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These diseases are characterized by persistent inflammation in the airways, leading to structural changes and compromised lung function. There are several treatments available for them, such as bronchodilators, immunomodulators, and oxygen therapy. However, there are still some shortcomings in the effectiveness and side effects of drugs. To achieve optimal therapeutic outcomes while minimizing systemic side effects, targeted therapies and precise drug delivery systems are crucial to the management of these diseases. This comprehensive review focuses on the role of drug delivery systems in chronic inflammatory respiratory diseases, particularly nanoparticle-based drug delivery systems, inhaled corticosteroids (ICSs), novel biologicals, gene therapy, and personalized medicine. By examining the latest advancements and strategies in these areas, we aim to provide a thorough understanding of the current landscape and future prospects for improving treatment outcomes in these challenging conditions.<\/jats:p>","DOI":"10.3390\/pharmaceutics15082151","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T10:42:29Z","timestamp":1692268949000},"page":"2151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Advancing Treatment Strategies: A Comprehensive Review of Drug Delivery Innovations for Chronic Inflammatory Respiratory Diseases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6922-1426","authenticated-orcid":false,"given":"Junming","family":"Wang","sequence":"first","affiliation":[{"name":"Center of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"},{"name":"Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai 201508, China"},{"name":"Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"},{"name":"Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai 201508, China"},{"name":"Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Shao","sequence":"additional","affiliation":[{"name":"Center of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"},{"name":"Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai 201508, China"},{"name":"Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0137-5678","authenticated-orcid":false,"given":"Daikun","family":"He","sequence":"additional","affiliation":[{"name":"Center of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, China"},{"name":"Research Center for Chemical Injury, Emergency and Critical Medicine of Fudan University, Shanghai 201508, China"},{"name":"Key Laboratory of Chemical Injury, Emergency and Critical Medicine of Shanghai Municipal Health Commission, Shanghai 201508, China"},{"name":"Department of General Practice, Jinshan Hospital, Fudan University, Shanghai 201508, China"},{"name":"Department of General Practice, Zhongshan Hospital, Fudan University, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2102730","DOI":"10.1183\/13993003.02730-2021","article-title":"Global Initiative for Asthma Strategy 2021: Executive summary and rationale for key changes","volume":"59","author":"Reddel","year":"2021","journal-title":"Eur. 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