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However, its therapeutic effect is limited due to its low solubility, poor stability, and high gut-liver first-pass metabolism, resulting in very low oral bioavailability. In this study, we developed a DMY-loaded self-emulsifying drug delivery system (DMY-SEDDS) to enhance the oral bioavailability and anti-alcoholism effect of DMY. DMY-SEDDS improved the oral absorption of DMY by facilitating lymphatic transport. The area under the concentration-time curve (AUC) of DMY in the DMY-SEDDS group was 4.13-fold higher than in the DMY suspension group. Furthermore, treatment with DMY-SEDDS significantly enhanced the activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) in the liver of mice (p &lt; 0.05). Interestingly, DMY-SEDDS also increased ADH activity in the stomach of mice with alcoholism (p &lt; 0.01), thereby enhancing ethanol metabolism in the gastrointestinal tract and reducing ethanol absorption into the bloodstream. As a result, the blood alcohol concentration of mice with alcoholism was significantly decreased after DMY-SEDDS treatment (p &lt; 0.01). In the acute alcoholism mice model, compared to saline treatment, DMY-SEDDS prolonged the onset of LORR (loss of righting reflex) (p &lt; 0.05) and significantly shortened the duration of LORR (p &lt; 0.01). Additionally, DMY-SEDDS treatment significantly reduced gastric injury in acute alcoholism mice. Collectively, these findings demonstrate the potential of DMY-SEDDS as a treatment in the treatment of alcoholism.<\/jats:p>","DOI":"10.3390\/pharmaceutics15092296","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:57:17Z","timestamp":1694159837000},"page":"2296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect"],"prefix":"10.3390","volume":"15","author":[{"given":"Jianxia","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"},{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3667-364X","authenticated-orcid":false,"given":"Shu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Natural Products, West China School of Pharmacy, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamin","family":"Mao","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4609-2477","authenticated-orcid":false,"given":"Qiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ye","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Materia Medica, Structure-Specific Small Molecule Drugs Key Laboratory of Sichuan Provincial Universities, School of Pharmacy, Chengdu Medical College, Chengdu 610500, China"},{"name":"Development and Regeneration Key Lab of Sichuan Province, Department of Pathology, Department of Anatomy and Histology and Embryology, Chengdu Medical College, Chengdu 610500, China"},{"name":"Chengdu Nature\u2019s Grace Biological Technology Co., Ltd., Chengdu 610213, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2019). 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