{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:00:07Z","timestamp":1792897207568,"version":"4.5.0"},"reference-count":96,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID), FONDECYT Postdoctoral Project","award":["3210302"],"award-info":[{"award-number":["3210302"]}],"id":[{"id":"https:\/\/ror.org\/05btm5233","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo (ANID), FONDECYT Postdoctoral Project","award":["DI21-0060"],"award-info":[{"award-number":["DI21-0060"]}],"id":[{"id":"https:\/\/ror.org\/05btm5233","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Directorate of Universidad de La Frontera, DIUFRO project","award":["3210302"],"award-info":[{"award-number":["3210302"]}],"id":[{"id":"https:\/\/ror.org\/04v0snf24","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Research Directorate of Universidad de La Frontera, DIUFRO project","award":["DI21-0060"],"award-info":[{"award-number":["DI21-0060"]}],"id":[{"id":"https:\/\/ror.org\/04v0snf24","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Biofilms are responsible for the most prevalent oral infections such as caries, periodontal disease, and pulp and periapical lesions, which affect the quality of life of people. Antibiotics have been widely used to treat these conditions as therapeutic and prophylactic compounds. However, due to the emergence of microbial resistance to antibiotics, there is an urgent need to develop and evaluate new antimicrobial agents. This scoping review offers an extensive and detailed synthesis of the potential role of selenium nanoparticles (SeNPs) in combating oral pathogens responsible for causing infectious diseases. A systematic search was conducted up until May 2022, encompassing the MEDLINE, Embase, Scopus, and Lilacs databases. We included studies focused on evaluating the antimicrobial efficacy of SeNPs on planktonic and biofilm forms and their side effects in in vitro studies. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of twenty-two articles were considered eligible for this scoping review. Most of the studies reported relevant antimicrobial efficacy against C. albicans, S. mutans, E. faecalis, and P. gingivalis, as well as effective antioxidant activity and limited toxicity. Further research is mandatory to critically assess the effectiveness of this alternative treatment in ex vivo and in vivo settings, with detailed information about SeNPs concentrations employed, their physicochemical properties, and the experimental conditions to provide enough evidence to address the construction and development of well-designed and safe protocols.<\/jats:p>","DOI":"10.3390\/pharmaceutics15092253","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:42:53Z","timestamp":1693474973000},"page":"2253","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5642-6965","authenticated-orcid":false,"given":"Eul\u00e0lia","family":"Sans-Serramitjana","sequence":"first","affiliation":[{"name":"Center of Plant, Soil Interaction and Natural Resources Biotechnology, Scientific and Biotechnological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Obreque","sequence":"additional","affiliation":[{"name":"Center for Research in Dental Sciences (CICO), Endodontic Laboratory, Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Center for Research in Dental Sciences (CICO), Endodontic Laboratory, Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-6956","authenticated-orcid":false,"given":"Carlos","family":"Zaror","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontics, Faculty of Dentistry, Universidad de La Frontera, Manuel Montt #112, Temuco 4811230, Chile"},{"name":"Center for Research in Epidemiology, Economics and Oral Public Health (CIEESPO), Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7474-1595","authenticated-orcid":false,"given":"Mar\u00eda de La Luz","family":"Mora","sequence":"additional","affiliation":[{"name":"Center of Plant, Soil Interaction and Natural Resources Biotechnology, Scientific and Biotechnological Bioresource Nucleus (BIOREN-UFRO), Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-3386","authenticated-orcid":false,"given":"Miguel","family":"Vi\u00f1as","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology & Antimicrobials, Department of Pathology & Experimental Therapeutics, Faculty of Medicine & Health Sciences, University of Barcelona, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Betancourt","sequence":"additional","affiliation":[{"name":"Center for Research in Dental Sciences (CICO), Endodontic Laboratory, Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Department of Integral Adultos, Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Farah, C., Balasubramaniam, R., and McCullough, M. 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