{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:35Z","timestamp":1791996635022,"version":"4.4.0"},"reference-count":75,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Bialystok","award":["B.SUB.23.403"],"award-info":[{"award-number":["B.SUB.23.403"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The mucosal membrane of the oral cavity, due to its unique structure and availability, constitutes an appropriate site for the delivery of drugs, both with local and systemic effects. Mucoadhesive buccal films are drug dosage forms that due to their convenience of application, flexibility and size, are characterized by patients\u2019 compliance. Sodium alginate and pectin are natural polymers from the polysaccharides group, with mucoadhesive properties, that are widely applied to obtain buccal films. However, their hydrophilic nature and poor water resistance limit their application in sustained drug release formulations. Hence, the aim of this investigation was to design alginate\/pectin buccal films by a one-step crosslinking technique\u2014with the application of calcium carbonate. This technique was applied to prepare crosslinked alginate and alginate\/pectin mucoadhesive films with a model antifungal drug\u2014posaconazole. The obtained formulations were evaluated for the impact of crosslinking and pectin\u2019s presence on their pharmaceutical, mucoadhesive, mechanical and physicochemical properties. Additionally, the antifungal activity of the prepared films against Candida spp. was evaluated. It was shown that pectin\u2019s presence in the formulations improved flexibility, mucoadhesion and antifungal activity. The crosslinking process reduced mucoadhesiveness and antifungal activity but significantly enhanced the mechanical properties and stability and enabled prolonged drug release.<\/jats:p>","DOI":"10.3390\/pharmaceutics15102415","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:28:29Z","timestamp":1696318109000},"page":"2415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mucoadhesive Alginate\/Pectin Films Crosslinked by Calcium Carbonate as Carriers of a Model Antifungal Drug\u2014Posaconazole"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-5350","authenticated-orcid":false,"given":"Marta","family":"Szekalska","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bia\u0142ystok, Mickiewicza 2C, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5025-4864","authenticated-orcid":false,"given":"Anna","family":"Czajkowska-Ko\u015bnik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bia\u0142ystok, Mickiewicza 2C, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-9883","authenticated-orcid":false,"given":"Bartosz","family":"Maciejewski","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Gda\u0144sk, Hallera 107, 80-416 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6191-6053","authenticated-orcid":false,"given":"Iwona","family":"Misztalewska-Turkowicz","sequence":"additional","affiliation":[{"name":"Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Bia\u0142ystok, Cio\u0142kowskiego 1K, 15-245 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka Zofia","family":"Wilczewska","sequence":"additional","affiliation":[{"name":"Department of Polymers and Organic Synthesis, Faculty of Chemistry, University of Bia\u0142ystok, Cio\u0142kowskiego 1K, 15-245 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1744-2932","authenticated-orcid":false,"given":"Jurga","family":"Bernatoniene","sequence":"additional","affiliation":[{"name":"Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Sukileliu pr. 13, LT-50161 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1013-610X","authenticated-orcid":false,"given":"Katarzyna","family":"Winnicka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bia\u0142ystok, Mickiewicza 2C, 15-222 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1773-2247(13)50055-4","article-title":"Mucosal drug delivery: Barriers, in vitro models and formulation strategies","volume":"23","author":"Boegh","year":"2013","journal-title":"J. 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