film Coating Agent for Use in Food Supplement Products. Available online: https:\/\/www.efsa.europa.eu\/en\/efsajournal\/pub\/414."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/toxsci\/kfq207","article-title":"Comprehensive investigation of hydroxypropyl methylcellulose, propylene glycol, polysorbate 80, and hydroxypropyl-beta-cyclodextrin for use in general toxicology studies","volume":"117","author":"Thackaberry","year":"2010","journal-title":"Toxicol. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1000e113","DOI":"10.4172\/2161-0495.1000e113","article-title":"Propylene glycol in neonates: Never prescribed, frequently administered, hardly evaluated","volume":"2","author":"Allegaert","year":"2012","journal-title":"J. Clin. Toxicol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1091581815622442","article-title":"Daly. Tolerable levels of nonclinical vehicles and formulations used in studies by multiple routes in multiple species with notes on methods to improve utility","volume":"35","author":"Gad","year":"2016","journal-title":"Int. J. Toxicol."},{"key":"ref_52","unstructured":"(2023, June 13). Acute Toxicity. Available online: https:\/\/www.ilo.org\/legacy\/english\/protection\/safework\/ghs\/ghsfinal\/ghsc05.pdf."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1055\/s-0034-1389985","article-title":"Toxicity study of a self-nanoemulsifying drug delivery system containing N-methyl pyrrolidone","volume":"65","author":"Agrawal","year":"2015","journal-title":"Drug Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s40268-013-0012-x","article-title":"Open-label taste-testing study to evaluate the acceptability of both strawberry-flavored and orange-flavored amylmetacresol\/2,4-dichlorobenzyl alcohol throat lozenges in healthy children","volume":"13","author":"Thompson","year":"2013","journal-title":"Drugs R&D"},{"key":"ref_55","first-page":"387","article-title":"Chewable Tablets","volume":"Volume 1","author":"Lieberman","year":"1981","journal-title":"Pharmaceutical Dosage Forms"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.clinthera.2013.06.007","article-title":"The bad taste of medicines: Overview of basic research on bitter taste","volume":"35","author":"Mennella","year":"2013","journal-title":"Clin. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.addr.2014.02.012","article-title":"Playing hide and seek with poorly tasting paediatric medicines: Do not forget the excipients","volume":"73","author":"Walsh","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jddst.2018.11.002","article-title":"Development and stability of an oral suspension of procarbazine in pediatrics","volume":"49","author":"Bravo","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1081\/DDC-120037477","article-title":"Taste masking technologies in oral pharmaceuticals: Recent developments and approaches","volume":"30","author":"Sohi","year":"2004","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_60","first-page":"8043837","article-title":"Toward improving medication adherence: The suppression of bitter taste in edible taste films","volume":"18","author":"Cherian","year":"2018","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_61","unstructured":"Promoting the Quality of Medicines (PQM) (2019). Product Information Report: Praziquantel."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijpharm.2009.05.007","article-title":"Characterization and in vitro release of praziquantel from poly(\u03b5-caprolactone) implants","volume":"377","author":"Cheng","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_63","first-page":"10526","article-title":"Preparation and characterization of a new solid form of praziquantel, an essential anthelmintic drug. Praziquantel racemic monohydrate","volume":"146","author":"Maggio","year":"2020","journal-title":"Eur. J. Pharm. Sci."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/8\/2050\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:22:45Z","timestamp":1760127765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/8\/2050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,30]]},"references-count":63,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["pharmaceutics15082050"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15082050","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,30]]}}}